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MKAQRDTPIRRGDSGRPGGRDGAARSGKRTANEAGSRRLRTHAGKISASAREVGVPKSGPRTSPMSRPVE RPARPRNTTQAKARAKARKAKAPKVVRPRLGECLIARLALIDLRPRTLVNKVPFVVLVISSLGVGLGLTL WLSTDSAERSYQLGDAREQARMLQQQKEALERDVREAESAPALAETARKQGMIPTRDTAHLVQGPGGNWV VVGTPKPADGVPPPPLNTKLPDAGPPSLKPPEIPLEVPVRVVPGPGGPPPPARSGPQMWLRVPDGATTLG GQHLPQELPQLPGMLNGPAAAQVQVPGFMPTPGLPIPGSTMRVPVPAPAPTEVPVRLQPGLVSPAVTSPV ISTSPVPTPVNSEQFGPVTATAPGTSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00907 | - | - | 100% (377) | hypothetical protein MLBr_00907 |
| M. leprae Br4923 | MLBr_00048 | - | 9e-07 | 30.17% (179) | hypothetical protein MLBr_00048 |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-05 | 27.70% (278) | putative secreted protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2188c | - | 1e-123 | 61.71% (397) | hypothetical protein Mb2188c |
| M. gilvum PYR-GCK | Mflv_2981 | - | 9e-87 | 50.14% (363) | hypothetical protein Mflv_2981 |
| M. tuberculosis H37Rv | Rv2164c | - | 1e-124 | 61.96% (397) | hypothetical protein Rv2164c |
| M. abscessus ATCC 19977 | MAB_1999 | - | 2e-64 | 42.82% (369) | hypothetical protein MAB_1999 |
| M. marinum M | MMAR_3201 | - | 1e-117 | 56.78% (428) | proline rich membrane protein |
| M. avium 104 | MAV_2329 | - | 1e-126 | 59.25% (427) | hypothetical protein MAV_2329 |
| M. smegmatis MC2 155 | MSMEG_4234 | - | 1e-80 | 50.82% (368) | hypothetical protein MSMEG_4234 |
| M. thermoresistible (build 8) | TH_2459 | - | 4e-05 | 34.33% (134) | PUTATIVE mce-family protein mce1f |
| M. ulcerans Agy99 | MUL_3509 | - | 1e-116 | 56.81% (426) | proline rich membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3530 | - | 4e-85 | 51.92% (339) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2981|M.gilvum_PYR-GCK ---------------------------------------MKAKKPLRNAA
Mvan_3530|M.vanbaalenii_PYR-1 ---------------------------------------MKAQKPMRKTA
MSMEG_4234|M.smegmatis_MC2_155 ---------------------------------------MKAKR------
MLBr_00907|M.leprae_Br4923 ---------------------------------------MKAQRDTPIRR
MAV_2329|M.avium_104 ---------------------------------------MKAERETAKRR
MMAR_3201|M.marinum_M ---------------------------------------MKAKREARVPG
MUL_3509|M.ulcerans_Agy99 ---------------------------------------MKAKREARVPG
Mb2188c|M.bovis_AF2122/97 ---------------------------------------MRAKREAPKSR
Rv2164c|M.tuberculosis_H37Rv ---------------------------------------MRAKREAPKSR
MAB_1999|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2459|M.thermoresistible__bu MLTRFIRTQLILFTIAAIVGVSVMVFAYMQVPMLLGIGRMTVKIELPEAG
Mflv_2981|M.gilvum_PYR-GCK AEPARR----SERTSGRSRATTTKPKAGGKRGTAREAKRTPVDAQPRGRK
Mvan_3530|M.vanbaalenii_PYR-1 TG-----------EPGRARTSAKKSPRAAKRRPVRETKRTPVDAPPRGRQ
MSMEG_4234|M.smegmatis_MC2_155 --------------PGPVRDADRRR---GKRQPG--VARGSAEAPPRKRR
MLBr_00907|M.leprae_Br4923 --------------GDSGRPGGRDGAARSGKRTANEAGSRRLRTHAGKIS
MAV_2329|M.avium_104 --------------GGSDRRGARDGSARRGRRPAADAGAAR-RARGGPAS
MMAR_3201|M.marinum_M --------------KRQSGDRGGGRDGSVARTTRRTPADASRRVRAGKKK
MUL_3509|M.ulcerans_Agy99 --------------KRQSGDRGGGRDGSVARTTRRTPADASRRGRAGKKK
Mb2188c|M.bovis_AF2122/97 --------------SSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTS
Rv2164c|M.tuberculosis_H37Rv --------------SSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTS
MAB_1999|M.abscessus_ATCC_1997 ----------------MIGVRKKAGEAPKKTKPAKSAKPTKRRNGASKAT
TH_2459|M.thermoresistible__bu GLYRFSNVTYRGTQVGKVQSVTLTDDGVEATMSLVGSAKIPADLRAEVRS
.
