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M. thermoresistible (build 8) TH_1738 (-)

annotation: MCE-FAMILY PROTEIN MCE4F
coordinates: 3335875 - 3337542
length: 556

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1738--100% (556)MCE-FAMILY PROTEIN MCE4F
M. thermoresistible (build 8)TH_2459-e-10238.95% (570) PUTATIVE mce-family protein mce1f
M. thermoresistible (build 8)TH_4161-3e-8836.26% (546) PUTATIVE virulence factor mce family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3524cmce4F1e-17653.82% (563) MCE-family protein MCE4F
M. gilvum PYR-GCKMflv_1561-0.059.82% (565) virulence factor Mce family protein
M. tuberculosis H37RvRv3494cmce4F1e-17653.82% (563) MCE-family protein MCE4F
M. leprae Br4923MLBr_02594mce1F7e-7734.87% (499) putative secreted protein
M. abscessus ATCC 19977MAB_4148c-1e-16153.10% (548) MCE-family protein
M. marinum MMMAR_4982mce4F1e-17754.64% (560) MCE-family protein Mce4F
M. avium 104MAV_0953-1e-10138.49% (582) mce-family protein mce1f
M. smegmatis MC2 155MSMEG_5895-0.059.22% (564) virulence factor mce family protein
M. ulcerans Agy99MUL_4057mce4F1e-17654.46% (560) MCE-family protein Mce4F
M. vanbaalenii PYR-1Mvan_5197-0.060.64% (564) virulence factor Mce family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3524c|M.bovis_AF2122/97           MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
Rv3494c|M.tuberculosis_H37Rv        MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
MMAR_4982|M.marinum_M               MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
MUL_4057|M.ulcerans_Agy99           MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
Mflv_1561|M.gilvum_PYR-GCK          MLDRLTRIQLSIFAIVTVLSVGAVALFYLHVPAAVGIGAYNVTANFVAGG
Mvan_5197|M.vanbaalenii_PYR-1       MLDRLTRLQLMIFAIVTVLSVGAVSLFYLHVPSAVGIGAYNVTANFVAGG
MSMEG_5895|M.smegmatis_MC2_155      MIDRLTRLQLTIFAIVTVFTVGAISLFYLQLPAAVGIGTYHVNANFVAGG
MAB_4148c|M.abscessus_ATCC_199      -MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVASG
TH_1738|M.thermoresistible__bu      MLSRLVRMQLAVFTAVALISVLAIAVFYIQVPKTLGFGSYRVTADFAGSG
MLBr_02594|M.leprae_Br4923          MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSATG
MAV_0953|M.avium_104                MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPATG
                                     :  : : ** :*     : :  : ::*:: *  .*:*   :. :: . *

Mb3524c|M.bovis_AF2122/97           GLYKNANVTYRGVAVGRVESVGLNPN-GVTAHMRLNSGTAIPSNVTATVR
Rv3494c|M.tuberculosis_H37Rv        GLYKNANVTYRGVAVGRVESVGLNPN-GVTAHMRLNSGTAIPSNVTATVR
MMAR_4982|M.marinum_M               GLYKNANVTYRGVAVGRVESVGLNPN-GVTAQMRLNSGTAIPSNVTATVK
MUL_4057|M.ulcerans_Agy99           GLYKNANVTYRGVAVGRVESVGLNPN-GVTAQMRLNSGTAIPSNVTATVK
Mflv_1561|M.gilvum_PYR-GCK          GIYQNANVTYRGVTIGHVESVGLSDN-SVVARMQLNSDTPVPENVTATVK
Mvan_5197|M.vanbaalenii_PYR-1       GIYQNANVTYRGVTIGHVKSVGLSDT-GVVAHMQLNSGTPVPENVTATVK
MSMEG_5895|M.smegmatis_MC2_155      GIYPNANVTYRGVTVGRVESVGLAPD-GVVAKMRLNSNTSIPENVTATVK
MAB_4148c|M.abscessus_ATCC_199      GLYQNANVTFRGVQIGRVTDVELTPE-GVTATMRLNDNVKVPGNVVAAVK
TH_1738|M.thermoresistible__bu      GIYPNANVAYRGTTIGKVTGVSLTHDNDVRVEMRIDDDRKVPANVNAYVK
MLBr_02594|M.leprae_Br4923          GLYPTANVTYRGIAIGKVTDVEPTAT-GAEATMSIDSRYKIPIDSAANVH
MAV_0953|M.avium_104                GLYRFSNVTYRGVQLGKVTAVGLTPS-GVKATLSLSTSPKVPADLTAEVL
                                    *:*  :**::**  :*:*  *      .. . : :.    :* :  * * 

