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HRSPPRLAPSDVTEGTFSPYSPYNTSLYEEYDYTIDDVEGALPDGLRGTLYRNGPGKLDAGGQQLGHLFD GDGMLSMFVMSDGTVRFRNRYVRTKHYEKSLASKGAPYRALGTMRPGGILANALRLPANVANTGVVMHAG KLLALWEGGRPTRIHPDTLDTLGAHDFDGGLKWLGAFSAHPKWDFATGDMFNFGLAMFPTPKLICYRVDR TGRLHRLGHVPLPRPMFNHDVGLTHHHMVFVIPPLVFPLRRSLEAGIGVRNFIDAIDFDATRGTMIALVP RDGGRSRILHTDPSLHLHLSNAYEDGEDTVVELVDYHSSWQELNGQLSLVPTLAQTATMPYGGQLTRLRI TPSGHVSREPITDLYGEFPMLNVKTMASQNRYTYLSAALGGNIYPNAVAKIDNTTGKETVYRLPDGHLPH EAIFAAHPDGVDEDDGWLLVPVIDGVENIASLIILDAKDIEAGPVYQGRLRHHLPLTFHGCYTPRVAAPA *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1564 | - | - | 100% (491) | lignostilbene-alpha,beta-dioxygenase |
| M. smegmatis MC2 155 | MSMEG_6224 | - | 3e-43 | 33.41% (452) | retinal pigment epithelial membrane protein |
| M. smegmatis MC2 155 | MSMEG_5609 | - | 5e-34 | 28.57% (476) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0937c | - | 2e-33 | 27.73% (476) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1332 | - | 6e-41 | 32.71% (480) | carotenoid oxygenase |
| M. tuberculosis H37Rv | Rv0913c | - | 1e-33 | 27.73% (476) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 2e-34 | 29.09% (519) | putative dioxygenase |
| M. marinum M | MMAR_4614 | - | 2e-32 | 26.64% (488) | dioxygenase |
| M. avium 104 | MAV_3153 | - | 1e-84 | 37.00% (500) | retinal pigment epithelial membrane protein |
| M. thermoresistible (build 8) | TH_3525 | - | 0.0 | 64.07% (462) | PUTATIVE lignostilbene-alpha,beta-dioxygenase |
| M. ulcerans Agy99 | MUL_0155 | - | 3e-31 | 26.43% (488) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_0203 | - | 7e-94 | 40.00% (460) | carotenoid oxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1564|M.smegmatis_MC2_155 --MHRSPPRLAPSDVTEGTFSPYSPYNTSLYEEYDYTIDDVEGALPDGLR
TH_3525|M.thermoresistible__bu ----MSP---EPVGSRQQDFSGFTP----LHEEYDYLLDEVAGAVPEQLR
MAV_3153|M.avium_104 --------MQAPSRYWEN-----------IVGETDLDVTDITGTLPDGLV
Mvan_0203|M.vanbaalenii_PYR-1 ----MGPDDLSSLGVSEP-----------QPAEHDYRVEQIDGTIPAGLR
Mflv_1332|M.gilvum_PYR-GCK --MTETAPDQTESARSIFEVGNYAP----VPDELTTFDLPVEGTIPAELD
MAB_3874c|M.abscessus_ATCC_199 --MTATA--QPAASTSPYLSGIWEP----VQQEMDSVDLEVTGTLPAHLD
Mb0937c|M.bovis_AF2122/97 MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLD
Rv0913c|M.tuberculosis_H37Rv MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLD
MMAR_4614|M.marinum_M MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIPHDLD
MUL_0155|M.ulcerans_Agy99 MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIPHDLD
: * :* *
MSMEG_1564|M.smegmatis_MC2_155 GTLYRNGPGKLDAG-GQQLGHLFDGDGMLSMFVMSDG-TVRFRNRYVRTK
TH_3525|M.thermoresistible__bu GTVYRNGPGRLEAG-GQPLGHLFDGDGMLSMFRFADG-RVRFRNRYVRTR
MAV_3153|M.avium_104 GTLYRNGSGRWTVG-STQVESIFDADGMVSAFVLDGS-GVRFRNRFVRTR
Mvan_0203|M.vanbaalenii_PYR-1 GTLYRNGPGRWEDHKGRPLRHLFDGDGMLSAFTIDAA-GVHYRNRYVRTR
Mflv_1332|M.gilvum_PYR-GCK GWYLRNGPNPR-----EATGHWFTGDGMIHGVRIENGRAAWYRNRWVRT-
