For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
WRFDDFVLDTGRFELRRGDEVIRVEPQVFDVLTQLIVNHERVVTKVELFDTVWGGRFVGEAALTSRIKAA RRALGDDGESQRYIRTIRGRGYQFVGTLLPDDAGDGVNAPMRAQPLQQHEAVALDTADTAEGSAEPVEPP PRQHIAFCRAGDGVRLAYAVVGEGPPLVRAANWMTHLGYDIESPVWSHWVRDLSRNHTFIRYDERGCGLS DWEAADFSFDDWVADLESVVEALGLERFPLLGVSQGGAVAVAYAARHPERVSRLVLCGAYARGRAVRAVG DEEKRAAALDLELARVGWGRDDPAFRQVFAAQFLPDGTRADWAAFDQLQRRTTSPENAVRFLEAFGRIDV RDEAREVRCPTLVMHSRDDHRVPVRFGEELAALIEDARMVALDSNNHLLTGTEPAWQVFRQELEGFLALD GS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3856 | - | - | 100% (423) | transcriptional regulator, CadC |
| M. smegmatis MC2 155 | MSMEG_3297 | - | e-176 | 72.51% (422) | transcriptional regulator, CadC |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 8e-22 | 29.60% (277) | hydrolase, alpha/beta hydrolase fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 8e-13 | 27.78% (270) | lignin peroxidase LIPJ |
| M. gilvum PYR-GCK | Mflv_3121 | - | 0.0 | 74.94% (419) | transcriptional regulator, CadC |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 1e-12 | 27.78% (270) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_00174 | - | 7e-08 | 38.46% (91) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3878 | - | 3e-12 | 26.81% (317) | lipase/esterase LipG |
| M. marinum M | MMAR_3505 | - | 5e-24 | 32.82% (259) | hydrolase |
| M. avium 104 | MAV_5228 | - | 2e-13 | 29.00% (269) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_2963 | - | 2e-14 | 31.78% (236) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 5e-15 | 26.94% (271) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_3415 | - | 0.0 | 77.62% (420) | transcriptional regulator, CadC |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1935c|M.bovis_AF2122/97 ----------MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFV
Rv1900c|M.tuberculosis_H37Rv ----------MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFV
MUL_4838|M.ulcerans_Agy99 ----------MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASI
MAV_5228|M.avium_104 ----------MPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSI
MMAR_3505|M.marinum_M --------------MSDDRVRYARNGDVHLAYRVFGQSGPTVIWVPGWMV
Mflv_3121|M.gilvum_PYR-GCK ----------------------MTSAD-ALSSSPRVWRWDDYVLDLGRYE
Mvan_3415|M.vanbaalenii_PYR-1 MPPTAGADLAATRGCRHRYCCRVTSADSALSPHRRVWRWDDFVLDVGCYE
MSMEG_3856|M.smegmatis_MC2_155 -----------------------------------MWRFDDFVLDTGRFE
TH_2963|M.thermoresistible__bu --------------------------------------------------
MAB_3878|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00174|M.leprae_Br4923 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 P---IDSIDDEPSLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGP
Rv1900c|M.tuberculosis_H37Rv P---IDSIDDEPSLYR-FHRRLASFSRVIRLDHRGVGLSSRLAAITTLGP
MUL_4838|M.ulcerans_Agy99 P---VDTIDSEPSMYR-FHRRLASFSRLIRFDHRGVGLSSRVSSPDALGP
MAV_5228|M.avium_104 P---IDSVDAEPSMYR-FHRRLAAFARVIRLDQRGIGLSSRVPSVDVIGP
MMAR_3505|M.marinum_M SN--VDTIDEPGSPYAPGIERASQQVRLVVWDRRGTGLSD--PATHLLSL
Mflv_3121|M.gilvum_PYR-GCK LRAGDSVIRVEPQVFDVLTQLVSHHDRCVSKEE----LFDTVWGGRFVGE
Mvan_3415|M.vanbaalenii_PYR-1 LRRGDTMIRVEPQVFDVLAQLVSNHGRFVSKEE----LFDTVWGGRFVGE
MSMEG_3856|M.smegmatis_MC2_155 LRRGDEVIRVEPQVFDVLTQLIVNHERVVTKVE----LFDTVWGGRFVGE
TH_2963|M.thermoresistible__bu ------------------------------------------------MP
MAB_3878|M.abscessus_ATCC_1997 -------------------------------------MVPLSSEVPTRSG
MLBr_00174|M.leprae_Br4923 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 KFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLVLAADYPERVR-------
Rv1900c|M.tuberculosis_H37Rv KFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLVLAADYPERVR-------
MUL_4838|M.ulcerans_Agy99 RFWAEDAIAVMDAAGCQQATILASGFTATTALVLAADYPERVR-------
MAV_5228|M.avium_104 EFWARDVVSVMDAVGCERATVVAPSFTSMTGLVLAADYPDRVS-------
MMAR_3505|M.marinum_M DERLEDLRAIVDSVGLDRAALWGTSEGGAVSILFAATYPDRVG-------
Mflv_3121|M.gilvum_PYR-GCK AALTSRIKAVRRALGDDGEAQRYIRTVRGRGYRFVGTLHGEDS-------
Mvan_3415|M.vanbaalenii_PYR-1 AALTSRIKAVRRALGDDGEAQRYIRTVRGRGYQFVGRLLDDGT-------
MSMEG_3856|M.smegmatis_MC2_155 AALTSRIKAARRALGDDGESQRYIRTIRGRGYQFVGTLLPDDAGDGVNAP
TH_2963|M.thermoresistible__bu RFSRAGTTIDYTDTGAPAGRLEAPTILFGHGLLFSG--------------
MAB_3878|M.abscessus_ATCC_1997 IARNGDVELFYEDLGNPGDPAVVLVMGVAAQLPMWPDGFCRQL-------
MLBr_00174|M.leprae_Br4923 ----MRILAVDDDRAVRESLRRSLSFNGYS--------------------
.
Mb1935c|M.bovis_AF2122/97 ----SLIVVNGSARP-LWAPDYPVGAQVRRADPFLTVALEPDAVEQGFDV
Rv1900c|M.tuberculosis_H37Rv ----SLIVVNGSARP-LWAPDYPVGAQVRRADPFLTVALEPDAVERGFDV
MUL_4838|M.ulcerans_Agy99 ----SLVLINASART-LHAPDYELGIRSNTAEPFLTLGTDPDAVEQGFDV
MAV_5228|M.avium_104 ----SLVIINGAART-VYAPDYPMGARIETLDPYTTVAVDPDAVDQGFDM
MMAR_3505|M.marinum_M ----LLSLFGTAARFSQDLPDFPWGFTPAEVQSQLCAIEDDWGRGALAEL
Mflv_3121|M.gilvum_PYR-GCK ------------ATPDEASVEHV---VRETPRQHIAFARAADGVRLAYAE
Mvan_3415|M.vanbaalenii_PYR-1 ------------APAPTAAPEPAPEPVPEPPRQHIAFTRAADGVRLAYAV
MSMEG_3856|M.smegmatis_MC2_155 MRAQPLQQHEAVALDTADTAEGSAEPVEPPPRQHIAFCRAGDGVRLAYAV
TH_2963|M.thermoresistible__bu --------------------------------------------------
MAB_3878|M.abscessus_ATCC_1997 -------------------------------------------LDQGYRV
MLBr_00174|M.leprae_Br4923 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 LSIVAPTVAGDDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLGHI
Rv1900c|M.tuberculosis_H37Rv LSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHI
MUL_4838|M.ulcerans_Agy99 LRIMAPSVAHDDAFRHWWDLAGNRAASPSTARAFINAVQASDARDSLPHI
MAV_5228|M.avium_104 LGLIAPSVAGDAAFRSWWDAAGNRAASPSMARAMILSIRHADVRDRLARI
MMAR_3505|M.marinum_M FYGQAAEVPG---MRELFGRLQRSVSSPSMAKLWWQAFMATDVRAVLGSI
Mflv_3121|M.gilvum_PYR-GCK SGDGPPLVKAAN----WMTHLGYDSESP----VWRHGVREMSLRYRFIRY
Mvan_3415|M.vanbaalenii_PYR-1 SGEGRPLVRAAN----WMTHLGYDIESP----VWRHWVRDMSLRHKFIRY
MSMEG_3856|M.smegmatis_MC2_155 VGEGPPLVRAAN----WMTHLGYDIESP----VWSHWVRDLSRNHTFIRY
TH_2963|M.thermoresistible__bu -------------------------------WQFNLQIYALRRYYRCLAI
MAB_3878|M.abscessus_ATCC_1997 IRFDNRDCG-------------------------LSTKLDGQKAPGSVQR
MLBr_00174|M.leprae_Br4923 ----------------------------------VELANDGVEALEMVAR
Mb1935c|M.bovis_AF2122/97 EAPTLILHRVGS-TYIPVGHGRYLAEHIAGSRLVELP-GTDTLYWVGDTG
Rv1900c|M.tuberculosis_H37Rv EAPTLILHRVGS-TYIPVGHGRYLAEHIAGSRLVELP-GTDTLYWVGDTG
MUL_4838|M.ulcerans_Agy99 TAPTLILHRVGT-KFVPVEHGRYLAEHIAGSRLVELP-GSDSLYWVGDTA
MAV_5228|M.avium_104 TTPTLILHRTDC-VFTSVDHGRYLAEHIAGSRFVSLP-GEDTLYWVGDTG
MMAR_3505|M.marinum_M RVPTLVLARPGD-QLVPLESSAALAAAIPNAQFRLLPPGPHTPFDIIDD-
Mflv_3121|M.gilvum_PYR-GCK DERGCGLSDWDVGDFTFDDWVADLETVVDAVGLDRFH-------------
Mvan_3415|M.vanbaalenii_PYR-1 DERGCGLSDWEVGAFTFDDWVTDLESVVEAVGLERFP-------------
MSMEG_3856|M.smegmatis_MC2_155 DERGCGLSDWEAADFSFDDWVADLESVVEALGLERFP-------------
TH_2963|M.thermoresistible__bu DWRGQGASSGAARPYDMDTLTEDAAHLVRSLGVAPAH-------------
MAB_3878|M.abscessus_ATCC_1997 RVVRYALGMGSKVPYTLIDMAEDVRSLVDHLGLEKVH-------------
MLBr_00174|M.leprae_Br4923 DRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLT-------------
.
Mb1935c|M.bovis_AF2122/97 PMLDEIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLL
Rv1900c|M.tuberculosis_H37Rv PMLDEIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLL
MUL_4838|M.ulcerans_Agy99 ALLDEVEEFITGVRGGFVTERVLTAVMFTGIVGSTQRAATVGDLRWRDLL
MAV_5228|M.avium_104 PMLDEIEEFITGVRGGSEAERLLTTIVFTDIVGSTERAAALGDYRWRDLL
MMAR_3505|M.marinum_M -LAREVLDFFTGESGAPADERVLKTVLFTDIVSSTEKLSTMGDTAWRHQL
Mflv_3121|M.gilvum_PYR-GCK -LMGVSQGGAVAVAYAARHPDKVSRLVLCGAYARGRAVRALSDD------
Mvan_3415|M.vanbaalenii_PYR-1 -LLGVSQGGAVAVAYAARHPDRVTRLVLCGAYARGRVVRAMNDD------
MSMEG_3856|M.smegmatis_MC2_155 -LLGVSQGGAVAVAYAARHPERVSRLVLCGAYARGRAVRAVGDE------
TH_2963|M.thermoresistible__bu -YVGLSMGGFVGIRLAARHPELVRSLVLMNTSAGPEDPAKADRY------
MAB_3878|M.abscessus_ATCC_1997 -IAGASMGGMIVQVFAGTYPERVHSVGIIYSATGRPFSRLPSWELIK---
MLBr_00174|M.leprae_Br4923 --ARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKP------