Mb3524c|M.bovis_AF2122/97           SVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETL
Rv3494c|M.tuberculosis_H37Rv        SVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETL
MMAR_4982|M.marinum_M               SVSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETL
MUL_4057|M.ulcerans_Agy99           SMSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETL
Mflv_1561|M.gilvum_PYR-GCK          SVSAIGEQYIDLVPPEDASQQMLRDGSDIGLDRTAIGQDIAGLLAEADTL
Mvan_5197|M.vanbaalenii_PYR-1       SVSAIGEQYIDLVPPQEASDATLRDGSDIGVDRTAIGQDIAGLLAEAENL
MSMEG_5895|M.smegmatis_MC2_155      SVSAVGEQYIDLVPPDDTHVGKLRNGATIAQENTRVGQDISGLLHEADTL
MAB_4148c|M.abscessus_ATCC_199      SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
TH_1738|M.thermoresistible__bu      SMSAIGEQYVDLVPPEHASTESLRGGSHIGRDRTFINGDIAGMLREAQAL
MLBr_02594|M.leprae_Br4923          SVSAVGEQYLDLVSSGNPG-KYLAPGQTITK--SKIPIEIGPALDSVNRG
MAV_0953|M.avium_104                SVSAVGEQYVDLRPRTNSP-PYLHDGSVIAMRDTKIPQPVGPMLDQVNAL
                                    *:**:****:** .        *  *  *    : :   :.  * ..:  

Mb3524c|M.bovis_AF2122/97           LGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQ
Rv3494c|M.tuberculosis_H37Rv        LGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQ
MMAR_4982|M.marinum_M               VNSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQ
MUL_4057|M.ulcerans_Agy99           VNSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQ
Mflv_1561|M.gilvum_PYR-GCK          VQSVSDSRLQELLDETFTAFNGSGPELARLIQSSRLLVDEANANYPQVAQ
Mvan_5197|M.vanbaalenii_PYR-1       VQSVSNSRLQDLLSETFKAFNGSGPELARLIQSSRLLVDEANANYPEVSQ
MSMEG_5895|M.smegmatis_MC2_155      VSSVSNTRLQDLLRETFKAFNGSGPELARLIESSRLLIDEANANFPQTSQ
MAB_4148c|M.abscessus_ATCC_199      VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
TH_1738|M.thermoresistible__bu      VDSLDRSRLRDVLKETFAAFNGSGPELARLLESSRLLVEEAGDATDDTIG
MLBr_02594|M.leprae_Br4923          LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
MAV_0953|M.avium_104                VQSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRA
                                    : ::   :: .:* *:  . .* *  *  *:.*:: :          .  

Mb3524c|M.bovis_AF2122/97           LIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGAPDA
Rv3494c|M.tuberculosis_H37Rv        LIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLADAPDA
MMAR_4982|M.marinum_M               LIDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDA
MUL_4057|M.ulcerans_Agy99           LIDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDA
Mflv_1561|M.gilvum_PYR-GCK          LIDQAGPFLDAQIRSGDDIRSLAEGLGRLTTEVAGADPQLRTTLQTVPGA
Mvan_5197|M.vanbaalenii_PYR-1       LIDQAGPFLDAQIRSGDDIRSLAEGLGRLTTEVADADPQLRTTLQTVPGT
MSMEG_5895|M.smegmatis_MC2_155      LIDQAGPFLEAQLRSGDDIRSLADGLARLTGEVNNADPQLRTTLRTAPGT
MAB_4148c|M.abscessus_ATCC_199      LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
TH_1738|M.thermoresistible__bu      LVEQSQPLLDAQVTAGDDIRAVADGLARLTSHLREADPQFREVLQKAPAA
MLBr_02594|M.leprae_Br4923          IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
MAV_0953|M.avium_104                LTEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPET
                                    : ::  *:*::*  : . *.  . .:  ::      *  ::  *   . :

Mb3524c|M.bovis_AF2122/97           IDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAI
Rv3494c|M.tuberculosis_H37Rv        IDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAI
MMAR_4982|M.marinum_M               IDEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAI
MUL_4057|M.ulcerans_Agy99           IDEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAI
Mflv_1561|M.gilvum_PYR-GCK          AEVANETFDGIRPSFPMLAANLANFGRIGVIYNKSLEHALVVFPALLAAL
Mvan_5197|M.vanbaalenii_PYR-1       AEVVNETFDGIRPSFPMLAANLANFGRIGVIYHKSLEHALVVFPALLAAL
MSMEG_5895|M.smegmatis_MC2_155      TEAANTAFSGIRPSFPILAANLANFGRIGVIYSKSLEQALVIFPALMAAL
MAB_4148c|M.abscessus_ATCC_199      SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
TH_1738|M.thermoresistible__bu      ADQATTLFDGIRPTFPVLAANLANAGRIGVIYHKSIEQVLVIIPAVTAAI
MLBr_02594|M.leprae_Br4923          ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIA
MAV_0953|M.avium_104                ANEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIE
                                     : ..  :  :: ::*   *.:     :   *  .:*: **.:*   :  

