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MKAKKPLRNAAAEPARRSERTSGRSRATTTKPKAGGKRGTAREAKRTPVDAQPRGRKTTRDARPQRSAPR TTPISRPVDAPARPKSATQAKARAKARKAKAPKVVRPPLRERLLVRLASIDLNPRRLAARVPFVVLIISA LGLGLGVTLWLSTDAAERSYQLGSARQLNQALMQQKEALERDVLEAQAAPALAEAARELGMIPSRDTAHL VQDASGNWVVVGTPKPAEGVPPPPLNAPLPEPAPPAPPAPRVVEPREVPVRIPSAATPLAVPGMVPGAPA PLPGLAPVPGSEVPHAVSADIPMPGPVLPAAAPDPALVAPAPAPAPAPAPAPVPGAGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2981 | - | - | 100% (338) | hypothetical protein Mflv_2981 |
| M. gilvum PYR-GCK | Mflv_1703 | - | 2e-13 | 38.46% (143) | transglycosylase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3300 | - | 5e-12 | 35.20% (125) | hypothetical protein Mflv_3300 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2188c | - | 5e-83 | 49.74% (382) | hypothetical protein Mb2188c |
| M. tuberculosis H37Rv | Rv2164c | - | 2e-83 | 50.00% (382) | hypothetical protein Rv2164c |
| M. leprae Br4923 | MLBr_00907 | - | 3e-87 | 50.14% (363) | hypothetical protein MLBr_00907 |
| M. abscessus ATCC 19977 | MAB_1999 | - | 2e-76 | 50.47% (319) | hypothetical protein MAB_1999 |
| M. marinum M | MMAR_3201 | - | 8e-94 | 53.46% (361) | proline rich membrane protein |
| M. avium 104 | MAV_2329 | - | 2e-87 | 50.53% (380) | hypothetical protein MAV_2329 |
| M. smegmatis MC2 155 | MSMEG_4234 | - | 1e-108 | 60.00% (370) | hypothetical protein MSMEG_4234 |
| M. thermoresistible (build 8) | TH_3554 | - | 2e-07 | 31.90% (116) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3509 | - | 5e-95 | 53.46% (361) | proline rich membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3530 | - | 1e-137 | 72.89% (343) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2981|M.gilvum_PYR-GCK MKAKKPLRNAAAEPARRSERTSGRSRATTTKPKAGGKRGTAREAKRTPVD
Mvan_3530|M.vanbaalenii_PYR-1 MKAQKPMRKTATG-------EPGRARTSAKKSPRAAKRRPVRETKRTPVD
MSMEG_4234|M.smegmatis_MC2_155 MKAKR----------------PGPVRDADRRR---GKRQPG--VARGSAE
MAB_1999|M.abscessus_ATCC_1997 MIGVR-----------------KKAGEAPKKT------KPAKSAKPTKRR
MMAR_3201|M.marinum_M MKAKREARV--------PGKRQSGDRGGGRDGSVARTTRRTPADASRR--
MUL_3509|M.ulcerans_Agy99 MKAKREARV--------PGKRQSGDRGGGRDGSVARTTRRTPADASRR--
Mb2188c|M.bovis_AF2122/97 MRAKREA----------PKSRSSDRRRRADSPAAATRRTTTNSAPSRRIR
Rv2164c|M.tuberculosis_H37Rv MRAKREA----------PKSRSSDRRRRADSPAAATRRTTTNSAPSRRIR
MLBr_00907|M.leprae_Br4923 MKAQRDT----------PIRRGDSGRPGGRDGAARSGKRTANEAGSRRLR
MAV_2329|M.avium_104 MKAERET----------AKRRGGSDRRGARDGSARRGRRPAADAGAAR-R
TH_3554|M.thermoresistible__bu ------------------------VAADAAAPTAAAAAVPADPEGSSTFR
Mflv_2981|M.gilvum_PYR-GCK AQPRGRKTTRD-ARPQRSAPRTTPISRPVDAPARPKSAT---QAKARAKA
Mvan_3530|M.vanbaalenii_PYR-1 APPRGRQQTRD-ARPQRSAPRTTPIARPKDVPARPKSTS---QAKARAKA
MSMEG_4234|M.smegmatis_MC2_155 APPRKRRPSREPQRPLRSAPQTGPIPRQKTEPARPKTAS---QAKARAKA
MAB_1999|M.abscessus_ATCC_1997 NGASKATATGPSARPRRSAPQTMPIPVQRQAPEKIRPATSTRQAKARAKA
MMAR_3201|M.marinum_M VRAGKKKAPNREARIPMSGPQTTPMPRPAERPARPKNTG---QAKARAKA
MUL_3509|M.ulcerans_Agy99 GRAGKKKAPNREARIPMSGPQTTPMPRPAERPARPKNTG---QAKARAKA
Mb2188c|M.bovis_AF2122/97 SRAGKTSAPGRQARVSRPGPQTSPMLSPFDRPAPAKNTS---QAKARAKA
Rv2164c|M.tuberculosis_H37Rv SRAGKTSAPGRQARVSRPGPQTSPMLSPFDRPAPAKNTS---QAKARAKA
MLBr_00907|M.leprae_Br4923 THAGKISASAREVGVPKSGPRTSPMSRPVERPARPRNTT---QAKARAKA
MAV_2329|M.avium_104 ARGGPASAPTRESRAPKPGPQTSPVARPAERSARPKNTS---QAKARAKA
TH_3554|M.thermoresistible__bu ALAWSQEEGVDDVVPFTGDGAYPDGPFTEGGYTDGPFTG-----QARPEV
: :**.:.
