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MHDDVKYLDLHGDRVAYREAGQGPAVLLIHGMGGSSLTWKALLPHLATRYRVIAPDLLGHGQSDKPRGDY SLGAFAVWLRDLLDLLGIARVTLVGHSLGGGVAMQFVHQHPDYCERLVLISSGGLGPELGRSLRLLSTPG IELLLPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYASLSDPQTRTAFLRTLRSVVDAQGQAVSA LNRLHFTLGLPTLLIWGDQDRLIPPAHGEAAHAALPGSRLVILPAVGHFPQVEAPLAVADTLDDFIANSS PWHGPPRHADHAEAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | - | 100% (295) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4279 | - | e-107 | 69.31% (277) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 8e-67 | 45.91% (281) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 5e-63 | 44.84% (281) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2367 | - | 1e-107 | 67.70% (291) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 5e-63 | 44.84% (281) | hydrolase |
| M. leprae Br4923 | MLBr_02269 | - | 2e-13 | 26.81% (276) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 5e-64 | 47.10% (276) | hydrolase |
| M. marinum M | MMAR_1997 | - | 3e-63 | 43.77% (281) | hydrolase |
| M. avium 104 | MAV_4567 | - | 1e-102 | 63.87% (274) | dihydrolipoyllysine-residue acetyltransferase component of |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 4e-24 | 30.26% (271) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 4e-26 | 29.79% (282) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 2e-63 | 43.77% (281) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 ---------------MTERKRNLRPVRD------------------VAPP
Rv2715|M.tuberculosis_H37Rv ---------------MTERKRNLRPVRD------------------VAPP
MMAR_1997|M.marinum_M ---------------MTERKRNLRPVRE------------------VTAP
MUL_3358|M.ulcerans_Agy99 ---------------MTERKRNLRPVRE------------------VTAP
MAB_3034|M.abscessus_ATCC_1997 ---------------MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRP
Mflv_2367|M.gilvum_PYR-GCK ------------------------------------------------MT
MAV_4567|M.avium_104 ------------------------------------------------MS
Mvan_2912|M.vanbaalenii_PYR-1 -----------------------------------------------MHD
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFESIWSDLQG-----------------------VAF
TH_4528|M.thermoresistible__bu -----------------VWSDLQG-----------------------VAF
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 TLQFRTVHG----YRRAFRIAGSGP--AILLIHGIGDNSTTWN--GVHAK
Rv2715|M.tuberculosis_H37Rv TLQFRTVHG----YRRAFRIAGSGP--AILLIHGIGDNSTTWN--GVHAK
MMAR_1997|M.marinum_M SLQFRTIHG----YKRAFRIAGSGP--AILLIHGIGDNSTTWT--GIHAK
MUL_3358|M.ulcerans_Agy99 SLQFRTIHG----YKRAFRIAGSGP--AILLIHGIGDNSTTWT--GIHAK
MAB_3034|M.abscessus_ATCC_1997 RLAFRTIHG----YRRAYRIAGSGP--VLLLIHGIGDNSATWD--SVHAQ
Mflv_2367|M.gilvum_PYR-GCK DLRYLDLHG----DRCAYRDEGDGEE-TLLLLHGMAGSSETWR--AVIPH
MAV_4567|M.avium_104 ELKFLELHG----DRVAFRDQGEGE--VLLLIHGMAGSSETWR--SVIPP
Mvan_2912|M.vanbaalenii_PYR-1 DVKYLDLHG----DRVAYREAGQGP--AVLLIHGMGGSSLTWK--ALLPH
MSMEG_4867|M.smegmatis_MC2_155 SQGYLDVPVGDRKIRTRYLHAGNPQAPALLFLHGSGGHAEAYV--RNLAA
