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MKAERETAKRRGGSDRRGARDGSARRGRRPAADAGAARRARGGPASAPTRESRAPKPGPQTSPVARPAER SARPKNTSQAKARAKARKAKAPKVVRPRLTERLAARLAAIDLRPRTLASKVPFVVLVIGALGVGLGLTLW LSTDSAERSYKLSHARERTRLLQQQKEALERDVREAEAAPALAEAARKQGMIPTRDTAHLVQDPSGNWVV VGTPKPADGVPPPPLNSKLPDEAPQPPKPAPPAAEVPIRVELAPGGPVPARSGPEALLRAPDGASTLGGQ HLAPAVPPVPGTPPGVPGGPVAAPPALPGGPVAAVPPASPAMPTGPATGRPPGLTPGLPMPGLPMPAGPA VAPAPAEVSIPLGGLPVPAPGQLPAPLPPEVPVPVQLGRPGAAPQPVVPAAPLPQPVNGAQPGAAPVASP GAPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2329 | - | - | 100% (424) | hypothetical protein MAV_2329 |
| M. avium 104 | MAV_1297 | - | 2e-16 | 37.16% (183) | hypothetical protein MAV_1297 |
| M. avium 104 | MAV_4644 | - | 7e-15 | 33.18% (217) | hypothetical protein MAV_4644 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2188c | - | 1e-119 | 60.51% (395) | hypothetical protein Mb2188c |
| M. gilvum PYR-GCK | Mflv_2981 | - | 4e-87 | 50.53% (380) | hypothetical protein Mflv_2981 |
| M. tuberculosis H37Rv | Rv2164c | - | 1e-119 | 60.76% (395) | hypothetical protein Rv2164c |
| M. leprae Br4923 | MLBr_00907 | - | 1e-126 | 59.25% (427) | hypothetical protein MLBr_00907 |
| M. abscessus ATCC 19977 | MAB_1999 | - | 9e-69 | 48.19% (332) | hypothetical protein MAB_1999 |
| M. marinum M | MMAR_3201 | - | 1e-130 | 60.22% (445) | proline rich membrane protein |
| M. smegmatis MC2 155 | MSMEG_4234 | - | 4e-94 | 51.34% (411) | hypothetical protein MSMEG_4234 |
| M. thermoresistible (build 8) | TH_4426 | - | 1e-11 | 30.28% (218) | PUTATIVE AAA ATPase |
| M. ulcerans Agy99 | MUL_3509 | - | 1e-131 | 60.67% (445) | proline rich membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3530 | - | 2e-85 | 49.35% (383) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2981|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3530|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4234|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1999|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2329|M.avium_104 --------------------------------------------------
MLBr_00907|M.leprae_Br4923 --------------------------------------------------
Mb2188c|M.bovis_AF2122/97 --------------------------------------------------
Rv2164c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3201|M.marinum_M --------------------------------------------------
MUL_3509|M.ulcerans_Agy99 --------------------------------------------------
TH_4426|M.thermoresistible__bu VVRPAHPLYCAAVRAELTEPEVRGVRTELAGAAAPTDVVGRLRWTLHALD
Mflv_2981|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3530|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4234|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1999|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2329|M.avium_104 --------------------------------------------------
MLBr_00907|M.leprae_Br4923 --------------------------------------------------
Mb2188c|M.bovis_AF2122/97 --------------------------------------------------
Rv2164c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3201|M.marinum_M --------------------------------------------------
MUL_3509|M.ulcerans_Agy99 --------------------------------------------------
TH_4426|M.thermoresistible__bu SDAPPAAQQLTVAAEDALRLGDLGLCERFGRAAVGAAGSGAGLAARLPLA
Mflv_2981|M.gilvum_PYR-GCK ----------------------------MKAKKPLRNAAAEPARRSERTS
Mvan_3530|M.vanbaalenii_PYR-1 ----------------------------MKAQKPMRKTATG-------EP
MSMEG_4234|M.smegmatis_MC2_155 ----------------------------MKAKR----------------P
MAB_1999|M.abscessus_ATCC_1997 ----------------------------MIGVR-----------------
MAV_2329|M.avium_104 ----------------------------MKAERET----------AKRRG
MLBr_00907|M.leprae_Br4923 ----------------------------MKAQRDT----------PIRRG
Mb2188c|M.bovis_AF2122/97 ----------------------------MRAKREA----------PKSRS
Rv2164c|M.tuberculosis_H37Rv ----------------------------MRAKREA----------PKSRS
MMAR_3201|M.marinum_M ----------------------------MKAKREARV--------PGKRQ
MUL_3509|M.ulcerans_Agy99 ----------------------------MKAKREARV--------PGKRQ
TH_4426|M.thermoresistible__bu YALAFQGRGREADEVLAAVDSTGLTEHELMAWALPRAANQFWMLSQPERA
: .
