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KAQKPMRKTATGEPGRARTSAKKSPRAAKRRPVRETKRTPVDAPPRGRQQTRDARPQRSAPRTTPIARPK DVPARPKSTSQAKARAKARKAKAPKVVRPPLRQRILVRLASIELDPRRLIARVPFVVLVIGALGLGLGVT LWLSTDAAERSYQLGAARQLNQALLQQKEGLERDVLEAQAAPALAEAARNLGMIPSRDTAHLVQDPSGNW VVVGTPKPAEGVPPPPLNAPLPEPAPPAPPAPRVIEPLEVPVRLPSVTAPQAIPGTAPALPLAVPGAVPN VAVPNVEVPHAVSGQLPAPGPVPVPVPGPAPVPAAPLDAGTSQLPPAPAPGAPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3530 | - | - | 100% (335) | FHA domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3343 | - | 5e-11 | 35.53% (152) | FHA domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1015 | - | 6e-11 | 32.19% (233) | hypothetical protein Mvan_1015 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2188c | - | 2e-84 | 51.78% (365) | hypothetical protein Mb2188c |
| M. gilvum PYR-GCK | Mflv_2981 | - | 1e-137 | 72.89% (343) | hypothetical protein Mflv_2981 |
| M. tuberculosis H37Rv | Rv2164c | - | 6e-85 | 52.05% (365) | hypothetical protein Rv2164c |
| M. leprae Br4923 | MLBr_00907 | - | 1e-85 | 51.92% (339) | hypothetical protein MLBr_00907 |
| M. abscessus ATCC 19977 | MAB_1999 | - | 1e-76 | 52.34% (321) | hypothetical protein MAB_1999 |
| M. marinum M | MMAR_3201 | - | 9e-92 | 55.40% (352) | proline rich membrane protein |
| M. avium 104 | MAV_2329 | - | 1e-85 | 49.35% (383) | hypothetical protein MAV_2329 |
| M. smegmatis MC2 155 | MSMEG_4234 | - | 1e-112 | 62.91% (364) | hypothetical protein MSMEG_4234 |
| M. thermoresistible (build 8) | TH_1738 | - | 3e-06 | 29.81% (161) | MCE-FAMILY PROTEIN MCE4F |
| M. ulcerans Agy99 | MUL_3509 | - | 4e-93 | 55.68% (352) | proline rich membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3530|M.vanbaalenii_PYR-1 ------------------------------------MKAQKPMRKTATG-
Mflv_2981|M.gilvum_PYR-GCK ------------------------------------MKAKKPLRNAAAEP
MSMEG_4234|M.smegmatis_MC2_155 ------------------------------------MKAKR---------
MMAR_3201|M.marinum_M ------------------------------------MKAKREARVPGKRQ
MUL_3509|M.ulcerans_Agy99 ------------------------------------MKAKREARVPGKRQ
Mb2188c|M.bovis_AF2122/97 ------------------------------------MRAKREA--PKSRS
Rv2164c|M.tuberculosis_H37Rv ------------------------------------MRAKREA--PKSRS
MLBr_00907|M.leprae_Br4923 ------------------------------------MKAQRDT--PIRRG