MAB_3874c|M.abscessus_ATCC_199 GRYLRNGPNPAAEV-DPATYHLFSGDAMVHGLSLREGKAQWYRNRWVRT-
Mb0937c|M.bovis_AF2122/97 GIYLRNTENPLHPA--FATYHPFDGDGMIHVVGFRDG-KAFYRNRFIRTD
Rv0913c|M.tuberculosis_H37Rv GIYLRNTENPLHPA--FATYHPFDGDGMIHVVGFRDG-KAFYRNRFIRTD
MMAR_4614|M.marinum_M GVYLRNTENPLHPA--FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFIQTD
MUL_0155|M.ulcerans_Agy99 GVYLRNTENPLHPA--FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFIQTD
* ** . * .*.*: . : . :***:::*
MSMEG_1564|M.smegmatis_MC2_155 HYEKSLAS----KGAPYRALGTMRPGGILANALRLPANVANTGVVMHAGK
TH_3525|M.thermoresistible__bu HYRRSRHT----RGAPFRGLGTMRPGGVLANALRFPVNVANTAVIMHAGT
MAV_3153|M.avium_104 HYLRSTAA----GRLVDRGFAYQRPGGPRANALRLPANTANTSVMVNRNQ
Mvan_0203|M.vanbaalenii_PYR-1 HFG---------GRGGVSHMGTSAPGGWRANICRVPPNLANTNVVEHAGR
Mflv_1332|M.gilvum_PYR-GCK -------------DSFIDPFPLYR---EDGTRD-LRASVANTHVVNHAGK
MAB_3874c|M.abscessus_ATCC_199 -------------PSVSKTLGETRPAAISANAG-MGVIGPNTNVLGHAGR
Mb0937c|M.bovis_AF2122/97 GFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIA
Rv0913c|M.tuberculosis_H37Rv GFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIA
MMAR_4614|M.marinum_M GFQAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVHRGIA
MUL_0155|M.ulcerans_Agy99 GFRAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVYRGIA
. . . .. :: .
MSMEG_1564|M.smegmatis_MC2_155 LLALWEGGRPTRIHPDTLDTLGAHDFDGGLK-WLGAFSAHPKWDFATGDM
TH_3525|M.thermoresistible__bu LLALWEAGRPTEIDPDSLDTVGEYDYDGELR-WLGAFSAHPKWDPDTGEM
MAV_3153|M.avium_104 LLALWEGGPPHELDLDTLDTIGPCNLGGALRGPVRAYSAHYRYDPMTNTK
Mvan_0203|M.vanbaalenii_PYR-1 LYALWEGGPPHEIDPDTLETMGVRRFGGELR-WLGSYSAHPSFCPSSGAM
Mflv_1332|M.gilvum_PYR-GCK TLALVESSLP-YEITNDLRAVGAYDFGGKLA---DAMTAHPKICPTTGEL
MAB_3874c|M.abscessus_ATCC_199 TLALVEGGIANYELTEDLDTIGTCDFDGTLP---GGYTAHPHTDPDTGEM
Mb0937c|M.bovis_AF2122/97 LTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKTGEL
Rv0913c|M.tuberculosis_H37Rv LTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKTGEL
MMAR_4614|M.marinum_M LTSFYQCGDLYRVDPSSATTLGKENWSGNFP-FDWGVSAHPKVDGKTGEL
MUL_0155|M.ulcerans_Agy99 LTSFYQCGDLYRVDPSSATTLGKETWSGHFP-FDWGVSAHPKVDGKTGEL
:: : . ::* * : . :** :.
MSMEG_1564|M.smegmatis_MC2_155 FNFG---------------------------LAMFPTPKLICYRVDRTGR
TH_3525|M.thermoresistible__bu FNFG---------------------------LALAPIPKLVCYRVDPTGR
MAV_3153|M.avium_104 VNFGFDPYVPRIDPGHALRGPRRLRRLRELAAEAVPRVRLRLYETGADGV
Mvan_0203|M.vanbaalenii_PYR-1 FNFG---------------------------VELMPRPHLRIYRTDRTGR
Mflv_1332|M.gilvum_PYR-GCK HFFG---------------------------YGNIFTPHVTYHRADAHGE
MAB_3874c|M.abscessus_ATCC_199 HAVS---------------------------YSFARGSTVQYSVIDAHGR
Mb0937c|M.bovis_AF2122/97 LFFN----------------------------YSKQEPYMRYGVVDQNNE
Rv0913c|M.tuberculosis_H37Rv LFFN----------------------------YSKQEPYMRYGVVDQNNE
MMAR_4614|M.marinum_M LFFN----------------------------YSKQEPYMRYGVVDQDNE
MUL_0155|M.ulcerans_Agy99 LFFN----------------------------YSKQEPYMRYGVVDQDNE
.. : . .
