For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PPTAGADLAATRGCRHRYCCRVTSADSALSPHRRVWRWDDFVLDVGCYELRRGDTMIRVEPQVFDVLAQL VSNHGRFVSKEELFDTVWGGRFVGEAALTSRIKAVRRALGDDGEAQRYIRTVRGRGYQFVGRLLDDGTAP APTAAPEPAPEPVPEPPRQHIAFTRAADGVRLAYAVSGEGRPLVRAANWMTHLGYDIESPVWRHWVRDMS LRHKFIRYDERGCGLSDWEVGAFTFDDWVTDLESVVEAVGLERFPLLGVSQGGAVAVAYAARHPDRVTRL VLCGAYARGRVVRAMNDDEKRAAALDLDLARVGWGRDDPAFRQVFAAQFLPDGTRADWAAFDQLQRRTTS PENAVRFLEEFAHIDVRDQCGQVRCPTLILHSRDDHRVPMRYGEELAALIPDARLVALSSNNHLLTGAEP AWRVFCDEVETFLAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3415 | - | - | 100% (436) | transcriptional regulator, CadC |
| M. vanbaalenii PYR-1 | Mvan_1079 | - | 8e-12 | 32.17% (115) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 5e-11 | 24.91% (285) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 9e-14 | 28.37% (289) | lignin peroxidase LIPJ |
| M. gilvum PYR-GCK | Mflv_3121 | - | 0.0 | 82.52% (412) | transcriptional regulator, CadC |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 2e-13 | 28.37% (289) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_02269 | - | 3e-07 | 22.87% (258) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3934c | - | 1e-10 | 26.79% (209) | alpha/beta fold hydrolase |
| M. marinum M | MMAR_3505 | - | 5e-24 | 32.82% (259) | hydrolase |
| M. avium 104 | MAV_5228 | - | 3e-15 | 28.74% (247) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_3856 | - | 0.0 | 77.62% (420) | transcriptional regulator, CadC |
| M. thermoresistible (build 8) | TH_3727 | - | 7e-11 | 25.59% (254) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 2e-14 | 27.94% (247) | lignin peroxidase LipJ |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3415|M.vanbaalenii_PYR-1 --MPPTAGADLAATRGCRHRYCCRVTSADSALSPHRRVWRWDDFVLDVGC
Mflv_3121|M.gilvum_PYR-GCK ------------------------MTSAD-ALSSSPRVWRWDDYVLDLGR
MSMEG_3856|M.smegmatis_MC2_155 -------------------------------------MWRFDDFVLDTGR
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAB_3934c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVP-IDSIDDEP
Rv1900c|M.tuberculosis_H37Rv MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVP-IDSIDDEP
MUL_4838|M.ulcerans_Agy99 MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIP-VDTIDSEP
MAV_5228|M.avium_104 MPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSIP-IDSVDAEP
MMAR_3505|M.marinum_M ----MSDDRVRYARNGDVHLAYRVFGQSGPTVIWVPGWMVSNVDTIDEPG
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_3415|M.vanbaalenii_PYR-1 YELRRGDTMIRVEPQVFDVLAQLVSNHGRFVSKEELFDTVWGGRFVGEAA
Mflv_3121|M.gilvum_PYR-GCK YELRAGDSVIRVEPQVFDVLTQLVSHHDRCVSKEELFDTVWGGRFVGEAA
