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VAGTRYWDDIDGEFDIPVEEITGTLPEGLTGTLYRNGSGRWNIGSSPVESIYDADGMVSAFVLNGAGVRF RNRFVRTRHFVQSTRAGRPIGRGFSAQRPGGIRANALRLPVNTANTSVMMNNDRLLALWEGGRPHELDPD SLDTYGMSDLGGALRGPVGAYSAHYTLDPETGAKVNFGFDPYFPRIDLRWALRGVSGAERRRRLRDLVGE AVPRVRLRLYETDTDGVTRYLRAVPLPGMGIVHDMALTRRYAIFVVSPMRINPWALTGHASFWDSMRFLT DTPTYFLLAPRSGGPVRTVETDAFYHWHFTNAYDDGDDVVVELPRFAPHTYEGVKNYTAHVRSGSAQVGG ADPSDAVVLTRFRIGSSGRVTREPLADFGCEFPQIDPRRSTRRHDYSYVAVQDPVRFQGQGIARIDHRSG AGQVFCPPGNVLVEPTFVPRPGGDAEDDGWVITVGYQESHHRSRLMVFDAAGIADGPVAEAWLPFHVPMS YHGTFTSRVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3359 | - | - | 100% (502) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_0203 | - | 6e-98 | 41.01% (495) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_4940 | - | 1e-32 | 27.92% (530) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0937c | - | 3e-32 | 25.64% (507) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1807 | - | 7e-35 | 27.88% (513) | carotenoid oxygenase |
| M. tuberculosis H37Rv | Rv0913c | - | 7e-32 | 25.64% (507) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 3e-27 | 25.95% (551) | putative dioxygenase |
| M. marinum M | MMAR_4614 | - | 3e-35 | 27.22% (485) | dioxygenase |
| M. avium 104 | MAV_3153 | - | 0.0 | 75.25% (501) | retinal pigment epithelial membrane protein |
| M. smegmatis MC2 155 | MSMEG_1564 | - | 4e-81 | 36.29% (496) | lignostilbene-alpha,beta-dioxygenase |
| M. thermoresistible (build 8) | TH_3525 | - | 1e-96 | 41.12% (501) | PUTATIVE lignostilbene-alpha,beta-dioxygenase |
| M. ulcerans Agy99 | MUL_0155 | - | 4e-35 | 27.22% (485) | dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4614|M.marinum_M ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
MUL_0155|M.ulcerans_Agy99 ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
Mb0937c|M.bovis_AF2122/97 ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
Rv0913c|M.tuberculosis_H37Rv ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
Mflv_1807|M.gilvum_PYR-GCK MTAGTHPEVVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLRVVEGQIP
Mvan_3359|M.vanbaalenii_PYR-1 -----------------------MVAGTRYWDDIDGEFDIPVEEITGTLP
MAV_3153|M.avium_104 -----------------------MQAPSRYWENIVGETDLDVTDITGTLP
MSMEG_1564|M.smegmatis_MC2_155 ------MHRSPPRLAPSDVTEGTFSPYSPYNTSLYEEYDYTIDDVEGALP
TH_3525|M.thermoresistible__bu --------MSP---EPVGSRQQDFSGFTP----LHEEYDYLLDEVAGAVP
MAB_3874c|M.abscessus_ATCC_199 ------------MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTGTLP
: * :*
MMAR_4614|M.marinum_M HDLDGVYLRNTENPLHP-AFKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
MUL_0155|M.ulcerans_Agy99 HDLDGVYLRNTENPLHP-AFKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
Mb0937c|M.bovis_AF2122/97 ADLDGIYLRNTENPLHP-AFATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
Rv0913c|M.tuberculosis_H37Rv ADLDGIYLRNTENPLHP-AFATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
Mflv_1807|M.gilvum_PYR-GCK GDLDGVYLRNTENPLHP-ALKYYHPFDGDGMLHMVGFRDG-KAFYRNRFV
