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MPATSYSRLMTDRGHWDRRYTARGSLSVDDVALPARFTPFADVFPTGGRAVELACGAGAASVWLAKRGLS VWACDASSVAIAQAEDLAERCGQAHRCRFEVVDLDAGLPAGDPVDVLLCNMFRDPRLDGPIVDRLAVGGV LAISALSEVGAAPGRFRARPGELVAAFGSLELITHGEEAGQAWLLARRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2956 | - | - | 100% (189) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 4e-08 | 29.66% (145) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_5314 | - | 3e-06 | 32.93% (82) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0333 | - | 3e-06 | 30.32% (155) | hypothetical protein Mb0333 |
| M. gilvum PYR-GCK | Mflv_3243 | - | 2e-65 | 65.73% (178) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv3120 | - | 5e-07 | 29.95% (197) | hypothetical protein Rv3120 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2640 | - | 3e-52 | 57.63% (177) | methyltransferase |
| M. avium 104 | MAV_2957 | - | 6e-56 | 61.36% (176) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4544 | - | 1e-49 | 58.10% (179) | methyltransferase small subunit |
| M. thermoresistible (build 8) | TH_2727 | - | 4e-25 | 61.18% (85) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_3115 | - | 6e-52 | 56.50% (177) | methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2956|M.vanbaalenii_PYR-1 ------------------------------------MPATSYSRLMTDRG
Mflv_3243|M.gilvum_PYR-GCK ------------------------------------MAD-------ADRE
MMAR_2640|M.marinum_M MSRTAERADRLSIRYPVCSPTAQVRRSCRGRRMVARVAE-------SDRR
MUL_3115|M.ulcerans_Agy99 ---------------------------------MARVAE-------SDRR
MAV_2957|M.avium_104 ------------------------------------MGE-------ADRH
TH_2727|M.thermoresistible__bu --------------------------------------------------
MSMEG_4544|M.smegmatis_MC2_155 ------------------------------------MSE-------HDRA
Mb0333|M.bovis_AF2122/97 ----------------------------MGPKGSLRLVKRQPELLVAQHE
Rv3120|M.tuberculosis_H37Rv ----------------------------MSPSPSALLAD------HPDRI
Mvan_2956|M.vanbaalenii_PYR-1 HWDRRYTARGSLS---VDDVALPARFTPFADVFPTGGRAVELACGAGAAS
Mflv_3243|M.gilvum_PYR-GCK HWDRRYTARDRTL---AGHAALPAVFASHSDLFPTAGYAIELACGTGAAA
MMAR_2640|M.marinum_M RWDRRYASLGPAA---VSAARPPALLQAHLKLVPTAGRALDLGCGQGLGA
MUL_3115|M.ulcerans_Agy99 RWDRRYASLGPAA---VSAVRPPALLQAHLKLVPAAGRALDLGCGQGLGA
MAV_2957|M.avium_104 RWDERYAANGPPP---LSSVAPPGVFARHADVFPAAGRALDLACGQGTAA
TH_2727|M.thermoresistible__bu --------------------------------------------------
MSMEG_4544|M.smegmatis_MC2_155 RWDAAYTDRPLGAGLPDGPAGPPRAFAGHVDEFPTAGSALDVACGSGENS
Mb0333|M.bovis_AF2122/97 HWQDTYRAHPVLYG---TRPSEPGVYAAEVFNADGVQRVLELAAGHGRDT
Rv3120|M.tuberculosis_H37Rv RWNAKYECADPTE----AVFAPISWLGDVLQFGVPEGPVLELACGRSGTA
Mvan_2956|M.vanbaalenii_PYR-1 VWLAKRGLSVWACDASSVAIAQAEDLAERCGQAHRCRFEVVDLDAGLPA-
Mflv_3243|M.gilvum_PYR-GCK VWLARRGLRVWACDISPVAVAAATERARLDGQSERCTFEVVDLDHGIPG-
MMAR_2640|M.marinum_M VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCCFDVVDLDDGLPD-
MUL_3115|M.ulcerans_Agy99 VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCRFDVVDLDDGLPD-
MAV_2957|M.avium_104 VWLALRGLRVLGLDVSPVAIGQARDLARRAGVGERCRFDVADLDRGLPV-
TH_2727|M.thermoresistible__bu -------MDVLGVDVSPIAIAQARALAAANGVSNRCRFEVFDLDDGLPA-
MSMEG_4544|M.smegmatis_MC2_155 VWLARRGLHVWGIDVSPVAITQATQFAARNGVAQRCRFDVVDLDDGLPD-
Mb0333|M.bovis_AF2122/97 LYFAGQGFTVVATDFSDVAVAQLRRSAQARGVSARVQPIVHDLRQPLPVK
Rv3120|M.tuberculosis_H37Rv LGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSG-
* . * * *: * . * ** .
