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MGPDDLSSLGVSEPQPAEHDYRVEQIDGTIPAGLRGTLYRNGPGRWEDHKGRPLRHLFDGDGMLSAFTID AAGVHYRNRYVRTRHFGGRGGVSHMGTSAPGGWRANICRVPPNLANTNVVEHAGRLYALWEGGPPHEIDP DTLETMGVRRFGGELRWLGSYSAHPSFCPSSGAMFNFGVELMPRPHLRIYRTDRTGRLRHFRSAALPYAA MVHDFAITERYIVFLISPIIPDAMSVALGRAPIGDTLRYRPERGSVVLLVPRAGGKIRRIECEAVLQFHL SNAFDDGDDVVIDAITYADGRLLERIARFHTTSLADMPSQFTRFRVGATGRVGAEPLTDSPSEFPRHHPA REGRPHRYAYVNTRRTLGTLYDTVTKLDLADQTELSYPAPEPGNSFCEPVFAPRPGATAEDDGWLLTVEY RAAHKTSRLVILDAADPSRGPVATAQLASHIPQGFHGNFSARTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0203 | - | - | 100% (464) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_3359 | - | 6e-98 | 41.01% (495) | carotenoid oxygenase |
| M. vanbaalenii PYR-1 | Mvan_5460 | - | 2e-44 | 33.41% (440) | carotenoid oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0937c | - | 3e-41 | 29.06% (468) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_2111 | - | 2e-41 | 31.64% (493) | carotenoid oxygenase |
| M. tuberculosis H37Rv | Rv0913c | - | 7e-41 | 29.06% (468) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3874c | - | 4e-35 | 27.95% (508) | putative dioxygenase |
| M. marinum M | MMAR_4614 | - | 3e-38 | 27.89% (459) | dioxygenase |
| M. avium 104 | MAV_3153 | - | 4e-91 | 38.78% (490) | retinal pigment epithelial membrane protein |
| M. smegmatis MC2 155 | MSMEG_1564 | - | 7e-94 | 40.00% (460) | lignostilbene-alpha,beta-dioxygenase |
| M. thermoresistible (build 8) | TH_3525 | - | 7e-97 | 43.84% (463) | PUTATIVE lignostilbene-alpha,beta-dioxygenase |
| M. ulcerans Agy99 | MUL_0155 | - | 1e-37 | 27.67% (459) | dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0203|M.vanbaalenii_PYR-1 ----MGPDDLSSLGVSEP-----------QPAEHDYRVEQIDGTIPAGLR
MAV_3153|M.avium_104 --------MQAPSRYWEN-----------IVGETDLDVTDITGTLPDGLV
MSMEG_1564|M.smegmatis_MC2_155 --MHRSPPRLAPSDVTEGTFSPYSPYNTSLYEEYDYTIDDVEGALPDGLR
TH_3525|M.thermoresistible__bu ----MSP---EPVGSRQQDFSGFTP----LHEEYDYLLDEVAGAVPEQLR
Mflv_2111|M.gilvum_PYR-GCK ----------MANRYLEGAFAP-------ISEEHTLTDLDVIGTIPDHLD
MAB_3874c|M.abscessus_ATCC_199 -MTATAQPAASTSPYLSGIWEP-------VQQEMDSVDLEVTGTLPAHLD
Mb0937c|M.bovis_AF2122/97 MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLD
Rv0913c|M.tuberculosis_H37Rv MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLD
MMAR_4614|M.marinum_M MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIPHDLD
MUL_0155|M.ulcerans_Agy99 MDVEIVGKYLSTLPEDDDHPYRTGPWRPQTTEWNADDLTVVEGEIPHDLD
. . : * :* *