Mflv_2981|M.gilvum_PYR-GCK GRSRATTTKPKAGGKRGTAREAKRTPVDAQPRGRKTTRD-ARPQRSAPRT
Mvan_3530|M.vanbaalenii_PYR-1 GRARTSAKKSPRAAKRRPVRETKRTPVDAPPRGRQQTRD-ARPQRSAPRT
MSMEG_4234|M.smegmatis_MC2_155 GPVRDADRRR---GKRQPG--VARGSAEAPPRKRRPSREPQRPLRSAPQT
MAB_1999|M.abscessus_ATCC_1997 KKAGEAPKKT------KPAKSAKPTKRRNGASKATATGPSARPRRSAPQT
MAV_2329|M.avium_104 GSDRRGARDGSARRGRRPAADAGAAR-RARGGPASAPTRESRAPKPGPQT
MLBr_00907|M.leprae_Br4923 DSGRPGGRDGAARSGKRTANEAGSRRLRTHAGKISASAREVGVPKSGPRT
Mb2188c|M.bovis_AF2122/97 SDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGPQT
Rv2164c|M.tuberculosis_H37Rv SDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGPQT
MMAR_3201|M.marinum_M SGDRGGGRDGSVARTTRRTPADASRR--VRAGKKKAPNREARIPMSGPQT
MUL_3509|M.ulcerans_Agy99 SGDRGGGRDGSVARTTRRTPADASRR--GRAGKKKAPNREARIPMSGPQT
TH_4426|M.thermoresistible__bu VAFLRTVRERVSSPTAATTLDALSATFAMNAGRPQQALQTATEVLASPTA
. ..* :
Mflv_2981|M.gilvum_PYR-GCK TPISRPVDAPARPKSAT----QAKARAKARKAKAP---------------
Mvan_3530|M.vanbaalenii_PYR-1 TPIARPKDVPARPKSTS----QAKARAKARKAKAP---------------
MSMEG_4234|M.smegmatis_MC2_155 GPIPRQKTEPARPKTAS----QAKARAKARKAKAP---------------
MAB_1999|M.abscessus_ATCC_1997 MPIPVQRQAPEKIRPATST-RQAKARAKARKAKAP---------------
MAV_2329|M.avium_104 SPVARPAERSARPKNTS----QAKARAKARKAKAP---------------
MLBr_00907|M.leprae_Br4923 SPMSRPVERPARPRNTT----QAKARAKARKAKAP---------------
Mb2188c|M.bovis_AF2122/97 SPMLSPFDRPAPAKNTS----QAKARAKARKAKAP---------------
Rv2164c|M.tuberculosis_H37Rv SPMLSPFDRPAPAKNTS----QAKARAKARKAKAP---------------
MMAR_3201|M.marinum_M TPMPRPAERPARPKNTG----QAKARAKARKAKAP---------------
MUL_3509|M.ulcerans_Agy99 TPMPRPAERPARPKNTG----QAKARAKARKAKAP---------------
TH_4426|M.thermoresistible__bu DGTAIGWAGAAAALSAARMGRFTEVDALAERAMSAGHPGLLRFTSGFGQT
. : ::. * *.:* :.