Mb3524c|M.bovis_AF2122/97           ITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
Rv3494c|M.tuberculosis_H37Rv        ITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
MMAR_4982|M.marinum_M               TTAAGGVPQDEGAKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
MUL_4057|M.ulcerans_Agy99           TTAAGGVPQDEGAKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
Mflv_1561|M.gilvum_PYR-GCK          NTVAGGVPTDEGGKLDFKIHLQDPPPCATGFIPATQIRSPADTTLRELPT
Mvan_5197|M.vanbaalenii_PYR-1       NTVAGGVPTDEGGKLDFKIHLQDPPPCSTGFVPATQIRSPADTTLRELPT
MSMEG_5895|M.smegmatis_MC2_155      NTVAGGVPSDEGGKLDFKIDLGDPPPCSVGFLPATEIRSPADTTLRDLPT
MAB_4148c|M.abscessus_ATCC_199      LTVAGGAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPR
TH_1738|M.thermoresistible__bu      IAIANQFPADEGAKGDFKLNFGDPPPCITGFVPPSEIRSPADTTLRDVPK
MLBr_02594|M.leprae_Br4923          QTASAT-FPN-MAALDLALSINQPPPCLTGFIPAAEWRSPADTSLQPLPV
MAV_0953|M.avium_104                QAAAAPNHPEGTAQGDFALTIDDPPICTVGFMPPNTWRSPDDLSDIDTPD
                                     : :     :  .  *: : : :** * .**:*.   *:* * :    * 

Mb3524c|M.bovis_AF2122/97           DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTN-
Rv3494c|M.tuberculosis_H37Rv        DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTN-
MMAR_4982|M.marinum_M               DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYVPVGRN-
MUL_4057|M.ulcerans_Agy99           DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYFPVGRN-
Mflv_1561|M.gilvum_PYR-GCK          DLYCKVPQNDPS-VVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPLGSN-
Mvan_5197|M.vanbaalenii_PYR-1       DLYCKVPQSDPS-VVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGNN-
MSMEG_5895|M.smegmatis_MC2_155      DLYCKTAQNDPA-VVRGARNYPCQEFPGKRAPTVQLCRDPNGYVPIGSN-
MAB_4148c|M.abscessus_ATCC_199      DMYCKTAQNDPS-AVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSN-
TH_1738|M.thermoresistible__bu      ELYCKVPHNDPA-VVRGARNYPCMEFPGKRAATVQQCRDPEGYVPIGSN-
MLBr_02594|M.leprae_Br4923          GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTN-
MAV_0953|M.avium_104                GLYCKLPQDSPL-SVRGARNYPCMGHPGKRAPTVEICNSDQPFMPLAMKQ
                                      *** . . .   ***:** **   *****.: . *.. . :.*:. : 

Mb3524c|M.bovis_AF2122/97           ----PWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPP
Rv3494c|M.tuberculosis_H37Rv        ----PWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPP
MMAR_4982|M.marinum_M               ----PWRGPPVPYDTPVTDGLNVLPPNKFPYIPPDSDPDPGTPIVGPPPP
MUL_4057|M.ulcerans_Agy99           ----PWRGPPVPYDTPVTDGLNVLPPNKFPYIPPDSDPDPGTPIVGPPPP
Mflv_1561|M.gilvum_PYR-GCK          ----PWRGPPVPVGTPVQDGRNILPPNKFPMIPPQVDPDPGPPSVQLPP-
Mvan_5197|M.vanbaalenii_PYR-1       ----PWRGPPVPVGTPIQDGRNILPPNKFPMIPPQVDPDPGPPSVQLPP-
MSMEG_5895|M.smegmatis_MC2_155      ----PWRGPPVPYGQPIEDGRNILPPNKFPMIPPQVDPDPGPPVVQLPP-
MAB_4148c|M.abscessus_ATCC_199      ----PWRGPPAPYDTPVEDPRNILPPNKFPNIPPGAEPDPGTPTLPPPS-
TH_1738|M.thermoresistible__bu      ----PWRGPPVPVGTPITDPRMILPQNKYPYIPPQADYDPGPPVVQLPP-
MLBr_02594|M.leprae_Br4923          ----PWFGDPNQLLTCPAPGARCDQ-----------PVKPGLVIP-APTV
MAV_0953|M.avium_104                HVLGPYPLDPNLLAQGVPPDDRVTVNDRIFGPVEGTPLPPGAVPRGAPAG
                                        *:   *                             **      *. 