Mvan_3359|M.vanbaalenii_PYR-1 EGLTGTLYRNGSGRWNIGSSPVESIYDADGMVSAFVLNGA-GVRFRNRFV
MAV_3153|M.avium_104 DGLVGTLYRNGSGRWTVGSTQVESIFDADGMVSAFVLDGS-GVRFRNRFV
MSMEG_1564|M.smegmatis_MC2_155 DGLRGTLYRNGPGKLDAGGQQLGHLFDGDGMLSMFVMSDG-TVRFRNRYV
TH_3525|M.thermoresistible__bu EQLRGTVYRNGPGRLEAGGQPLGHLFDGDGMLSMFRFADG-RVRFRNRYV
MAB_3874c|M.abscessus_ATCC_199 AHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWYRNRWV
* * ** . :..*.*: . : . :***::
MMAR_4614|M.marinum_M QTDGFQAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVHR
MUL_0155|M.ulcerans_Agy99 QTDGFRAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVYR
Mb0937c|M.bovis_AF2122/97 RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
Rv0913c|M.tuberculosis_H37Rv RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
Mflv_1807|M.gilvum_PYR-GCK RTDALAAENEAGGPLWPGIAEPIELAKRDYGWGARTLMKDASSTDVIVHR
Mvan_3359|M.vanbaalenii_PYR-1 RTRHFVQSTRAGRPIGRGFSAQRPGGIRAN---ALRLPVNTANTSVMMNN
MAV_3153|M.avium_104 RTRHYLRSTAAGRLVDRGFAYQRPGGPRAN---ALRLPANTANTSVMVNR
MSMEG_1564|M.smegmatis_MC2_155 RTKHYEKSLASKGAPYRALGTMRPGGILAN---ALRLPANVANTGVVMHA
TH_3525|M.thermoresistible__bu RTRHYRRSRHTRGAPFRGLGTMRPGGVLAN---ALRFPVNVANTAVIMHA
MAB_3874c|M.abscessus_ATCC_199 RTPSVSKT----------LGETRPAAISAN----AGMGVIGPNTNVLGHA
:* :. . : ..* *:
MMAR_4614|M.marinum_M GIALTSFYQCGDLYRVDPSSATTLGKENWSGNFP-FDWGVSAHPKVDGKT
MUL_0155|M.ulcerans_Agy99 GIALTSFYQCGDLYRVDPSSATTLGKETWSGHFP-FDWGVSAHPKVDGKT
Mb0937c|M.bovis_AF2122/97 GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKT
Rv0913c|M.tuberculosis_H37Rv GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKT
Mflv_1807|M.gilvum_PYR-GCK GVALTSHYQCGDLYRIDPCTGADLGKEDWNGGFP-TDWGVSAHPKVDDRT
Mvan_3359|M.vanbaalenii_PYR-1 -DRLLALWEGGRPHELDPDSLDTYGMSDLGGALRGPVGAYSAHYTLDPET
MAV_3153|M.avium_104 -NQLLALWEGGPPHELDLDTLDTIGPCNLGGALRGPVRAYSAHYRYDPMT
MSMEG_1564|M.smegmatis_MC2_155 -GKLLALWEGGRPTRIHPDTLDTLGAHDFDGGLK-WLGAFSAHPKWDFAT
TH_3525|M.thermoresistible__bu -GTLLALWEAGRPTEIDPDSLDTVGEYDYDGELR-WLGAFSAHPKWDPDT
MAB_3874c|M.abscessus_ATCC_199 -GRTLALVEGGIANYELTEDLDTIGTCDFDGTLP---GGYTAHPHTDPDT
: : * * * : . :** * *
MMAR_4614|M.marinum_M GELLFFNYS-------------------------------KQEPYMRYGV
MUL_0155|M.ulcerans_Agy99 GELLFFNYS-------------------------------KQEPYMRYGV
Mb0937c|M.bovis_AF2122/97 GELLFFNYS-------------------------------KQEPYMRYGV
Rv0913c|M.tuberculosis_H37Rv GELLFFNYS-------------------------------KQEPYMRYGV
Mflv_1807|M.gilvum_PYR-GCK GELLFFNYS-------------------------------KQAPFMRYGV
Mvan_3359|M.vanbaalenii_PYR-1 GAKVNFGFDPYFPRIDLRWALRGVSGAERRRRLRDLVGEAVPRVRLRLYE
MAV_3153|M.avium_104 NTKVNFGFDPYVPRIDPGHALR---GPRRLRRLRELAAEAVPRVRLRLYE
MSMEG_1564|M.smegmatis_MC2_155 GDMFNFGLA------------------------------MFPTPKLICYR
TH_3525|M.thermoresistible__bu GEMFNFGLA------------------------------LAPIPKLVCYR
MAB_3874c|M.abscessus_ATCC_199 GEMHAVSYS------------------------------FARGSTVQYSV
. .. :