MSMEG_1564|M.smegmatis_MC2_155 LHRLGHVPLPRPMFNHDVGLTHHHMVFVIPPLVFPLRRSLEAGI------
TH_3525|M.thermoresistible__bu LTTLGAVRLSAPMFNHDVGLTKRHMVFVVPPLVFRPSKLAGAAL------
MAV_3153|M.avium_104 TRYLRAVPLPGMGVVHDMALTTRYAVFVLSPLRIN---PWALT-------
Mvan_0203|M.vanbaalenii_PYR-1 LRHFRSAALPYAAMVHDFAITERYIVFLISPIIPD---AMSVAL------
Mflv_1332|M.gilvum_PYR-GCK LVINRPLDVPALTMMHDFALTQNHVVFMDLPIVFDLDIAMR---------
MAB_3874c|M.abscessus_ATCC_199 ARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVPVPRLLR
Mb0937c|M.bovis_AF2122/97 LVHYVDVPLPGPRLLHDMAFTENYVILNDFPLFWDPRLLERDVH------
Rv0913c|M.tuberculosis_H37Rv LVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDPRLLERDVH------
MMAR_4614|M.marinum_M LAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDPQLLEHNLH------
MUL_0155|M.ulcerans_Agy99 LAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDPQLLEHNLH------
: . **. :* .: :: *:
MSMEG_1564|M.smegmatis_MC2_155 ---------------------------GVRNFIDAIDFDATRGTMIALVP
TH_3525|M.thermoresistible__bu ---------------------------GLHDYIDALEYDAERPTMIALVP
MAV_3153|M.avium_104 ---------------------------GRQSYWESIRFKPDAPSYFVLAP
Mvan_0203|M.vanbaalenii_PYR-1 ---------------------------GRAPIGDTLRYRPERGSVVLLVP
Mflv_1332|M.gilvum_PYR-GCK ----------------------------GEG-DMPYRWDDGYGARFGLLR
MAB_3874c|M.abscessus_ATCC_199 KPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMP
Mb0937c|M.bovis_AF2122/97 ----------------------------------LPRFYPEIPSRFAVVA
Rv0913c|M.tuberculosis_H37Rv ----------------------------------LPRFYPEIPSRFAVVA
MMAR_4614|M.marinum_M ----------------------------------LPRFYPDMPSRFAVIP
MUL_0155|M.ulcerans_Agy99 ----------------------------------LPRFYPDMPSRFAVIP
: : . :
MSMEG_1564|M.smegmatis_MC2_155 RD------GGRSRILHTDPSLHLHLSNAYEDGEDTVVELVDYHSS-----
TH_3525|M.thermoresistible__bu RD------GGRVRIVHTEPLMHLHIANAYDDGADTVVELLNYDAS-----
MAV_3153|M.avium_104 RD------GGAVRVVETDPFYHWHFTNAYDDGDDVVVELPRFAPQTYAGM
Mvan_0203|M.vanbaalenii_PYR-1 RA------GGKIRRIECEAVLQFHLSNAFDDGDDVVIDAITYADG-----
Mflv_1332|M.gilvum_PYR-GCK R--DDP--FGDVRWFDIGPCYIFHVANAYETTSADGDRLVLQAVR-----
MAB_3874c|M.abscessus_ATCC_199 REGDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLVR-----
Mb0937c|M.bovis_AF2122/97 RRGN------DIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQ---P
Rv0913c|M.tuberculosis_H37Rv RRGN------DIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQ---P
MMAR_4614|M.marinum_M RRGST----ADIRWFEADPTFVLHFTNAYEEGDEIVLDGFFEGAPH---P
MUL_0155|M.ulcerans_Agy99 RRGST----ADIRWFEADPTFVLHFTNAYEEGDEIVLDGFFEGAPH---P
* * .. . * *.:.