Mflv_2981|M.gilvum_PYR-GCK TTRD-ARPQRSAPRTTPISRPVDAPARPK---SATQAKARAKARKAKAPK
Mvan_3530|M.vanbaalenii_PYR-1 QTRD-ARPQRSAPRTTPIARPKDVPARPK---STSQAKARAKARKAKAPK
MSMEG_4234|M.smegmatis_MC2_155 PSREPQRPLRSAPQTGPIPRQKTEPARPK---TASQAKARAKARKAKAPK
MLBr_00907|M.leprae_Br4923 ASAREVGVPKSGPRTSPMSRPVERPARPR---NTTQAKARAKARKAKAPK
MAV_2329|M.avium_104 APTRESRAPKPGPQTSPVARPAERSARPK---NTSQAKARAKARKAKAPK
MMAR_3201|M.marinum_M APNREARIPMSGPQTTPMPRPAERPARPK---NTGQAKARAKARKAKAPK
MUL_3509|M.ulcerans_Agy99 APNREARIPMSGPQTTPMPRPAERPARPK---NTGQAKARAKARKAKAPK
Mb2188c|M.bovis_AF2122/97 APGRQARVSRPGPQTSPMLSPFDRPAPAK---NTSQAKARAKARKAKAPK
Rv2164c|M.tuberculosis_H37Rv APGRQARVSRPGPQTSPMLSPFDRPAPAK---NTSQAKARAKARKAKAPK
MAB_1999|M.abscessus_ATCC_1997 ATGPSARPRRSAPQTMPIPVQRQAPEKIRPATSTRQAKARAKARKAKAPK
TH_2459|M.thermoresistible__bu MSAVGEQYIELLPRTDSPPYLENGSVIPRSDTSVPQAVGPMLEQLSTLVN
. *:* . . : .. ** . : :. :
Mflv_2981|M.gilvum_PYR-GCK VVRPPLRERLLVR----LASIDLNPRRLAARVPFVVLIISALG-----LG
Mvan_3530|M.vanbaalenii_PYR-1 VVRPPLRQRILVR----LASIELDPRRLIARVPFVVLVIGALG-----LG
MSMEG_4234|M.smegmatis_MC2_155 VVRPPLRERILLR----LSSIELNPRELVARVPFVVLVIAALG-----LG
MLBr_00907|M.leprae_Br4923 VVRPRLGECLIAR----LALIDLRPRTLVNKVPFVVLVISSLG-----VG
MAV_2329|M.avium_104 VVRPRLTERLAAR----LAAIDLRPRTLASKVPFVVLVIGALG-----VG
MMAR_3201|M.marinum_M VVRPKLTERMAVR----LASMDLRPHALLSRVPFVVLVIGSLG-----VG
MUL_3509|M.ulcerans_Agy99 VVRPKLTERMAVR----LASMDLRPHALLSRVPFVVLVIGSLG-----VG
Mb2188c|M.bovis_AF2122/97 LVRPTPMERLAAR----LTSIDLRPRTLANKVPFVVLVIGSLG-----VG
Rv2164c|M.tuberculosis_H37Rv LVRPTPMERLAAR----LTSIDLRPRTLANKVPFVVLVIGSLG-----VG
MAB_1999|M.abscessus_ATCC_1997 VIRVPLRERVLAR----LSEVDLRPHVWITRVPFVVFVIGALG-----VG
TH_2459|M.thermoresistible__bu TIPKDSLSRLLDESFEAFNDTGYEFGSLLDSSATVTRDANAVADQTRLLA
: . : . : . *. ::. :.
