For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTSSATAPGPDVADPSGDHRDLAEFGYDQQLHRRLGRFESFAAGFSFVSILTTIFQLFGLGFGFGGPAFF WTWPAVFVGQFLVALCFAELAARYPISGAIYQWSRRMGGEVIGWFGGWFMILAQIVTASAAAIALQVVLP TIWPGFQIIGDDPALTSASGATNAVLLGTVLLVVTTTINCLGVKWMSRVNSAGVVCEIVGVIAVIGVFFT HAQRGPQVVFDTGHAGGQPGYIWAWIVSGLMAAYVMVGFGSAGELAEETRNPRRVAPRTIRLALSVSALG GGLMILGALMAAPSLTDGRLATEGLPYVLDTVLSSPWGTVLLIDVCIAITICTLAIQTAASRLMFSMARD GRLPASAILAKVNGRTGTPIWPSVLIGVLCIAVLLVNVGNSAIFATLASVCIILIYLAYLMVTAPLLYRR FKGWPAQRNQVDAEGLPLFSLGRFGIVVNVLAVLYGAVMIVNLGWPRAEIFNPTGEYPVLQWAGPLSIAA TVLLGALCFPRGKTHPKPVTIGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2184 | - | - | 100% (513) | amino acid permease |
| M. smegmatis MC2 155 | MSMEG_6701 | - | 3e-63 | 28.46% (506) | amino acid permease |
| M. smegmatis MC2 155 | MSMEG_1069 | - | 4e-53 | 29.29% (495) | amino acid permease-associated region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 3e-24 | 26.13% (421) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_3084 | - | 1e-122 | 45.73% (492) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 3e-24 | 26.13% (421) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 3e-12 | 25.21% (365) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_4090 | - | 0.0 | 68.65% (504) | putative amino-acid permease |
| M. marinum M | MMAR_2243 | - | 1e-24 | 25.24% (424) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_2087 | - | 7e-23 | 26.54% (456) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 9e-22 | 25.54% (466) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 5e-23 | 27.16% (475) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1845 | - | 1e-60 | 27.80% (500) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 ---------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLT
Rv2320c|M.tuberculosis_H37Rv ---------MPTTSMSLRELMLRRRPVSGAPVASGASGNLKRSFGTFQLT
MUL_1244|M.ulcerans_Agy99 ---------MPATSIRLREQMLRRRPAGGAPVAEGAAGSLKRSFGTFELT
MAV_2087|M.avium_104 -------------------------------MAPGTADHLRRGIGTFQLT
TH_0471|M.thermoresistible__bu ----------------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLT
MSMEG_2184|M.smegmatis_MC2_155 ---------MTSSATAPGPDVADPSGDHRDLAEFGYDQQLHRRLGRFESF
MAB_4090|M.abscessus_ATCC_1997 ------MNASTATGTAAPSAAISAASDSDDLAAFGYKPQLHRSLGKFASF
Mflv_3084|M.gilvum_PYR-GCK -------------------MVINQPHADSGMQDFGYKESLDRSIGKFASF
Mvan_1845|M.vanbaalenii_PYR-1 MSTTQPTSDARGRNEGDGFYDFHDKDDAAHLHALGYKSEFKRDMSPWANF
MMAR_2243|M.marinum_M ------------------------------MSQPTGEPRLRRALGVAGLV
MLBr_01305|M.leprae_Br4923 --------------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQ
: :
Mb2347c|M.bovis_AF2122/97 MFGVG-ATIGTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYAEL
Rv2320c|M.tuberculosis_H37Rv MFGVG-ATIGTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYAEL
MUL_1244|M.ulcerans_Agy99 MFGVG-STVGTGIFFVLAEAVP-EAGPAVIVSFIIAGVAAGLAAICCAEL
MAV_2087|M.avium_104 MFGVG-STIGTGIFFVMSQAVP-EAGPAVIVSFLLAGVAAGLAAVCYAEL
TH_0471|M.thermoresistible__bu VFGVS-VVIGAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEF
MSMEG_2184|M.smegmatis_MC2_155 AAGFSFVSILTTIFQLFGLGFG-FGGPAFFWTWPAVFVGQFLVALCFAEL
MAB_4090|M.abscessus_ATCC_1997 AAGFSFVSILTTIFQLFAFGFS-FGGPAFFWTWPIVFLGQYMVALNFAEL
Mflv_3084|M.gilvum_PYR-GCK AAGVSYISILTGTFQLFYFGFG-TAGPAYLWSWPLVFVGQMAVALCFMEL
Mvan_1845|M.vanbaalenii_PYR-1 SLGFTYLSPVVGIYTLFAFALA-TGGPPMIWSLVIVGVGQLLVALTFSEI
MMAR_2243|M.marinum_M AFGLAYIDPLA-MFDTFGVVSQ-TTHGHVPTAYVVTFVAMLFTAASYAVL
MLBr_01305|M.leprae_Br4923 MIGIG-GAIGTGLFLGAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGEL
*. . : : :
Mb2347c|M.bovis_AF2122/97 ASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVN
Rv2320c|M.tuberculosis_H37Rv ASAVPISGSAYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVN
MUL_1244|M.ulcerans_Agy99 ASAVPVSGSSYSYAYATLGEAVAMGVASCLLLEYGVATAAVAVGLSGYVN
MAV_2087|M.avium_104 ASAVPVSGSSYSYAYTTLGEVVAMGVAACLLLEYGVATAAVSVNWSGYLN
TH_0471|M.thermoresistible__bu ASTVPVAGSAYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLG
MSMEG_2184|M.smegmatis_MC2_155 AARYPISGAIYQWSRRMGGEVIGWFGGWFMILAQIVTASAAAIALQVVLP
MAB_4090|M.abscessus_ATCC_1997 AARYPISGAIYQWARRLGGAAVGWFAGWFMIIAQIVTASAAAIALQVVLP
Mflv_3084|M.gilvum_PYR-GCK AAKYPVAGSVYNWSKKLASRLVGWTSGWLMLTASIVTISAVALAYQLNLP
Mvan_1845|M.vanbaalenii_PYR-1 VAQFPVAGGVYPWARRLWGRRYAWMTGWVYLVALLVTIASVAYGSGPFIA
MMAR_2243|M.marinum_M VHAYPSAGSAYTFARRSFGGNVGFLTGWALMLDYLLLPLVNYLLIGIYLN
MLBr_01305|M.leprae_Br4923 VLHRPSSGSFVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLH
. * :*. :: . . . : : :
Mb2347c|M.bovis_AF2122/97 KLLSNLFGFQMPHVLSAAPWDTHPG----WVNLPAVILIGLCALLLIRGA
Rv2320c|M.tuberculosis_H37Rv KLLSNLFGFQMPHVLSAAPWDTHPG----WVNLPAVILIGLCALLLIRGA
MUL_1244|M.ulcerans_Agy99 KLLHNVFGFQLPQALSEAPWDERPGEAAGYLNLPAIILIGLCALLLIRGV
MAV_2087|M.avium_104 KLLSNVVGFQLPHALSAAPWDAQPG----YVNLPAVMLIGMCALLLIRGA
TH_0471|M.thermoresistible__bu ----EVFEFAG-ATTRLGPITLDWG---------ALLIIGFVTVLLATGT
MSMEG_2184|M.smegmatis_MC2_155 TIWPGFQIIGDDPALTSASGATNAV-------LLGTVLLVVTTTINCLGV
MAB_4090|M.abscessus_ATCC_1997 TVWSGFQLIGTDSSLTSVSGASNAV-------LLGSLLLVATTAINAVGV
Mflv_3084|M.gilvum_PYR-GCK RLWSGFQIIGDGS--GTYDYAANAV-------LLGSLLIAFTTLVNALGV
Mvan_1845|M.vanbaalenii_PYR-1 ATFGIDATVNNVIA-----FS--------------LLLLAVATAINFMGT
MMAR_2243|M.marinum_M AQFPAVPAPVF-----------------------CLAAIALVTTVNIVGV
MLBr_01305|M.leprae_Br4923 RWTIFTALPQWT---------------------LALLALAVVLVMNLISV
: : ..