Mvan_2956|M.vanbaalenii_PYR-1 -----GDPVDVLLCNMFRDPRLDGPIVDR---LAVGGVLAISALS-----
Mflv_3243|M.gilvum_PYR-GCK -----VGPADVVLCSMFRDPRLDAALVER---LAPGGLLAVSALS-----
MMAR_2640|M.marinum_M -----GPPVDVIVCHNFRDRRLDAAIIDR---LAPGGLVALVALS-----
MUL_3115|M.ulcerans_Agy99 -----GPPVDLIVCHNFRDRRLDAAIIER---LAPGGLVALVALS-----
MAV_2957|M.avium_104 -----GPPADVIVCCKFRDRRLDRAIVER---LAPGGLLAIAVLS-----
TH_2727|M.thermoresistible__bu -----GPPADVILCHLYRDPRLDRPIIER---LAPGGLLAITVLS-----
MSMEG_4544|M.smegmatis_MC2_155 -----GPPVDVVLCHRFRDPRLYEALRAR---LAPGGLLAICVLS-----
Mb0333|M.bovis_AF2122/97 TGSIDGAFAHMALCMALSTSEIHAVVAEVGRVLRPGGKFIYTVRH-----
Rv3120|M.tuberculosis_H37Rv -----DGRFALVLCRLFWHPPTFRQACEA---VAPGGVVAWEAWRRPIDV
: :* : ** . .
Mvan_2956|M.vanbaalenii_PYR-1 EVGAAPGRFRARPGELVAAFGSLELITHGE---EAGQAWLLARRR-----
Mflv_3243|M.gilvum_PYR-GCK EVGAAPGRFRAGPGELLRAFGAVDVIEHGE---ADGQAWLLGRRRGLPQR
MMAR_2640|M.marinum_M EVGAAAGTYRAAPGELSAAFAELDPIAAGE---GDGRAWLLARA------
MUL_3115|M.ulcerans_Agy99 EVGAAAGTYRAAPGELSTAFAELDPIAAGE---GDGRAWLLARA------
MAV_2957|M.avium_104 EVGAGPGPFRAAPGELTAAFADLQPIAAGE---ADGQAWLLARASQSEPM
TH_2727|M.thermoresistible__bu EVGVGPX---------SHTLAGPAPQAR-------SRAWPVAGNRSS---
MSMEG_4544|M.smegmatis_MC2_155 EVGAEAGRFRAPAGELRAHFGALQVIAENE---RDGEAWLLAR-------
Mb0333|M.bovis_AF2122/97 TGDAHYGAGQAHGDDIFECAGFAVHFFRRELVARLATGWVLEEVHDFEEG
Rv3120|M.tuberculosis_H37Rv ARDTRRAEWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL---
.. . :
Mvan_2956|M.vanbaalenii_PYR-1 -------------------
Mflv_3243|M.gilvum_PYR-GCK APQAHRDPDDRPAHPDELL
MMAR_2640|M.marinum_M -------------------
MUL_3115|M.ulcerans_Agy99 -------------------
MAV_2957|M.avium_104 VERR---------------
TH_2727|M.thermoresistible__bu -------------------
MSMEG_4544|M.smegmatis_MC2_155 -------------------
Mb0333|M.bovis_AF2122/97 ELPRRLWRVTVTKPA----
Rv3120|M.tuberculosis_H37Rv -------------------