Mflv_2981|M.gilvum_PYR-GCK LGVTLWLSTDAAERS-------YQLGSARQLNQALMQQKEALERDVLEAQ
Mvan_3530|M.vanbaalenii_PYR-1 LGVTLWLSTDAAERS-------YQLGAARQLNQALLQQKEGLERDVLEAQ
MSMEG_4234|M.smegmatis_MC2_155 LGITLWLSTSAAERS-------YQLGHARQVNQGLLQQKEALERDVLEAQ
MLBr_00907|M.leprae_Br4923 LGLTLWLSTDSAERS-------YQLGDAREQARMLQQQKEALERDVREAE
MAV_2329|M.avium_104 LGLTLWLSTDSAERS-------YKLSHARERTRLLQQQKEALERDVREAE
MMAR_3201|M.marinum_M LGLTLWLSTDAAERS-------YQLSHARERTRMLQQQKESLERDVREAE
MUL_3509|M.ulcerans_Agy99 LGLTLWLSTDAAERS-------YQLSHARERTRMLQQQKESLERDVREAE
Mb2188c|M.bovis_AF2122/97 LGLTLWLSTDAAERS-------YQLSNARERTRMLQQHKEALERDVREAA
Rv2164c|M.tuberculosis_H37Rv LGLTLWLSTDAAERS-------YQLSNARERTRMLQQHKEALERDVREAA
MAB_1999|M.abscessus_ATCC_1997 LAITLWLSTDAAERS-------YQLGTQRRTNEELLQRKEALERDVLRAE
TH_2459|M.thermoresistible__bu EDAEPFLDAQAQTTDSIRVWAASLAGITDQLDKNDPQIRTVLREGPGFAQ
:*.:.: . . . . * : *... *
Mflv_2981|M.gilvum_PYR-GCK AAPALAEAAR-----ELGMIPSRDTAHLVQDASGNWVVVGTP--------
Mvan_3530|M.vanbaalenii_PYR-1 AAPALAEAAR-----NLGMIPSRDTAHLVQDPSGNWVVVGTP--------
MSMEG_4234|M.smegmatis_MC2_155 AAPALAEAAR-----NLGMIPSRDTAHLVQDPTGNWVVVGTP--------
MLBr_00907|M.leprae_Br4923 SAPALAETAR-----KQGMIPTRDTAHLVQGPGGNWVVVGTP--------
MAV_2329|M.avium_104 AAPALAEAAR-----KQGMIPTRDTAHLVQDPSGNWVVVGTP--------
MMAR_3201|M.marinum_M SAPALAEAAR-----KQGMIPTRDTAHLVQAPDGNWVVVGTP--------
MUL_3509|M.ulcerans_Agy99 SAPALAEAAR-----KQGMIPTRDTAHLVQAPDGNWVVVGTP--------
Mb2188c|M.bovis_AF2122/97 SAPALAEAAR-----RQGMIPTRDTAHLAQDPDGNWVVVGTP--------
Rv2164c|M.tuberculosis_H37Rv SAPALAEAAR-----RQGMIPTRDTAHLVQDPDGNWVVVGTP--------
MAB_1999|M.abscessus_ATCC_1997 SAPALADSAR-----DLGMIPSRDIAHLVRDPQGNWLLVGAP--------
TH_2459|M.thermoresistible__bu ETAQLLEQARPTLPVLLANMTTFGKIGVSYNPSIEQLLVLVPPFVAQIQT
:. * : ** . :.: . : . : ::* .*
Mflv_2981|M.gilvum_PYR-GCK ----KPAEGVP-----------------------------------PPPL
Mvan_3530|M.vanbaalenii_PYR-1 ----KPAEGVP-----------------------------------PPPL
MSMEG_4234|M.smegmatis_MC2_155 ----KPAEGVP-----------------------------------PPPL
MLBr_00907|M.leprae_Br4923 ----KPADGVP-----------------------------------PPPL
MAV_2329|M.avium_104 ----KPADGVP-----------------------------------PPPL
MMAR_3201|M.marinum_M ----KPADGVP-----------------------------------PPPL
MUL_3509|M.ulcerans_Agy99 ----KPADGVP-----------------------------------PPPL
Mb2188c|M.bovis_AF2122/97 ----KPADGVP-----------------------------------PPPL
Rv2164c|M.tuberculosis_H37Rv ----KPADGVP-----------------------------------PPPL