Mb2347c|M.bovis_AF2122/97 SESARVNAIMVLIKLGVLGMFMIIAFSAYSADHL-KDFVP----------
Rv2320c|M.tuberculosis_H37Rv SESARVNAIMVLIKLGVLGMFMIIAFSAYSADHL-KDFVP----------
MUL_1244|M.ulcerans_Agy99 SESAKVNAIMVLIKLGVLGMFVILALTAYDTNHL-KDFAP----------
MAV_2087|M.avium_104 SESAKVNAIMVMVKLGVLVVFGILAFTAFDMHHL-DDFAP----------
TH_0471|M.thermoresistible__bu KLSANVSLAITVIKVGVVLLVVIVGAFFIKAANY-TPFIPPAEAGGEAGR
MSMEG_2184|M.smegmatis_MC2_155 KWMSRVNSAGVVCEIVGVIAVIGVFFTHAQRGPQ-VVFDTG---------
MAB_4090|M.abscessus_ATCC_1997 NWMSRINSIGVTCEIVGVVAVVGMLFGHAERGPS-VVLHTG---------
Mflv_3084|M.gilvum_PYR-GCK RLMSRINSSGVFIELIAAVLIVFLLAINVQHSPE-IFFSTNG--------
Mvan_1845|M.vanbaalenii_PYR-1 KVLAKAAIIGFSAEIIGALVVGGWLLIAHREHNIGIIFDSFG--------
MMAR_2243|M.marinum_M VIMNRLNFALVGLQLAFVLVFITVSLLYLRDHPDASLLQPLYS-------
MLBr_01305|M.leprae_Br4923 EWFGELEFWAALIKVCALMAFLVVGTIFLGGRYPVDGHNTGLS-------
. :: . .
Mb2347c|M.bovis_AF2122/97 -----------------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDP
Rv2320c|M.tuberculosis_H37Rv -----------------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDP
MUL_1244|M.ulcerans_Agy99 -----------------FGVAGVGAAAGTIFFSFIGLDAVSTAGEEVRNP
MAV_2087|M.avium_104 -----------------FGVAGVGTAAGTIFFSYIGLDAVSTAGDEVTNP
TH_0471|M.thermoresistible__bu SLDQSLFSLITGAEGSSYGWYGLLAGASIVFFAFIGFDIIATTAEETKNP
MSMEG_2184|M.smegmatis_MC2_155 -----------HAGGQPGYIWAWIVSGLMAAYVMVGFGSAGELAEETRNP
MAB_4090|M.abscessus_ATCC_1997 -----------DAG--SGYPWAFLAAGLMAAYVLVGFGSASELAEETRNP
Mflv_3084|M.gilvum_PYR-GCK ----------YGAGESMGFLGAFLIASLASGYVMYGFDTASSLGEETVEP
Mvan_1845|M.vanbaalenii_PYR-1 ------------AGGDGDYMWAFAAAALIGLYQYYGFEACGDVAEEVPDP
MMAR_2243|M.marinum_M ---------------AGFRGGDILGGAAVVALSFVGFDAVSTMAEEARNP
MLBr_01305|M.leprae_Br4923 -------LWTSHGGLFPTGVAPLIVVSSGVMFAYAAVELVGTAAGETVEP
. .. . . *. :*
Mb2347c|M.bovis_AF2122/97 QKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQ--ETAGLAIILD
Rv2320c|M.tuberculosis_H37Rv QKTMPRALIAALVVVTGVYVLVALAALGTQPWQDFAEQ--ETAGLAIILD
MUL_1244|M.ulcerans_Agy99 QQSVPRALIAALFVVTGVYVLVAFAALGTQPWQMFAGQ--EEAGLATILD
MAV_2087|M.avium_104 QKTMPRALIAALLTVTGVYVFVALAALGTQPWQDFGGQ--QEAGLATILD
TH_0471|M.thermoresistible__bu QRDVARGIMATLGIVTVLYVAVSLVLTGMVHYTELRAAG-ENANLATAFA
MSMEG_2184|M.smegmatis_MC2_155 RRVAPRTIRLALSVSALGGGLMILGALMAAPSLTDGRL--ATEGLPYVLD
MAB_4090|M.abscessus_ATCC_1997 RRVAPRTILSAIVVSAIGGALMILGALMAAPSLTDGQL--ATGGLPYVLD
Mflv_3084|M.gilvum_PYR-GCK RRTAPKAIARAILASFVIGGGILVFAVMAAPNLQDPQLGESSGGLQYIVQ
Mvan_1845|M.vanbaalenii_PYR-1 GRLIPKAMRRTIYIGGAAATFVCLSLILAVADIPAVIAGEDTDPVSTVLG
MMAR_2243|M.marinum_M RRTVPLAIILTVLIGGATFLSVSYCATLVEPDYRAITTP-NSAALQIVVS
MLBr_01305|M.leprae_Br4923 KKIMPRAINSVIARIAIFYVGSVILLALLLPYSAFKAS---ESPFVTFFS
: . : .: . .
