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DITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLDGIYLRNTENPLHPAFATYHPF DGDGMIHVVGFRDGKAFYRNRFIRTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVI VHRGIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTGELLFFNYSKQEPYMRYG VVDQNNELVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDPRLLERDVHLPRFYPEIPSRFAVVARRG NDIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDTGGTKWEKLFRFLALDRLQSRLHRWRLNMV TGAVHEEQLSESITEFGTINADYAASSYRYTYAATGKPSWFLFDGLVKHDLLTGNHECYSFGDGVYGSET AMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDGPICKLALPERISSGTHSAWVPGAELRRWD HAESPAAAVGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0913c | - | - | 100% (502) | POSSIBLE DIOXYGENASE |
| M. tuberculosis H37Rv | Rv0654 | - | 1e-45 | 28.93% (522) | dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0937c | - | 0.0 | 99.80% (502) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1807 | - | 0.0 | 73.81% (504) | carotenoid oxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 1e-47 | 28.20% (532) | putative dioxygenase |
| M. marinum M | MMAR_4614 | - | 0.0 | 85.38% (506) | dioxygenase |
| M. avium 104 | MAV_0560 | - | 6e-43 | 29.47% (509) | carotenoid oxygenase |
| M. smegmatis MC2 155 | MSMEG_5609 | - | 0.0 | 74.95% (507) | carotenoid oxygenase |
| M. thermoresistible (build 8) | TH_3959 | - | 4e-46 | 29.86% (509) | PUTATIVE Carotenoid oxygenase |
| M. ulcerans Agy99 | MUL_0155 | - | 0.0 | 85.18% (506) | dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4940 | - | 0.0 | 71.64% (529) | carotenoid oxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0913c|M.tuberculosis_H37Rv ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
Mb0937c|M.bovis_AF2122/97 ----MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVP
MMAR_4614|M.marinum_M ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
MUL_0155|M.ulcerans_Agy99 ----MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIP
Mflv_1807|M.gilvum_PYR-GCK MTAGTHPEVVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLRVVEGQIP
Mvan_4940|M.vanbaalenii_PYR-1 MSLHSHPEIVGKFLSTLPEDDDHPYRTGPWRPQTTEWDDDDLKVVEGRIP
MSMEG_5609|M.smegmatis_MC2_155 ----MHTEVVAKYLSTLPEDDTHPYRTGAWRPQTTEWDADDLTVVEGEIP
MAV_0560|M.avium_104 --------------------MANRYLQGPFAPMHHEYTLTGLEVVG-TIP
TH_3959|M.thermoresistible__bu --------------------VSNRYLTGAFAPLTEEYTLTDLEVTG-TIP
MAB_3874c|M.abscessus_ATCC_199 -----------MTATAQPAASTSPYLSGIWEPVQQEMDSVDLEVTG-TLP
* * : * * .* .. :*
Rv0913c|M.tuberculosis_H37Rv ADLDGIYLRNTENPLHPA-FATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
Mb0937c|M.bovis_AF2122/97 ADLDGIYLRNTENPLHPA-FATYHPFDGDGMIHVVGFRDG-KAFYRNRFI
MMAR_4614|M.marinum_M HDLDGVYLRNTENPLHPA-FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