Mflv_2981|M.gilvum_PYR-GCK RKAKAPKVVRPPLRERLLVRLASIDLNPRRLAARVPFVVLIISALGLGLG
Mvan_3530|M.vanbaalenii_PYR-1 RKAKAPKVVRPPLRQRILVRLASIELDPRRLIARVPFVVLVIGALGLGLG
MSMEG_4234|M.smegmatis_MC2_155 RKAKAPKVVRPPLRERILLRLSSIELNPRELVARVPFVVLVIAALGLGLG
MAB_1999|M.abscessus_ATCC_1997 RKAKAPKVIRVPLRERVLARLSEVDLRPHVWITRVPFVVFVIGALGVGLA
MMAR_3201|M.marinum_M RKAKAPKVVRPKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLGVGLG
MUL_3509|M.ulcerans_Agy99 RKAKAPKVVRPKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLGVGLG
Mb2188c|M.bovis_AF2122/97 RKAKAPKLVRPTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLGVGLG
Rv2164c|M.tuberculosis_H37Rv RKAKAPKLVRPTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLGVGLG
MLBr_00907|M.leprae_Br4923 RKAKAPKVVRPRLGECLIARLALIDLRPRTLVNKVPFVVLVISSLGVGLG
MAV_2329|M.avium_104 RKAKAPKVVRPRLTERLAARLAAIDLRPRTLASKVPFVVLVIGALGVGLG
TH_3554|M.thermoresistible__bu QWVPEQPVEESGAWSRLPVALFSVAG-----------VAVLLALGGVAYG
: . : . . : * : *..::. *:. .
Mflv_2981|M.gilvum_PYR-GCK VTLWLSTDAAERSYQLGSARQLNQALMQQKEALERDVLEAQAAPALAEAA
Mvan_3530|M.vanbaalenii_PYR-1 VTLWLSTDAAERSYQLGAARQLNQALLQQKEGLERDVLEAQAAPALAEAA
MSMEG_4234|M.smegmatis_MC2_155 ITLWLSTSAAERSYQLGHARQVNQGLLQQKEALERDVLEAQAAPALAEAA
MAB_1999|M.abscessus_ATCC_1997 ITLWLSTDAAERSYQLGTQRRTNEELLQRKEALERDVLRAESAPALADSA
MMAR_3201|M.marinum_M LTLWLSTDAAERSYQLSHARERTRMLQQQKESLERDVREAESAPALAEAA
MUL_3509|M.ulcerans_Agy99 LTLWLSTDAAERSYQLSHARERTRMLQQQKESLERDVREAESAPALAEAA
Mb2188c|M.bovis_AF2122/97 LTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASAPALAEAA
Rv2164c|M.tuberculosis_H37Rv LTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASAPALAEAA
MLBr_00907|M.leprae_Br4923 LTLWLSTDSAERSYQLGDAREQARMLQQQKEALERDVREAESAPALAETA
MAV_2329|M.avium_104 LTLWLSTDSAERSYKLSHARERTRLLQQQKEALERDVREAEAAPALAEAA
TH_3554|M.thermoresistible__bu LTSVSEDEPDPPVTEX------XXQVLFAAGVVAVLVALIAAIVTLRDGD
:* . .. : : : * : :* :
Mflv_2981|M.gilvum_PYR-GCK RELGMIPSRDTAHLVQDASGNWVVVGTP--KPAEGVPPPPLNAPLP---E
Mvan_3530|M.vanbaalenii_PYR-1 RNLGMIPSRDTAHLVQDPSGNWVVVGTP--KPAEGVPPPPLNAPLP---E
MSMEG_4234|M.smegmatis_MC2_155 RNLGMIPSRDTAHLVQDPTGNWVVVGTP--KPAEGVPPPPLNAPLPPDAP
MAB_1999|M.abscessus_ATCC_1997 RDLGMIPSRDIAHLVRDPQGNWLLVGAP--KPAEGVAPAPLNSVIP----
MMAR_3201|M.marinum_M RKQGMIPTRDTAHLVQAPDGNWVVVGTP--KPADGVPPPPLNTKLPEEGP
