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IGGAGSSGRLLLSGTRRDCRNHATPTVGRMDDLHAVLASARSHALGDIPRRSARKQPDKIAIIDGDVCLS FAEFERLVDRAAAALSDNGFGVGDRLALLAHNCWQYAVLAFATARAGVVLVPINFMLTAEEISFILGHSQ VTGFVVEADLVPTAEAAMQLAGNVATGAALVPPGQSLPDGWTDFAQWLQTDSTAPNPHIDDDQLIRLMYT SGTESHPKGAQHSSRSLMGNYVSTIIAGSMESADIEIHSLPLYHCAQLDNFLITDVYLGATSIIVSRPDP ELVLRTIEKHEVTNYFAPPTVWISLLRSPVFDQVDLSSLRKGYYGASAMPVEILAEMRERLPNLRLWNFY GQTEMAPLASALGPDEQDAHAGSAGRPVINVETAILDDDNSPVAPGVVGEIAHRSPHLMLGYLDDDAKTA ESFRGGWFHSGDLGYYDGHGLLHVVDRKKDMIKTGGENVASREVEEVIYRHSAVEEVAVFGLPHPVWVEA VVAAVVVRDGMEVTEDELASHCRAHLAGFKTPKQVYFVDSLPKNPSGKLLKRSLREQFGVDRGALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2882 | - | - | 100% (557) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4008 | - | 1e-80 | 36.43% (516) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 3e-76 | 37.14% (517) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 1e-69 | 34.13% (504) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4559 | - | 0.0 | 69.87% (521) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 7e-70 | 34.33% (504) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-57 | 29.45% (506) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 2e-77 | 35.50% (507) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0409 | fadD5 | 5e-70 | 33.86% (505) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_5018 | - | 5e-70 | 34.59% (503) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2883 | - | 0.0 | 86.16% (513) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2591 | - | 0.0 | 83.04% (519) | PUTATIVE feruloyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-59 | 31.87% (502) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2882|M.vanbaalenii_PYR-1 --MIGGAGSSGRLLLSGTRRDCRNHATPTVGRMDDLHAVLASARSHALGD
MSMEG_2883|M.smegmatis_MC2_155 --------------------------------------MLASTRSHALGD
TH_2591|M.thermoresistible__bu --------------------------------MDDLHAVVASARGHALGD
Mflv_4559|M.gilvum_PYR-GCK ------------------------------MPEDLLAAQIRRVRSQTVGD
Mb0172|M.bovis_AF2122/97 --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Rv0166|M.tuberculosis_H37Rv --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
MAV_5018|M.avium_104 ---------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVN
MAB_4569c|M.abscessus_ATCC_199 --------------------MTDTIDATVQSAG---LAQPYRARRQNWCN
MUL_4126|M.ulcerans_Agy99 ----------------------------------------MTSDPRTVPT
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Mvan_2882|M.vanbaalenii_PYR-1 IPRRSARKQPDKIAIIDGDVCLSFAEFERLVDRAAAALSDNGFGVGDRLA
MSMEG_2883|M.smegmatis_MC2_155 IPRRSARRCPDKVAIIDGDVTLTFAEFEHHVDRAAAALQDNGFGVGDRVA
TH_2591|M.thermoresistible__bu IPRRSARRHPDKVAIIDGDVTWTFAEFEHWVDRAAAALSDHGFAPGDRVA
Mflv_4559|M.gilvum_PYR-GCK IPRRSARRHPHKLAIVDGTTRLTFAELDAHVDRVASALRDSGFGKGDRIA
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
MAV_5018|M.avium_104 QLERHALMQPNATALRFLGKGLTWGELHGRVRALADALSRRGVGFGDRVM
MAB_4569c|M.abscessus_ATCC_199 QLARHALMQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVL
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTDERSFTVSELNDEVYRAAAALIELGVKPAARVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
. * *: : :: . * .* *. . :
Mvan_2882|M.vanbaalenii_PYR-1 LLAHNCWQYAVLAFATARAGVVLVPINFMLTAEEISFILGHSQVTGFVVE
MSMEG_2883|M.smegmatis_MC2_155 VLAHNCWQYAVLAFATARAGVVLVPVNFMLTAEEICYILGHSRAGGFLVE
TH_2591|M.thermoresistible__bu VLSRNCRQFAVLAFATARAGVVLVPINFMLTAEEISYILGHCGARGFLVE
Mflv_4559|M.gilvum_PYR-GCK LLSHNCWQYAVLAFATARAGVVMVPVNFMLGPDEIAFILGHSKVTGFVVE
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
MAV_5018|M.avium_104 VLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVITE
MAB_4569c|M.abscessus_ATCC_199 ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * : . *. : :* : : .