. . :
Mb1935c|M.bovis_AF2122/97 DNHDTIVCHEIQRFGGREVNTAGDGFVATFTSPS---AAIACADDIVDAV
Rv1900c|M.tuberculosis_H37Rv DNHDTIVCHEIQRFGGREVNTAGDGFVATFTSPS---AAIACADDIVDAV
MUL_4838|M.ulcerans_Agy99 DNHDNLVRHEIQRFGGREVNTAGDGFVATFSSPS---AAINCADAVVDAV
MAV_5228|M.avium_104 DNHDRIVRHELQRFGGREVNTAGDGFVATFSSPS---AAISCADALVDAV
MMAR_3505|M.marinum_M NGHDSVVDNLLLRYGGTRAKHTGDGVFALFDAPT---KAARCALQLVPAL
Mflv_3121|M.gilvum_PYR-GCK EKRAAALDLELARVGWGRDDPAFRQVFAAQFLPDGTRADWAAFDQLQRRT
Mvan_3415|M.vanbaalenii_PYR-1 EKRAAALDLDLARVGWGRDDPAFRQVFAAQFLPDGTRADWAAFDQLQRRT
MSMEG_3856|M.smegmatis_MC2_155 EKRAAALDLELARVGWGRDDPAFRQVFAAQFLPDGTRADWAAFDQLQRRT
TH_2963|M.thermoresistible__bu --RTMARIYRFTGIGPLRRAVLPLMFGPAFLADPDSEDVIDEWERRLRRY
MAB_3878|M.abscessus_ATCC_1997 TALNAPGKNATAEEWLEFEVNNGIVYNGPDNLPSREQLRQRILDHRARSD
MLBr_00174|M.leprae_Br4923 ---DDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANP
Mb1935c|M.bovis_AF2122/97 AALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVS
Rv1900c|M.tuberculosis_H37Rv AALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVS
MUL_4838|M.ulcerans_Agy99 AVLGIEVRVGIHAGEVEVR----GADVADLAVHIGARVCALAGSSEVLVS
MAV_5228|M.avium_104 AALGIEVRVGIHAGEVEVRGAR-KDDIAGMAVHIGARVAALAGPGEVLVS
MMAR_3505|M.marinum_M AALNIAIRAGIHTGECERR----GQEWSGMAVHIGARIGVLADAGEVFAS
Mflv_3121|M.gilvum_PYR-GCK TSPENAVHFLEEFARIDVRDLCARVQCPTLVLHSRDDHRVPMRYGEELAS
Mvan_3415|M.vanbaalenii_PYR-1 TSPENAVRFLEEFAHIDVRDQCGQVRCPTLILHSRDDHRVPMRYGEELAA
MSMEG_3856|M.smegmatis_MC2_155 TSPENAVRFLEAFGRIDVRDEAREVRCPTLVMHSRDDHRVPVRFGEELAA
TH_2963|M.thermoresistible__bu PRSSVRDAVLAVANRAGVEDELAAIDVPTLVIGGAQDAATPPAHAQALAA
MAB_3878|M.abscessus_ATCC_1997 YKIGTVRQFDAILGTGSLLRFTRAVVAPAVVIHGRNDPLVPYQNGRVVAK
MLBr_00174|M.leprae_Br4923 RRVLTRSRILEEVWGFDFP-----TSGNALEVYVGYLRRKTEADG-----
: : .
Mb1935c|M.bovis_AF2122/97 STVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR--
Rv1900c|M.tuberculosis_H37Rv STVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR--
MUL_4838|M.ulcerans_Agy99 STVRDIVTGSSHRFAERGEHELKGVPGRWRLCALVREHLTGQR--
MAV_5228|M.avium_104 STLRDIVTGSRHRFGDRGETALKGVPGQWRLYRLLREHAAAER--
MMAR_3505|M.marinum_M RTVRDLTAGSGLTFESLGPQQLKGLPEQIEIYRVSAA--------
Mflv_3121|M.gilvum_PYR-GCK -----LIPDARLVALSSNNHLLTATEPAWQVFCAEVAAFLV----
Mvan_3415|M.vanbaalenii_PYR-1 -----LIPDARLVALSSNNHLLTGAEPAWRVFCDEVETFLAV---
MSMEG_3856|M.smegmatis_MC2_155 -----LIEDARMVALDSNNHLLTGTEPAWQVFRQELEGFLALDGS
TH_2963|M.thermoresistible__bu G-----IRGARLEIIDDCGH--SSPLERPDVVTELLRGFLLEHT-
MAB_3878|M.abscessus_ATCC_1997 N-----MRNARFALIERMGHDLPEPVWKPVTSELLTTFECAVQD-
MLBr_00174|M.leprae_Br4923 -------ESRLIHTVRGVGYVLRETPP------------------
.