MAV_2329|M.avium_104 ------------------------------------MKAERET--AKRRG
MAB_1999|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1738|M.thermoresistible__bu MLSRLVRMQLAVFTAVALISVLAIAVFYIQVPKTLGFGSYRVTADFAGSG
Mvan_3530|M.vanbaalenii_PYR-1 ------EPGRARTSAKKSPRAAKRRPVRETKRTPVDAPPRGRQQTRD-AR
Mflv_2981|M.gilvum_PYR-GCK ARRSERTSGRSRATTTKPKAGGKRGTAREAKRTPVDAQPRGRKTTRD-AR
MSMEG_4234|M.smegmatis_MC2_155 -------PGPVRDADRRR---GKRQPG--VARGSAEAPPRKRRPSREPQR
MMAR_3201|M.marinum_M -------SGDRGGGRDGSVARTTRRTPADASRR--VRAGKKKAPNRE-AR
MUL_3509|M.ulcerans_Agy99 -------SGDRGGGRDGSVARTTRRTPADASRR--GRAGKKKAPNRE-AR
Mb2188c|M.bovis_AF2122/97 -------SDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQ-AR
Rv2164c|M.tuberculosis_H37Rv -------SDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQ-AR
MLBr_00907|M.leprae_Br4923 -------DSGRPGGRDGAARSGKRTANEAGSRRLRTHAGKISASARE-VG
MAV_2329|M.avium_104 -------GSDRRGARDGSARRGRRPAADAGAAR-RARGGPASAPTRE-SR
MAB_1999|M.abscessus_ATCC_1997 ------MIGVRKKAGEAPKKTKPAKSAKPTKRR--NGASKATATGPS-AR
TH_1738|M.thermoresistible__bu GIYPNANVAYRGTTIGKVTGVSLTHDNDVRVEMRIDDDRKVPANVNAYVK
Mvan_3530|M.vanbaalenii_PYR-1 PQRSAPRTTPIARPKDVPARPK---STSQAKAR----------AKARKAK
Mflv_2981|M.gilvum_PYR-GCK PQRSAPRTTPISRPVDAPARPK---SATQAKAR----------AKARKAK
MSMEG_4234|M.smegmatis_MC2_155 PLRSAPQTGPIPRQKTEPARPK---TASQAKAR----------AKARKAK
MMAR_3201|M.marinum_M IPMSGPQTTPMPRPAERPARPK---NTGQAKAR----------AKARKAK
MUL_3509|M.ulcerans_Agy99 IPMSGPQTTPMPRPAERPARPK---NTGQAKAR----------AKARKAK
Mb2188c|M.bovis_AF2122/97 VSRPGPQTSPMLSPFDRPAPAK---NTSQAKAR----------AKARKAK
Rv2164c|M.tuberculosis_H37Rv VSRPGPQTSPMLSPFDRPAPAK---NTSQAKAR----------AKARKAK
MLBr_00907|M.leprae_Br4923 VPKSGPRTSPMSRPVERPARPR---NTTQAKAR----------AKARKAK
MAV_2329|M.avium_104 APKPGPQTSPVARPAERSARPK---NTSQAKAR----------AKARKAK
MAB_1999|M.abscessus_ATCC_1997 PRRSAPQTMPIPVQRQAPEKIRPATSTRQAKAR----------AKARKAK
TH_1738|M.thermoresistible__bu SMSAIGEQYVDLVPPEHASTESLRGGSHIGRDRTFINGDIAGMLREAQAL
. . . : .: * : :*
Mvan_3530|M.vanbaalenii_PYR-1 APKVVRPPLRQRILVRLASIELDPRRLIARVPFVVLVIGALG------LG
Mflv_2981|M.gilvum_PYR-GCK APKVVRPPLRERLLVRLASIDLNPRRLAARVPFVVLIISALG------LG
MSMEG_4234|M.smegmatis_MC2_155 APKVVRPPLRERILLRLSSIELNPRELVARVPFVVLVIAALG------LG
MMAR_3201|M.marinum_M APKVVRPKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLG------VG
MUL_3509|M.ulcerans_Agy99 APKVVRPKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLG------VG