Mvan_2882|M.vanbaalenii_PYR-1 ADLVPTAEAAMQLAGN--VATGAALVPPGQSLPDGWTDFAQWLQTDS-TA
MSMEG_2883|M.smegmatis_MC2_155 ADLVPTAEAAMRLGGS--VTTTAALVLPGQGLPAGWTDFDRWLQTDS-PA
TH_2591|M.thermoresistible__bu ADLVPTAEAAMRLGGS--VTTTAALVLPGQALPPGWTDFDRWLQTTS-PA
Mflv_4559|M.gilvum_PYR-GCK TALVPVADEAMAAAGEDCAVTTRIAITSGDPVPAGWQDYAHWSQSAATPA
Mb0172|M.bovis_AF2122/97 AALAPVAIGVRNIQPL-----LSVIVVAGGSSQDSVFGYEDLLNEAGDVH
Rv0166|M.tuberculosis_H37Rv AALAPVAIGVRNIQPL-----LSVIVVAGGSSQDSVFGYEDLLNEAGDVH
MMAR_0409|M.marinum_M EVLAQVAVGVREIAPA-----LSTIVVAGGASDPTVVGYDELISETGDPP
MAV_5018|M.avium_104 AVLAPVATGVRDIESL-----LDTVVVAGGSSDDAVLGYDDLIDETGAAH
MAB_4569c|M.abscessus_ATCC_199 TVLAPVAAAVRQQAPA-----LETVIVAGSASENGVLGYEEVIAEPGEPH
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGAVTA
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGK----LRALGVNPDEEEPPGSTDETLAELIARSSS
. :
Mvan_2882|M.vanbaalenii_PYR-1 PNPHIDDDQLIRLMYTSGTESHPKGAQHSSRSLMGNYVSTIIAGSMES-A
MSMEG_2883|M.smegmatis_MC2_155 PAPYVADDQMIRLMYTSGTESHPKGAMHSTRSLMGNYISSIIAGSMEG-T
TH_2591|M.thermoresistible__bu PHPYVADDQMIRLMYTSGTESRPKGAMHSSRSLMGNYVSTIIAGSMES-G
Mflv_4559|M.gilvum_PYR-GCK PAVEIADDDVLRLMYTSGTESRPKGVMHTSRSLMWQYISSIVAGSMSG-E
Mb0172|M.bovis_AF2122/97 EPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANINS
Rv0166|M.tuberculosis_H37Rv EPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANINS
MMAR_0409|M.marinum_M EPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANINS
MAV_5018|M.avium_104 QPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADINN
MAB_4569c|M.abscessus_ATCC_199 AEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDLNS
MUL_4126|M.ulcerans_Agy99 RAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITA-D
MLBr_02546|M.leprae_Br4923 APAPKVRKRASIIILTSGTTGTPKGANRN-TPASLAPLGGILSKVPFRAH
. :: *:** . .**.