MUL_0155|M.ulcerans_Agy99 HDLDGVYLRNTENPLHPA-FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFI
Mflv_1807|M.gilvum_PYR-GCK GDLDGVYLRNTENPLHPA-LKYYHPFDGDGMLHMVGFRDG-KAFYRNRFV
Mvan_4940|M.vanbaalenii_PYR-1 DDLDGVYLRNTENPLHPA-LKYYHPFDGDGMLHIVGFRDG-KAFYRNRFV
MSMEG_5609|M.smegmatis_MC2_155 ADLDGVYLRNTENPMHPA-FKVYHPFDGDGMLHVVGFRDG-KAFYRNRFV
MAV_0560|M.avium_104 DYLDGRYLRNGANPIGDVDPERYHWFLGDGMVHGIRIRDGKAEWYRNRWV
TH_3959|M.thermoresistible__bu DYLDGRYLRNGPNPVGEIDPELYHWFVGDGMVHGIRLRDGRAEWYRNRWV
MAB_3874c|M.abscessus_ATCC_199 AHLDGRYLRNGPNPAAEVDPATYHLFSGDAMVHGLSLREGKAQWYRNRWV
*** **** ** ** * **.*:* : :*:* :****::
Rv0913c|M.tuberculosis_H37Rv RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
Mb0937c|M.bovis_AF2122/97 RTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHR
MMAR_4614|M.marinum_M QTDGFQAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVHR
MUL_0155|M.ulcerans_Agy99 QTDGFRAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVYR
Mflv_1807|M.gilvum_PYR-GCK RTDALAAENEAGGPLWPGIAEPIELAKRDYGWGARTLMKDASSTDVIVHR
Mvan_4940|M.vanbaalenii_PYR-1 RTDAFAEENEAGGPLWPGIAEPLELARRDYGWGARTLMKDASSTDVVVHR
MSMEG_5609|M.smegmatis_MC2_155 RTDGLLEENAEGGPLWPGIAEPVELAKRDYGWGARTLMKDASSTDVTVHR
MAV_0560|M.avium_104 RS--------------PATSKALGQPAP---PGHFGFFPIGANTNVIGHA
TH_3959|M.thermoresistible__bu RG--------------PLTARALGERPP---SEECSVSGIGANTNVIGHA
MAB_3874c|M.abscessus_ATCC_199 RT--------------PSVSKTLGETRPAAISANAGMGVIGPNTNVLGHA
: * :..: . ...*:* :
Rv0913c|M.tuberculosis_H37Rv GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTG
Mb0937c|M.bovis_AF2122/97 GIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTG
MMAR_4614|M.marinum_M GIALTSFYQCGDLYRVDPSSATTLGKENWSGNFPFDWGVSAHPKVDGKTG
MUL_0155|M.ulcerans_Agy99 GIALTSFYQCGDLYRVDPSSATTLGKETWSGHFPFDWGVSAHPKVDGKTG
Mflv_1807|M.gilvum_PYR-GCK GVALTSHYQCGDLYRIDPCTGADLGKEDWNGGFPTDWGVSAHPKVDDRTG
Mvan_4940|M.vanbaalenii_PYR-1 GVALTSHYQCGDLYRIDPRTGAALGKEDWHGTFPSDWGVSAHPKIDDHTG
MSMEG_5609|M.smegmatis_MC2_155 GVALTSFYQCGDLYRINPHTGDTLGKENWNGGFPVDWGVSAHPKNDDRTG
MAV_0560|M.avium_104 GKTLALIEGGIANYELT-EELDTVGVCDFAGTLTG--GYAAHPHRDPETG
TH_3959|M.thermoresistible__bu GKTIALVESGVTNYELT-EELDTVGPCDFDGTLTG--GYTAHPKRDPETG
MAB_3874c|M.abscessus_ATCC_199 GRTLALVEGGIANYELT-EDLDTIGTCDFDGTLPG--GYTAHPHTDPDTG
* ::: *.: :* : * :. * :***: * **
Rv0913c|M.tuberculosis_H37Rv ELLFFNYSKQ-EPYMRYGVVDQNNELVHYVDVPLPGPRLPHDMAFTENYV
Mb0937c|M.bovis_AF2122/97 ELLFFNYSKQ-EPYMRYGVVDQNNELVHYVDVPLPGPRLLHDMAFTENYV
MMAR_4614|M.marinum_M ELLFFNYSKQ-EPYMRYGVVDQDNELAHYVDIPLPGPRLPHDMAFTENYA
MUL_0155|M.ulcerans_Agy99 ELLFFNYSKQ-EPYMRYGVVDQDNELAHYVDIPLPGPRLPHDMAFTENYA
Mflv_1807|M.gilvum_PYR-GCK ELLFFNYSKQ-APFMRYGVVSPAGDVVHNVDVPLPGPRLPHDMAFTENYV
Mvan_4940|M.vanbaalenii_PYR-1 ELLFFNYSKQ-APYMRYGVVSPAGEVVHNVDVPLPGPRLPHDMAFTENYV