MSMEG_3856|M.smegmatis_MC2_155 FELRRGDEVIRVEPQVFDVLTQLIVNHERVVTKVELFDTVWGGRFVGEAA
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAB_3934c|M.abscessus_ATCC_199 -------------------------------------------------M
Mb1935c|M.bovis_AF2122/97 SLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMD
Rv1900c|M.tuberculosis_H37Rv SLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMD
MUL_4838|M.ulcerans_Agy99 SMYR-FHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMD
MAV_5228|M.avium_104 SMYR-FHRRLAAFARVIRLDQRGIGLSSRVPSVDVIGPEFWARDVVSVMD
MMAR_3505|M.marinum_M SPYAPGIERASQQVRLVVWDRRGTGLSD--PATHLLSLDERLEDLRAIVD
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_3415|M.vanbaalenii_PYR-1 LTSRIKAVRRALGDDGEAQRYIRTVRGRGYQFVGRLLDDGT---------
Mflv_3121|M.gilvum_PYR-GCK LTSRIKAVRRALGDDGEAQRYIRTVRGRGYRFVGTLHGEDS---------
MSMEG_3856|M.smegmatis_MC2_155 LTSRIKAARRALGDDGESQRYIRTIRGRGYQFVGTLLPDDAGDGVNAPMR
MLBr_02269|M.leprae_Br4923 ------MINLAYEDRG----------------------------------
MAB_3934c|M.abscessus_ATCC_199 PLANINGIQISYDDRGP---------------------------------
Mb1935c|M.bovis_AF2122/97 AVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARP--------
Rv1900c|M.tuberculosis_H37Rv AVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARP--------
MUL_4838|M.ulcerans_Agy99 AAGCQQATILASGFTATTALVLAADYPERVRSLVLINASART--------
MAV_5228|M.avium_104 AVGCERATVVAPSFTSMTGLVLAADYPDRVSSLVIINGAART--------
MMAR_3505|M.marinum_M SVGLDRAALWGTSEGGAVSILFAATYPDRVGLLSLFGTAARFS-------
TH_3727|M.thermoresistible__bu --------------------------------------------------
Mvan_3415|M.vanbaalenii_PYR-1 ----------APAPTAAPEPAPEPVPEPPRQHIAFTRAADGVRLAYAVSG
Mflv_3121|M.gilvum_PYR-GCK ----------ATPDEASVEHV---VRETPRQHIAFARAADGVRLAYAESG
MSMEG_3856|M.smegmatis_MC2_155 AQPLQQHEAVALDTADTAEGSAEPVEPPPRQHIAFCRAGDGVRLAYAVVG
MLBr_02269|M.leprae_Br4923 -------------------------------------TGEPVVFIAGRGG
MAB_3934c|M.abscessus_ATCC_199 --------------------------------LALGASGDPVVFISGRGG
Mb1935c|M.bovis_AF2122/97 ----------LWAPDYPVGAQVRRADPFLTVALEPDAVEQGFDVLSIVAP
Rv1900c|M.tuberculosis_H37Rv ----------LWAPDYPVGAQVRRADPFLTVALEPDAVERGFDVLSIVAP
MUL_4838|M.ulcerans_Agy99 ----------LHAPDYELGIRSNTAEPFLTLGTDPDAVEQGFDVLRIMAP
MAV_5228|M.avium_104 ----------VYAPDYPMGARIETLDPYTTVAVDPDAVDQGFDMLGLIAP
MMAR_3505|M.marinum_M ----------QDLPDFPWGFTPAEVQSQLCAIEDDWGRGALAELFYGQAA
TH_3727|M.thermoresistible__bu --------------------------------MATITTSDGVEIFYRDWG
.
Mvan_3415|M.vanbaalenii_PYR-1 EGRPLVRAANWMTHLGYDIESPVWRHWVRDMSLRHKFIRYDERGCGLSDW