Mb2347c|M.bovis_AF2122/97 NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA--RF
Rv2320c|M.tuberculosis_H37Rv NVTHGEWASTILAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA--RF
MUL_1244|M.ulcerans_Agy99 NVTHSAWASTVLAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLPA--RF
MAV_2087|M.avium_104 HVTHGSWASTILAAGAVISIFSVTLVTMYGITRILFAMGRDGLLPP--RF
TH_0471|M.thermoresistible__bu -ANGIDWAAKVISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLPR--PL
MSMEG_2184|M.smegmatis_MC2_155 TVLSSPWG-TVLLIDVCIAITICTLAIQTAASRLMFSMARDGRLPASAIL
MAB_4090|M.abscessus_ATCC_1997 SKLASPFG-TLLLIDVAIAVFVCTLAIQTAASRLMFSMARDGKLPFSAVL
Mflv_3084|M.gilvum_PYR-GCK QVMWGPLG-TIFLACIVIAVTVCCLAVHTAAIRLTFAMARDNALPFGEKL
Mvan_1845|M.vanbaalenii_PYR-1 -EAFGPVGSKIILVIVLISFLSCAMSLQAAASRLAYSYGRDEMIMGSSLL
MMAR_2243|M.marinum_M --AGGHSLQTFFIIAYMCACSAAALSSQVSVTRILYAMGRDGVLPR-AVF
MLBr_01305|M.leprae_Br4923 KVGFYGAG-DLMNIVVLTAALSSLNAGLYATGRVMHSIAINGSGPK---F
.: . . *: .: . : :
Mb2347c|M.bovis_AF2122/97 AKVNPRTMTPVHNTVIVAIFASTLAAFIP------LDSLADMVSIGTLTA
Rv2320c|M.tuberculosis_H37Rv AKVNPRTMTPVHNTVIVAIFASTLAAFIP------LDSLADMVSIGTLTA
MUL_1244|M.ulcerans_Agy99 AAVHPRFQTPVSNTVVVAIAAAVLAALVP------LNRLADMVSIGTLTA
MAV_2087|M.avium_104 ARVNPRTMTPVNNTVIVAVAAATLAAFIP------LQNLADMVSIGTLTA
TH_0471|M.thermoresistible__bu SKTGPR-GTPVRITVLVGALVAIAASVFP------VGNLEEMVNIGTLFA
MSMEG_2184|M.smegmatis_MC2_155 AKVNGRTGTPIWPSVLIGVLCIAVLLVNVGNS-AIFATLASVCIILIYLA
MAB_4090|M.abscessus_ATCC_1997 SHVNPRTGTPIAPAVVVGVCCVLILAVNFGNA-ALFTSLCSVCIALIYLA
Mflv_3084|M.gilvum_PYR-GCK ATVNPKTQTPIVPAVTIGIISILILVINVANV-QIFTVLTSIAIIMIYLA
Mvan_1845|M.vanbaalenii_PYR-1 KKFSPTRHVPPYALLLAAVVPAVIIVGSKFST-DAITKIISFAALGIYIG
MMAR_2243|M.marinum_M GRISRRFRTPIGAALVVSAVSTLALIADL-------ETMASIVSFGALAA
MLBr_01305|M.leprae_Br4923 TARMSKNGVPYGGILLAAVICLCGVALNAFNPGQAFEIVLSVAALGIIAG
.* : . : .. .