MSMEG_5609|M.smegmatis_MC2_155 ELLFFNYGKQ-APYMHFGVVDQNNNLVHYTDVELPGPRLPHDMAFTENYV
MAV_0560|M.avium_104 ELHAVSYNPYRGNRVQYSVIDVEGRARRTVDVTVGGSPMMHDFSLTERYV
TH_3959|M.thermoresistible__bu ELHAVSYSMYRGNTVQYSVIGTDGRARRTVDIEVTGSPMMHDFSLTERHI
MAB_3874c|M.abscessus_ATCC_199 EMHAVSYSFARGSTVQYSVIDAHGRARRTVDIPVHGAPMMHDFTLTEKYV
*: ..*. :::.*:. . : .*: : *. : **:::**.:
Rv0913c|M.tuberculosis_H37Rv ILNDFPLFWDPRLLERDVHLPR----------------------------
Mb0937c|M.bovis_AF2122/97 ILNDFPLFWDPRLLERDVHLPR----------------------------
MMAR_4614|M.marinum_M ILNDFPLFWDPQLLEHNLHLPR----------------------------
MUL_0155|M.ulcerans_Agy99 ILNDFPLFWDPQLLEHNLHLPR----------------------------
Mflv_1807|M.gilvum_PYR-GCK ILNDFPLFWDTGLLEHNIHLPR----------------------------
Mvan_4940|M.vanbaalenii_PYR-1 ILNDFPLFWDTGLLEHNIHFPR----------------------------
MSMEG_5609|M.smegmatis_MC2_155 ILNDFPMFWDAEFLKHNAHIPR----------------------------
MAV_0560|M.avium_104 VFYDLPVTFDA-AVGAAMTAPRGLRPIARLMLSALIGRVAIPDPIAARLP
TH_3959|M.thermoresistible__bu VLYDLPVTFDA-RQAVSMTVPRGLRLPARLVLSALIGRVRVPDPIAARQP
MAB_3874c|M.abscessus_ATCC_199 VFYDLPVTLDMSMISQSVPVPRLLRKPAQIVMNSLIGKVKIPGPIAAKAS
:: *:*: * **
Rv0913c|M.tuberculosis_H37Rv ------------FYPEIPSRFAVVARRGN------DIRWFEADPTFVLHF
Mb0937c|M.bovis_AF2122/97 ------------FYPEIPSRFAVVARRGN------DIRWFEADPTFVLHF
MMAR_4614|M.marinum_M ------------FYPDMPSRFAVIPRRGST----ADIRWFEADPTFVLHF
MUL_0155|M.ulcerans_Agy99 ------------FYPDMPSRFAVIPRRGST----ADIRWFEADPTFVLHF
Mflv_1807|M.gilvum_PYR-GCK ------------FHRDVPSRFAVLPRRGDT----SQIMWFEADPTYVLHF
Mvan_4940|M.vanbaalenii_PYR-1 ------------FHRDMPSRFAVVPRRGDT----SQIKWFETAPTYVLHF
MSMEG_5609|M.smegmatis_MC2_155 ------------LHRDLPSRFAVVPRRG------GDIKWFEADTTYVLHF
MAV_0560|M.avium_104 -AATTDRRMPYSWNPNYPARVGVMPRDGEDAD----VRWFDVEPCYVFHP
TH_3959|M.thermoresistible__bu RGNSSDRRFPYSWNPRYPARIGVMPRDGSNKD----VRWFDVEPCYVFHP
MAB_3874c|M.abscessus_ATCC_199 QYSGKSPSIPYSWNPKYPARIGVMPREGDDASRHAPVRWFEIDPCYVFHP
*:*..*:.* * : **: . :*:*
Rv0913c|M.tuberculosis_H37Rv TNAYEQG----DEIVLDGFYEGDPQPLDT---GG--TKWEKLFRFLALDR
Mb0937c|M.bovis_AF2122/97 TNAYEQG----DEIVLDGFYEGDPQPLDT---GG--TKWEKLFRFLALDR
MMAR_4614|M.marinum_M TNAYEEG----DEIVLDGFFEGAPHPLET---SASSTKWEKLFRFLALDR
MUL_0155|M.ulcerans_Agy99 TNAYEEG----DEIVLDGFFEGAPHPLET---SASSTKWEKLFRFLALDR
Mflv_1807|M.gilvum_PYR-GCK PNAFEDG----DEIVLDGFFQGDPEPTQG-VDNGMSRKWQQIFRSLSLDG
Mvan_4940|M.vanbaalenii_PYR-1 PNAYEDG----DEIVLDGFFQGDPEPTDG-VDNGMSGKWRQIFRSLSLDG
MSMEG_5609|M.smegmatis_MC2_155 TNAFEDG----DEIVMDGFFQGSPEPDDDPADNGMSRKWQRFFRYLSLDG
MAV_0560|M.avium_104 MNAYEED----GTIVLDVVRNPKMFDRDR----------------TGPNE
TH_3959|M.thermoresistible__bu MNAYDDG----DTIVLDVIRHPKMFDTDN----------------LGPNE
MAB_3874c|M.abscessus_ATCC_199 LNGYSEMRNGAEVIVIDLVRYDSMFSQDV----------------LGPSD
*.:.: **:* . : . .