MAB_1999|M.abscessus_ATCC_1997 ----KPAEGVA-----------------------------------PAPL
TH_2459|M.thermoresistible__bu YAPTTSPNGLPNGEFSLGLGDPAACTVGFLPPSAWRSPADTTVVDTPEGL
...:*:. * *
Mflv_2981|M.gilvum_PYR-GCK NAPLP---EPAPPAPPAPRVVEPREVPVRIPSAA---------TPLAVPG
Mvan_3530|M.vanbaalenii_PYR-1 NAPLP---EPAPPAPPAPRVIEPLEVPVRLPSVT---------APQAIPG
MSMEG_4234|M.smegmatis_MC2_155 NAPLPPDAPPPPPAPPAPRVVEPREVPIRVPEAPGLQGLPGIQAAPGIPG
MLBr_00907|M.leprae_Br4923 NTKLPDAGPPSL-KPPEI----PLEVPVRVVPGPGGPPPPARSGPQMWLR
MAV_2329|M.avium_104 NSKLPDEAPQPP-KPAPP----AAEVPIRVELAPGGP-VPARSGPEALLR
MMAR_3201|M.marinum_M NTKLPEEGPPAPPKPAAL----PPEVPVRVMPGPDDPALLPRTGPQLLPR
MUL_3509|M.ulcerans_Agy99 NSKLPEEGPPAPPKPAAL----PPEVPVRVMPGPDDPALLPRTGPQLLPR
Mb2188c|M.bovis_AF2122/97 NTKLPED-PPPPPKPAAV----PLEVPVRVTPGPDDPAPPARSGPEVLVR
Rv2164c|M.tuberculosis_H37Rv NTKLPED-PPPPPKPAAV----PLEVPVRVTPGPDDPAPPARSGPEVLVR
MAB_1999|M.abscessus_ATCC_1997 NSVIPDDADAVPKAGNSV------EVPVQLPPVP----PPVAVVPHMAP-
TH_2459|M.thermoresistible__bu YCKLPQDSPVAVRGARNYP---CMEHPGKRAPTVELCNDPEGYKPVATRQ
:* * * : .
Mflv_2981|M.gilvum_PYR-GCK MVPG-----------------------------APAPLPG----------
Mvan_3530|M.vanbaalenii_PYR-1 TAPA-----------------------------LPLAVPG----------
MSMEG_4234|M.smegmatis_MC2_155 AVQG-----------------------------VPGAVPG----------
MLBr_00907|M.leprae_Br4923 VPDGATTLGGQHLPQELPQLP----GMLNGPAAAQVQVPG----------
MAV_2329|M.avium_104 APDGASTLGGQHLAPAVPPVPGTPPGVPGGPVAAPPALPGGPVAAVPPAS
MMAR_3201|M.marinum_M TPDGSSTLGAGTN--HLPGQPPIEIPGQVPGAPGPVPLPGQ---------
MUL_3509|M.ulcerans_Agy99 TPDGSSTLGADTN--HLPGQPPIEIPGQVPGAPGPVPLPGQ---------
Mb2188c|M.bovis_AF2122/97 TPDGTATLGGAT---HLPTQAGPQLP-------GPVPIPG----------
Rv2164c|M.tuberculosis_H37Rv TPDGTATLGGAT---HLPTQAGPQLP-------GPVPIPG----------
MAB_1999|M.abscessus_ATCC_1997 ----------------------------------PTAAPA----------
TH_2459|M.thermoresistible__bu HALGPYPFDPNLVSQGVPIDARARLDDNTFGPVEGTPLPPG---------
*
Mflv_2981|M.gilvum_PYR-GCK --------------LAP---VPGSE-------------------------
Mvan_3530|M.vanbaalenii_PYR-1 --------------AVPNVAVPNVE-------------------------
MSMEG_4234|M.smegmatis_MC2_155 --------------ETP-HVAPGAQPQ-----------------------
MLBr_00907|M.leprae_Br4923 -FMPT-----------PGLPIPGSTMR-----------------------
MAV_2329|M.avium_104 PAMPTGPATGRPPGLTPGLPMPGLPMPAGPAVAP---------APAEVSI
MMAR_3201|M.marinum_M --LPGVAGPVTGPGQLPGPAAGAVQVPPAPVVLPAP---VPAQVPAEVPV
MUL_3509|M.ulcerans_Agy99 --LPGVAGPVTGPGQLPGPAAGAVQVPPAPVVLPAP---VPAQVPAEVPV
