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TAGTHPEVVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLRVVEGQIPGDLDGVYLRNTENPLHPALKY YHPFDGDGMLHMVGFRDGKAFYRNRFVRTDALAAENEAGGPLWPGIAEPIELAKRDYGWGARTLMKDASS TDVIVHRGVALTSHYQCGDLYRIDPCTGADLGKEDWNGGFPTDWGVSAHPKVDDRTGELLFFNYSKQAPF MRYGVVSPAGDVVHNVDVPLPGPRLPHDMAFTENYVILNDFPLFWDTGLLEHNIHLPRFHRDVPSRFAVL PRRGDTSQIMWFEADPTYVLHFPNAFEDGDEIVLDGFFQGDPEPTQGVDNGMSRKWQQIFRSLSLDGMQT RLHRWRFNLKTGAVREEHLSDSFTEFGMINPGFSGRPHRYTYAETGKPGWFLFDGLVKHDLHTGTEQRFT FDDGVFGSETAMAPRVGGTDEDDGYLVTLTTDMNTDASYCLVFDAARVGDGPVCKLQLPERISSGTHSTW AAGCDLPRWRDSESAAGAIGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1807 | - | - | 100% (512) | carotenoid oxygenase |
| M. gilvum PYR-GCK | Mflv_1332 | - | 9e-48 | 30.95% (475) | carotenoid oxygenase |
| M. gilvum PYR-GCK | Mflv_2111 | - | 1e-46 | 31.71% (514) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0937c | - | 0.0 | 73.61% (504) | dioxygenase |
| M. tuberculosis H37Rv | Rv0913c | - | 0.0 | 73.81% (504) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 6e-49 | 28.79% (535) | putative dioxygenase |
| M. marinum M | MMAR_4614 | - | 0.0 | 75.45% (505) | dioxygenase |
| M. avium 104 | MAV_4505 | - | 2e-45 | 31.25% (528) | Sim14 protein |
| M. smegmatis MC2 155 | MSMEG_5609 | - | 0.0 | 79.33% (508) | carotenoid oxygenase |
| M. thermoresistible (build 8) | TH_3959 | - | 1e-49 | 31.26% (515) | PUTATIVE Carotenoid oxygenase |
| M. ulcerans Agy99 | MUL_0155 | - | 0.0 | 75.25% (505) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4940 | - | 0.0 | 84.73% (537) | carotenoid oxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0937c|M.bovis_AF2122/97 ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
Rv0913c|M.tuberculosis_H37Rv ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
MMAR_4614|M.marinum_M ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
MUL_0155|M.ulcerans_Agy99 ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
Mflv_1807|M.gilvum_PYR-GCK MTAGTHPEVVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLRVVEGQIP
Mvan_4940|M.vanbaalenii_PYR-1 MSLHSHPEIVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLKVVEGRIP
MSMEG_5609|M.smegmatis_MC2_155 ----MHTEVVAKYLSTLPEDDTHPYRTGAWRPQTTEWDADDLTVVEGEIP
MAB_3874c|M.abscessus_ATCC_199 -----------MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTG-TLP
MAV_4505|M.avium_104 -----------MTTTRTVAN---PYLDGFLAPVRAEVTAFDLPVTG-RIP
TH_3959|M.thermoresistible__bu -----------------VSN---RYLTGAFAPLTEEYTLTDLEVTG-TIP
* * * * ** .. :*
Mb0937c|M.bovis_AF2122/97 ADLDGIYLRNTENPLHP-AFATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
Rv0913c|M.tuberculosis_H37Rv ADLDGIYLRNTENPLHP-AFATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
MMAR_4614|M.marinum_M HDLDGVYLRNTENPLHP-AFKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