Mvan_0203|M.vanbaalenii_PYR-1 GTLYRNGPGRWEDHKGRPLRHLFDGDGMLSAFTIDAA-GVHYRNRYVRTR
MAV_3153|M.avium_104 GTLYRNGSGRWTVG-STQVESIFDADGMVSAFVLDGS-GVRFRNRFVRTR
MSMEG_1564|M.smegmatis_MC2_155 GTLYRNGPGKLDAG-GQQLGHLFDGDGMLSMFVMSDG-TVRFRNRYVRTK
TH_3525|M.thermoresistible__bu GTVYRNGPGRLEAG-GQPLGHLFDGDGMLSMFRFADG-RVRFRNRYVRTR
Mflv_2111|M.gilvum_PYR-GCK GRYLRNGP-NPIGDLDPALYHWFIGDGMVHGIRIRDGRAEWYRNRWVRG-
MAB_3874c|M.abscessus_ATCC_199 GRYLRNGP-NPAAEVDPATYHLFSGDAMVHGLSLREGKAQWYRNRWVRT-
Mb0937c|M.bovis_AF2122/97 GIYLRNTENPLHPA--FATYHPFDGDGMIHVVGFRDG-KAFYRNRFIRTD
Rv0913c|M.tuberculosis_H37Rv GIYLRNTENPLHPA--FATYHPFDGDGMIHVVGFRDG-KAFYRNRFIRTD
MMAR_4614|M.marinum_M GVYLRNTENPLHPA--FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFIQTD
MUL_0155|M.ulcerans_Agy99 GVYLRNTENPLHPA--FKTYHPFDGDGMLHVVGFRDG-KAFYRNRFIQTD
* ** * .*.*: . : . :***:::
Mvan_0203|M.vanbaalenii_PYR-1 HFG-----GRGGVSHMGTSAPGGWRANICRVPPNLANTN----VVEHAGR
MAV_3153|M.avium_104 HYLRSTAAGRLVDRGFAYQRPGGPRANALRLPANTANTS----VMVNRNQ
MSMEG_1564|M.smegmatis_MC2_155 HYEKSLASKGAPYRALGTMRPGGILANALRLPANVANTG----VVMHAGK
TH_3525|M.thermoresistible__bu HYRRSRHTRGAPFRGLGTMRPGGVLANALRFPVNVANTA----VIMHAGT
Mflv_2111|M.gilvum_PYR-GCK ---------PAAARALGESVPDG-RFPISG---IGANTN----VIGHAGK
MAB_3874c|M.abscessus_ATCC_199 ---------PSVSKTLGETRPAA-ISANAGMGVIGPNTN----VLGHAGR
Mb0937c|M.bovis_AF2122/97 GFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIA
Rv0913c|M.tuberculosis_H37Rv GFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIA
MMAR_4614|M.marinum_M GFQAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVHRGIA
MUL_0155|M.ulcerans_Agy99 GFRAENEAGEPLWPGLAEPIQLAKRDQGWGARTLMKDASSTDVIVYRGIA
:. . :: :: .
Mvan_0203|M.vanbaalenii_PYR-1 LYALWEGGPPHEIDPDTLETMGVRRFGGELR-WLGSYSAHPSFCPSSGAM
MAV_3153|M.avium_104 LLALWEGGPPHELDLDTLDTIGPCNLGGALRGPVRAYSAHYRYDPMTNTK
MSMEG_1564|M.smegmatis_MC2_155 LLALWEGGRPTRIHPDTLDTLGAHDFDGGLK-WLGAFSAHPKWDFATGDM
TH_3525|M.thermoresistible__bu LLALWEAGRPTEIDPDSLDTVGEYDYDGELR-WLGAFSAHPKWDPDTGEM
Mflv_2111|M.gilvum_PYR-GCK TLALIEAGVPNYELTDDLDTVGTCDFDGTLS---GGYTAHPKRDPDTGEL
MAB_3874c|M.abscessus_ATCC_199 TLALVEGGIANYELTEDLDTIGTCDFDGTLP---GGYTAHPHTDPDTGEM
Mb0937c|M.bovis_AF2122/97 LTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKTGEL
Rv0913c|M.tuberculosis_H37Rv LTSFYQCGDLYRIDPYSANTLGKESWHGRFP-FDWGVSAHPKVDNKTGEL
MMAR_4614|M.marinum_M LTSFYQCGDLYRVDPSSATTLGKENWSGNFP-FDWGVSAHPKVDGKTGEL
MUL_0155|M.ulcerans_Agy99 LTSFYQCGDLYRVDPSSATTLGKETWSGHFP-FDWGVSAHPKVDGKTGEL
:: : * *:* * : . :** :.