Mb2188c|M.bovis_AF2122/97 APKLVRPTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLG------VG
Rv2164c|M.tuberculosis_H37Rv APKLVRPTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLG------VG
MLBr_00907|M.leprae_Br4923 APKVVRPRLGECLIARLALIDLRPRTLVNKVPFVVLVISSLG------VG
MAV_2329|M.avium_104 APKVVRPRLTERLAARLAAIDLRPRTLASKVPFVVLVIGALG------VG
MAB_1999|M.abscessus_ATCC_1997 APKVIRVPLRERVLARLSEVDLRPHVWITRVPFVVFVIGALG------VG
TH_1738|M.thermoresistible__bu VDSLDRSRLRDVLKETFAAFNGSGPELARLLESSRLLVEEAGDATDDTIG
. .: * : : :: .: : ::: * :*
Mvan_3530|M.vanbaalenii_PYR-1 LG------VTLWLSTDAAERSYQLGAARQLNQALLQQ---KEGLERDVLE
Mflv_2981|M.gilvum_PYR-GCK LG------VTLWLSTDAAERSYQLGSARQLNQALMQQ---KEALERDVLE
MSMEG_4234|M.smegmatis_MC2_155 LG------ITLWLSTSAAERSYQLGHARQVNQGLLQQ---KEALERDVLE
MMAR_3201|M.marinum_M LG------LTLWLSTDAAERSYQLSHARERTRMLQQQ---KESLERDVRE
MUL_3509|M.ulcerans_Agy99 LG------LTLWLSTDAAERSYQLSHARERTRMLQQQ---KESLERDVRE
Mb2188c|M.bovis_AF2122/97 LG------LTLWLSTDAAERSYQLSNARERTRMLQQH---KEALERDVRE
Rv2164c|M.tuberculosis_H37Rv LG------LTLWLSTDAAERSYQLSNARERTRMLQQH---KEALERDVRE
MLBr_00907|M.leprae_Br4923 LG------LTLWLSTDSAERSYQLGDAREQARMLQQQ---KEALERDVRE
MAV_2329|M.avium_104 LG------LTLWLSTDSAERSYKLSHARERTRLLQQQ---KEALERDVRE
MAB_1999|M.abscessus_ATCC_1997 LA------ITLWLSTDAAERSYQLGTQRRTNEELLQR---KEALERDVLR
TH_1738|M.thermoresistible__bu LVEQSQPLLDAQVTAGDDIRAVADGLARLTSHLREADPQFREVLQKAPAA
* : :::. *: . * . :* *::
Mvan_3530|M.vanbaalenii_PYR-1 AQAAPALAEAAR--------------NLGMIPSR---DTAHLVQDPSGNW
Mflv_2981|M.gilvum_PYR-GCK AQAAPALAEAAR--------------ELGMIPSR---DTAHLVQDASGNW
MSMEG_4234|M.smegmatis_MC2_155 AQAAPALAEAAR--------------NLGMIPSR---DTAHLVQDPTGNW
MMAR_3201|M.marinum_M AESAPALAEAAR--------------KQGMIPTR---DTAHLVQAPDGNW
MUL_3509|M.ulcerans_Agy99 AESAPALAEAAR--------------KQGMIPTR---DTAHLVQAPDGNW
Mb2188c|M.bovis_AF2122/97 AASAPALAEAAR--------------RQGMIPTR---DTAHLAQDPDGNW
Rv2164c|M.tuberculosis_H37Rv AASAPALAEAAR--------------RQGMIPTR---DTAHLVQDPDGNW
MLBr_00907|M.leprae_Br4923 AESAPALAETAR--------------KQGMIPTR---DTAHLVQGPGGNW
MAV_2329|M.avium_104 AEAAPALAEAAR--------------KQGMIPTR---DTAHLVQDPSGNW
MAB_1999|M.abscessus_ATCC_1997 AESAPALADSAR--------------DLGMIPSR---DIAHLVRDPQGNW
TH_1738|M.thermoresistible__bu ADQATTLFDGIRPTFPVLAANLANAGRIGVIYHKSIEQVLVIIPAVTAAI
* *.:* : * *:* : : : .
