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VVPGNVGFAEMADRLADASAASQRMMTATAERAGRDLGGVLNALALLRENTAVPDVLQQAGLEVCRTAVF DWVMVSRVAGSTWRPVVRYEMGADGRVTVDVDESGCGVDTSDIPLMSPLVEAEVVRRRLPALVLDAGHEP RVHRPLVDRAGTTQYVVAPVVVEGAVIGLIHASSAAPGRVLTDLDRDLLRMFADGVGLVYERAALAERSE RQRCAVTEVCDAAVRSFDEVNPIAAFGLGSEPGLVSPDGDSVPAPFAGICESRGAGRGGTRLARLTARER EVLALLASGATNAQLADRLTVAESTVKSHVKHILHKLGAGNRAAAIACYLRESPDRERQRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0348 | - | - | 100% (341) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_3973 | - | 6e-37 | 34.16% (322) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_0349 | - | 8e-37 | 36.09% (327) | response regulator receiver protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 1e-09 | 43.90% (82) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_0730 | - | 8e-10 | 30.86% (175) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3133c | devR | 1e-09 | 43.90% (82) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1522 | - | 4e-11 | 53.23% (62) | putative two-component system response regulator LuxR |
| M. marinum M | MMAR_2876 | - | 4e-39 | 34.64% (332) | putative regulatory protein |
| M. avium 104 | MAV_5280 | - | 9e-10 | 47.54% (61) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0331 | - | 3e-73 | 50.30% (334) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_4501 | - | 1e-36 | 33.13% (323) | PUTATIVE conserved hypothetical regulatory protein |
| M. ulcerans Agy99 | MUL_2876 | - | 1e-38 | 35.63% (334) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0348|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0331|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2876|M.marinum_M ----------------MIDAVDMPDPPAFPTLADDEHPGWASRPIRESDA
MUL_2876|M.ulcerans_Agy99 MGFSPRRAIPERTVGGVIDVVDMPDPPAFPTLADDEHPGWASRPIRESDA
TH_4501|M.thermoresistible__bu ----------------MTIAGDVPDSGSDETLAG--HPGWASRPAAESDA
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0348|M.vanbaalenii_PYR-1 -----------------------MVPGN---------------VGFAEMA
MSMEG_0331|M.smegmatis_MC2_155 -----------------------MMTTKERPIGTELLSRSSSAVATTLLS
MMAR_2876|M.marinum_M TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESLGDVHAVNAL
MUL_2876|M.ulcerans_Agy99 TRHYREAFGDCNVDPTDDPMAVVAEAIDVNAAAVRHALESQGDVHAVNAL
TH_4501|M.thermoresistible__bu ARRYRETFADWGVDPTDDPMSVVSEAIDTRANEVRNALETCGDEEAIAAL
MAB_1522|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5280|M.avium_104 --------------------------------------------------
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0348|M.vanbaalenii_PYR-1 DRLADASAASQRMMTATAERAGRDLGGVLNALALLRENTAVPDVLQQAGL
MSMEG_0331|M.smegmatis_MC2_155 EKAFAAGRATHRDLASPGEQISAALDALLASLDEVRQATSPAETLECAPR
MMAR_2876|M.marinum_M ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
MUL_2876|M.ulcerans_Agy99 ETLLDLSSLEREMIEDGAARRTLALLQVQEALSKLRAVDDVAMIVDRAPR
TH_4501|M.thermoresistible__bu ESVLDLCSLERELIEDGAQRRTFALLQVQEGLSKLRAVDDVATIVDRAPR
MAB_1522|M.abscessus_ATCC_1997 ----------------------------------------------MTD-
MAV_5280|M.avium_104 ----------------------------------------------MTDP
Mb3157c|M.bovis_AF2122/97 --------------------------------------------------
Rv3133c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0730|M.gilvum_PYR-GCK -----------------------------------------------MTG
Mvan_0348|M.vanbaalenii_PYR-1 EVCRTAVFDWVMVSRVAGSTWRPVVRYEMGADGRVTVDVDES-GCGVDTS
MSMEG_0331|M.smegmatis_MC2_155 ALATSAVFQRVMLSRVSGSTWLPDAVYGVDGQRRRDVRFECYPDERLEDL
MMAR_2876|M.marinum_M ELVESCGFDRAVLFRVHEGRMVMESAYFGEDREGAEKMVAFA-----QSV
MUL_2876|M.ulcerans_Agy99 ELVESCGFDRAVLFRVHEGRLVMESAYFGEDREGAEKMVAFA-----QSV
TH_4501|M.thermoresistible__bu ELVESCGFDRAVLFRVHEGRMFMESAYFGEDRAGAEKMVAFA-----QSV
MAB_1522|M.abscessus_ATCC_1997 -TEVGVLLVDDQELVRTG--LRRILRRKDGFAIVGECADGSEVAAAVSRA
MAV_5280|M.avium_104 APEITVLLVDDQDLVRSG--LRRILRRKDGFVIVAECADGDEVPAAVAAH
Mb3157c|M.bovis_AF2122/97 --MVKVFLVDDHEVVRRG--LVDLLGADPELDVVGEAGSVAEAMARVPAA
Rv3133c|M.tuberculosis_H37Rv --MVKVFLVDDHEVVRRG--LVDLLGADPELDVVGEAGSVAEAMARVPAA
Mflv_0730|M.gilvum_PYR-GCK PGRVRVVVGDDHPMFRDG--VVRALQSSGAIDVVAEADDGTAALAAIREH
Mvan_0348|M.vanbaalenii_PYR-1 DIPLMSPLVEAEVVRRRLPALVLDAGHEPRVHRPLVDRAGTTQYVVAPVV
MSMEG_0331|M.smegmatis_MC2_155 QIPLASPLVEAEVVRRRLPALVSDAHHETRVHPPLIERMQAGEYVVAPIT
MMAR_2876|M.marinum_M APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
MUL_2876|M.ulcerans_Agy99 APLLDHMLIETQMIRRHAPAIVRDARNDPRVNRPIVDFSLTHSYVAAPVM
TH_4501|M.thermoresistible__bu APPLDHMLLETQMIRRHAPAIVRDARNDPRVNRPIVEFSMTRSYVAAPVM
: : : . : * : . . .