MUL_3509|M.ulcerans_Agy99 RKQGMIPTRDTAHLVQAPDGNWVVVGTP--KPADGVPPPPLNSKLPEEGP
Mb2188c|M.bovis_AF2122/97 RRQGMIPTRDTAHLAQDPDGNWVVVGTP--KPADGVPPPPLNTKLPEDPP
Rv2164c|M.tuberculosis_H37Rv RRQGMIPTRDTAHLVQDPDGNWVVVGTP--KPADGVPPPPLNTKLPEDPP
MLBr_00907|M.leprae_Br4923 RKQGMIPTRDTAHLVQGPGGNWVVVGTP--KPADGVPPPPLNTKLPDAGP
MAV_2329|M.avium_104 RKQGMIPTRDTAHLVQDPSGNWVVVGTP--KPADGVPPPPLNSKLPDEAP
TH_3554|M.thermoresistible__bu TPAPASTTEPTEPTTTEPAGTVVTEAPPPAEPAAPQPPRTVYETVPQTQA
.:. . . *. : ..* :** .* .: :*
Mflv_2981|M.gilvum_PYR-GCK PAPPAPPAPRVVEPREVP-----------------VRIPSAA--------
Mvan_3530|M.vanbaalenii_PYR-1 PAPPAPPAPRVIEPLEVP-----------------VRLPSVT--------
MSMEG_4234|M.smegmatis_MC2_155 PPPPAPPAPRVVEPREVP-----------------IRVPEAPGLQGLP--
MAB_1999|M.abscessus_ATCC_1997 --DDADAVPKAGNSVEVP-----------------VQLPPVP--------
MMAR_3201|M.marinum_M PAPPKPAALPPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGSSTLGAGTN
MUL_3509|M.ulcerans_Agy99 PAPPKPAALPPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGSSTLGADTN
Mb2188c|M.bovis_AF2122/97 P-PPKPAAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGA-T
Rv2164c|M.tuberculosis_H37Rv P-PPKPAAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGA-T
MLBr_00907|M.leprae_Br4923 P-SLKPPEIPLEVPVRVVPGPGGPPPPARSGPQMWLRVPDGATTLGG--Q
MAV_2329|M.avium_104 Q-PPKPAPPAAEVPIRVELAPGGP-VPARSGPEALLRAPDGASTLGG--Q
TH_3554|M.thermoresistible__bu PPPPAEAPPPAQEP------------------------------------
. .
Mflv_2981|M.gilvum_PYR-GCK -----TPLAVPG---MVPGAPAPLPGLAP-------------VPGSE---
Mvan_3530|M.vanbaalenii_PYR-1 -----APQAIPG---TAPALPLAVPGAVPN----------VAVPNVE---
MSMEG_4234|M.smegmatis_MC2_155 --GIQAAPGIPG---AVQGVPGAVPGETP-----------HVAPGAQP--
MAB_1999|M.abscessus_ATCC_1997 ----PPVAVVPH---MAP--PTAAP--APV----------VEAPIGQ---
MMAR_3201|M.marinum_M HLPGQPPIEIPGQVPGAPG-PVPLPGQLPGVAGPVTGPGQLPGPAAG---
MUL_3509|M.ulcerans_Agy99 HLPGQPPIEIPGQVPGAPG-PVPLPGQLPGVAGPVTGPGQLPGPAAG---
Mb2188c|M.bovis_AF2122/97 HLPTQAGPQLPG-PVPIPGAPGPMPAPPLG-----------AVPS-----
Rv2164c|M.tuberculosis_H37Rv HLPTQAGPQLPG-PVPIPGAPGPMPAPPLG-----------AVPS-----
MLBr_00907|M.leprae_Br4923 HLP-QELPQLP----GMLNGPAAAQVQVPG-----------FMPT-----
MAV_2329|M.avium_104 HLA-PAVPPVPGTPPGVPGGPVAAPPALPGGPVAAVPPASPAMPTGPATG
TH_3554|M.thermoresistible__bu -----------------PPAEEPPPAEEPP--------------------
.