Mvan_0203|M.vanbaalenii_PYR-1 FNFG---------------------------VELMPRPHLRIYRTDRTGR
MAV_3153|M.avium_104 VNFGFDPYVPRIDPGHALRGPRRLRRLRELAAEAVPRVRLRLYETGADGV
MSMEG_1564|M.smegmatis_MC2_155 FNFG---------------------------LAMFPTPKLICYRVDRTGR
TH_3525|M.thermoresistible__bu FNFG---------------------------LALAPIPKLVCYRVDPTGR
Mflv_2111|M.gilvum_PYR-GCK HAVS---------------------------YSMLRGNTVQYSVIDTGGR
MAB_3874c|M.abscessus_ATCC_199 HAVS---------------------------YSFARGSTVQYSVIDAHGR
Mb0937c|M.bovis_AF2122/97 LFFN----------------------------YSKQEPYMRYGVVDQNNE
Rv0913c|M.tuberculosis_H37Rv LFFN----------------------------YSKQEPYMRYGVVDQNNE
MMAR_4614|M.marinum_M LFFN----------------------------YSKQEPYMRYGVVDQDNE
MUL_0155|M.ulcerans_Agy99 LFFN----------------------------YSKQEPYMRYGVVDQDNE
.. : . .
Mvan_0203|M.vanbaalenii_PYR-1 LRHFRSAALPYAAMVHDFAITERYIVFLISPIIPD---------------
MAV_3153|M.avium_104 TRYLRAVPLPGMGVVHDMALTTRYAVFVLSPLRIN---------------
MSMEG_1564|M.smegmatis_MC2_155 LHRLGHVPLPRPMFNHDVGLTHHHMVFVIPPLVFPL--------------
TH_3525|M.thermoresistible__bu LTTLGAVRLSAPMFNHDVGLTKRHMVFVVPPLVFRP--------------
Mflv_2111|M.gilvum_PYR-GCK ARRTVDIEVAGSPMMHDFSLTERHVIFYDLPVTFDTRRAVEMT-VPRGLR
MAB_3874c|M.abscessus_ATCC_199 ARRTVDIPVHGAPMMHDFTLTEKYVVFYDLPVTLDMSMISQSVPVPRLLR
Mb0937c|M.bovis_AF2122/97 LVHYVDVPLPGPRLLHDMAFTENYVILNDFPLFWDP--------------
Rv0913c|M.tuberculosis_H37Rv LVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDP--------------
MMAR_4614|M.marinum_M LAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDP--------------
MUL_0155|M.ulcerans_Agy99 LAHYVDIPLPGPRLPHDMAFTENYAILNDFPLFWDP--------------
: . **. :* .: :: *:
Mvan_0203|M.vanbaalenii_PYR-1 -----AMSVALGRAPIGDTLRYR----------------PERGSVVLLVP
MAV_3153|M.avium_104 -----PWALT-GRQSYWESIRFK----------------PDAPSYFVLAP
MSMEG_1564|M.smegmatis_MC2_155 ---RRSLEAGIGVRNFIDAIDFD----------------ATRGTMIALVP
TH_3525|M.thermoresistible__bu ---SKLAGAALGLHDYIDALEYD----------------AERPTMIALVP
Mflv_2111|M.gilvum_PYR-GCK LPARLVLSALIGRVRIPDPVAARQPSGSGSDRRFPYSWNPRYPARIGVMP
MAB_3874c|M.abscessus_ATCC_199 KPAQIVMNSLIGKVKIPGPIAAKASQYSGKSPSIPYSWNPKYPARIGVMP
Mb0937c|M.bovis_AF2122/97 ----RLLERDVHLPRFY----------------------PEIPSRFAVVA
Rv0913c|M.tuberculosis_H37Rv ----RLLERDVHLPRFY----------------------PEIPSRFAVVA
MMAR_4614|M.marinum_M ----QLLEHNLHLPRFY----------------------PDMPSRFAVIP
MUL_0155|M.ulcerans_Agy99 ----QLLEHNLHLPRFY----------------------PDMPSRFAVIP
. : . : .