MUL_0155|M.ulcerans_Agy99 HDLDGVYLRNTENPLHP-AFKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
Mflv_1807|M.gilvum_PYR-GCK GDLDGVYLRNTENPLHP-ALKYYHPFDGDGMLHMVGFRDG-KAFYRNRFV
Mvan_4940|M.vanbaalenii_PYR-1 DDLDGVYLRNTENPLHP-ALKYYHPFDGDGMLHIVGFRDG-KAFYRNRFV
MSMEG_5609|M.smegmatis_MC2_155 ADLDGVYLRNTENPMHP-AFKVYHPFDGDGMLHVVGFRDG-KAFYRNRFV
MAB_3874c|M.abscessus_ATCC_199 AHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWYRNRWV
MAV_4505|M.avium_104 DHLDGRYLRNGPNPVAEVDPATYHWFSGDGMVHGVALRDGRARWYRNRWV
TH_3959|M.thermoresistible__bu DYLDGRYLRNGPNPVGEIDPELYHWFVGDGMVHGIRLRDGRAEWYRNRWV
*** **** ** ** * **.*:* : :*:* :****::
Mb0937c|M.bovis_AF2122/97 RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
Rv0913c|M.tuberculosis_H37Rv RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
MMAR_4614|M.marinum_M QTDGFQAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVHR
MUL_0155|M.ulcerans_Agy99 QTDGFRAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVYR
Mflv_1807|M.gilvum_PYR-GCK RTDALAAENEAGGPLWPGIAEPIELAKRDYGWGARTLMKDASSTDVIVHR
Mvan_4940|M.vanbaalenii_PYR-1 RTDAFAEENEAGGPLWPGIAEPLELARRDYGWGARTLMKDASSTDVVVHR
MSMEG_5609|M.smegmatis_MC2_155 RTDGLLEENAEGGPLWPGIAEPVELAKRDYGWGARTLMKDASSTDVTVHR
MAB_3874c|M.abscessus_ATCC_199 RTPSVSKTLGETRPAAISANAGMGVIG--------------PNTNVLGHA
MAV_4505|M.avium_104 RTAHVCAALGEPAPGGLDPRAGMLSVG--------------PNTNVLSHA
TH_3959|M.thermoresistible__bu RGPLTARALGERPP---SEECSVSGIG--------------ANTNVIGHA
: * . : ..*:* :
Mb0937c|M.bovis_AF2122/97 GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTG
Rv0913c|M.tuberculosis_H37Rv GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTG
MMAR_4614|M.marinum_M GIALTSFYQCGDLYRVDPSSATTLGKENWSGNFPFDWGVSAHPKVDGKTG
MUL_0155|M.ulcerans_Agy99 GIALTSFYQCGDLYRVDPSSATTLGKETWSGHFPFDWGVSAHPKVDGKTG
Mflv_1807|M.gilvum_PYR-GCK GVALTSHYQCGDLYRIDPCTGADLGKEDWNGGFPTDWGVSAHPKVDDRTG
Mvan_4940|M.vanbaalenii_PYR-1 GVALTSHYQCGDLYRIDPRTGAALGKEDWHGTFPSDWGVSAHPKIDDHTG
MSMEG_5609|M.smegmatis_MC2_155 GVALTSFYQCGDLYRINPHTGDTLGKENWNGGFPVDWGVSAHPKNDDRTG
MAB_3874c|M.abscessus_ATCC_199 GRTLALVEGGIANYELT-EDLDTIGTCDFDGTLPG--GYTAHPHTDPDTG
MAV_4505|M.avium_104 GQTLALVEGGGANYRLT-EDLDTVGTCDFDGTLFG--GYTAHPHRDPRTG
TH_3959|M.thermoresistible__bu GKTIALVESGVTNYELT-EELDTVGPCDFDGTLTG--GYTAHPKRDPETG
* ::: *.: :* : * : * :***: * **
Mb0937c|M.bovis_AF2122/97 ELLFFNYSK-QEPYMRYGVVDQNNELVHYVDVPLPGPRLLHDMAFTENYV
Rv0913c|M.tuberculosis_H37Rv ELLFFNYSK-QEPYMRYGVVDQNNELVHYVDVPLPGPRLPHDMAFTENYV
MMAR_4614|M.marinum_M ELLFFNYSK-QEPYMRYGVVDQDNELAHYVDIPLPGPRLPHDMAFTENYA
MUL_0155|M.ulcerans_Agy99 ELLFFNYSK-QEPYMRYGVVDQDNELAHYVDIPLPGPRLPHDMAFTENYA
Mflv_1807|M.gilvum_PYR-GCK ELLFFNYSK-QAPFMRYGVVSPAGDVVHNVDVPLPGPRLPHDMAFTENYV
Mvan_4940|M.vanbaalenii_PYR-1 ELLFFNYSK-QAPYMRYGVVSPAGEVVHNVDVPLPGPRLPHDMAFTENYV