Mflv_2981|M.gilvum_PYR-GCK ----------------------------------------KVVRPPLRER
Mvan_3530|M.vanbaalenii_PYR-1 ----------------------------------------KVVRPPLRQR
MSMEG_4234|M.smegmatis_MC2_155 ----------------------------------------KVVRPPLRER
MAB_1999|M.abscessus_ATCC_1997 ----------------------------------------KVIRVPLRER
MAV_2329|M.avium_104 ----------------------------------------KVVRPRLTER
MLBr_00907|M.leprae_Br4923 ----------------------------------------KVVRPRLGEC
Mb2188c|M.bovis_AF2122/97 ----------------------------------------KLVRPTPMER
Rv2164c|M.tuberculosis_H37Rv ----------------------------------------KLVRPTPMER
MMAR_3201|M.marinum_M ----------------------------------------KVVRPKLTER
MUL_3509|M.ulcerans_Agy99 ----------------------------------------KVVRPKLTER
TH_4426|M.thermoresistible__bu TARQLTGAPDQALALARRLTEIAQLQQPGRAIGELLIAEVLITRGDLDEA
: * :
Mflv_2981|M.gilvum_PYR-GCK LLVRLASIDLNPRRLAARVPFVVLIIS----ALGLGLGVTLWLSTDAAER
Mvan_3530|M.vanbaalenii_PYR-1 ILVRLASIELDPRRLIARVPFVVLVIG----ALGLGLGVTLWLSTDAAER
MSMEG_4234|M.smegmatis_MC2_155 ILLRLSSIELNPRELVARVPFVVLVIA----ALGLGLGITLWLSTSAAER
MAB_1999|M.abscessus_ATCC_1997 VLARLSEVDLRPHVWITRVPFVVFVIG----ALGVGLAITLWLSTDAAER
MAV_2329|M.avium_104 LAARLAAIDLRPRTLASKVPFVVLVIG----ALGVGLGLTLWLSTDSAER
MLBr_00907|M.leprae_Br4923 LIARLALIDLRPRTLVNKVPFVVLVIS----SLGVGLGLTLWLSTDSAER
Mb2188c|M.bovis_AF2122/97 LAARLTSIDLRPRTLANKVPFVVLVIG----SLGVGLGLTLWLSTDAAER
Rv2164c|M.tuberculosis_H37Rv LAARLTSIDLRPRTLANKVPFVVLVIG----SLGVGLGLTLWLSTDAAER
MMAR_3201|M.marinum_M MAVRLASMDLRPHALLSRVPFVVLVIG----SLGVGLGLTLWLSTDAAER
MUL_3509|M.ulcerans_Agy99 MAVRLASMDLRPHALLSRVPFVVLVIG----SLGVGLGLTLWLSTDAAER
TH_4426|M.thermoresistible__bu VALLRAAVKVLTPTGYSWAPLAAMLLARALGEQGAAPEAAIALSRAESRH
: : :.: . .*:..:::. * . :: ** :.:
Mflv_2981|M.gilvum_PYR-GCK -------SYQLGSARQLNQALMQQKEALER-----------DVLEAQAAP
Mvan_3530|M.vanbaalenii_PYR-1 -------SYQLGAARQLNQALLQQKEGLER-----------DVLEAQAAP
MSMEG_4234|M.smegmatis_MC2_155 -------SYQLGHARQVNQGLLQQKEALER-----------DVLEAQAAP
MAB_1999|M.abscessus_ATCC_1997 -------SYQLGTQRRTNEELLQRKEALER-----------DVLRAESAP
MAV_2329|M.avium_104 -------SYKLSHARERTRLLQQQKEALER-----------DVREAEAAP
MLBr_00907|M.leprae_Br4923 -------SYQLGDAREQARMLQQQKEALER-----------DVREAESAP
Mb2188c|M.bovis_AF2122/97 -------SYQLSNARERTRMLQQHKEALER-----------DVREAASAP