Mvan_0203|M.vanbaalenii_PYR-1 RAGG------KIRRIECEAVLQFHLSNAFDDGDDVVIDAITYADG-----
MAV_3153|M.avium_104 RDGG------AVRVVETDPFYHWHFTNAYDDGDDVVVELPRFAPQTYAGM
MSMEG_1564|M.smegmatis_MC2_155 RDGG------RSRILHTDPSLHLHLSNAYEDGEDTVVELVDYHSSWQELN
TH_3525|M.thermoresistible__bu RDGG------RVRIVHTEPLMHLHIANAYDDGADTVVELLNYDASWTQLN
Mflv_2111|M.gilvum_PYR-GCK RDGG----SADVRWFDVEPCYVFHPMNAYDSPAD--DTIVLDVVR-----
MAB_3874c|M.abscessus_ATCC_199 REGDDASRHAPVRWFEIDPCYVFHPLNGYSEMRNGAEVIVIDLVR-----
Mb0937c|M.bovis_AF2122/97 RRGN------DIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDT
Rv0913c|M.tuberculosis_H37Rv RRGN------DIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDT
MMAR_4614|M.marinum_M RRGST----ADIRWFEADPTFVLHFTNAYEEGDEIVLDGFFEGAPHPLET
MUL_0155|M.ulcerans_Agy99 RRGST----ADIRWFEADPTFVLHFTNAYEEGDEIVLDGFFEGAPHPLET
* *. * .. :. * *.:.. :
Mvan_0203|M.vanbaalenii_PYR-1 -----RLLERIARFHTTSLADMPSQFTRFRVGAT-GRVGAEPLTDSPSEF
MAV_3153|M.avium_104 KNYTAHIRSDIAQVDDYGAIEDAVVLTRFRIAAS-GRVTREPLADFGCEF
MSMEG_1564|M.smegmatis_MC2_155 -----GQLSLVPTLAQTATMPYGGQLTRLRITPS-GHVSREPITDLYGEF
TH_3525|M.thermoresistible__bu -----AQLLTVDGTVPDTTMPYGGVLRRIRITRS-GRVIHEPLTDLRGDF
Mflv_2111|M.gilvum_PYR-GCK -------HPKMFDTDHLGPNEGPPTLERWTVDLVAGKVRESRVDDRAQEF
MAB_3874c|M.abscessus_ATCC_199 -------YDSMFSQDVLGPSDAKGQLDRWTIDLAKGTVHMERKDDRHLEF
Mb0937c|M.bovis_AF2122/97 GG-----TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHEEQLSESITEF
Rv0913c|M.tuberculosis_H37Rv GG-----TKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHEEQLSESITEF
MMAR_4614|M.marinum_M SAS---STKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKEERLSESITEF
MUL_0155|M.ulcerans_Agy99 SAS---STKWEKLFRFLALDRLQTRLHRWRLNLVTGAVKEERLSESITEF
: * : * * . : :*
Mvan_0203|M.vanbaalenii_PYR-1 PRHHPAREGRPHRYAYVNTRR----TLGTLYDTVTKLDLADQTELSYPAP
MAV_3153|M.avium_104 PQIDPRRGTMRHHVSYLTVQD----PAKFPGQGIARVDHRTGEAQTYCP-
MSMEG_1564|M.smegmatis_MC2_155 PMLNVKTMASQNRYTYLSAAL----GGNIYPNAVAKIDNTTGKETVYRLP
TH_3525|M.thermoresistible__bu PMLNPRVSGRRHRYTYLVVGV----EGSTYPNAVAKLDHHTGASTLHRLP
