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VPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSIPIDSVDAEPSMYRFHRRLAAFARVIRLDQR GIGLSSRVPSVDVIGPEFWARDVVSVMDAVGCERATVVAPSFTSMTGLVLAADYPDRVSSLVIINGAART VYAPDYPMGARIETLDPYTTVAVDPDAVDQGFDMLGLIAPSVAGDAAFRSWWDAAGNRAASPSMARAMIL SIRHADVRDRLARITTPTLILHRTDCVFTSVDHGRYLAEHIAGSRFVSLPGEDTLYWVGDTGPMLDEIEE FITGVRGGSEAERLLTTIVFTDIVGSTERAAALGDYRWRDLLDNHDRIVRHELQRFGGREVNTAGDGFVA TFSSPSAAISCADALVDAVAALGIEVRVGIHAGEVEVRGARKDDIAGMAVHIGARVAALAGPGEVLVSST LRDIVTGSRHRFGDRGETALKGVPGQWRLYRLLREHAAAER
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5228 | - | - | 100% (461) | hydrolase, alpha/beta hydrolase fold family protein |
| M. avium 104 | MAV_1250 | - | 1e-22 | 39.63% (164) | adenylate and guanylate cyclase catalytic domain-containing |
| M. avium 104 | MAV_3122 | - | 2e-11 | 31.67% (180) | adenylate and guanylate cyclase catalytic domain-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 0.0 | 72.47% (454) | lignin peroxidase LIPJ |
| M. gilvum PYR-GCK | Mflv_2091 | - | 8e-19 | 36.31% (157) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 0.0 | 72.03% (454) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_01399 | - | 2e-12 | 33.58% (137) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_2330 | - | 2e-09 | 33.86% (127) | putative purine cyclase-like protein |
| M. marinum M | MMAR_0286 | lipJ | 0.0 | 71.21% (455) | lignin peroxidase LipJ |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 1e-73 | 38.79% (464) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1244 | - | 4e-22 | 39.63% (164) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 0.0 | 70.55% (455) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_4613 | - | 4e-20 | 40.38% (156) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MMAR_0286|M.marinum_M MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
MUL_4838|M.ulcerans_Agy99 MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
Mb1935c|M.bovis_AF2122/97 MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
Rv1900c|M.tuberculosis_H37Rv MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
MAV_5228|M.avium_104 MPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSIPIDSVDAEPS
MSMEG_4477|M.smegmatis_MC2_155 ------MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPE
MLBr_01399|M.leprae_Br4923 -------------------------------------------MPPSAKS
MAB_2330|M.abscessus_ATCC_1997 -----------------------------------------MDVEPSGLD
Mflv_2091|M.gilvum_PYR-GCK ---------------------------------------MLILVCVLAVL
Mvan_4613|M.vanbaalenii_PYR-1 -----------------------------------------MALLVLAAV
TH_1244|M.thermoresistible__bu ---------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQIAIVVVALAGL
MMAR_0286|M.marinum_M MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
MUL_4838|M.ulcerans_Agy99 MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
Mb1935c|M.bovis_AF2122/97 LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
Rv1900c|M.tuberculosis_H37Rv LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
MAV_5228|M.avium_104 MYRFHRRLAAFARVIRLDQRGIGLSSRVPSVDVIGPEFWARDVVSVMDAV
MSMEG_4477|M.smegmatis_MC2_155 FKSFFDQLASFCRVAIFDKAGTGLSDPVPKVRTLDDR--AAEIEAVMDAV
MLBr_01399|M.leprae_Br4923 TYP-------------GQVEGAPHDGTPSAPQEPDEDTVTVPAPALIRRS
MAB_2330|M.abscessus_ATCC_1997 AEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEVPSTESASRH
Mflv_2091|M.gilvum_PYR-GCK AAGLGIALAVQTR---RLTSARQEAEELRHRLDTR---------------
Mvan_4613|M.vanbaalenii_PYR-1 VVGLAVALAVQSR---RLRTARQEADELRRRLDTR---------------
TH_1244|M.thermoresistible__bu ALAEAVALAVLWG---RLRRERRAADELRRRLDTR---------------
MMAR_0286|M.marinum_M GCQEATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
MUL_4838|M.ulcerans_Agy99 GCQQATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
Mb1935c|M.bovis_AF2122/97 GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
Rv1900c|M.tuberculosis_H37Rv GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