Mflv_3121|M.gilvum_PYR-GCK DGPPLVKAANWMTHLGYDSESPVWRHGVREMSLRYRFIRYDERGCGLSDW
MSMEG_3856|M.smegmatis_MC2_155 EGPPLVRAANWMTHLGYDIESPVWSHWVRDLSRNHTFIRYDERGCGLSDW
MLBr_02269|M.leprae_Br4923 AGR------TWQPHQVPAFLAAG-----------YRVITFDNRGIG-ATE
MAB_3934c|M.abscessus_ATCC_199 AGR------SWHLHQVPAFRAAG-----------YRTITFNNRGIPPTTE
Mb1935c|M.bovis_AF2122/97 TVAGDDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLGHIEAPTLI
Rv1900c|M.tuberculosis_H37Rv TVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLI
MUL_4838|M.ulcerans_Agy99 SVAHDDAFRHWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLI
MAV_5228|M.avium_104 SVAGDAAFRSWWDAAGNRAASPSMARAMILSIRHADVRDRLARITTPTLI
MMAR_3505|M.marinum_M EVPG---MRELFGRLQRSVSSPSMAKLWWQAFMATDVRAVLGSIRVPTLV
TH_3727|M.thermoresistible__bu SGQP-----IVFSHGWPLTADDWDPQMLFFLNAGYRVIAHDRRGHGRSSP
:
Mvan_3415|M.vanbaalenii_PYR-1 EVGAFTFDDWVTDLESVVEAVGLERFPLLG---VSQGGAVAVAYAARHPD
Mflv_3121|M.gilvum_PYR-GCK DVGDFTFDDWVADLETVVDAVGLDRFHLMG---VSQGGAVAVAYAARHPD
MSMEG_3856|M.smegmatis_MC2_155 EAADFSFDDWVADLESVVEALGLERFPLLG---VSQGGAVAVAYAARHPE
MLBr_02269|M.leprae_Br4923 NTEGFTTQTMVADTAVLIESLGAVPARIVG---VSMGSFIAQELMVARPE
MAB_3934c|M.abscessus_ATCC_199 SADGFTLQDMVDDTAALIEQLGAAPARLVG---FSMGALIAQELTLTRPE
Mb1935c|M.bovis_AF2122/97 LHRVGSTYIPVGHGRYLAEHIAGSRLVELP-GTDTLYWVGDTGPMLDEIE
Rv1900c|M.tuberculosis_H37Rv LHRVGSTYIPVGHGRYLAEHIAGSRLVELP-GTDTLYWVGDTGPMLDEIE
MUL_4838|M.ulcerans_Agy99 LHRVGTKFVPVEHGRYLAEHIAGSRLVELP-GSDSLYWVGDTAALLDEVE
MAV_5228|M.avium_104 LHRTDCVFTSVDHGRYLAEHIAGSRFVSLP-GEDTLYWVGDTGPMLDEIE
MMAR_3505|M.marinum_M LARPGDQLVPLESSAALAAAIPNAQFRLLPPGPHTPFDIIDD--LAREVL
TH_3727|M.thermoresistible__bu VPDGHDMDHYADDLAALVEHLGLRDAVHVG--HSTGGGVVVRYLARHGEE
: : : :
Mvan_3415|M.vanbaalenii_PYR-1 RVTRLVLCGAYARGRVVRAMNDDEKRAAALDLDLARVGWGRD--DPAFRQ
Mflv_3121|M.gilvum_PYR-GCK KVSRLVLCGAYARGRAVRALSDDEKRAAALDLELARVGWGRD--DPAFRQ
MSMEG_3856|M.smegmatis_MC2_155 RVSRLVLCGAYARGRAVRAVGDEEKRAAALDLELARVGWGRD--DPAFRQ
MLBr_02269|M.leprae_Br4923 LVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQLPSGYNAK--VRLLEN
MAB_3934c|M.abscessus_ATCC_199 LVTAAVFMGTRGREDATRSFFRKAELELSASGVEVPAAYQAA--MRLLLN
Mb1935c|M.bovis_AF2122/97 EFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDL--LDNHDT
Rv1900c|M.tuberculosis_H37Rv EFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDL--LDNHDT
MUL_4838|M.ulcerans_Agy99 EFITGVRGGFVTERVLTAVMFTGIVGSTQRAATVGDLRWRDL--LDNHDN
MAV_5228|M.avium_104 EFITGVRGGSEAERLLTTIVFTDIVGSTERAAALGDYRWRDL--LDNHDR
MMAR_3505|M.marinum_M DFFTGESGAPADERVLKTVLFTDIVSSTEKLSTMGDTAWRHQ--LNGHDS
TH_3727|M.thermoresistible__bu RTAKAVLIAAVPPLMVRTDANPGGLPKSVFDDFQAQLAANRSEFYRALAS
.