Mvan_2882|M.vanbaalenii_PYR-1 DIEIHSLPLYHCAQLDNFLITDVYLGATSIIVSR--PDPELVLRTIEKHE
MSMEG_2883|M.smegmatis_MC2_155 DIEIHSLPLYHCAQMDNFFITDIYLGATSIILPR--PEPELVLRTIEKYG
TH_2591|M.thermoresistible__bu DVEIHSLPLYHCAQLDNFLITDVYLGATSIILPR--PDPELVLRTIERHR
Mflv_4559|M.gilvum_PYR-GCK DVEIHSMPLYHCAQLDNFLITDVYLGATSIILPG--PDPEAILRTIEAEQ
Mb0172|M.bovis_AF2122/97 DVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
Rv0166|M.tuberculosis_H37Rv DVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
MMAR_0409|M.marinum_M DVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAER
MAV_5018|M.avium_104 DVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAAEK
MAB_4569c|M.abscessus_ATCC_199 DVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLESEG
MUL_4126|M.ulcerans_Agy99 DRHLCINPFFHNFGYKAGILACLQTGAT--LFPHLTFDPLRTLQAIERHR
MLBr_02546|M.leprae_Br4923 EVTLLPAPMFHALGYLHATLA-MFLGSTLVLRRR--FKPATVLEDIEKHQ
: : *::* :: : * . : .* * :
Mvan_2882|M.vanbaalenii_PYR-1 VTNYFAPPTVWISLLR--SPVFDQVDLSSLRKGYYGASAMPVEILAEMRE
MSMEG_2883|M.smegmatis_MC2_155 VTNYFAPPTVWISLLR--SPVFDQVDLTSLRKGYYGASAMPVEILAEMRE
TH_2591|M.thermoresistible__bu VTNYFAPPTVWISLLR--SPVFDTVDLSSLRKGYYGASAMPAEILAEIRD
Mflv_4559|M.gilvum_PYR-GCK VTNFFAPPTVWIALLR--CPAFDRYDLTSLRKGYYGASAMPREILHELRD
Mb0172|M.bovis_AF2122/97 VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
Rv0166|M.tuberculosis_H37Rv VTGIFLVPAQWQAVCT--EQQARPRDLR-LRVLSWGAAPAPDALLRQMSA
MMAR_0409|M.marinum_M VSGIFLVPAQWQAVCA--EQQARPRELS-LRVMSWGAAPAPDALLRQMSE
MAV_5018|M.avium_104 VTGIFLVPAQWQAVCA--EQRARPRDLK-LRVISWGAAPAPDALLREMSA
MAB_4569c|M.abscessus_ATCC_199 VTGIFLVPAQWQAVCA--AQQANPRKVR-LKTLSWGAAPATDVLLRTMSE
MUL_4126|M.ulcerans_Agy99 ITVLPGPPTIYQTLLD--HPARDDYDLSSLRFAVTGAATVPVVLVERMQS
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
: *. : .: *: ..: :
Mvan_2882|M.vanbaalenii_PYR-1 RLPNLRLWNFYGQTEMAPLASALGPDE-QDAHAGSAGRPVINVETAILDD
MSMEG_2883|M.smegmatis_MC2_155 RLPNLRLWNFYGQTEMAPLASALGPDE-QDAHAGAAGRPVINVETAILDD
TH_2591|M.thermoresistible__bu RLPGLRLWNFYGQTEMAPLATALGPDE-QDAHAGAAGRPVTNVETVILDD
Mflv_4559|M.gilvum_PYR-GCK RLPNVSLWNFYGQTEIAPLASSLGPDE-QDRHGGAAGRPAVNVETAILDD
Mb0172|M.bovis_AF2122/97 TFPETQILAAFGQTEMSPVTCMLLGED-AIAKRGSVGRVIPTVAARVVDQ
Rv0166|M.tuberculosis_H37Rv TFPETQILAAFGQTEMSPVTCMLLGED-AIAKRGSVGRVIPTVAARVVDQ
MMAR_0409|M.marinum_M VFPGTQIMAAFGQTEMSPVTCMLLGED-AIRKRGSVGKVIPTVSARVVDD
MAV_5018|M.avium_104 MFPGTQILAAFGQTEMSPVTCMLLGED-AIRKRGSVGKVIPTVAARVVDE
MAB_4569c|M.abscessus_ATCC_199 TFPDARILAAFGQTEMSPVTCMLMGDD-AIRKMGSVGRVIPTVSARVVDD
MUL_4126|M.ulcerans_Agy99 ELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFELRIGPD
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIA-FATIAGPKD-LQINSATVGPVVKGVKVKILDD
: : :* ** . .: : * . : :
Mvan_2882|M.vanbaalenii_PYR-1 DNSPVAPGVVGEIAHRSPHLMLGYLDDDAKTAESFRGG-WFHSGDLGYYD
MSMEG_2883|M.smegmatis_MC2_155 DNRPVPPGEVGEIAHRSPHLMLGYLDDEAKTAEAFRGG-WFHSGDLGYYD
TH_2591|M.thermoresistible__bu DGAVLPAGTVGEIAHRSPHLMLGYYDDPAKTAEAFRGG-WFHSGDLGYFD
Mflv_4559|M.gilvum_PYR-GCK SDNPVPPGTVGEIAHRSPHLMVGYLDDPQRTAEAFRGD-WFHSGDLGYYD
Mb0172|M.bovis_AF2122/97 NMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRMD
