For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KAKRPGPVRDADRRRGKRQPGVARGSAEAPPRKRRPSREPQRPLRSAPQTGPIPRQKTEPARPKTASQAK ARAKARKAKAPKVVRPPLRERILLRLSSIELNPRELVARVPFVVLVIAALGLGLGITLWLSTSAAERSYQ LGHARQVNQGLLQQKEALERDVLEAQAAPALAEAARNLGMIPSRDTAHLVQDPTGNWVVVGTPKPAEGVP PPPLNAPLPPDAPPPPPAPPAPRVVEPREVPIRVPEAPGLQGLPGIQAAPGIPGAVQGVPGAVPGETPHV APGAQPQAPGPVIGPLTGPAPMAVPMPVPAEVPLATPQAPQQAAPLVNTPAPQQVPAPAPLPGAVPQGAP LGALPGAQPAVPDPATAVEHFSPAVAPVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4234 | - | - | 100% (380) | hypothetical protein MSMEG_4234 |
| M. smegmatis MC2 155 | MSMEG_5700 | - | 2e-16 | 34.34% (198) | secreted protein |
| M. smegmatis MC2 155 | MSMEG_3531 | - | 1e-12 | 32.76% (174) | hypothetical protein MSMEG_3531 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2188c | - | 4e-88 | 50.75% (398) | hypothetical protein Mb2188c |
| M. gilvum PYR-GCK | Mflv_2981 | - | 1e-108 | 60.00% (370) | hypothetical protein Mflv_2981 |
| M. tuberculosis H37Rv | Rv2164c | - | 1e-88 | 51.01% (398) | hypothetical protein Rv2164c |
| M. leprae Br4923 | MLBr_00907 | - | 4e-81 | 50.82% (368) | hypothetical protein MLBr_00907 |
| M. abscessus ATCC 19977 | MAB_1999 | - | 3e-77 | 49.86% (351) | hypothetical protein MAB_1999 |
| M. marinum M | MMAR_3201 | - | 9e-99 | 52.12% (424) | proline rich membrane protein |
| M. avium 104 | MAV_2329 | - | 2e-94 | 51.34% (411) | hypothetical protein MAV_2329 |
| M. thermoresistible (build 8) | TH_1481 | ftsY | 1e-07 | 30.97% (113) | PROBABLE CELL DIVISION PROTEIN FTSY (SRP RECEPTOR) (SIGNAL |
| M. ulcerans Agy99 | MUL_3509 | - | 1e-98 | 50.83% (423) | proline rich membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3530 | - | 1e-112 | 62.91% (364) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2981|M.gilvum_PYR-GCK -------------------------MKAKKPLRNAAAEPARRSERTSGRS
Mvan_3530|M.vanbaalenii_PYR-1 -------------------------MKAQKPMRKTATG-------EPGRA
MSMEG_4234|M.smegmatis_MC2_155 -------------------------MKAKR----------------PGPV
MMAR_3201|M.marinum_M -------------------------MKAKREARVPG----------KRQS
MUL_3509|M.ulcerans_Agy99 -------------------------MKAKREARVPG----------KRQS
Mb2188c|M.bovis_AF2122/97 -------------------------MRAKREAPKSR----------SSDR
