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MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDPGRLAALEKSSDRIATLAVDLTDDDAPQRIVSAALE RWGRIDFLVNNAGIGSPKPLHETDDETLDRFLDIMLRAPFRLARDVIVHMQPGSAIINITSTFAVVGGLR GGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPGVTLTPMVASRLEDERFRKINTEMTPHQRLGRVEDV ASTVAFLCSEGGSFINGQTIVVDGGWSTTKYLSDFALNAHWVER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | - | 100% (254) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_1861 | - | 6e-34 | 35.39% (243) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0894 | - | 9e-32 | 35.66% (244) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 7e-28 | 32.65% (245) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1783 | - | 1e-131 | 89.84% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 8e-28 | 32.65% (245) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-23 | 32.77% (238) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 8e-29 | 33.89% (239) | short chain dehydrogenase |
| M. marinum M | MMAR_0302 | - | 1e-113 | 78.74% (254) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5213 | - | 1e-120 | 81.18% (255) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5632 | - | 1e-125 | 85.60% (257) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4328 | - | 1e-125 | 84.67% (261) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4820 | - | 1e-97 | 73.95% (238) | short-chain type dehydrogenase/reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1783|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5632|M.smegmatis_MC2_155 --------------------------------------------------
TH_4328|M.thermoresistible__bu --------------------------------------------------
MAV_5213|M.avium_104 --------------------------------------------------
MMAR_0302|M.marinum_M --------------------------------------------------
MUL_4820|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2882c|M.bovis_AF2122/97 --------------------------------------------------
Rv2857c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4967|M.vanbaalenii_PYR-1 ------------MQVAIVTGASSGIGFGCATTLAEQGMAVLGTGRDPGRL
Mflv_1783|M.gilvum_PYR-GCK ---------MQTAQVAIVTGASSGIGFGCATALADRGMVVLGTGRDAGRL
MSMEG_5632|M.smegmatis_MC2_155 ------------MQVAIITGASSGIGFGCATKLAEAGMAVLGVGRDKERL
TH_4328|M.thermoresistible__bu ----------VNMQVAIVTGASSGIGFGCATKLAEQGMAVLGTGRDSGRL
MAV_5213|M.avium_104 ------------MQVAIVTGASSGIGLGCATRLAGTGMAVLGTGRDPKRL
MMAR_0302|M.marinum_M ------------MQVAIITGATGGIGFGCAAKLAEMGMAVLGTGRDERRL
MUL_4820|M.ulcerans_Agy99 ------------MQVAIITAATGGIGFGCAAKFAEMSMAVVGTARDERRL
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
MAB_4632|M.abscessus_ATCC_1997 ---MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQL
Mb2882c|M.bovis_AF2122/97 ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
Rv2857c|M.tuberculosis_H37Rv ---MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAG
.**::*.. *:* . . . . ::
Mvan_4967|M.vanbaalenii_PYR-1 AALEKSS-------DRIATLAVDLTDDDAPQRIVSAALERWG-RIDFLVN
Mflv_1783|M.gilvum_PYR-GCK AELEKAAPEP----GRIATLAVDLTDDDAPQRIVSAALDRWG-RIDFLVN
MSMEG_5632|M.smegmatis_MC2_155 AELAQTIDAP----DRVATLALDLTDDDAPQRIVDAAVTRWG-KVDFLIN
TH_4328|M.thermoresistible__bu AGLEKTLRKAGVPADRIATLAVDLTADEAPQRIVDAAVSRWG-HIDFLIN
MAV_5213|M.avium_104 AELETAIGDP----DRVATVAVDLTDDDAPRRIVDRALQRWG-HIDFLIN
MMAR_0302|M.marinum_M AELTQLPGGP----DRIATHPVDLTDDDAPGQLTRAALERWG-RIDFLIN
MUL_4820|M.ulcerans_Agy99 AELTQLPGGP----DRIATHPVDPTDDDAPGQLTRAALDRWG-RIDFLIN
MLBr_02565|M.leprae_Br4923 ALDETANRVG------GTTLSLDVTADDAVDKITEHLHDYQGGHADILVN
MAB_4632|M.abscessus_ATCC_1997 REVAAKVQAAG---RQAEVVVADLSDTEASAALAQKAVDRFG-RLDVVVN
Mb2882c|M.bovis_AF2122/97 GAAADELSG--------LFVPTDVCDEDAVNGLFDGAAETYG-RIDIAFN