Mb2347c|M.bovis_AF2122/97 FSVVAVGVIVLRVRE-----------PDLPRGFKVPGYPVT----PVLSV
Rv2320c|M.tuberculosis_H37Rv FSVVAVGVIVLRVRE-----------PDLPRGFKVPGYPVT----PVLSV
MUL_1244|M.ulcerans_Agy99 FIVVSVGVIILRVRE-----------PALPRGFWVPGYPVT----PILSI
MAV_2087|M.avium_104 FVVVSVGVIVLRVRE-----------PDLPRGFRVPGYPVT----PVLSI
TH_0471|M.thermoresistible__bu FALVSAGVIVLRRTR-----------PDLKRGFRVPFVPWL----PLAAI
MSMEG_2184|M.smegmatis_MC2_155 YLMVTAPLLYRRFKG----WPAQRNQVDAEGLPLFSLGRFG----IVVNV
MAB_4090|M.abscessus_ATCC_1997 YLMVTTPLLLRRLGIGGSTWDANLGQTDADGRKLFSLGRCG----LPINI
Mflv_3084|M.gilvum_PYR-GCK YLMVTGPLLKKRIQG---HWPPP----DLKEGGYFTMGKWG----MPVNI
Mvan_1845|M.vanbaalenii_PYR-1 FQMVVLAALRARLKG-------------WVPSGKYSLGKWG----LAVNI
MMAR_2243|M.marinum_M FTLVHLAVTKHFLID-----------QRRRGWRSWALYAAM----PAVGV
MLBr_01305|M.leprae_Br4923 WGTIVLCQLRLHKMAKAG--------IMRRPRFRMPLAPYSGYLTLAFLF
: : . .
Mb2347c|M.bovis_AF2122/97 LACGYILASLHWYTWLAFSGWVAVAVIFYLMWGRHHSALNEEVP------
Rv2320c|M.tuberculosis_H37Rv LACGYILASLHWYTWLAFSGWVAVAVIFYLMWGRHHSALNEEVP------
MUL_1244|M.ulcerans_Agy99 LACGYLLYSLHWYTWIAFGGWVGIALIFYLFWGRHHSRLNAPALHDNPTG
MAV_2087|M.avium_104 MACGYILASLHWYTWIAFSGWVLLALIFYFVWGRHHSALNDAAVD--PSG
TH_0471|M.thermoresistible__bu AACLWLMLNLTGLTWVRFLGWMALGLVLYFFYGRHHSMLGRGMTDISARR
MSMEG_2184|M.smegmatis_MC2_155 LAVLYGAVMIVNLGWPRAEIFNPTGEYPVLQWAGPLSIAATVLLGALCFP
MAB_4090|M.abscessus_ATCC_1997 LAVGYGAFMILNLSWPRPAVFDPTGEHPYLVWMAPICIIAVLLAGLVAYP
Mflv_3084|M.gilvum_PYR-GCK VAVIWGIGMALNLAWPRAAVY---GEGWYYEWGAFIYIGVILGAGLVWYF
Mvan_1845|M.vanbaalenii_PYR-1 AALVYGVTAMINMAWPR-----TPDAPWYDNWIVALSAAVVIGIGLVYMV
MMAR_2243|M.marinum_M VLTGWLWTSLSVGAFAIGFAWLGIGTSYLAVLTRGFRKPAPAVDFDADAA
MLBr_01305|M.leprae_Br4923 AVLVVMAFDKPIGTWTVASLIVIVPALIAGWYSIRKRVMTIARERMGYTG
:
Mb2347c|M.bovis_AF2122/97 ---------------------
Rv2320c|M.tuberculosis_H37Rv ---------------------
MUL_1244|M.ulcerans_Agy99 EER------------------
MAV_2087|M.avium_104 QER------------------
TH_0471|M.thermoresistible__bu TG-------------------
MSMEG_2184|M.smegmatis_MC2_155 RGK-------THPKPVTIGA-
MAB_4090|M.abscessus_ATCC_1997 RHT-------ASTTEETVR--
Mflv_3084|M.gilvum_PYR-GCK VKGRNHIGTLKSHAAESLDG-
Mvan_1845|M.vanbaalenii_PYR-1 VHPLHDKSTAPYADAIPTK--
MMAR_2243|M.marinum_M PIQTEIDLTKEGTLQ------
MLBr_01305|M.leprae_Br4923 PFPAIANPPVQPSERSHSQNP