Rv2164c|M.tuberculosis_H37Rv -------SYQLSNARERTRMLQQHKEALER-----------DVREAASAP
MMAR_3201|M.marinum_M -------SYQLSHARERTRMLQQQKESLER-----------DVREAESAP
MUL_3509|M.ulcerans_Agy99 -------SYQLSHARERTRMLQQQKESLER-----------DVREAESAP
TH_4426|M.thermoresistible__bu GLKSMLFAPELALARAWTRAARGDRHGAVXXXXACWWWRWWDXXTPPGPP
: :*. * . :.. * . ..*
Mflv_2981|M.gilvum_PYR-GCK ALAEAARELGMIPS-------------RDTAHLVQDASGNWVVVG-----
Mvan_3530|M.vanbaalenii_PYR-1 ALAEAARNLGMIPS-------------RDTAHLVQDPSGNWVVVG-----
MSMEG_4234|M.smegmatis_MC2_155 ALAEAARNLGMIPS-------------RDTAHLVQDPTGNWVVVG-----
MAB_1999|M.abscessus_ATCC_1997 ALADSARDLGMIPS-------------RDIAHLVRDPQGNWLLVG-----
MAV_2329|M.avium_104 ALAEAARKQGMIPT-------------RDTAHLVQDPSGNWVVVG-----
MLBr_00907|M.leprae_Br4923 ALAETARKQGMIPT-------------RDTAHLVQGPGGNWVVVG-----
Mb2188c|M.bovis_AF2122/97 ALAEAARRQGMIPT-------------RDTAHLAQDPDGNWVVVG-----
Rv2164c|M.tuberculosis_H37Rv ALAEAARRQGMIPT-------------RDTAHLVQDPDGNWVVVG-----
MMAR_3201|M.marinum_M ALAEAARKQGMIPT-------------RDTAHLVQAPDGNWVVVG-----
MUL_3509|M.ulcerans_Agy99 ALAEAARKQGMIPT-------------RDTAHLVQAPDGNWVVVG-----
TH_4426|M.thermoresistible__bu APPAGGGGGGDVETPPGPPAPPAEVEERDDAEIPPGPPSPPAGGGGGGEI
* . . * : : ** *.: . . *
Mflv_2981|M.gilvum_PYR-GCK TPKPAEGVPPPPLNAPLP---EPAPPAPPA-PRVVEPREVP---------
Mvan_3530|M.vanbaalenii_PYR-1 TPKPAEGVPPPPLNAPLP---EPAPPAPPA-PRVIEPLEVP---------
MSMEG_4234|M.smegmatis_MC2_155 TPKPAEGVPPPPLNAPLPPDAPPPPPAPPA-PRVVEPREVP---------
MAB_1999|M.abscessus_ATCC_1997 APKPAEGVAPAPLNSVIP------DDADAV-PKAGNSVEVP---------
MAV_2329|M.avium_104 TPKPADGVPPPPLNSKLPDEAPQ-PPKPAP-PAAEVPIRVELAPGGP-VP
MLBr_00907|M.leprae_Br4923 TPKPADGVPPPPLNTKLPDAGPP-SLKPPE-IPLEVPVRVVPGPGGPPPP
Mb2188c|M.bovis_AF2122/97 TPKPADGVPPPPLNTKLPEDPPP-PPKPAA-VPLEVPVRVTPGPDDPAPP
Rv2164c|M.tuberculosis_H37Rv TPKPADGVPPPPLNTKLPEDPPP-PPKPAA-VPLEVPVRVTPGPDDPAPP
MMAR_3201|M.marinum_M TPKPADGVPPPPLNTKLPEEGPPAPPKPAA-LPPEVPVRVMPGPDDPALL
MUL_3509|M.ulcerans_Agy99 TPKPADGVPPPPLNSKLPEEGPPAPPKPAA-LPPEVPVRVMPGPDDPALL
TH_4426|M.thermoresistible__bu APPPTPGEPGAVIDQSSQNVTVPAPPTPGSETSTALEVFSPPVPPGEVSG
:* *: * . . ::
Mflv_2981|M.gilvum_PYR-GCK --------VRIPSAA----------------TPLAVPG---MVPGAPAPL
Mvan_3530|M.vanbaalenii_PYR-1 --------VRLPSVT----------------APQAIPG---TAPALPLAV
MSMEG_4234|M.smegmatis_MC2_155 --------IRVPEAPG---LQGLP----GIQAAPGIPG---AVQGVPGAV