Rv2857c|M.tuberculosis_H37Rv GAAADELSG--------LFVPTDVCDEDAVNGLFDGAAETYG-RIDIAFN
* :* : * : *. .*
Mvan_4967|M.vanbaalenii_PYR-1 NAGIGSPK--PLHETDDETLDRFLDIMLRAPFRLARDVIVH--MQPGSAI
Mflv_1783|M.gilvum_PYR-GCK NAGIGSPK--PLHETDDETLDHFLGVMLRAPFRLARDVIVH--MQPGSAI
MSMEG_5632|M.smegmatis_MC2_155 NAGVGSPK--PLHETDDESLDYFLGLMLRAPFRLARDVIPH--MGPGSAI
TH_4328|M.thermoresistible__bu NAGVGSPK--PLGETDDDTLDHFLGLMLRAPFRLARDVLPH--MRPGSAI
MAV_5213|M.avium_104 NAGVGSPK--PLHETDDETLDYFLNLMLRAPFRLAREVLPH--LPPGSAI
MMAR_0302|M.marinum_M AAGVGSPK--PVHETDDESLDYVLSLMLRAPFRLTREVLPH--LRPGSAI
MUL_4820|M.ulcerans_Agy99 AAGEGSPK--SVHETDDESLDYVLSLMLRAPFRLTREVLPH--LRPGSAI
MLBr_02565|M.leprae_Br4923 NAGITRDK--LLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRV
MAB_4632|M.abscessus_ATCC_1997 NVGGTMPK--PFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLKSDNASV
Mb2882c|M.bovis_AF2122/97 NAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSI
Rv2857c|M.tuberculosis_H37Rv NAGISPPEDNLIENTELAAWQRVQDVNLKSVYLCCRAALRHMVLAGKGSI
.* : . : . : : . : : . :
Mvan_4967|M.vanbaalenii_PYR-1 INITSTFAVVG-GLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPG
Mflv_1783|M.gilvum_PYR-GCK INVTSTFAVVG-GLRGGAYSAAKGGLTALTSHIACQYGAQGIRCNAVAPG
MSMEG_5632|M.smegmatis_MC2_155 INVTSTFAVVG-GLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPG
TH_4328|M.thermoresistible__bu INITSTFAVVG-GLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPG
MAV_5213|M.avium_104 INVTSTFAVVG-GLRGGAYSAAKGGLTALTTHIACQYGASGIRCNAVAPG
MMAR_0302|M.marinum_M INITSTFAVVG-GLRGGAYSAAKGGLTALTTHIACQYGAQGIRCNAVAPG
MUL_4820|M.ulcerans_Agy99 INITSTFAVVG-GLRGGAYSAAKGGLAALTTHIACQYGAQGIRCNAVAPG
MLBr_02565|M.leprae_Br4923 IVLSSMAGIAG-NRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPG
MAB_4632|M.abscessus_ATCC_1997 INITSTMGRLP-GRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGIAPG
Mb2882c|M.bovis_AF2122/97 VNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVNALCPG
Rv2857c|M.tuberculosis_H37Rv VNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGIRVNALCPG
: :* . * ::*..: : . . * *.:.**
Mvan_4967|M.vanbaalenii_PYR-1 VTLTPMVASRLEDERFRKINTEMTP-HQRLGRVEDVASTVAFLCSEGGSF
Mflv_1783|M.gilvum_PYR-GCK VTLTPMVATRLEDERFRKINTEMTP-HQRLGRVEDIASTVAFLCSDGGEF
MSMEG_5632|M.smegmatis_MC2_155 VTLTPMVATRLEDDRFRKINTEMTP-HQRLGRVEDVASTVAFLCSEGGSF
TH_4328|M.thermoresistible__bu VTLTPMVATRLEDERFRKINTEMTP-HQRLGRVEDIAATVAFLCSPGAEF
MAV_5213|M.avium_104 VTVTPMVENRLQDPRFRKINTEMTP-HQRLGSVDDIAATVAFLCSPGGSF
MMAR_0302|M.marinum_M VIQTAMTQHRLADERFRRINVEMTP-HQRLGTVDDVANTVAFLCSEGGAF
MUL_4820|M.ulcerans_Agy99 VIQTAMTQHRLADERFRRLNVEITP-HQRLGTVDDVANTVAFLCSEGGAF
MLBr_02565|M.leprae_Br4923 FIETQMTAAIPLAT--REVGRRLNS-LLQGGLPVDVAETIAYFAIPASNA
MAB_4632|M.abscessus_ATCC_1997 SILTSALEVVAGNDEMRNTLEQNTP-LHRLGDPADIAAAAVYLASPAGSF
Mb2882c|M.bovis_AF2122/97 PVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASF
Rv2857c|M.tuberculosis_H37Rv PVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASF
* * : . ::* : .::. .
Mvan_4967|M.vanbaalenii_PYR-1 INGQTIVVDGGWSTTKYLSDFALNAHWVER-----
Mflv_1783|M.gilvum_PYR-GCK INGQTIVVDGGWSSTKYLSDFALNSEWVARQGTS-
MSMEG_5632|M.smegmatis_MC2_155 INGQTIVVDGGWSSTKYLSDHALNSDWVPR-----
TH_4328|M.thermoresistible__bu INGQTIVVDGGWSSTKYLSDHALTSEWVPR-----
MAV_5213|M.avium_104 INGQTIVVDGGWSSTKYLSEYALTSEWIAP-----
MMAR_0302|M.marinum_M INGQTIVVDGGWSSTKYLSDFALTAQWSPAQDDSK
MUL_4820|M.ulcerans_Agy99 INGQTIVVDGG------------------------
MLBr_02565|M.leprae_Br4923 VTGNVIRVCGQAMLGA-------------------
MAB_4632|M.abscessus_ATCC_1997 LTGKVLEVDGGLIAPNLDIPLPDLA----------
Mb2882c|M.bovis_AF2122/97 ITASTFLVDGGISSAYVTPL---------------
Rv2857c|M.tuberculosis_H37Rv ITASTFLVDGGISSAYVTPL---------------
:....: * *