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VADADREHWDRRYTARDRTLAGHAALPAVFASHSDLFPTAGYAIELACGTGAAAVWLARRGLRVWACDIS PVAVAAATERARLDGQSERCTFEVVDLDHGIPGVGPADVVLCSMFRDPRLDAALVERLAPGGLLAVSALS EVGAAPGRFRAGPGELLRAFGAVDVIEHGEADGQAWLLGRRRGLPQRAPQAHRDPDDRPAHPDELL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3243 | - | - | 100% (206) | methyltransferase type 12 |
| M. gilvum PYR-GCK | Mflv_2895 | - | 5e-13 | 35.25% (139) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_4692 | - | 5e-07 | 38.38% (99) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3351c | - | 5e-10 | 29.74% (195) | methyltransferase |
| M. tuberculosis H37Rv | Rv3322c | - | 5e-10 | 29.74% (195) | methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3178 | - | 1e-08 | 31.17% (154) | hypothetical protein MAB_3178 |
| M. marinum M | MMAR_2640 | - | 2e-53 | 56.67% (180) | methyltransferase |
| M. avium 104 | MAV_2957 | - | 3e-57 | 59.44% (180) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4544 | - | 3e-53 | 57.30% (185) | methyltransferase small subunit |
| M. thermoresistible (build 8) | TH_2727 | - | 4e-24 | 53.61% (97) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. ulcerans Agy99 | MUL_3115 | - | 1e-52 | 55.56% (180) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2956 | - | 2e-65 | 65.73% (178) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3351c|M.bovis_AF2122/97 ----------------------------------MSVQTDPALREHPNRV
Rv3322c|M.tuberculosis_H37Rv ----------------------------------MSVQTDPALREHPNRV
Mflv_3243|M.gilvum_PYR-GCK ------------------------------------MAD-------ADRE
Mvan_2956|M.vanbaalenii_PYR-1 ------------------------------------MPATSYSRLMTDRG
MMAR_2640|M.marinum_M MSRTAERADRLSIRYPVCSPTAQVRRSCRGRRMVARVAE-------SDRR
MUL_3115|M.ulcerans_Agy99 ---------------------------------MARVAE-------SDRR
MAV_2957|M.avium_104 ------------------------------------MGE-------ADRH
TH_2727|M.thermoresistible__bu --------------------------------------------------
MSMEG_4544|M.smegmatis_MC2_155 ------------------------------------MSE-------HDRA
MAB_3178|M.abscessus_ATCC_1997 ------------------------------------MHDHN--NPPSDEK
Mb3351c|M.bovis_AF2122/97 DWNARYER----AGSAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTA
Rv3322c|M.tuberculosis_H37Rv DWNARYER----AGSAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTA
Mflv_3243|M.gilvum_PYR-GCK HWDRRYTAR---DRTLAGHAALPAVFASHSDLFPTAGYAIELACGTGAAA
Mvan_2956|M.vanbaalenii_PYR-1 HWDRRYTAR---GSLSVDDVALPARFTPFADVFPTGGRAVELACGAGAAS
MMAR_2640|M.marinum_M RWDRRYAS--LGP-AAVSAARPPALLQAHLKLVPTAGRALDLGCGQGLGA
MUL_3115|M.ulcerans_Agy99 RWDRRYAS--LGP-AAVSAVRPPALLQAHLKLVPAAGRALDLGCGQGLGA
MAV_2957|M.avium_104 RWDERYAA--NGP-PPLSSVAPPGVFARHADVFPAAGRALDLACGQGTAA
TH_2727|M.thermoresistible__bu --------------------------------------------------
MSMEG_4544|M.smegmatis_MC2_155 RWDAAYTDRPLGAGLPDGPAGPPRAFAGHVDEFPTAGSALDVACGSGENS