MAV_5228|M.avium_104 GCERATVVAPSFTSMTGLVLAADYPDRVSSLVIIN-----GAARTVYAPD
MSMEG_4477|M.smegmatis_MC2_155 GFDDAVVLAMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDG
MLBr_01399|M.leprae_Br4923 SVSMP-NAAQWLHTTNRSPRLVAMVRRARRLLPGD---------------
MAB_2330|M.abscessus_ATCC_1997 FARASRTAGSWFRKMDRDPAVVAALRRARRSLPGD---------------
. . :
Mflv_2091|M.gilvum_PYR-GCK -----------------------QLLVSGGTKAVKTVWQTANILR-----
Mvan_4613|M.vanbaalenii_PYR-1 -----------------------QMLVTGSTKAVKTVWQTANILR-----
TH_1244|M.thermoresistible__bu -----------------------TTLMAGGREAVRTVWQTANILR-----
MMAR_0286|M.marinum_M YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
MUL_4838|M.ulcerans_Agy99 YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
Mb1935c|M.bovis_AF2122/97 YPVGAQVR-----------RADPFLTVALEPDAVEQGFDVLSIVAPTVAG
Rv1900c|M.tuberculosis_H37Rv YPVGAQVR-----------RADPFLTVALEPDAVERGFDVLSIVAPTVAG
MAV_5228|M.avium_104 YPMGARIE-----------TLDPYTTVAVDPDAVDQGFDMLGLIAPSVAG
MSMEG_4477|M.smegmatis_MC2_155 DPVDIRARSVAEMGDEYAPTVEQVIHFQEQARAVRGQWGSGAAVRCAMPS
MLBr_01399|M.leprae_Br4923 -------------------------PDFGDPLSTAGEGGPRAAAR-----
MAB_2330|M.abscessus_ATCC_1997 -------------------------PYFGDPLSTSGFGGASAVAR-----
:.
Mflv_2091|M.gilvum_PYR-GCK ----------------KDGFGAAVRSSIEELADWAEVERPDLARLSLNGR
Mvan_4613|M.vanbaalenii_PYR-1 ----------------RDGFGAAVRSSIEELADWAEVERPDLARLAPNGR
TH_1244|M.thermoresistible__bu ----------------TDGLGAAARSSIEDLADWAEVERPDLARLAANGK
MMAR_0286|M.marinum_M DDAFRDWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
MUL_4838|M.ulcerans_Agy99 DDAFRHWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
Mb1935c|M.bovis_AF2122/97 DDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLGHIEAPTLILHRV
Rv1900c|M.tuberculosis_H37Rv DDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLILHRV
MAV_5228|M.avium_104 DAAFRSWWDAAGNRAASPSMARAMILSIRHADVRDRLARITTPTLILHRT
MSMEG_4477|M.smegmatis_MC2_155 MGSMRQLG-MFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHAR
MLBr_01399|M.leprae_Br4923 ---------------AADRLLGDRGAASREVSLSVLQVWQALTEAIARRP
MAB_2330|M.abscessus_ATCC_1997 ---------------AADRLVTDRDTAVREFGFGALQIWQAFTEKVSKQP
. .
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MMAR_0286|M.marinum_M GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
MUL_4838|M.ulcerans_Agy99 GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
Mb1935c|M.bovis_AF2122/97 GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
Rv1900c|M.tuberculosis_H37Rv GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
MAV_5228|M.avium_104 DCVFTSVDHGRYLAEHIAGSRFVSLPGEDTLYWVGDTGPMLDEIEEFITG
MSMEG_4477|M.smegmatis_MC2_155 DDPAVPVQCSRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTG
MLBr_01399|M.leprae_Br4923 VN------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 AN------------------------------------------------
Mflv_2091|M.gilvum_PYR-GCK ------------LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFV
Mvan_4613|M.vanbaalenii_PYR-1 ------------VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHV
TH_1244|M.thermoresistible__bu ------------VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFV
MMAR_0286|M.marinum_M VRGG-FVTERVLTTVMFTDIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
MUL_4838|M.ulcerans_Agy99 VRGG-FVTERVLTAVMFTGIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
Mb1935c|M.bovis_AF2122/97 VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
Rv1900c|M.tuberculosis_H37Rv VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
MAV_5228|M.avium_104 VRGG-SEAERLLTTIVFTDIVGSTERAAALGDYRWRDLLDNHDRIVRHEL
MSMEG_4477|M.smegmatis_MC2_155 NHAAPHNSHRALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELS
MLBr_01399|M.leprae_Br4923 ----------PEVTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPL
MAB_2330|M.abscessus_ATCC_1997 ----------REVTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPL
.::*:.: : ** :: .