Mb3524c|M.bovis_AF2122/97           GQVAGPGPAPHQPAQPAPPPNDNGP-PPPFTSWMPPG--YPPEPPQVPYP
Rv3494c|M.tuberculosis_H37Rv        GQVAGPGPAPHQPAQPAPPPNDNGP-PPPFTSWMPPG--YPPEPPQVPYP
MMAR_4982|M.marinum_M               GVIPGPPPAPNQPAQPAPPPNDNGP-PPPFTSWMPPD--YPPQAPQIPYP
MUL_4057|M.ulcerans_Agy99           GVIPGPPPAPNQPAQPAPPPNDNGP-PPPFTSWMPPD--YPPQAPQIPYP
Mflv_1561|M.gilvum_PYR-GCK          GVTPGPGPAPHAPFPLPTPPNEQGPQPAPWPYFSPPDHVVPPYGRPPLAP
Mvan_5197|M.vanbaalenii_PYR-1       GVAPGPGPAPHAPFPLPVPPNEQGPPPPPWPYFAPPDQVVPPYGRPPLAP
MSMEG_5895|M.smegmatis_MC2_155      GVEPGPGPAPHAPFPLPVPPNTLGPPPPPLPYYAPPDQIVPPYGRTPPPP
MAB_4148c|M.abscessus_ATCC_199      ------PPAP------EVPPAGGDVMP-----------------------
TH_1738|M.thermoresistible__bu      GVPPGPGPALTPPYPTQIPPVTPGPPPPPLPFQPPPDQIVPPYGRPPAPP
MLBr_02594|M.leprae_Br4923          DNGLNPAPADR------LPGTPPPVSDPLS--------------------
MAV_0953|M.avium_104                PRGENPPPGSVGAAVPPVPSSGPPALAPMSRMSADLPPIAPLDVPTPTEL
                                           *.         *                               

Mb3524c|M.bovis_AF2122/97           ATIPPPPPPEGTGPPPGPAPGPQPQASGPAYT---------IYDQLSGAF
Rv3494c|M.tuberculosis_H37Rv        ATIPPPPPPEGTGPPPGPAPGPQPQASGPAYT---------IYDQLSGAF
MMAR_4982|M.marinum_M               KTLPPPPPPVGVGP----EPGPQPQASGPAYT---------TYDPLTGVF
MUL_4057|M.ulcerans_Agy99           KTLPPPPPPVGVGP----EPGPQPQASGPAYT---------TYDPLTGVF
Mflv_1561|M.gilvum_PYR-GCK          PPAPGPAPAPAPAPGAPPLPAEAPLASSTSVA---------TYDHN-GKF
Mvan_5197|M.vanbaalenii_PYR-1       PPAP-PAPAPAPAEGSPALPAEAPLASGTSVA---------TYDQN-GKF
MSMEG_5895|M.smegmatis_MC2_155      AGAPAPPPPAPPAPEG-ALPAEAPLAAPAGIG---------TYDQHSGVF
MAB_4148c|M.abscessus_ATCC_199      ---------------------VSAQSGPMAAR---------AYDPKNGVF
TH_1738|M.thermoresistible__bu      PPAE----------------GDRPQAAGVDVA---------TYDPATGKF
MLBr_02594|M.leprae_Br4923          ------QPRSGSVQCNGQQPNTCVYTPSGPPS--------AVYSPQSGEL
MAV_0953|M.avium_104                PPPPPPPAPAAPDQVDGAAPQAAPSAFAGKASKPAPSVVVAKYDPRTGRY
                                                             :                *.   *  

Mb3524c|M.bovis_AF2122/97           ADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL----
Rv3494c|M.tuberculosis_H37Rv        ADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL----
MMAR_4982|M.marinum_M               KDPAGGTGIFAGGISGASSAENWVDLMLAPRTM----
MUL_4057|M.ulcerans_Agy99           KDPAGGAGIFVGGISGASSAENWVDLMLAPRTM----
Mflv_1561|M.gilvum_PYR-GCK          VDPAGGVGVYAPGSDKLAPAENWVDLMLAPKQV----
Mvan_5197|M.vanbaalenii_PYR-1       VDPAGGVGVYAPGSDKLAPAENWVDLMLAPKQV----
MSMEG_5895|M.smegmatis_MC2_155      ADADGGTGVYA-GADAIAPAETWVDLMLDPRQA----
MAB_4148c|M.abscessus_ATCC_199      LDANNQPSVYAPALDRGTEAETWADLMLGPKPV----
TH_1738|M.thermoresistible__bu      LDPHTGISVYASGIAAPSIAENWVDLMTYPRTGSEPA
MLBr_02594|M.leprae_Br4923          VGPD-GVAYAVEN-STKTGDDGWKEMLAPAG------
MAV_0953|M.avium_104                VGPD-GKLYQQSDLVTPKAPKTWKDMLPT--------
                                     ..                 . * :::