TH_4528|M.thermoresistible__bu TQGYLDAGG----VRTRYLHAGEADKPVLIFLHGSGGHAEAYV--RNLEA
MLBr_02269|M.leprae_Br4923 ------------MINLAYEDRGTGEP--VVFIAGRGGAGRTWQPHQVPAF
. : * :::: * .. . ::
Mb2734|M.bovis_AF2122/97 LAQRFTVIAPDLLGHGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIVG
Rv2715|M.tuberculosis_H37Rv LAQRFTVIAPDLLGHGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIVG
MMAR_1997|M.marinum_M LAQRFTVIAPDLLGHGRSDKPRADYSIAAYANGMRDLLSVLDIERVTIIG
MUL_3358|M.ulcerans_Agy99 LAQRFTVIAPDLLGHGRSDKPRADYSIAAYANGMRDLLSVLDIERVTIIG
MAB_3034|M.abscessus_ATCC_1997 LAEHFTVIAPDLLGHGQSDKPRADYSVAAYANGMRDLLAVLDIERVTVVG
Mflv_2367|M.gilvum_PYR-GCK LAKRYRVIAPDLLGHGSSAKPRGDYSLGAFAAWLRDLLDELGIRSVTVVG
MAV_4567|M.avium_104 LAKKFRVIAPDLLGHGESAKPRTDYSLGAFAVWLRDFLDELGVSRATVVG
Mvan_2912|M.vanbaalenii_PYR-1 LATRYRVIAPDLLGHGQSDKPRGDYSLGAFAVWLRDLLDLLGIARVTLVG
MSMEG_4867|M.smegmatis_MC2_155 HAEHFSTWSIDMLGHGYTDKPGHPLEVAHYVDHVIAFLDTIGAQRAHISG
TH_4528|M.thermoresistible__bu HAEHFSTWSIDMLGHGYTDKPGHPLEVRHYVEHLAAVLDAIGADRAHISG
MLBr_02269|M.leprae_Br4923 LAAGYRVITFDNRGIGATENTEG-FTTQTMVADTAVLIESLGAVPARIVG
* : . : * * * : :. . .: :. . : *
Mb2734|M.bovis_AF2122/97 HSLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAM
Rv2715|M.tuberculosis_H37Rv HSLGGGVAMQFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAM
MMAR_1997|M.marinum_M HSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEAL
MUL_3358|M.ulcerans_Agy99 HSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEAL
MAB_3034|M.abscessus_ATCC_1997 HSLGGGVAMQFTYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDAL
Mflv_2367|M.gilvum_PYR-GCK QSLGGGVAMQFVYQHPDYCRRLVLISSGGLGQDVGWTLRLLSAPG---SE
MAV_4567|M.avium_104 HSLGGGVAMQFVYQHPDYAQRLILISSGGLGPDVGWVLRLLSAPG---AE
Mvan_2912|M.vanbaalenii_PYR-1 HSLGGGVAMQFVHQHPDYCERLVLISSGGLGPELGRSLRLLSTPG---IE
MSMEG_4867|M.smegmatis_MC2_155 ESLGGWVAARVAVDHPDRVEKLVLNTAGGSQADPEVMKRIITLSM-----
TH_4528|M.thermoresistible__bu ESLGGWVASRFAIDRPDRLDRLVLNTAGGSQADPEVMKRIITLSM-----
MLBr_02269|M.leprae_Br4923 VSMGSFIAQELMVARPELVRAAVLMATRGRLDRTRQFFHAAEAEFH--DS
*:*. :* .. *. :* . * :
Mb2734|M.bovis_AF2122/97 ALLRLPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAA
Rv2715|M.tuberculosis_H37Rv ALLRLPLVLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILDDLPEPTASAA
MMAR_1997|M.marinum_M ALLRLPMVLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDLPEPTASSA
MUL_3358|M.ulcerans_Agy99 ALLRLPMVLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDLPEPTASSA
MAB_3034|M.abscessus_ATCC_1997 GLLRLPMAMPMLRLGGAVARATFGRASMARDIPDVLRVLADLPEPRASAA
Mflv_2367|M.gilvum_PYR-GCK LLLPLIAPSPVVRAGDRVRAWFSARNIQSPRGAEMWSAYASLSDAHTRHA
MAV_4567|M.avium_104 LVLPVIAPTPVLSVGNKLRSWLRGAGIQSPRGAELWNAYSSLSDGETRQS
Mvan_2912|M.vanbaalenii_PYR-1 LLLPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYASLSDPQTRTA
MSMEG_4867|M.smegmatis_MC2_155 ----AAAENPTWDTVQARIKWLMAD--KSKDYDDIVASRQRVYRQPGFVA
TH_4528|M.thermoresistible__bu ----AAAENPSWDTVQARITWLMAD--KSKGYDDIVASRQKIYRQPGFVD
MLBr_02269|M.leprae_Br4923 GIQLPSGYNAKVRLLENLSRKTLNDDVAVADWIAMFNMWPIKSTPG----
.