MMAR_4614|M.marinum_M VDQDNELAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDP--------
MUL_0155|M.ulcerans_Agy99 VDQDNELAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDP--------
Mb0937c|M.bovis_AF2122/97 VDQNNELVHYVDVPLPGPRLLHDMAFTENYVILNDFPLFWDP--------
Rv0913c|M.tuberculosis_H37Rv VDQNNELVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDP--------
Mflv_1807|M.gilvum_PYR-GCK VSPAGDVVHNVDVPLPGPRLPHDMAFTENYVILNDFPLFWDT--------
Mvan_3359|M.vanbaalenii_PYR-1 TDTDGVTRYLRAVPLPGMGIVHDMALTRRYAIFVVSPMRINP--------
MAV_3153|M.avium_104 TGADGVTRYLRAVPLPGMGVVHDMALTTRYAVFVLSPLRINP--------
MSMEG_1564|M.smegmatis_MC2_155 VDRTGRLHRLGHVPLPRPMFNHDVGLTHHHMVFVIPPLVFPLRRS-----
TH_3525|M.thermoresistible__bu VDPTGRLTTLGAVRLSAPMFNHDVGLTKRHMVFVVPPLVFRPSKL-----
MAB_3874c|M.abscessus_ATCC_199 IDAHGRARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVP
. . : : . **. :* .: :: *:
MMAR_4614|M.marinum_M --------------------------------QLLEHNLHLPRFYPDMPS
MUL_0155|M.ulcerans_Agy99 --------------------------------QLLEHNLHLPRFYPDMPS
Mb0937c|M.bovis_AF2122/97 --------------------------------RLLERDVHLPRFYPEIPS
Rv0913c|M.tuberculosis_H37Rv --------------------------------RLLERDVHLPRFYPEIPS
Mflv_1807|M.gilvum_PYR-GCK --------------------------------GLLEHNIHLPRFHRDVPS
Mvan_3359|M.vanbaalenii_PYR-1 -----------------------------WALTGHASFWDSMRFLTDTPT
MAV_3153|M.avium_104 -----------------------------WALTGRQSYWESIRFKPDAPS
MSMEG_1564|M.smegmatis_MC2_155 ----------------------------LEAGIGVRNFIDAIDFDATRGT
TH_3525|M.thermoresistible__bu ----------------------------AGAALGLHDYIDALEYDAERPT
MAB_3874c|M.abscessus_ATCC_199 VPRLLRKPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPA
: :
MMAR_4614|M.marinum_M RFAVIPRRGSTA----DIRWFEADPTFVLHFTNAYEEGDE----IVLDG-
MUL_0155|M.ulcerans_Agy99 RFAVIPRRGSTA----DIRWFEADPTFVLHFTNAYEEGDE----IVLDG-
Mb0937c|M.bovis_AF2122/97 RFAVVARRGN------DIRWFEADPTFVLHFTNAYEQGDE----IVLDG-
Rv0913c|M.tuberculosis_H37Rv RFAVVARRGN------DIRWFEADPTFVLHFTNAYEQGDE----IVLDG-
Mflv_1807|M.gilvum_PYR-GCK RFAVLPRRGDTS----QIMWFEADPTYVLHFPNAFEDGDE----IVLDG-
Mvan_3359|M.vanbaalenii_PYR-1 YFLLAPRSGG------PVRTVETDAFYHWHFTNAYDDGDD----VVVELP
MAV_3153|M.avium_104 YFVLAPRDGG------AVRVVETDPFYHWHFTNAYDDGDD----VVVELP
MSMEG_1564|M.smegmatis_MC2_155 MIALVPRDGG------RSRILHTDPSLHLHLSNAYEDGED----TVVELV
TH_3525|M.thermoresistible__bu MIALVPRDGG------RVRIVHTEPLMHLHIANAYDDGAD----TVVELL
MAB_3874c|M.abscessus_ATCC_199 RIGVMPREGDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLV
: : .* *. .. :. * *.:.: : *::
MMAR_4614|M.marinum_M FFEGAPHPLE--TSASSTKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKE
MUL_0155|M.ulcerans_Agy99 FFEGAPHPLE--TSASSTKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKE
Mb0937c|M.bovis_AF2122/97 FYEGDPQPLD--TGG--TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHE
Rv0913c|M.tuberculosis_H37Rv FYEGDPQPLD--TGG--TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHE
Mflv_1807|M.gilvum_PYR-GCK FFQGDPEPTQGVDNGMSRKWQQIFRSLSLDGMQTRLHRWRFNLKTGAVRE