Rv0166|M.tuberculosis_H37Rv NMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSGDLVRMD
MMAR_0409|M.marinum_M EMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGG-WFHSGDLVRMD
MAV_5018|M.avium_104 NMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGG-WFHSGDLVRMD
MAB_4569c|M.abscessus_ATCC_199 NMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGG-WFHSGDLVRQD
MUL_4126|M.ulcerans_Agy99 T---------GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLD
MLBr_02546|M.leprae_Br4923 SGKEVPRGQVGRIFVGNAFPFEGYTGG---GGKQIIDG-LLSSGDVGYFD
*.: . : * .. . : . : :**: *
Mvan_2882|M.vanbaalenii_PYR-1 GHGLLHVVDRKKDMIKTGGENVASREVEEVIYRHSAVEEVAVFGLPHPVW
MSMEG_2883|M.smegmatis_MC2_155 EHGLLHVVDRKKDMIKTGGENVASREVEEAVYRHPAVEEVAVFGLPHPTW
TH_2591|M.thermoresistible__bu EHGMLHVVDRKKDMINTGGENVASREVEEVIYRHPAVEEVAVFGLPHPTW
Mflv_4559|M.gilvum_PYR-GCK EFGLLHVVDRKKDMIKSGGENVASREVEEVLYQHDDVQEAAVFGLPHPVW
Mb0172|M.bovis_AF2122/97 SDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKW
Rv0166|M.tuberculosis_H37Rv SDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKW
MMAR_0409|M.marinum_M EDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRADEKW
MAV_5018|M.avium_104 EDGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAHEKW
MAB_4569c|M.abscessus_ATCC_199 EDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEKW
MUL_4126|M.ulcerans_Agy99 EAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRL
MLBr_02546|M.leprae_Br4923 EHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEW
. : : .* .:* ** *: *:*: : : :.:.:* .
Mvan_2882|M.vanbaalenii_PYR-1 VEAVVAAVVVRDGMEVTEDELASHCRAHLAGFKTPKQVYFVDSLPKNPSG
MSMEG_2883|M.smegmatis_MC2_155 VEAVVAAVVTRDGAELTEDELLTHCRSCLAGFKTPKQVFFVESLPKNPSG
TH_2591|M.thermoresistible__bu VEAVVAAVVTRNGMTLGEEELLGHCREHLAGFKTPKQVFFVDSLPKNPSG
Mflv_4559|M.gilvum_PYR-GCK VEAVVAAVVPREGRVLDPDAVIAHCRSRLAGFKTPKQIFTVAELPKNPSG
Mb0172|M.bovis_AF2122/97 GEVPIAVAAVTN-DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAG
Rv0166|M.tuberculosis_H37Rv GEVPIAVAAVTN-DDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAG
MMAR_0409|M.marinum_M GEVPIAVAAVTK-DHLRIEDLDEYLTERLARYKHPKALEIVDALPRNPSG
MAV_5018|M.avium_104 GEVPIAVAAVAN-DNLALEDLDEFLTERLARYKHPKALEIVDALPRNPAG
MAB_4569c|M.abscessus_ATCC_199 GEVPVAVAAIHG-AALTLAELDGFLTARLARYKHPKDLVIVDALPRNPSG
MUL_4126|M.ulcerans_Agy99 GEVGRAFIVARPGFNLDEKSVIDYTREHLANFKAPRSVRFVDTLPRNAGG
MLBr_02546|M.leprae_Br4923 GARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNPTG
* . : : . ** :* *: : : **:*. *
Mvan_2882|M.vanbaalenii_PYR-1 KLLKRSLREQFG-VDRGALS----------------
MSMEG_2883|M.smegmatis_MC2_155 KLLKRVLRERFARTTTDAI-----------------
TH_2591|M.thermoresistible__bu KLLKRVLRERYSEKAPH-------------------
Mflv_4559|M.gilvum_PYR-GCK KLLKRELRERFASAMN--------------------
Mb0172|M.bovis_AF2122/97 KVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv KVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M KVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104 KVLKTELRIRYGGG----------------------
MAB_4569c|M.abscessus_ATCC_199 KVLKTELRQRFGIAD---------------------
MUL_4126|M.ulcerans_Agy99 KVVKPQLRELA-------------------------
MLBr_02546|M.leprae_Br4923 KVLKRELRDFEVH-----------------------
*::* **