Rv2164c|M.tuberculosis_H37Rv -------------------------MRAKREAPKSR----------SSDR
MLBr_00907|M.leprae_Br4923 -------------------------MKAQRDTPIRR----------GDSG
MAV_2329|M.avium_104 -------------------------MKAERETAKRR----------GGSD
MAB_1999|M.abscessus_ATCC_1997 ------------------------------------------------MI
TH_1481|M.thermoresistible__bu VSEGLWIAIAIIAVVLVAALIVGLVLYRRRRIRLTKRDEAKPVERGGGYT
Mflv_2981|M.gilvum_PYR-GCK RATTTKPKAGGKRGTAREAKRTPVDAQPRGRKTTRD-ARPQRSAPR----
Mvan_3530|M.vanbaalenii_PYR-1 RTSAKKSPRAAKRRPVRETKRTPVDAPPRGRQQTRD-ARPQRSAPR----
MSMEG_4234|M.smegmatis_MC2_155 RDADRRR---GKRQPG--VARGSAEAPPRKRRPSREPQRPLRSAPQ----
MMAR_3201|M.marinum_M GDRGGGRDGSVARTTRRTPADASRRVRAGKKKAPNREARIPMSGPQ----
MUL_3509|M.ulcerans_Agy99 GDRGGGRDGSVARTTRRTPADASRRGRAGKKKAPNREARIPMSGPQ----
Mb2188c|M.bovis_AF2122/97 RRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGPQ----
Rv2164c|M.tuberculosis_H37Rv RRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGPQ----
MLBr_00907|M.leprae_Br4923 RPGGRDGAARSGKRTANEAGSRRLRTHAGKISASAREVGVPKSGPR----
MAV_2329|M.avium_104 RRGARDGSARRGRRPAADAGAAR-RARGGPASAPTRESRAPKPGPQ----
MAB_1999|M.abscessus_ATCC_1997 GVRKKAGEAPKKTKPAKSAKPTKRRNGASKATATGPSARPRRSAPQ----
TH_1481|M.thermoresistible__bu TSSGITFSQSATPTKAPPTKAAPERIDTTGLPGVGDDATIPRDAPKRPIA
.*:
Mflv_2981|M.gilvum_PYR-GCK TTPISRPVDAPARPK----------------SATQAKARAKARKAKAPKV
Mvan_3530|M.vanbaalenii_PYR-1 TTPIARPKDVPARPK----------------STSQAKARAKARKAKAPKV
MSMEG_4234|M.smegmatis_MC2_155 TGPIPRQKTEPARPK----------------TASQAKARAKARKAKAPKV
MMAR_3201|M.marinum_M TTPMPRPAERPARPK----------------NTGQAKARAKARKAKAPKV
MUL_3509|M.ulcerans_Agy99 TTPMPRPAERPARPK----------------NTGQAKARAKARKAKAPKV
Mb2188c|M.bovis_AF2122/97 TSPMLSPFDRPAPAK----------------NTSQAKARAKARKAKAPKL
Rv2164c|M.tuberculosis_H37Rv TSPMLSPFDRPAPAK----------------NTSQAKARAKARKAKAPKL
MLBr_00907|M.leprae_Br4923 TSPMSRPVERPARPR----------------NTTQAKARAKARKAKAPKV
MAV_2329|M.avium_104 TSPVARPAERSARPK----------------NTSQAKARAKARKAKAPKV
MAB_1999|M.abscessus_ATCC_1997 TMPIPVQRQAPEKIRP-------------ATSTRQAKARAKARKAKAPKV
TH_1481|M.thermoresistible__bu DVRLPEPPAAPPKPPPPAEVPPTEPPAPPVATPSPAETAPPVEPEAAPET
: . .. *:: . .. **:
Mflv_2981|M.gilvum_PYR-GCK VR----------PPLRERLLVRLASIDLNPRRLAARVPFVVLIISALGLG