Mb2188c|M.bovis_AF2122/97 -----------APGPMPAPPLGAVPSP----------------APAENPV
Rv2164c|M.tuberculosis_H37Rv -----------APGPMPAPPLGAVPSP----------------APAENPV
MAB_1999|M.abscessus_ATCC_1997 ----------------PVVEAPIGQ-------------------------
TH_2459|M.thermoresistible__bu -------------VTAPPPRIPQAPSPPPNFAGTGPGALLPGQPLYTEPP
*
Mflv_2981|M.gilvum_PYR-GCK ------VPHAVSADIPMP--GPV-LPAAAPDPALVAP------------A
Mvan_3530|M.vanbaalenii_PYR-1 ------VPHAVSGQLPAP--GPVPVPVPGPAPVPAAP------------L
MSMEG_4234|M.smegmatis_MC2_155 ------APGPVIGPLTGP--APMAVPMPVPAEVPLATPQAPQQAAPLVNT
MLBr_00907|M.leprae_Br4923 ------VPVPAP--------APTEVPVRLQPGLVSPAVTSPVISTSPVPT
MAV_2329|M.avium_104 PL--GGLPVPAPGQLPAP--LPPEVPVPVQLGRPG-AAPQPVVPAAPLPQ
MMAR_3201|M.marinum_M PVPVPAVTAPPVAVVPAAPQAPLAAPVPGTAGLPVAPQAGVPAPVPALPA
MUL_3509|M.ulcerans_Agy99 PV--PAVTAPPVAVVPVAPQTPLAAPVPGTAGLPVAPQAAVPAPVPALPA
Mb2188c|M.bovis_AF2122/97 PL---QVGAAPPAGLPGP------APVAATPGLSGGSQ---PMVAPPAPV
Rv2164c|M.tuberculosis_H37Rv PL---QVGAAPPAGLPGP------APVAATPGLSGGSQ---PMVAPPAPV
MAB_1999|M.abscessus_ATCC_1997 ------DPAAVPQVAPVP-----AVPADVPPPVADAPQ-----ASNITNS
TH_2459|M.thermoresistible__bu VSPPGPAQVTEPDIVPAPPAQLPSATEVPVPPGVNPDDLHLPPGAVPVPG
. .
Mflv_2981|M.gilvum_PYR-GCK PAPAPAPAPAPV-----PGAGA----------------------------
Mvan_3530|M.vanbaalenii_PYR-1 DAGTSQLPPAPA-----PGAPA----------------------------
MSMEG_4234|M.smegmatis_MC2_155 PAPQQVPAPAPL-----PGAVPQGAPLGALPGAQPAVPDPATAVEHFSPA
MLBr_00907|M.leprae_Br4923 PVNSEQFGPVTA---TAPGTSR----------------------------
MAV_2329|M.avium_104 PVNGAQPGAAPV---ASPGAPR----------------------------
MMAR_3201|M.marinum_M PASGVQPGPAAA---AAPGVSR----------------------------
MUL_3509|M.ulcerans_Agy99 PASGIQPGPAAA---AAPGVSR----------------------------
Mb2188c|M.bovis_AF2122/97 PANGEQFGPVTAPVPTAPGAPR----------------------------
Rv2164c|M.tuberculosis_H37Rv PANGEQFGPVTAPVPTAPGAPR----------------------------
MAB_1999|M.abscessus_ATCC_1997 PVTGEQFNPVAT---TSPLPAA----------------------------
TH_2459|M.thermoresistible__bu PGSGTVISPSSSSSARDGGPTVAFARYNPRTGEYMASDGRLYRQSDLSST
. .
Mflv_2981|M.gilvum_PYR-GCK ----------
Mvan_3530|M.vanbaalenii_PYR-1 ----------
MSMEG_4234|M.smegmatis_MC2_155 VAPVA-----
MLBr_00907|M.leprae_Br4923 ----------
MAV_2329|M.avium_104 ----------
MMAR_3201|M.marinum_M ----------
MUL_3509|M.ulcerans_Agy99 ----------
Mb2188c|M.bovis_AF2122/97 ----------
Rv2164c|M.tuberculosis_H37Rv ----------
MAB_1999|M.abscessus_ATCC_1997 ----------
TH_2459|M.thermoresistible__bu PKSWQELMPT