Mb2734|M.bovis_AF2122/97 FGRTLRAVVDWRGQMVTMLDR-CYLTEAIPVQIIWGTKDVVLPVRHAHMA
Rv2715|M.tuberculosis_H37Rv FGRTLRAVVDWRGQMVTMLDR-CYLTEAIPVQIIWGTKDVVLPVRHAHMA
MMAR_1997|M.marinum_M FTRTLRAVVDWRGQIVTMLDR-CYLTQAIPVQIIWGSRDAVVPVRHAEMA
MUL_3358|M.ulcerans_Agy99 FTRTLRAVVDWRGQIVTMLDR-CYLTQAIPVQIIWGSRDAVVPVRHAEMA
MAB_3034|M.abscessus_ATCC_1997 FTRTLRAVVDWRGQVVTMLDR-CYLTESVPVQLIWGSDDLVIPVSHGHLA
Mflv_2367|M.gilvum_PYR-GCK FLRTLRSVVDYRGQAVSALNK-LHLTTELPLMVIWGDQDRIIPVDHGFAL
MAV_4567|M.avium_104 FLKTLRSVVDYRGQAVSALNR-LRLREELPVMAIWGERDGIIPVDHAYAA
Mvan_2912|M.vanbaalenii_PYR-1 FLRTLRSVVDAQGQAVSALNR-LHFTLGLPTLLIWGDQDRLIPPAHGEAA
MSMEG_4867|M.smegmatis_MC2_155 AMSDIMALQDPQIRARNLLGQAEYGSITAPTLVVWTSDDPTADVAEGRRI
TH_4528|M.thermoresistible__bu AMRNIMALQDPEIRARNLLGPEEYGAITAPTLVVWTSDDPTADVDEGKRI
MLBr_02269|M.leprae_Br4923 -LRCQTDVAPQNNRLP------AYRSIAAPVLVIGFAEDVVTPPSLGREV
: . : * : * .
Mb2734|M.bovis_AF2122/97 HAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRA
Rv2715|M.tuberculosis_H37Rv HAAMPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRA
MMAR_1997|M.marinum_M HAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRE
MUL_3358|M.ulcerans_Agy99 HAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRE
MAB_3034|M.abscessus_ATCC_1997 HAAMPGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRR
Mflv_2367|M.gilvum_PYR-GCK DQHRPGCRLEILDGVGHFPHVEKPDAVVDLLDDFIATTHASV--------
MAV_4567|M.avium_104 HEARTDARLEVLPDVGHFAQVEAPMRVVELIEDFIATGER----------
Mvan_2912|M.vanbaalenii_PYR-1 HAALPGSRLVILPAVGHFPQVEAPLAVADTLDDFIANSSPWHG-------
MSMEG_4867|M.smegmatis_MC2_155 ASMIPGARFEVMPGCGHWPQYEDPATFNALHLDFLLGR------------
TH_4528|M.thermoresistible__bu ASMIPGARFEVMPGCGHWPQYEDPATFNRLHIDFLLGRS-----------
MLBr_02269|M.leprae_Br4923 ADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAGVKGEWP-------
.. : ** : * . *:
Mb2734|M.bovis_AF2122/97 LLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv LLRRGGGEATVTGSADTRVAVLNAIGSNERSAT
MMAR_1997|M.marinum_M LLRTGGGERTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 LLRTGGGERTVSDPADTRVAVLSAMGSDERSAT
MAB_3034|M.abscessus_ATCC_1997 LLRTGVTEHAISGAARTRMAVLDAMGTDERSAT
Mflv_2367|M.gilvum_PYR-GCK -----------------RPADVPER--------
MAV_4567|M.avium_104 -----------------RDATSPQPG-------
Mvan_2912|M.vanbaalenii_PYR-1 ---------------PPRHADHAEAD-------
MSMEG_4867|M.smegmatis_MC2_155 ---------------------------------
TH_4528|M.thermoresistible__bu ---------------------------------
MLBr_02269|M.leprae_Br4923 ---------------------------------