MSMEG_5609|M.smegmatis_MC2_155 ELLFFNYGK-QAPYMHFGVVDQNNNLVHYTDVELPGPRLPHDMAFTENYV
MAB_3874c|M.abscessus_ATCC_199 EMHAVSYSFARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYV
MAV_4505|M.avium_104 ELHAVSYSFGRGRRVQYSVIDTAGRARRTVDIEVSGSPMMHDFSLTDEYV
TH_3959|M.thermoresistible__bu ELHAVSYSMYRGNTVQYSVIGTDGRARRTVDIEVTGSPMMHDFSLTERHI
*: ..*. : :::.*:. . : .*: : *. : **:::*:.:
Mb0937c|M.bovis_AF2122/97 ILNDFPLFWDPRLLERDVHLPR----------------------------
Rv0913c|M.tuberculosis_H37Rv ILNDFPLFWDPRLLERDVHLPR----------------------------
MMAR_4614|M.marinum_M ILNDFPLFWDPQLLEHNLHLPR----------------------------
MUL_0155|M.ulcerans_Agy99 ILNDFPLFWDPQLLEHNLHLPR----------------------------
Mflv_1807|M.gilvum_PYR-GCK ILNDFPLFWDTGLLEHNIHLPR----------------------------
Mvan_4940|M.vanbaalenii_PYR-1 ILNDFPLFWDTGLLEHNIHFPR----------------------------
MSMEG_5609|M.smegmatis_MC2_155 ILNDFPMFWDAEFLKHNAHIPR----------------------------
MAB_3874c|M.abscessus_ATCC_199 VFYDLPVTLDMSMISQSVPVPRLLRKPAQIVMNSLIGKVKIPGPIAAKAS
MAV_4505|M.avium_104 VIYDLPVTFDPVQVMP-ADVPRWLSAPARLVVQSLLGRVQLPGPMATAMN
TH_3959|M.thermoresistible__bu VLYDLPVTFDARQAVS-MTVPRGLRLPARLVLSALIGRVRVPDPIAARQP
:: *:*: * .**
Mb0937c|M.bovis_AF2122/97 ------------FYPEIPSRFAVVARRGN------DIRWFEADPTFVLHF
Rv0913c|M.tuberculosis_H37Rv ------------FYPEIPSRFAVVARRGN------DIRWFEADPTFVLHF
MMAR_4614|M.marinum_M ------------FYPDMPSRFAVIPRRGST----ADIRWFEADPTFVLHF
MUL_0155|M.ulcerans_Agy99 ------------FYPDMPSRFAVIPRRGST----ADIRWFEADPTFVLHF
Mflv_1807|M.gilvum_PYR-GCK ------------FHRDVPSRFAVLPRRGDT----SQIMWFEADPTYVLHF
Mvan_4940|M.vanbaalenii_PYR-1 ------------FHRDMPSRFAVVPRRGDT----SQIKWFETAPTYVLHF
MSMEG_5609|M.smegmatis_MC2_155 ------------LHRDLPSRFAVVPRRG------GDIKWFEADTTYVLHF
MAB_3874c|M.abscessus_ATCC_199 QYSGKSPSIPYSWNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFHP
MAV_4505|M.avium_104 RNRQPLHRMPYRWNDAYPARLGVMPRDGGNDE----VRWFDIEPCYVYHP
TH_3959|M.thermoresistible__bu RGNSSDRRFPYSWNPRYPARIGVMPRDGSNKD----VRWFDVEPCYVFHP
*:*:.*:.* * : **: . :* *
Mb0937c|M.bovis_AF2122/97 TNAYE----QGDEIVLDGFYEGDPQPLDT---GG--TKWEKLFRFLALDR
Rv0913c|M.tuberculosis_H37Rv TNAYE----QGDEIVLDGFYEGDPQPLDT---GG--TKWEKLFRFLALDR
MMAR_4614|M.marinum_M TNAYE----EGDEIVLDGFFEGAPHPLET---SASSTKWEKLFRFLALDR
MUL_0155|M.ulcerans_Agy99 TNAYE----EGDEIVLDGFFEGAPHPLET---SASSTKWEKLFRFLALDR
Mflv_1807|M.gilvum_PYR-GCK PNAFE----DGDEIVLDGFFQGDPEPTQG-VDNGMSRKWQQIFRSLSLDG
Mvan_4940|M.vanbaalenii_PYR-1 PNAYE----DGDEIVLDGFFQGDPEPTDG-VDNGMSGKWRQIFRSLSLDG
MSMEG_5609|M.smegmatis_MC2_155 TNAFE----DGDEIVMDGFFQGSPEPDDDPADNGMSRKWQRFFRYLSLDG
MAB_3874c|M.abscessus_ATCC_199 LNGYSEMRNGAEVIVIDLVRYDSMFSQDV----------------LGPSD
MAV_4505|M.avium_104 LNAYSEIRDGAKVLVLDVVRYSRMFDRDL----------------RGPGD
TH_3959|M.thermoresistible__bu MNAY----DDGDTIVLDVIRHPKMFDTDN----------------LGPNE
*.: .. :*:* . : . .