Mflv_2981|M.gilvum_PYR-GCK -----VPHAVSADIPMP--------------------GPV---------L
Mvan_3530|M.vanbaalenii_PYR-1 -----VPHAVSGQLPAP--------------------GPVP--------V
MSMEG_4234|M.smegmatis_MC2_155 ----QAPGPVIGPLTGP--------------------APMA--------V
MAB_1999|M.abscessus_ATCC_1997 -----DPAAVPQVAPVPA-------------------VPAD--------V
MMAR_3201|M.marinum_M -AVQVPPAPVVLPAPVPAQVP---AEVPVPVPVPAVTAPPVAVVPAAPQA
MUL_3509|M.ulcerans_Agy99 -AVQVPPAPVVLPAPVPAQVP---AEVPVPV--PAVTAPPVAVVPVAPQT
Mb2188c|M.bovis_AF2122/97 ------PAPAENPVPLQVG-----------------AAPPAG-------L
Rv2164c|M.tuberculosis_H37Rv ------PAPAENPVPLQVG-----------------AAPPAG-------L
MLBr_00907|M.leprae_Br4923 ------PGLPIPGSTMR------------------VPVPAP--------A
MAV_2329|M.avium_104 RPPGLTPGLPMPGLPMPAGPAVAPAPAEVSIPLGGLPVPAPGQLPAP--L
TH_3554|M.thermoresistible__bu ------PATEEPPPTTTR--------------------------------
* .
Mflv_2981|M.gilvum_PYR-GCK PAAAPDPALVAP------------APAPAPAPAPAPVPGAGA--------
Mvan_3530|M.vanbaalenii_PYR-1 PVPGPAPVPAAP------------LDAGTSQLPPAPAPGAPA--------
MSMEG_4234|M.smegmatis_MC2_155 PMPVPAEVPLATPQAPQQAAPLVNTPAPQQVPAPAPLPGAVPQGAPLGAL
MAB_1999|M.abscessus_ATCC_1997 PPPVADAPQASN-----------ITNSPVTGEQFNPVATTSPLPAA----
MMAR_3201|M.marinum_M PLAAPVPGTAGLPVA--------PQAGVPAPVPALPAPASGVQPGPAAA-
MUL_3509|M.ulcerans_Agy99 PLAAPVPGTAGLPVA--------PQAAVPAPVPALPAPASGIQPGPAAA-
Mb2188c|M.bovis_AF2122/97 PGPAPVAATPGLSG----------GSQPMVAP-PAPVPANGEQFGPVTAP
Rv2164c|M.tuberculosis_H37Rv PGPAPVAATPGLSG----------GSQPMVAP-PAPVPANGEQFGPVTAP
MLBr_00907|M.leprae_Br4923 PTEVPVRLQPGLVSP--------AVTSPVISTSPVPTPVNSEQFGPVTA-
MAV_2329|M.avium_104 PPEVPVPVQLGRPG---------AAPQPVVPAAPLPQPVNGAQPGAAPV-
TH_3554|M.thermoresistible__bu PRWLPTLPRPTLP------------TLPTIPGLPAPPAPPAEAP------
* . * .
Mflv_2981|M.gilvum_PYR-GCK -------------------------
Mvan_3530|M.vanbaalenii_PYR-1 -------------------------
MSMEG_4234|M.smegmatis_MC2_155 PGAQPAVPDPATAVEHFSPAVAPVA
MAB_1999|M.abscessus_ATCC_1997 -------------------------
MMAR_3201|M.marinum_M --AAPGVSR----------------
MUL_3509|M.ulcerans_Agy99 --AAPGVSR----------------
Mb2188c|M.bovis_AF2122/97 VPTAPGAPR----------------
Rv2164c|M.tuberculosis_H37Rv VPTAPGAPR----------------
MLBr_00907|M.leprae_Br4923 --TAPGTSR----------------
MAV_2329|M.avium_104 --ASPGAPR----------------
TH_3554|M.thermoresistible__bu -------------------------