Mvan_3530|M.vanbaalenii_PYR-1 VR----------PPLRQRILVRLASIELDPRRLIARVPFVVLVIGALGLG
MSMEG_4234|M.smegmatis_MC2_155 VR----------PPLRERILLRLSSIELNPRELVARVPFVVLVIAALGLG
MMAR_3201|M.marinum_M VR----------PKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLGVG
MUL_3509|M.ulcerans_Agy99 VR----------PKLTERMAVRLASMDLRPHALLSRVPFVVLVIGSLGVG
Mb2188c|M.bovis_AF2122/97 VR----------PTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLGVG
Rv2164c|M.tuberculosis_H37Rv VR----------PTPMERLAARLTSIDLRPRTLANKVPFVVLVIGSLGVG
MLBr_00907|M.leprae_Br4923 VR----------PRLGECLIARLALIDLRPRTLVNKVPFVVLVISSLGVG
MAV_2329|M.avium_104 VR----------PRLTERLAARLAAIDLRPRTLASKVPFVVLVIGALGVG
MAB_1999|M.abscessus_ATCC_1997 IR----------VPLRERVLARLSEVDLRPHVWITRVPFVVFVIGALGVG
TH_1481|M.thermoresistible__bu TPEPEPGAAPAAPQLDEIAPAEGRLDRLRGRLAKSQTAIGRSMLGLLGGG
: . * : :..: ::. ** *
Mflv_2981|M.gilvum_PYR-GCK -LGVTLWLSTDAAERSYQLGSARQLNQALMQQKEALERDVLEAQAAPALA
Mvan_3530|M.vanbaalenii_PYR-1 -LGVTLWLSTDAAERSYQLGAARQLNQALLQQKEGLERDVLEAQAAPALA
MSMEG_4234|M.smegmatis_MC2_155 -LGITLWLSTSAAERSYQLGHARQVNQGLLQQKEALERDVLEAQAAPALA
MMAR_3201|M.marinum_M -LGLTLWLSTDAAERSYQLSHARERTRMLQQQKESLERDVREAESAPALA
MUL_3509|M.ulcerans_Agy99 -LGLTLWLSTDAAERSYQLSHARERTRMLQQQKESLERDVREAESAPALA
Mb2188c|M.bovis_AF2122/97 -LGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASAPALA
Rv2164c|M.tuberculosis_H37Rv -LGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASAPALA
MLBr_00907|M.leprae_Br4923 -LGLTLWLSTDSAERSYQLGDAREQARMLQQQKEALERDVREAESAPALA
MAV_2329|M.avium_104 -LGLTLWLSTDSAERSYKLSHARERTRLLQQQKEALERDVREAEAAPALA
MAB_1999|M.abscessus_ATCC_1997 -LAITLWLSTDAAERSYQLGTQRRTNEELLQRKEALERDVLRAESAPALA
TH_1481|M.thermoresistible__bu DLDEESWEEIEDTLLIADLGPVVTTSVVEKLREQMAASRVRTEADARAVL
* * . . : .*. ::: * * *:
Mflv_2981|M.gilvum_PYR-GCK EAARELGMIPSRD---TAHLVQDASGNWVVVGTPKPAEGVPPPPLNAPLP
Mvan_3530|M.vanbaalenii_PYR-1 EAARNLGMIPSRD---TAHLVQDPSGNWVVVGTPKPAEGVPPPPLNAPLP
MSMEG_4234|M.smegmatis_MC2_155 EAARNLGMIPSRD---TAHLVQDPTGNWVVVGTPKPAEGVPPPPLNAPLP
MMAR_3201|M.marinum_M EAARKQGMIPTRD---TAHLVQAPDGNWVVVGTPKPADGVPPPPLNTKLP
MUL_3509|M.ulcerans_Agy99 EAARKQGMIPTRD---TAHLVQAPDGNWVVVGTPKPADGVPPPPLNSKLP
Mb2188c|M.bovis_AF2122/97 EAARRQGMIPTRD---TAHLAQDPDGNWVVVGTPKPADGVPPPPLNTKLP