Mvan_3530|M.vanbaalenii_PYR-1 VVVGTPKPAEG-----------VPPPPLNAPLP---EPAPPAPPAPRVIE
Mflv_2981|M.gilvum_PYR-GCK VVVGTPKPAEG-----------VPPPPLNAPLP---EPAPPAPPAPRVVE
MSMEG_4234|M.smegmatis_MC2_155 VVVGTPKPAEG-----------VPPPPLNAPLPPDAPPPPPAPPAPRVVE
MMAR_3201|M.marinum_M VVVGTPKPADG-----------VPPPPLNTKLP---EEGPPAPPKPAAL-
MUL_3509|M.ulcerans_Agy99 VVVGTPKPADG-----------VPPPPLNSKLP---EEGPPAPPKPAAL-
Mb2188c|M.bovis_AF2122/97 VVVGTPKPADG-----------VPPPPLNTKLP---EDPPP-PPKPAAV-
Rv2164c|M.tuberculosis_H37Rv VVVGTPKPADG-----------VPPPPLNTKLP---EDPPP-PPKPAAV-
MLBr_00907|M.leprae_Br4923 VVVGTPKPADG-----------VPPPPLNTKLP---DAGPP-SLKPPEI-
MAV_2329|M.avium_104 VVVGTPKPADG-----------VPPPPLNSKLP---DEAPQ-PPKPAPP-
MAB_1999|M.abscessus_ATCC_1997 LLVGAPKPAEG-----------VAPAPLNSVIP---DDADAVPKAGNSV-
TH_1738|M.thermoresistible__bu IAIANQFPADEGAKGDFKLNFGDPPPCITGFVPP--SEIRSPADTTLRDV
: :. **: .*. :. :* .
Mvan_3530|M.vanbaalenii_PYR-1 PLEVPVRLPSVT---------APQAIPGTAPA----------LPLAVPGA
Mflv_2981|M.gilvum_PYR-GCK PREVPVRIPSAA---------TPLAVPGMVPG----------APAPLPGL
MSMEG_4234|M.smegmatis_MC2_155 PREVPIRVPEAPGLQGLPGIQAAPGIPGAVQG----------VPGAVPGE
MMAR_3201|M.marinum_M PPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGSSTLGAGTNHLPGQPPIE
MUL_3509|M.ulcerans_Agy99 PPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGSSTLGADTNHLPGQPPIE
Mb2188c|M.bovis_AF2122/97 PLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGA-THLPTQAGPQ
Rv2164c|M.tuberculosis_H37Rv PLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGA-THLPTQAGPQ
MLBr_00907|M.leprae_Br4923 PLEVPVRVVPGPGGPPPPARSGPQMWLRVPDGATTLGG--QHLP-QELPQ
MAV_2329|M.avium_104 AAEVPIRVELAPGGP-VPARSGPEALLRAPDGASTLGG--QHLA-PAVPP
MAB_1999|M.abscessus_ATCC_1997 --EVPVQLPPVPPPVAVVPHMAPPTAAPAPVVEAPIGQD----PAAVPQV
TH_1738|M.thermoresistible__bu PKELYCKVPHNDPAVVRGARNYPCMEFPGKRAATVQQCR------DPEGY
*: :: .
Mvan_3530|M.vanbaalenii_PYR-1 VPN--VAVPNVE--VPHAVSG-----------QLPA-----------PGP
Mflv_2981|M.gilvum_PYR-GCK AP-----VPGSE--VPHAVSA-----------DIPM-----------PGP
MSMEG_4234|M.smegmatis_MC2_155 TP---HVAPGAQPQAPGPVIG-----------PLTG-----------PAP
MMAR_3201|M.marinum_M IPGQVPGAPG-PVPLPGQLPGVAGPVTGPGQLPGPAAG----AVQVPPAP
MUL_3509|M.ulcerans_Agy99 IPGQVPGAPG-PVPLPGQLPGVAGPVTGPGQLPGPAAG----AVQVPPAP
Mb2188c|M.bovis_AF2122/97 LPG-PVPIPGAPGPMPAPPLG-----------AVPS-----------PAP
Rv2164c|M.tuberculosis_H37Rv LPG-PVPIPGAPGPMPAPPLG-----------AVPS-----------PAP
MLBr_00907|M.leprae_Br4923 LP----GMLNGPAAAQVQVPG-----------FMPT-----------PGL
MAV_2329|M.avium_104 VPGTPPGVPGGPVAAPPALPGGPVAAVPPASPAMPTGPATGRPPGLTPGL
MAB_1999|M.abscessus_ATCC_1997 AP-----VPAVPADVPPPVAD------APQ------------------AS
TH_1738|M.thermoresistible__bu VPIGSNPWRGPPVPVGTPITDPRMILPQNKYPYIPPQADYD------PGP
* .