MAB_1522|M.abscessus_ATCC_1997 RPDVVIMDLRMKQMSGIEAIR-LLHAAQGPPALALTTFDDDELLSGALRA
MAV_5280|M.avium_104 RPDVVVMDLRMRRVDGIEATR-RLGGR--PPVLALTTFNEDELLSGALRA
Mb3157c|M.bovis_AF2122/97 RPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILA
Rv3133c|M.tuberculosis_H37Rv RPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILA
Mflv_0730|M.gilvum_PYR-GCK RPAVALLDYRMPGMDGAEVAAAVQRGALPTRVLLISAHDESAIVYRALAD
Mvan_0348|M.vanbaalenii_PYR-1 VEGAVIGLIHASSAAPGRVLTDLDRDLLRMFADGVGLVYERAALAERSER
MSMEG_0331|M.smegmatis_MC2_155 AGSTVLGLLHASRPTDGRPLTTAHRDLLRMFADGVGLSYEHALLVERIER
MMAR_2876|M.marinum_M PTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
MUL_2876|M.ulcerans_Agy99 PTGKMIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
TH_4501|M.thermoresistible__bu PTGKVIGFLHADRLYSGRIVDEIDRDTVWAFAEGFGYAYERTVLLERMRR
: : . . . :
MAB_1522|M.abscessus_ATCC_1997 GAAGFILKDSPAEELVRAVHAVARGEAYLDPAVTSRVLNAYRRAPAAV--
MAV_5280|M.avium_104 GAAGFVLKDSSAEELIRAVRAVARGEGYLDPAVTSRVLTTYRKAAPGP--
Mb3157c|M.bovis_AF2122/97 GASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAE----
Rv3133c|M.tuberculosis_H37Rv GASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAE----
Mflv_0730|M.gilvum_PYR-GCK GAAGFLPKESTRNELITAVLDCAKGRDVVAPSLAAGLAGEIRRRAE----
Mvan_0348|M.vanbaalenii_PYR-1 QRCAVTEVCDAAVRSFDEVNPIAAFGLGSEPGLVSPDGDSVPAPFAGICE
MSMEG_0331|M.smegmatis_MC2_155 QRRYVLDACDSAVRSAAGTDLTTPIPLRPRP-FRTNTVVSTQTSFTQTSQ
MMAR_2876|M.marinum_M QHAEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRA--
MUL_2876|M.ulcerans_Agy99 QHAEVRSALASADEAARALQDADLDLRKIEPVERSPAARSLAEVQTRV--
TH_4501|M.thermoresistible__bu LQAEVRNALASADEAARALQDADLDLRKIEPQERSPAARSLAEVHTRV--
. :
MAB_1522|M.abscessus_ATCC_1997 ------SGDAQDKLTARELDVLALIASGATNSEIAEQLVISEVTVKSHIG
MAV_5280|M.avium_104 ------HGAAIAELTTRERDVLTLIGKGLSNSEIADELCISGVTVKSHIG
Mb3157c|M.bovis_AF2122/97 ------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVS
Rv3133c|M.tuberculosis_H37Rv ------KQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVS
Mflv_0730|M.gilvum_PYR-GCK --------PEGPALSPREREVLVLIAAGSTIPAMARELFLAPSTVKTHVQ
Mvan_0348|M.vanbaalenii_PYR-1 SRGAGRGGTRLARLTAREREVLALLASGATNAQLADRLTVAESTVKSHVK
MSMEG_0331|M.smegmatis_MC2_155 RRES----SRLTILTSREREVLALLASGATNAQLADQLTVAESTVKSHVK
MMAR_2876|M.marinum_M ----------MAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVK
MUL_2876|M.ulcerans_Agy99 ----------MAMLTRREVEVLRLMAAGRTNQQIADELVISAGTVKSHVK
TH_4501|M.thermoresistible__bu ----------MAMLTRREIEVLRLMAAGRTNQQIADELVISAGTVKSHVK
*: :* :* *:. * : :* .: :: ***.::
MAB_1522|M.abscessus_ATCC_1997 RIFVKLDLRDRAAAIVYAYDHGIVTPK----
MAV_5280|M.avium_104 RIFGKLDLRDRAAAIVYAYDNGIVAPR----
Mb3157c|M.bovis_AF2122/97 RLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv RLLAKLGMERRTQAAVFATELKRSRPPGDGP
Mflv_0730|M.gilvum_PYR-GCK RLYEKLGVSDRGAAVAEAMRRKLLD------
Mvan_0348|M.vanbaalenii_PYR-1 HILHKLGAGNRAAAIACYLRESPDRERQRR-
MSMEG_0331|M.smegmatis_MC2_155 HILHKLGASNRAAAISFYLRETRGRSRS---
MMAR_2876|M.marinum_M RVLRKLHATNRAEAASAYVRLASVPEVG---
MUL_2876|M.ulcerans_Agy99 RVLRKLHATNRAEAASAYVRLASVSEVG---
TH_4501|M.thermoresistible__bu RVLRKLHATNRAEAASAYVRLASVPEVG---
:: ** * *