Mb0937c|M.bovis_AF2122/97 LQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAAT--
Rv0913c|M.tuberculosis_H37Rv LQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAAT--
MMAR_4614|M.marinum_M LQTRLHRWRLNLVTGAVKEERLSESITEFGTINSDYAARQYRYAYAAT--
MUL_0155|M.ulcerans_Agy99 LQTRLHRWRLNLVTGAVKEERLSESITEFGTINSDYAARQYRYAYAAT--
Mflv_1807|M.gilvum_PYR-GCK MQTRLHRWRFNLKTGAVREEHLSDSFTEFGMINPGFSGRPHRYTYAET--
Mvan_4940|M.vanbaalenii_PYR-1 MQTRLHRWRFNLVTGEAREEQLSDSITEFGMINPAYSGRPYRYTYAAT--
MSMEG_5609|M.smegmatis_MC2_155 MQTRLHRWRFNLVTGETREEQLSDSLTEFGMINPDFATQDYRYIYAAT--
MAB_3874c|M.abscessus_ATCC_199 AKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGYLPDVE
MAV_4505|M.avium_104 TRPTLDRWTVNLATGAVGSELRDDRPQEFPRINEALLGRRHRFGYTVGTD
TH_3959|M.thermoresistible__bu GPPTLDRWTVDLADGKVRESRIDDRGQEFPRVDERLVGRRHRYGYAP---
*.** .:: * . . .: ** :: :*: *
Mb0937c|M.bovis_AF2122/97 ----GKPSWFLFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVG----
Rv0913c|M.tuberculosis_H37Rv ----GKPSWFLFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVG----
MMAR_4614|M.marinum_M ----GKPGWFLFDGLVKHDLLTGNQEGISFGEGVYGSETQMAPRVG----
MUL_0155|M.ulcerans_Agy99 ----GKPGWFLFDGLVKHDLLTGNQEGISFGEGVYGSETQMAPRVG----
Mflv_1807|M.gilvum_PYR-GCK ----GKPGWFLFDGLVKHDLHTGTEQRFTFDDGVFGSETAMAPRVG----
Mvan_4940|M.vanbaalenii_PYR-1 ----GKPGWFLFDGLVRHDLHTGTEQRYGFGDGVYGSETAMAPRVGSAAA
MSMEG_5609|M.smegmatis_MC2_155 ----GKPGWFLFDGLVRHDLRTGSEERYTFADGVYGSETAMAPRVG----
MAB_3874c|M.abscessus_ATCC_199 N-FFGSGEAAGAS-IVKYDYETGSTLSSRLDPAIVLGEMSFVPNPT----
MAV_4505|M.avium_104 GGYLSDGASEMSTGLYKHDYATGSRRVAPLDPDLLIGEMCFVPNPAG---
TH_3959|M.thermoresistible__bu --TVGEG-TSGGNVLLKHDFVGGNTQSRVFEPYHELGEFVFQPSSA----
.. : ::* *. : .* : *
Mb0937c|M.bovis_AF2122/97 ---------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAA
Rv0913c|M.tuberculosis_H37Rv ---------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAA
MMAR_4614|M.marinum_M ---------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAA
MUL_0155|M.ulcerans_Agy99 ---------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAA
Mflv_1807|M.gilvum_PYR-GCK ---------------------GTDEDDGYLVTLTTDMNTDASYCLVFDAA
Mvan_4940|M.vanbaalenii_PYR-1 DHIGGSAAAHIGGSAAAHIGGSAAEDDGYLVTLTTDMAADASYCLVFDAA
MSMEG_5609|M.smegmatis_MC2_155 ---------------------GSGEDDGYLVTLISDMNDDASYCLVFDAA
MAB_3874c|M.abscessus_ATCC_199 ---------------------CAAEDDGVLIGFAVDRRSDEGQLLLLDAT
MAV_4505|M.avium_104 -------------------GQDGTEDDGILMGFGYHRGRDENQLVLLDAQ
TH_3959|M.thermoresistible__bu ---------------------DAAEDDGVVMGYVYDRTTDRSELAILDAQ
**** :: . * . ::**
Mb0937c|M.bovis_AF2122/97 RPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Rv0913c|M.tuberculosis_H37Rv RPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
MMAR_4614|M.marinum_M RIADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
MUL_0155|M.ulcerans_Agy99 RIADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
Mflv_1807|M.gilvum_PYR-GCK RVGDGPVCKLQLPERISSGTHSTWAAGCDLPRWRDSESAAGAIGL
Mvan_4940|M.vanbaalenii_PYR-1 RVGDGPVCKLQLPERISSGTHSTWAPGADLPQWRESDSAAGAIGL
MSMEG_5609|M.smegmatis_MC2_155 RVGDGPVCKLALPERISSGTHSTWVSGAELRRWHTSDDAAAAIGM
MAB_3874c|M.abscessus_ATCC_199 SLDL--MATVHLPQRVPAGFHGNWAPR------------------
MAV_4505|M.avium_104 SLEQ--VAAVHLPQRVPMGFHGNWVPAG-----------------
TH_3959|M.thermoresistible__bu TLED--VARIRLPHRVPAGFHGNWVPSDG----------------
:. : **.*:. * *. *..