Mflv_2091|M.gilvum_PYR-GCK DKHEGHVVKSQGDGFMVAFAKPEQAVRCGLDIQHSLARRPND---IRVRM
Mvan_4613|M.vanbaalenii_PYR-1 DAHDGYVVKSQGDGFMVAFARPEQAVRCGLAIQHSLDKRPNG---IRVRI
TH_1244|M.thermoresistible__bu KKHDGYVIKSQGDGFMVAFARPEQAVRCSVELQRALRKRPDR---IRVRI
MMAR_0286|M.marinum_M QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVAVLG-----IEVRV
MUL_4838|M.ulcerans_Agy99 QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVAVLG-----IEVRV
Mb1935c|M.bovis_AF2122/97 QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVAALG-----IEVRI
Rv1900c|M.tuberculosis_H37Rv QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVAALG-----IEVRI
MAV_5228|M.avium_104 QRFGGREVNTAGDGFVATFSSPSAAISCADALVDAVAALG-----IEVRV
MSMEG_4477|M.smegmatis_MC2_155 GRFGGVVVKSTGDGHLSTFEGPTHAIRYAEALRSDAETLG-----IQIRA
MLBr_01399|M.leprae_Br4923 LDAGGHIVKRMGDGIMAVFRDPSVAVQAVLAATEAMKSVEVGGYTPRIRV
MAB_2330|M.abscessus_ATCC_1997 LSAGGQVVKRMGDGIMAVFDDPVTALRAIIPARDALKNVEIQGYTPVMRI
* :: *** : .* * *: :*
Mflv_2091|M.gilvum_PYR-GCK GVHTGKSVLRG----DDVFGRNVAMAARVAAAADGGEILVSSAVHRALAD
Mvan_4613|M.vanbaalenii_PYR-1 GIHVGKSVLRG----DDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTD
TH_1244|M.thermoresistible__bu GIHLGRSVRRG----DDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNS
MMAR_0286|M.marinum_M GIHAGEVEVR----GADVAGLAVHIGARVCALAGSSEVLVSSTVRDIVTG
MUL_4838|M.ulcerans_Agy99 GIHAGEVEVR----GADVADLAVHIGARVCALAGSSEVLVSSTVRDIVTG
Mb1935c|M.bovis_AF2122/97 GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
Rv1900c|M.tuberculosis_H37Rv GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
MAV_5228|M.avium_104 GIHAGEVEVRG-ARKDDIAGMAVHIGARVAALAGPGEVLVSSTLRDIVTG
MSMEG_4477|M.smegmatis_MC2_155 AIHTGECELLG----DDIGGIAVHIAARILGQARAGEILVSRTVRDLVVG
MLBr_01399|M.leprae_Br4923 GIHTGRPQRLA----ADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQ
MAB_2330|M.abscessus_ATCC_1997 GIHAGTPQRIG----SDWLGVDVNIAARVMESAAKGGLAISQPALAKVPL
.:* * * . * :.**: * . : :* . :
Mflv_2091|M.gilvum_PYR-GCK CEDLA--------FDEQRDVELKGFSGSHTLYPVR---------------
Mvan_4613|M.vanbaalenii_PYR-1 ADDIV--------VDGERDAHLKGFSGSHTLYSVR---------------
TH_1244|M.thermoresistible__bu AGDAGSDEVAGFDVDDGREVSLKGFPGRHRLFAVR---------------
MMAR_0286|M.marinum_M SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
MUL_4838|M.ulcerans_Agy99 SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
Mb1935c|M.bovis_AF2122/97 SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
Rv1900c|M.tuberculosis_H37Rv SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
MAV_5228|M.avium_104 SRHRFG---------DRGETALKGVPGQWRLYRL----------------
MSMEG_4477|M.smegmatis_MC2_155 SGTSFA---------DRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEAL
MLBr_01399|M.leprae_Br4923 SDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIKAR-------------
MAB_2330|M.abscessus_ATCC_1997 AFLDHMGLTPTPVRRPLFSSRPAGVPENMKMYLLETR-------------
. *.. : :
Mflv_2091|M.gilvum_PYR-GCK -------------------------------------SASASR-------
Mvan_4613|M.vanbaalenii_PYR-1 -------------------------------------SASASR-------
TH_1244|M.thermoresistible__bu -------------------------------------GQAGFRPRPRPE-
MMAR_0286|M.marinum_M ----------------------------------VREHLTGQR-------
MUL_4838|M.ulcerans_Agy99 ----------------------------------VREHLTGQR-------
Mb1935c|M.bovis_AF2122/97 ----------------------------------MRDDATRTR-------
Rv1900c|M.tuberculosis_H37Rv ----------------------------------MRDDATRTR-------
MAV_5228|M.avium_104 ----------------------------------LREHAAAER-------
MSMEG_4477|M.smegmatis_MC2_155 LAAEPTPAARTATRRADRAVAAVAKRTPWALRGVARLTMSATRR------
MLBr_01399|M.leprae_Br4923 ----------------------------------RELTASDETAQTNSLT
MAB_2330|M.abscessus_ATCC_1997 ----------------------------------RQLPAPGDDGRV----
.