Rv2164c|M.tuberculosis_H37Rv EAARRQGMIPTRD---TAHLVQDPDGNWVVVGTPKPADGVPPPPLNTKLP
MLBr_00907|M.leprae_Br4923 ETARKQGMIPTRD---TAHLVQGPGGNWVVVGTPKPADGVPPPPLNTKLP
MAV_2329|M.avium_104 EAARKQGMIPTRD---TAHLVQDPSGNWVVVGTPKPADGVPPPPLNSKLP
MAB_1999|M.abscessus_ATCC_1997 DSARDLGMIPSRD---IAHLVRDPQGNWLLVGAPKPAEGVAPAPLNSVIP
TH_1481|M.thermoresistible__bu REVLISELRPDLDRSVKALPHDDKPSVLLVVGVNGTGKTTTVGKLARVLV
. : * * * . ::**. ... .. * :
Mflv_2981|M.gilvum_PYR-GCK ---EPAPPAPPAPRVVEPREVPVRIPSAA---------TPLAVPGMVPG-
Mvan_3530|M.vanbaalenii_PYR-1 ---EPAPPAPPAPRVIEPLEVPVRLPSVT---------APQAIPGTAPA-
MSMEG_4234|M.smegmatis_MC2_155 PDAPPPPPAPPAPRVVEPREVPIRVPEAPGLQGLPGIQAAPGIPGAVQG-
MMAR_3201|M.marinum_M EEGPPAPPKPAAL----PPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGS
MUL_3509|M.ulcerans_Agy99 EEGPPAPPKPAAL----PPEVPVRVMPGPDDPALLPRTGPQLLPRTPDGS
Mb2188c|M.bovis_AF2122/97 ED-PPPPPKPAAV----PLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGT
Rv2164c|M.tuberculosis_H37Rv ED-PPPPPKPAAV----PLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGT
MLBr_00907|M.leprae_Br4923 DAGPPSL-KPPEI----PLEVPVRVVPGPGGPPPPARSGPQMWLRVPDGA
MAV_2329|M.avium_104 DEAPQPP-KPAPP----AAEVPIRVELAPGGP-VPARSGPEALLRAPDGA
MAB_1999|M.abscessus_ATCC_1997 DDADAVPKAGNSV------EVPVQLPPVP----PPVAVVPHMAP------
TH_1481|M.thermoresistible__bu ADGRRVVLGAADTFRAAAADQLETWASRVGAEVVRGREGADPASVAFDAV
: .
Mflv_2981|M.gilvum_PYR-GCK ----------------------------APAPLPG---------------
Mvan_3530|M.vanbaalenii_PYR-1 ----------------------------LPLAVPG---------------
MSMEG_4234|M.smegmatis_MC2_155 ----------------------------VPGAVPG---------------
MMAR_3201|M.marinum_M STLGAGTN--HLPGQPPIEIPGQVPGAPGPVPLPGQ-----------LPG
MUL_3509|M.ulcerans_Agy99 STLGADTN--HLPGQPPIEIPGQVPGAPGPVPLPGQ-----------LPG
Mb2188c|M.bovis_AF2122/97 ATLGGAT---HLPTQAGPQLP-------GPVPIPG---------------
Rv2164c|M.tuberculosis_H37Rv ATLGGAT---HLPTQAGPQLP-------GPVPIPG---------------
MLBr_00907|M.leprae_Br4923 TTLGGQHLPQELPQLP----GMLNGPAAAQVQVPG-----------FMPT
MAV_2329|M.avium_104 STLGGQHLAPAVPPVPGTPPGVPGGPVAAPPALPGGPVAAVPPASPAMPT
MAB_1999|M.abscessus_ATCC_1997 -----------------------------PTAAPA---------------
TH_1481|M.thermoresistible__bu DTGIKNG------------------ADVVLIDTAGR--------------
..