Mvan_3530|M.vanbaalenii_PYR-1 VPVPVPGPAP----------------------------VPAAP-------
Mflv_2981|M.gilvum_PYR-GCK V-LPAAAPDP----------------------------ALVAP-------
MSMEG_4234|M.smegmatis_MC2_155 MAVPMPVPAE----------------------------VPLATPQAPQQA
MMAR_3201|M.marinum_M VVLPAPVPAQVP-AEVPVPVPVPAVTAPPVAVVPAAPQAPLAAPVPGTAG
MUL_3509|M.ulcerans_Agy99 VVLPAPVPAQVP-AEVPVPV--PAVTAPPVAVVPVAPQTPLAAPVPGTAG
Mb2188c|M.bovis_AF2122/97 AENPVPLQVG----------------AAPPAG------LPGPAPVAATPG
Rv2164c|M.tuberculosis_H37Rv AENPVPLQVG----------------AAPPAG------LPGPAPVAATPG
MLBr_00907|M.leprae_Br4923 PIPGSTMR------------------VPVPAP------APTEVPVRLQPG
MAV_2329|M.avium_104 PMPGLPMPAGPAVAPAPAEVSIPLGGLPVPAPGQLPAPLPPEVPVPVQLG
MAB_1999|M.abscessus_ATCC_1997 NITNSPVTGE----------------------------------------
TH_1738|M.thermoresistible__bu PVVQLPPGVPPG----------PGPALTPPYPTQIPPVTPGPPPPPLPFQ
.
Mvan_3530|M.vanbaalenii_PYR-1 -----LDAGTSQLPPAPAPGAPA---------------------------
Mflv_2981|M.gilvum_PYR-GCK -----APAPAPAPAPAPVPGAGA---------------------------
MSMEG_4234|M.smegmatis_MC2_155 APLVNTPAPQQVPAPAPLPGAVPQGAPLGALPGAQPAVPDPATAVEHFSP
MMAR_3201|M.marinum_M LPVAPQAGVPAPVPALPAPASGVQPGPAAA---AAPGVSR----------
MUL_3509|M.ulcerans_Agy99 LPVAPQAAVPAPVPALPAPASGIQPGPAAA---AAPGVSR----------
Mb2188c|M.bovis_AF2122/97 LSG--GSQPMVAP-PAPVPANGEQFGPVTAPVPTAPGAPR----------
Rv2164c|M.tuberculosis_H37Rv LSG--GSQPMVAP-PAPVPANGEQFGPVTAPVPTAPGAPR----------
MLBr_00907|M.leprae_Br4923 LVSPAVTSPVISTSPVPTPVNSEQFGPVTA---TAPGTSR----------
MAV_2329|M.avium_104 RPG-AAPQPVVPAAPLPQPVNGAQPGAAPV---ASPGAPR----------
MAB_1999|M.abscessus_ATCC_1997 -----QFNPVATTSPLPAA-------------------------------
TH_1738|M.thermoresistible__bu PPPDQIVPPYGRPPAPPPPAEGDRPQAAGVDVATYDPATGKFLDPHTGIS
. * .
Mvan_3530|M.vanbaalenii_PYR-1 -----------------------------
Mflv_2981|M.gilvum_PYR-GCK -----------------------------
MSMEG_4234|M.smegmatis_MC2_155 AVAPVA-----------------------
MMAR_3201|M.marinum_M -----------------------------
MUL_3509|M.ulcerans_Agy99 -----------------------------
Mb2188c|M.bovis_AF2122/97 -----------------------------
Rv2164c|M.tuberculosis_H37Rv -----------------------------
MLBr_00907|M.leprae_Br4923 -----------------------------
MAV_2329|M.avium_104 -----------------------------
MAB_1999|M.abscessus_ATCC_1997 -----------------------------
TH_1738|M.thermoresistible__bu VYASGIAAPSIAENWVDLMTYPRTGSEPA