MAB_3178|M.abscessus_ATCC_1997 SWDEFYQS----HDALWSGNANPQLVAEISSLPPR--TALDAGCGEGGDA
Mb3351c|M.bovis_AF2122/97 LALAAHGRQVTAIDVSDVALLQLDSEAVRRG--VADRLNLVQADLGCWEP
Rv3322c|M.tuberculosis_H37Rv LALAAHGRQVTAIDVSDVALLQLDSEAVRRG--VADRLNLVQADLGCWEP
Mflv_3243|M.gilvum_PYR-GCK VWLARRGLRVWACDISPVAVAAATERARLDG--QSERCTFEVVDLDHGIP
Mvan_2956|M.vanbaalenii_PYR-1 VWLAKRGLSVWACDASSVAIAQAEDLAERCG--QAHRCRFEVVDLDAGLP
MMAR_2640|M.marinum_M VWLARRGLDVLGLDISPVAIAQARDLAERSG--VSARCCFDVVDLDDGLP
MUL_3115|M.ulcerans_Agy99 VWLARRGLDVLGLDISPVAIAQARDLAERSG--VSARCRFDVVDLDDGLP
MAV_2957|M.avium_104 VWLALRGLRVLGLDVSPVAIGQARDLARRAG--VGERCRFDVADLDRGLP
TH_2727|M.thermoresistible__bu -------MDVLGVDVSPIAIAQARALAAANG--VSNRCRFEVFDLDDGLP
MSMEG_4544|M.smegmatis_MC2_155 VWLARRGLHVWGIDVSPVAITQATQFAARNG--VAQRCRFDVVDLDDGLP
MAB_3178|M.abscessus_ATCC_1997 IWLAQHGWQVTGMDFAHTALRRAADNAVKVDPELANRISWTQADLTAWQP
* . * : *: * . . * ** *
Mb3351c|M.bovis_AF2122/97 GETRFALVLSRLFWDAA-----IFHRACEAVMPGGVLAWESLALSGAEAG
Rv3322c|M.tuberculosis_H37Rv GETRFALVLSRLFWDAA-----IFHRACEAVMPGGVLAWESLALSGAEAG
Mflv_3243|M.gilvum_PYR-GCK GVGPADVVLCSMFRDPR-----LDAALVERLAPGGLLAVSALS----EVG
Mvan_2956|M.vanbaalenii_PYR-1 AGDPVDVLLCNMFRDPR-----LDGPIVDRLAVGGVLAISALS----EVG
MMAR_2640|M.marinum_M DGPPVDVIVCHNFRDRR-----LDAAIIDRLAPGGLVALVALS----EVG
MUL_3115|M.ulcerans_Agy99 DGPPVDLIVCHNFRDRR-----LDAAIIERLAPGGLVALVALS----EVG
MAV_2957|M.avium_104 VGPPADVIVCCKFRDRR-----LDRAIVERLAPGGLLAIAVLS----EVG
TH_2727|M.thermoresistible__bu AGPPADVILCHLYRDPR-----LDRPIIERLAPGGLLAITVLS----EVG
MSMEG_4544|M.smegmatis_MC2_155 DGPPVDVVLCHRFRDPR-----LYEALRARLAPGGLLAICVLS----EVG
MAB_3178|M.abscessus_ATCC_1997 N-RQFDLVTSHFMHLPTNLREPVFAALAAAVAPGGTLLIVGHHP--SDMQ
:: . : : ** : :
Mb3351c|M.bovis_AF2122/97 TASAKRRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA-
Rv3322c|M.tuberculosis_H37Rv TASAKRRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA-
Mflv_3243|M.gilvum_PYR-GCK AAPGRFRAGPGE----LLRAFGAVDVIEHGEADGQAWLLGRRRGLPQRAP
Mvan_2956|M.vanbaalenii_PYR-1 AAPGRFRARPGE----LVAAFGSLELITHGEEAGQAWLLARRR-------
MMAR_2640|M.marinum_M AAAGTYRAAPGE----LSAAFAELDPIAAGEGDGRAWLLARA--------
MUL_3115|M.ulcerans_Agy99 AAAGTYRAAPGE----LSTAFAELDPIAAGEGDGRAWLLARA--------
MAV_2957|M.avium_104 AGPGPFRAAPGE----LTAAFADLQPIAAGEADGQAWLLARASQSEPMVE
TH_2727|M.thermoresistible__bu VGPX-------------SHTLAGPAPQAR----SRAWPVAGNRSS-----
MSMEG_4544|M.smegmatis_MC2_155 AEAGRFRAPAGE----LRAHFGALQVIAENERDGEAWLLAR---------
MAB_3178|M.abscessus_ATCC_1997 AAIGRPDLPDWYFTAEDIADTLNPKEWTIIVAESRSRKFTRDDEEFDIAD
. . : .
Mb3351c|M.bovis_AF2122/97 -----------------
Rv3322c|M.tuberculosis_H37Rv -----------------
Mflv_3243|M.gilvum_PYR-GCK QAHRDPDDRPAHPDELL
Mvan_2956|M.vanbaalenii_PYR-1 -----------------
MMAR_2640|M.marinum_M -----------------
MUL_3115|M.ulcerans_Agy99 -----------------
MAV_2957|M.avium_104 RR---------------
TH_2727|M.thermoresistible__bu -----------------
MSMEG_4544|M.smegmatis_MC2_155 -----------------
MAB_3178|M.abscessus_ATCC_1997 TVLRAERKPTTESA---