Mvan_3359|M.vanbaalenii_PYR-1 RFAPHTYEGVKNYTAHVRSGSAQVGG-ADPSDAVVLTRFRIGSS-GRVTR
MAV_3153|M.avium_104 RFAPQTYAGMKNYTAHIRSDIAQVDDYGAIEDAVVLTRFRIAAS-GRVTR
MSMEG_1564|M.smegmatis_MC2_155 DYH----SSWQELNGQLSLVPTLAQT-ATMPYGGQLTRLRITPS-GHVSR
TH_3525|M.thermoresistible__bu NYD----ASWTQLNAQLLTVDGTVPD-TTMPYGGVLRRIRITRS-GRVIH
MAB_3874c|M.abscessus_ATCC_199 RYDS----------------MFSQDVLGPSDAKGQLDRWTIDLAKGTVHM
: * * : * *
MMAR_4614|M.marinum_M ERLSESITEFGTINSDYAARQYRYAYAATGK----PGWFLFDGLVKHDLL
MUL_0155|M.ulcerans_Agy99 ERLSESITEFGTINSDYAARQYRYAYAATGK----PGWFLFDGLVKHDLL
Mb0937c|M.bovis_AF2122/97 EQLSESITEFGTINADYAASSYRYTYAATGK----PSWFLFDGLVKHDLL
Rv0913c|M.tuberculosis_H37Rv EQLSESITEFGTINADYAASSYRYTYAATGK----PSWFLFDGLVKHDLL
Mflv_1807|M.gilvum_PYR-GCK EHLSDSFTEFGMINPGFSGRPHRYTYAETGK----PGWFLFDGLVKHDLH
Mvan_3359|M.vanbaalenii_PYR-1 EPLADFGCEFPQIDPRRSTRRHDYSYVAVQD----PVRFQGQGIARIDHR
MAV_3153|M.avium_104 EPLADFGCEFPQIDPRRGTMRHHVSYLTVQD----PAKFPGQGIARVDHR
MSMEG_1564|M.smegmatis_MC2_155 EPITDLYGEFPMLNVKTMASQNRYTYLSAAL----GGNIYPNAVAKIDNT
TH_3525|M.thermoresistible__bu EPLTDLRGDFPMLNPRVSGRRHRYTYLVVGV----EGSTYPNAVAKLDHH
MAB_3874c|M.abscessus_ATCC_199 ERKDDRHLEFPRINETFTGKKHRYGYLPDVENFFGSGEAAGASIVKYDYE
* : :* :: * .:.: *
MMAR_4614|M.marinum_M TGNQEGISFGEGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLV
MUL_0155|M.ulcerans_Agy99 TGNQEGISFGEGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLV
Mb0937c|M.bovis_AF2122/97 TGNHECYSFGDGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLV
Rv0913c|M.tuberculosis_H37Rv TGNHECYSFGDGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLV
Mflv_1807|M.gilvum_PYR-GCK TGTEQRFTFDDGVFGSETAMAPRVGGTDEDDGYLVTLTTDMNTDASYCLV
Mvan_3359|M.vanbaalenii_PYR-1 SGAGQVF-CPPGNVLVEPTFVPRPGGDAEDDGWVITVGYQESHHRSRLMV
MAV_3153|M.avium_104 TGEAQTY-CPPGHVLVEPIFVPRPGGTAEDDGWLLTVGYDESRHRSRLMV
MSMEG_1564|M.smegmatis_MC2_155 TGKETVYRLPDGHLPHEAIFAAHPDGVDEDDGWLLVPVIDGVENIASLII
TH_3525|M.thermoresistible__bu TGASTLHRLPPGHLAHEPVFIPRPGGAAEDDGWLAVVVQDCHRHRAHLRL
MAB_3874c|M.abscessus_ATCC_199 TGSTLSSRLDPAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLL
:* . * : .. **** : : . . :
MMAR_4614|M.marinum_M FDAARIADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
MUL_0155|M.ulcerans_Agy99 FDAARIADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
Mb0937c|M.bovis_AF2122/97 FDAARPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Rv0913c|M.tuberculosis_H37Rv FDAARPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Mflv_1807|M.gilvum_PYR-GCK FDAARVGDGPVCKLQLPERISSGTHSTWAAGCDLPRWRDSESAAGAIGL
Mvan_3359|M.vanbaalenii_PYR-1 FDAAGIADGPVAEAWLPFHVPMSYHGTFTSRVAR---------------
MAV_3153|M.avium_104 VDAAHVADGPVAEAWLQFHVPMSYHGTFTTRVAQRTG------------
MSMEG_1564|M.smegmatis_MC2_155 LDAKDIEAGPVYQGRLRHHLPLTFHGCYTPRVAAPA-------------
TH_3525|M.thermoresistible__bu LDAGAVSADPVFTGHLRHSMPLTFHGCFTPRVGRSG-------------
MAB_3874c|M.abscessus_ATCC_199 LDATSLD--LMATVHLPQRVPAGFHGNWAPR------------------
.** : * :. *. :..