MAB_1999|M.abscessus_ATCC_1997 --------VQLPPVP---------------PPVAVVPH---MAP--PTAA
MAV_2329|M.avium_104 ARSGPEALLRAPDGAS---TLGG--QHLA-PAVPPVPGTPPGVPGGPVAA
MLBr_00907|M.leprae_Br4923 ARSGPQMWLRVPDGAT---TLGG--QHLP-QELPQLP----GMLNGPAAA
Mb2188c|M.bovis_AF2122/97 ARSGPEVLVRTPDGTA---TLGGA-THLPTQAGPQLPG-PVPIPGAPGPM
Rv2164c|M.tuberculosis_H37Rv ARSGPEVLVRTPDGTA---TLGGA-THLPTQAGPQLPG-PVPIPGAPGPM
MMAR_3201|M.marinum_M PRTGPQLLPRTPDGSS---TLGAGTNHLPGQPPIEIPGQVPGAPG-PVPL
MUL_3509|M.ulcerans_Agy99 PRTGPQLLPRTPDGSS---TLGADTNHLPGQPPIEIPGQVPGAPG-PVPL
TH_4426|M.thermoresistible__bu GGSNMLELPGFPGGTIGGPEIAHNVEVTGPPAEASVPG-VDASVATEAGT
* . :*
Mflv_2981|M.gilvum_PYR-GCK PGLAP-------------VPGSE--------------VPHAVSADIPMP-
Mvan_3530|M.vanbaalenii_PYR-1 PGAVPN----------VAVPNVE--------------VPHAVSGQLPAP-
MSMEG_4234|M.smegmatis_MC2_155 PGETP-----------HVAPGAQP------------QAPGPVIGPLTGP-
MAB_1999|M.abscessus_ATCC_1997 P--APV----------VEAPIGQ--------------DPAAVPQVAPVPA
MAV_2329|M.avium_104 PPALPGGPVAAVPPASPAMPTGPATG------RPPGLTPGLPMPGLPMPA
MLBr_00907|M.leprae_Br4923 QVQVPG-----------FMPT-----------------PGLPIPGSTMR-
Mb2188c|M.bovis_AF2122/97 PAPPLG-----------AVPS-----------------PAPAENPVPLQV
Rv2164c|M.tuberculosis_H37Rv PAPPLG-----------AVPS-----------------PAPAENPVPLQV
MMAR_3201|M.marinum_M PGQLPGVAGPVTGPGQLPGPAAG----------AVQVPPAPVVLPAPVPA
MUL_3509|M.ulcerans_Agy99 PGQLPGVAGPVTGPGQLPGPAAG----------AVQVPPAPVVLPAPVPA
TH_4426|M.thermoresistible__bu PPVPPGPTAPIEHAAETSVPAEVEIPGAEIDHRAEVATPPVDGPPVEVEN
* *
Mflv_2981|M.gilvum_PYR-GCK -----------------GPV---------LPAAAPDPALVAP--------
Mvan_3530|M.vanbaalenii_PYR-1 -----------------GPVP--------VPVPGPAPVPAAP--------
MSMEG_4234|M.smegmatis_MC2_155 -----------------APMA--------VPMPVPAEVPLATPQAPQQAA
MAB_1999|M.abscessus_ATCC_1997 -----------------VPAD--------VPPPVADAPQASN--------
MAV_2329|M.avium_104 GPAVAPAPAEVSIPLGGLPVPAPGQLPAPLPPEVPVPVQLGRPG------
MLBr_00907|M.leprae_Br4923 -----------------VPVPAP------APTEVPVRLQPGLVSP-----
Mb2188c|M.bovis_AF2122/97 G----------------AAPPAG------LPGPAPVAATPGLSG------
Rv2164c|M.tuberculosis_H37Rv G----------------AAPPAG------LPGPAPVAATPGLSG------
MMAR_3201|M.marinum_M QVP-AEVPVPVPVPAVTAPPVAVVPAAPQAPLAAPVPGTAGLPVA-----
MUL_3509|M.ulcerans_Agy99 QVP-AEVPVPV--PAVTAPPVAVVPVAPQTPLAAPVPGTAGLPVA-----
TH_4426|M.thermoresistible__bu SVEVATPPHXXGPGAVVDXXXXRRPGADPRPXPLPVAAQLHPRPVG-CDG
* .