Mvan_3415|M.vanbaalenii_PYR-1 VFAAQFLPDGTRADWAAFDQLQRRTTSPENAVRFLEEFA--HIDVRDQCG
Mflv_3121|M.gilvum_PYR-GCK VFAAQFLPDGTRADWAAFDQLQRRTTSPENAVHFLEEFA--RIDVRDLCA
MSMEG_3856|M.smegmatis_MC2_155 VFAAQFLPDGTRADWAAFDQLQRRTTSPENAVRFLEAFG--RIDVRDEAR
MLBr_02269|M.leprae_Br4923 LSRKTLNDDVAVADWIAMFNMWPIKSTP-GLRCQTDVAP--QNNRLPAYR
MAB_3934c|M.abscessus_ATCC_199 FSPKTLNNDAAIKDWIDMFTLWPEPASG-GIDHQRSAIP--APDRPGAYA
Mb1935c|M.bovis_AF2122/97 IVCHEIQRFGGREVNTAGDGFVATFTSPSAAIACADDIVD-AVAALGIEV
Rv1900c|M.tuberculosis_H37Rv IVCHEIQRFGGREVNTAGDGFVATFTSPSAAIACADDIVD-AVAALGIEV
MUL_4838|M.ulcerans_Agy99 LVRHEIQRFGGREVNTAGDGFVATFSSPSAAINCADAVVD-AVAVLGIEV
MAV_5228|M.avium_104 IVRHELQRFGGREVNTAGDGFVATFSSPSAAISCADALVD-AVAALGIEV
MMAR_3505|M.marinum_M VVDNLLLRYGGTRAKHTGDGVFALFDAPTKAARCALQLVP-ALAALNIAI
TH_3727|M.thermoresistible__bu GPFYGFNRDGVEPSEALIANWWRQGMMGDAKAHYDGIVAFSQTDFTEDLT
:
Mvan_3415|M.vanbaalenii_PYR-1 QVRCPTLILHSR------DDHRVPMRYGEELAALIPDARLVALSSNNHLL
Mflv_3121|M.gilvum_PYR-GCK RVQCPTLVLHSR------DDHRVPMRYGEELASLIPDARLVALSSNNHLL
MSMEG_3856|M.smegmatis_MC2_155 EVRCPTLVMHSR------DDHRVPVRFGEELAALIEDARMVALDSNNHLL
MLBr_02269|M.leprae_Br4923 SIAAPVLVIGFA------EDVVTPPSLGREVADVLPNGRYLQIPDAGHLG
MAB_3934c|M.abscessus_ATCC_199 DIKVPSLVIGFT------DDMTLPPYLGKEVADAIPGGQYVEISDAGHLG
Mb1935c|M.bovis_AF2122/97 RIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIV
Rv1900c|M.tuberculosis_H37Rv RIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIV
MUL_4838|M.ulcerans_Agy99 RVGIHAGEVEVR----GADVADLAVHIGARVCALAGSSEVLVSSTVRDIV
MAV_5228|M.avium_104 RVGIHAGEVEVRGAR-KDDIAGMAVHIGARVAALAGPGEVLVSSTLRDIV
MMAR_3505|M.marinum_M RAGIHTGECERR----GQEWSGMAVHIGARIGVLADAGEVFASRTVRDLT
TH_3727|M.thermoresistible__bu KITVPVLVMHGD-----DDQVVPYANSGPLTAELLRNAKLKTYQGFPHGM
: * .. .
Mvan_3415|M.vanbaalenii_PYR-1 TGAEPAW-RVFCDEVETFLAV---------------
Mflv_3121|M.gilvum_PYR-GCK TATEPAW-QVFCAEVAAFLV----------------
MSMEG_3856|M.smegmatis_MC2_155 TGTEPAW-QVFRQELEGFLALDGS------------
MLBr_02269|M.leprae_Br4923 FFERPE--AVNAAALQFFAGVKGEWP----------
MAB_3934c|M.abscessus_ATCC_199 FIERPD--EVNRVILEFFASTAQTV-----------
Mb1935c|M.bovis_AF2122/97 AGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
Rv1900c|M.tuberculosis_H37Rv AGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
MUL_4838|M.ulcerans_Agy99 TGSSHRFAERGEHELKGVPGRWRLCALVREHLTGQR
MAV_5228|M.avium_104 TGSRHRFGDRGETALKGVPGQWRLYRLLREHAAAER
MMAR_3505|M.marinum_M AGSGLTFESLGPQQLKGLPEQIEIYRVSAA------
TH_3727|M.thermoresistible__bu MTTHAEV--VNADILEFLRS----------------
: .