Rv0913c|M.tuberculosis_H37Rv LQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAATGK
Mb0937c|M.bovis_AF2122/97 LQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAATGK
MMAR_4614|M.marinum_M LQTRLHRWRLNLVTGAVKEERLSESITEFGTINSDYAARQYRYAYAATGK
MUL_0155|M.ulcerans_Agy99 LQTRLHRWRLNLVTGAVKEERLSESITEFGTINSDYAARQYRYAYAATGK
Mflv_1807|M.gilvum_PYR-GCK MQTRLHRWRFNLKTGAVREEHLSDSFTEFGMINPGFSGRPHRYTYAETGK
Mvan_4940|M.vanbaalenii_PYR-1 MQTRLHRWRFNLVTGEAREEQLSDSITEFGMINPAYSGRPYRYTYAATGK
MSMEG_5609|M.smegmatis_MC2_155 MQTRLHRWRFNLVTGETREEQLSDSLTEFGMINPDFATQDYRYIYAATGK
MAV_0560|M.avium_104 GPPTLDRWVIDLAAGKVRESRIDDRGQEFPRIDERLVGKRHRYGYTPTVL
TH_3959|M.thermoresistible__bu GPPTLDRWTVDLADGKVRESRIDDRGQEFPRVDERLVGRRHRYGYAPTVG
MAB_3874c|M.abscessus_ATCC_199 AKGQLDRWTIDLAKGTVHMERKDDRHLEFPRINETFTGKKHRYGYLPDVE
*.** .:: * .: .: .: ** :: :** *
Rv0913c|M.tuberculosis_H37Rv ----PSWFLFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVG------
Mb0937c|M.bovis_AF2122/97 ----PSWFLFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVG------
MMAR_4614|M.marinum_M ----PGWFLFDGLVKHDLLTGNQEGISFGEGVYGSETQMAPRVG------
MUL_0155|M.ulcerans_Agy99 ----PGWFLFDGLVKHDLLTGNQEGISFGEGVYGSETQMAPRVG------
Mflv_1807|M.gilvum_PYR-GCK ----PGWFLFDGLVKHDLHTGTEQRFTFDDGVFGSETAMAPRVG------
Mvan_4940|M.vanbaalenii_PYR-1 ----PGWFLFDGLVRHDLHTGTEQRYGFGDGVYGSETAMAPRVGSAAADH
MSMEG_5609|M.smegmatis_MC2_155 ----PGWFLFDGLVRHDLRTGSEERYTFADGVYGSETAMAPRVG------
MAV_0560|M.avium_104 ----EGIEGGDCLLKHDLIGGSTQSRSLGPQKALGEFVFHPSSP------
TH_3959|M.thermoresistible__bu ----EGTSGGNVLLKHDFVGGNTQSRVFEPYHELGEFVFQPSSA------
MAB_3874c|M.abscessus_ATCC_199 NFFGSGEAAGASIVKYDYETGSTLSSRLDPAIVLGEMSFVPNPT------
. ::::* *. : .* : *
Rv0913c|M.tuberculosis_H37Rv -------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAARP
Mb0937c|M.bovis_AF2122/97 -------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAARP
MMAR_4614|M.marinum_M -------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAARI
MUL_0155|M.ulcerans_Agy99 -------------------SSAEDDGYLVTLTTDMNDDASYCLVFDAARI
Mflv_1807|M.gilvum_PYR-GCK -------------------GTDEDDGYLVTLTTDMNTDASYCLVFDAARV
Mvan_4940|M.vanbaalenii_PYR-1 IGGSAAAHIGGSAAAHIGGSAAEDDGYLVTLTTDMAADASYCLVFDAARV
MSMEG_5609|M.smegmatis_MC2_155 -------------------GSGEDDGYLVTLISDMNDDASYCLVFDAARV
MAV_0560|M.avium_104 -------------------TAAEDEGVLMGYVYDRATNRSELAILDAQTL
TH_3959|M.thermoresistible__bu -------------------DAAEDDGVVMGYVYDRTTDRSELAILDAQTL
MAB_3874c|M.abscessus_ATCC_199 -------------------CAAEDDGVLIGFAVDRRSDEGQLLLLDATSL
: **:* :: * : . ::**
Rv0913c|M.tuberculosis_H37Rv GDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Mb0937c|M.bovis_AF2122/97 GDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
MMAR_4614|M.marinum_M ADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
MUL_0155|M.ulcerans_Agy99 ADGPVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
Mflv_1807|M.gilvum_PYR-GCK GDGPVCKLQLPERISSGTHSTWAAGCDLPRWRDSESAAGAIGL
Mvan_4940|M.vanbaalenii_PYR-1 GDGPVCKLQLPERISSGTHSTWAPGADLPQWRESDSAAGAIGL
MSMEG_5609|M.smegmatis_MC2_155 GDGPVCKLALPERISSGTHSTWVSGAELRRWHTSDDAAAAIGM
MAV_0560|M.avium_104 ED--VASIKLPHRVPAGFHGNWVPSTN----------------
TH_3959|M.thermoresistible__bu ED--VARIRLPHRVPAGFHGNWVPSDG----------------
MAB_3874c|M.abscessus_ATCC_199 DL--MATVHLPQRVPAGFHGNWAPR------------------
:. : **.*:.:* *. *..