Mflv_2981|M.gilvum_PYR-GCK ----APAPAPAPAPAPVPGAGA----------------------------
Mvan_3530|M.vanbaalenii_PYR-1 ----LDAGTSQLPPAPAPGAPA----------------------------
MSMEG_4234|M.smegmatis_MC2_155 PLVNTPAPQQVPAPAPLPGAVPQGAPLGALPGAQPAVPDPATAVEHFSPA
MAB_1999|M.abscessus_ATCC_1997 ---ITNSPVTGEQFNPVATTSPLPAA------------------------
MAV_2329|M.avium_104 ---AAPQPVVPAAPLPQPVNGAQPGAAPV---ASPGAPR-----------
MLBr_00907|M.leprae_Br4923 ---AVTSPVISTSPVPTPVNSEQFGPVTA---TAPGTSR-----------
Mb2188c|M.bovis_AF2122/97 ----GSQPMVAP-PAPVPANGEQFGPVTAPVPTAPGAPR-----------
Rv2164c|M.tuberculosis_H37Rv ----GSQPMVAP-PAPVPANGEQFGPVTAPVPTAPGAPR-----------
MMAR_3201|M.marinum_M ---PQAGVPAPVPALPAPASGVQPGPAAA---AAPGVSR-----------
MUL_3509|M.ulcerans_Agy99 ---PQAAVPAPVPALPAPASGIQPGPAAA---AAPGVSR-----------
TH_4426|M.thermoresistible__bu PRRPHRGGVVTASRQPRRLTGRVDAPHLHRHRGQPGDAQHQHGHHRRQRE
*
Mflv_2981|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3530|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4234|M.smegmatis_MC2_155 VAPVA---------------------------------------------
MAB_1999|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2329|M.avium_104 --------------------------------------------------
MLBr_00907|M.leprae_Br4923 --------------------------------------------------
Mb2188c|M.bovis_AF2122/97 --------------------------------------------------
Rv2164c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3201|M.marinum_M --------------------------------------------------
MUL_3509|M.ulcerans_Agy99 --------------------------------------------------
TH_4426|M.thermoresistible__bu RGFHGDRATITHTLVFNARLMMLVSALTIESPVTTAYRMAPNAAAAIVPT
Mflv_2981|M.gilvum_PYR-GCK -------------------
Mvan_3530|M.vanbaalenii_PYR-1 -------------------
MSMEG_4234|M.smegmatis_MC2_155 -------------------
MAB_1999|M.abscessus_ATCC_1997 -------------------
MAV_2329|M.avium_104 -------------------
MLBr_00907|M.leprae_Br4923 -------------------
Mb2188c|M.bovis_AF2122/97 -------------------
Rv2164c|M.tuberculosis_H37Rv -------------------
MMAR_3201|M.marinum_M -------------------
MUL_3509|M.ulcerans_Agy99 -------------------
TH_4426|M.thermoresistible__bu AYSTVDIPASSTINIVVLA