MSMEG_1564|M.smegmatis_MC2_155 WQELNGQLSLVPTLAQTATMPYGGQLTRLRITP-SGHVSREPITDLYGEF
TH_3525|M.thermoresistible__bu WTQLNAQLLTVDGTVPDTTMPYGGVLRRIRITR-SGRVIHEPLTDLRGDF
MAV_3153|M.avium_104 KNYTAHIRSDIAQVDDYGAIEDAVVLTRFRIAA-SGRVTREPLADFGCEF
Mvan_0203|M.vanbaalenii_PYR-1 -----RLLERIARFHTTSLADMPSQFTRFRVGA-TGRVGAEPLTDSPSEF
Mflv_1332|M.gilvum_PYR-GCK -------YPELWRDN--GGFDAEGVMWTWTVDLRTGAVSESQLDDRSVEF
MAB_3874c|M.abscessus_ATCC_199 -------YDSMFSQDVLGPSDAKGQLDRWTIDLAKGTVHMERKDDRHLEF
Mb0937c|M.bovis_AF2122/97 LDTGG--TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHEEQLSESITEF
Rv0913c|M.tuberculosis_H37Rv LDTGG--TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHEEQLSESITEF
MMAR_4614|M.marinum_M LETSASSTKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKEERLSESITEF
MUL_0155|M.ulcerans_Agy99 LETSASSTKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKEERLSESITEF
: : .* * . : :*
MSMEG_1564|M.smegmatis_MC2_155 PMLNVKTMASQNRYTYLSAA----LGGNIYPNAVAKIDNTTGKETVYRLP
TH_3525|M.thermoresistible__bu PMLNPRVSGRRHRYTYLVVG----VEGSTYPNAVAKLDHHTGASTLHRLP
MAV_3153|M.avium_104 PQIDPRRGTMRHHVSYLTVQ----DPAKFPGQGIARVDHRTGEAQTYCP-
Mvan_0203|M.vanbaalenii_PYR-1 PRHHPAREGRPHRYAYVNTR----RTLGTLYDTVTKLDLADQTELSYPAP
Mflv_1332|M.gilvum_PYR-GCK PRIDDRLATLPARY-----------AVSVGDKNLIRHDLTTGAAEVHRFG
MAB_3874c|M.abscessus_ATCC_199 PRINETFTGKKHRYGYLPDVENFFGSGEAAGASIVKYDYETGSTLSSRLD
Mb0937c|M.bovis_AF2122/97 GTINADYAASSYRYTYAATG----KPSWFLFDGLVKHDLLTGNHECYSFG
Rv0913c|M.tuberculosis_H37Rv GTINADYAASSYRYTYAATG----KPSWFLFDGLVKHDLLTGNHECYSFG
MMAR_4614|M.marinum_M GTINSDYAARQYRYAYAATG----KPGWFLFDGLVKHDLLTGNQEGISFG
MUL_0155|M.ulcerans_Agy99 GTINSDYAARQYRYAYAATG----KPGWFLFDGLVKHDLLTGNQEGISFG
. : : : *
MSMEG_1564|M.smegmatis_MC2_155 -DGHLPHEAIFAAHPDGVDEDDGWLLVPVIDGVENIASLIILDAKDIEAG
TH_3525|M.thermoresistible__bu -PGHLAHEPVFIPRPGGAAEDDGWLAVVVQDCHRHRAHLRLLDAGAVSAD
MAV_3153|M.avium_104 -PGHVLVEPIFVPRPGGTAEDDGWLLTVGYDESRHRSRLMVVDAAHVADG
Mvan_0203|M.vanbaalenii_PYR-1 EPGNSFCEPVFAPRPGATAEDDGWLLTVEYRAAHKTSRLVILDAADPSRG
Mflv_1332|M.gilvum_PYR-GCK -SGGPGEAVFVPSTSGPADESSGWYLGYVYDPERNGSDLVVIDASDFSGP
MAB_3874c|M.abscessus_ATCC_199 PAIVLGEMSFVPNPTCAAEDD-GVLIGFAVDRRSDEGQLLLLDATSLD--
Mb0937c|M.bovis_AF2122/97 -DGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDG
Rv0913c|M.tuberculosis_H37Rv -DGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDG
MMAR_4614|M.marinum_M -EGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARIADG
MUL_0155|M.ulcerans_Agy99 -EGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARIADG
. :. * . . :.**
MSMEG_1564|M.smegmatis_MC2_155 PVYQGRLRHHLPLTFHGCYTPRVAAPA-------------
TH_3525|M.thermoresistible__bu PVFTGHLRHSMPLTFHGCFTPRVGRSG-------------
MAV_3153|M.avium_104 PVAEAWLQFHVPMSYHGTFTTRVAQRTG------------
Mvan_0203|M.vanbaalenii_PYR-1 PVATAQLASHIPQGFHGNFSARTS----------------
Mflv_1332|M.gilvum_PYR-GCK PVARVHLPQRVPYGFHGNWISA------------------
MAB_3874c|M.abscessus_ATCC_199 LMATVHLPQRVPAGFHGNWAPR------------------
Mb0937c|M.bovis_AF2122/97 PICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Rv0913c|M.tuberculosis_H37Rv PICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
MMAR_4614|M.marinum_M PVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
MUL_0155|M.ulcerans_Agy99 PVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
: * :. *. : .