Mflv_2111|M.gilvum_PYR-GCK PRVDERRVGKRHRYGYAPCVG--DGTGDDE---LLKHDLVGGNSLTRAFG
MAB_3874c|M.abscessus_ATCC_199 PRINETFTGKKHRYGYLPDVENFFGSGEAAGASIVKYDYETGSTLSSRLD
Mb0937c|M.bovis_AF2122/97 GTINADYAASSYRYTYAATGK----PSWFLFDGLVKHDLLTGNHECYSFG
Rv0913c|M.tuberculosis_H37Rv GTINADYAASSYRYTYAATGK----PSWFLFDGLVKHDLLTGNHECYSFG
MMAR_4614|M.marinum_M GTINSDYAARQYRYAYAATGK----PGWFLFDGLVKHDLLTGNQEGISFG
MUL_0155|M.ulcerans_Agy99 GTINSDYAARQYRYAYAATGK----PGWFLFDGLVKHDLLTGNQEGISFG
. : * : : *
Mvan_0203|M.vanbaalenii_PYR-1 EPGNSFCEPVFAPRPGATAEDDGWLLTVEYRAAHKTSRLVILDAADPSRG
MAV_3153|M.avium_104 -PGHVLVEPIFVPRPGGTAEDDGWLLTVGYDESRHRSRLMVVDAAHVADG
MSMEG_1564|M.smegmatis_MC2_155 -DGHLPHEAIFAAHPDGVDEDDGWLLVPVIDGVENIASLIILDAKDIEAG
TH_3525|M.thermoresistible__bu -PGHLAHEPVFIPRPGGAAEDDGWLAVVVQDCHRHRAHLRLLDAGAVSAD
Mflv_2111|M.gilvum_PYR-GCK -NGKVAGEFVFHPSSPDAAEDDGVLMGYVYDRTTDRSELAILDAATLED-
MAB_3874c|M.abscessus_ATCC_199 -PAIVLGEMSFVPNPTCAAEDDGVLIGFAVDRRSDEGQLLLLDATSLDL-
Mb0937c|M.bovis_AF2122/97 -DGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDG
Rv0913c|M.tuberculosis_H37Rv -DGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDG
MMAR_4614|M.marinum_M -EGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARIADG
MUL_0155|M.ulcerans_Agy99 -EGVYGSETQMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARIADG
. * : . **** * . . :.**
Mvan_0203|M.vanbaalenii_PYR-1 PVATAQLASHIPQGFHGNFSARTS----------------
MAV_3153|M.avium_104 PVAEAWLQFHVPMSYHGTFTTRVAQRTG------------
MSMEG_1564|M.smegmatis_MC2_155 PVYQGRLRHHLPLTFHGCYTPRVAAPA-------------
TH_3525|M.thermoresistible__bu PVFTGHLRHSMPLTFHGCFTPRVGRSG-------------
Mflv_2111|M.gilvum_PYR-GCK -VATVKLPHRVPSGFHGNWVPTA-----------------
MAB_3874c|M.abscessus_ATCC_199 -MATVHLPQRVPAGFHGNWAPR------------------
Mb0937c|M.bovis_AF2122/97 PICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
Rv0913c|M.tuberculosis_H37Rv PICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL
MMAR_4614|M.marinum_M PVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
MUL_0155|M.ulcerans_Agy99 PVCKLELPERISSGTHSTWVPGNELRRWHHADSAPSAIGL
: * :. *. : .