Mflv_2981|M.gilvum_PYR-GCK ---------LAP---VPGSE----------------------------VP
Mvan_3530|M.vanbaalenii_PYR-1 ---------AVPNVAVPNVE----------------------------VP
MSMEG_4234|M.smegmatis_MC2_155 ---------ETP-HVAPGAQPQ--------------------------AP
MMAR_3201|M.marinum_M VAGPVTGPGQLPGPAAGAVQVPPAPVVLPAPVPAQVPAEVPVPVPVPAVT
MUL_3509|M.ulcerans_Agy99 VAGPVTGPGQLPGPAAGAVQVPPAPVVLPAPVPAQVPAEVPVPV--PAVT
Mb2188c|M.bovis_AF2122/97 ------APGPMPAPPLGAVPSP-------------APAENPVPL---QVG
Rv2164c|M.tuberculosis_H37Rv ------APGPMPAPPLGAVPSP-------------APAENPVPL---QVG
MLBr_00907|M.leprae_Br4923 -----------PGLPIPGSTMR--------------------------VP
MAV_2329|M.avium_104 GPATGRPPGLTPGLPMPGLPMPAGPAVAP------APAEVSIPL--GGLP
MAB_1999|M.abscessus_ATCC_1997 -----------PVVEAPIGQ----------------------------DP
TH_1481|M.thermoresistible__bu -------LHTKTGLMDELGKVKRVVKKRAAVDEVLLVLDATIGQNSLPQA
.
Mflv_2981|M.gilvum_PYR-GCK HAVSADIPMP--GPV-LPAAAPDPALVAP------------APAPAPAPA
Mvan_3530|M.vanbaalenii_PYR-1 HAVSGQLPAP--GPVPVPVPGPAPVPAAP------------LDAGTSQLP
MSMEG_4234|M.smegmatis_MC2_155 GPVIGPLTGP--APMAVPMPVPAEVPLATPQAPQQAAPLVNTPAPQQVPA
MMAR_3201|M.marinum_M APPVAVVPAAPQAPLAAPVPGTAGLPVAPQAGVPAPVPALPAPASGVQPG
MUL_3509|M.ulcerans_Agy99 APPVAVVPVAPQTPLAAPVPGTAGLPVAPQAAVPAPVPALPAPASGIQPG
Mb2188c|M.bovis_AF2122/97 AAPPAGLPGP------APVAATPGLSGGSQ---PMVAPPAPVPANGEQFG
Rv2164c|M.tuberculosis_H37Rv AAPPAGLPGP------APVAATPGLSGGSQ---PMVAPPAPVPANGEQFG
MLBr_00907|M.leprae_Br4923 VPAP--------APTEVPVRLQPGLVSPAVTSPVISTSPVPTPVNSEQFG
MAV_2329|M.avium_104 VPAPGQLPAP--LPPEVPVPVQLGRPG-AAPQPVVPAAPLPQPVNGAQPG
MAB_1999|M.abscessus_ATCC_1997 AAVPQVAPVP-----AVPADVPPPVADAPQ-----ASNITNSPVTGEQFN
TH_1481|M.thermoresistible__bu KVFAEVVDITGVVLTKLDGTAKGGIVFRVQQELGVPVKLVGLGEGPDDLA
Mflv_2981|M.gilvum_PYR-GCK PAPV-----PGAGA---------------------------------
Mvan_3530|M.vanbaalenii_PYR-1 PAPA-----PGAPA---------------------------------
MSMEG_4234|M.smegmatis_MC2_155 PAPL-----PGAVPQGAPLGALPGAQPAVPDPATAVEHFSPAVAPVA
MMAR_3201|M.marinum_M PAAA---AAPGVSR---------------------------------
MUL_3509|M.ulcerans_Agy99 PAAA---AAPGVSR---------------------------------
Mb2188c|M.bovis_AF2122/97 PVTAPVPTAPGAPR---------------------------------
Rv2164c|M.tuberculosis_H37Rv PVTAPVPTAPGAPR---------------------------------
MLBr_00907|M.leprae_Br4923 PVTA---TAPGTSR---------------------------------
MAV_2329|M.avium_104 AAPV---ASPGAPR---------------------------------
MAB_1999|M.abscessus_ATCC_1997 PVAT---TSPLPAA---------------------------------
TH_1481|M.thermoresistible__bu PFEPAAFVDALLG----------------------------------
. .