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MPEDLLAAQIRRVRSQTVGDIPRRSARRHPHKLAIVDGTTRLTFAELDAHVDRVASALRDSGFGKGDRIA LLSHNCWQYAVLAFATARAGVVMVPVNFMLGPDEIAFILGHSKVTGFVVETALVPVADEAMAAAGEDCAV TTRIAITSGDPVPAGWQDYAHWSQSAATPAPAVEIADDDVLRLMYTSGTESRPKGVMHTSRSLMWQYISS IVAGSMSGEDVEIHSMPLYHCAQLDNFLITDVYLGATSIILPGPDPEAILRTIEAEQVTNFFAPPTVWIA LLRCPAFDRYDLTSLRKGYYGASAMPREILHELRDRLPNVSLWNFYGQTEIAPLASSLGPDEQDRHGGAA GRPAVNVETAILDDSDNPVPPGTVGEIAHRSPHLMVGYLDDPQRTAEAFRGDWFHSGDLGYYDEFGLLHV VDRKKDMIKSGGENVASREVEEVLYQHDDVQEAAVFGLPHPVWVEAVVAAVVPREGRVLDPDAVIAHCRS RLAGFKTPKQIFTVAELPKNPSGKLLKRELRERFASAMN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4559 | - | - | 100% (529) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 1e-90 | 38.75% (511) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_0714 | - | 2e-78 | 36.84% (513) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 1e-72 | 35.48% (513) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 9e-73 | 35.67% (513) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-52 | 28.99% (507) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 1e-80 | 36.71% (523) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0409 | fadD5 | 3e-75 | 36.81% (508) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_2610 | - | 4e-76 | 35.07% (519) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_2883 | - | 0.0 | 72.27% (512) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2591 | - | 0.0 | 68.39% (522) | PUTATIVE feruloyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 6e-61 | 32.29% (511) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2882 | - | 0.0 | 69.87% (521) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2883|M.smegmatis_MC2_155 --------------------------------------MLASTRSHALGD
Mvan_2882|M.vanbaalenii_PYR-1 --MIGGAGSSGRLLLSGTRRDCRNHATPTVGRMDDLHAVLASARSHALGD
TH_2591|M.thermoresistible__bu --------------------------------MDDLHAVVASARGHALGD
Mflv_4559|M.gilvum_PYR-GCK ------------------------------MPEDLLAAQIRRVRSQTVGD
Mb0172|M.bovis_AF2122/97 --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Rv0166|M.tuberculosis_H37Rv --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
MAB_4569c|M.abscessus_ATCC_199 --------------------MTDTIDATVQSAG---LAQPYRARRQNWCN
MUL_4126|M.ulcerans_Agy99 ----------------------------------------MTSDPRTVPT
MAV_2610|M.avium_104 ---------------------------------------------MLIGD
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MSMEG_2883|M.smegmatis_MC2_155 IPRRSARRCPDKVAIIDGDVTLTFAEFEHHVDRAAAALQDNGFGVGDRVA
Mvan_2882|M.vanbaalenii_PYR-1 IPRRSARKQPDKIAIIDGDVCLSFAEFERLVDRAAAALSDNGFGVGDRLA
TH_2591|M.thermoresistible__bu IPRRSARRHPDKVAIIDGDVTWTFAEFEHWVDRAAAALSDHGFAPGDRVA
Mflv_4559|M.gilvum_PYR-GCK IPRRSARRHPHKLAIVDGTTRLTFAELDAHVDRVASALRDSGFGKGDRIA
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
MAB_4569c|M.abscessus_ATCC_199 QLARHALMQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVL
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTDERSFTVSELNDEVYRAAAALIELGVKPAARVG
MAV_2610|M.avium_104 IATNNSRRYPDKRALVDADRALTWSQVDDRARRLAAFLIGRGLVPGDRVM
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
* *: : :. . * * *. . :
MSMEG_2883|M.smegmatis_MC2_155 VLAHNCWQYAVLAFATARAGVVLVPVNFMLTAEEICYILGHSRAGGFLVE
Mvan_2882|M.vanbaalenii_PYR-1 LLAHNCWQYAVLAFATARAGVVLVPINFMLTAEEISFILGHSQVTGFVVE
TH_2591|M.thermoresistible__bu VLSRNCRQFAVLAFATARAGVVLVPINFMLTAEEISYILGHCGARGFLVE
Mflv_4559|M.gilvum_PYR-GCK LLSHNCWQYAVLAFATARAGVVMVPVNFMLGPDEIAFILGHSKVTGFVVE
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
MAB_4569c|M.abscessus_ATCC_199 ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MAV_2610|M.avium_104 VIARNCIEWPEISFGLAKAGLITVPVNIRLAPDEVAHVRDDSGARAVIIH
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * : . * : :* : : .
MSMEG_2883|M.smegmatis_MC2_155 ADLVPTAEAAMRLGGS--VTTTAALVLPGQGLPAGWTDFDRWLQTDS-PA
Mvan_2882|M.vanbaalenii_PYR-1 ADLVPTAEAAMQLAGN--VATGAALVPPGQSLPDGWTDFAQWLQTDS-TA
TH_2591|M.thermoresistible__bu ADLVPTAEAAMRLGGS--VTTTAALVLPGQALPPGWTDFDRWLQTTS-PA
Mflv_4559|M.gilvum_PYR-GCK TALVPVADEAMAAAGEDCAVTTRIAITSGDPVPAGWQDYAHWSQSAATPA
Mb0172|M.bovis_AF2122/97 AALAPVAIGVRNIQPL-----LSVIVVAGGSSQDSVFGYEDLLNEAGDVH
Rv0166|M.tuberculosis_H37Rv AALAPVAIGVRNIQPL-----LSVIVVAGGSSQDSVFGYEDLLNEAGDVH
MMAR_0409|M.marinum_M EVLAQVAVGVREIAPA-----LSTIVVAGGASDPTVVGYDELISETGDPP
MAB_4569c|M.abscessus_ATCC_199 TVLAPVAAAVRQQAPA-----LETVIVAGSASENGVLGYEEVIAEPGEPH
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTDTGAVTA
MAV_2610|M.avium_104 ADHLDKFLGELTELAL----ILGVGAHSMLGTSELVTDYETALAQAQPGA
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGK----LRALGVNPDEEEPPGSTDETLAELIARSSS
MSMEG_2883|M.smegmatis_MC2_155 PAPYVADDQMIRLMYTSGTESHPKGAMHSTRSLMGNYISSIIAGSMEG-T
Mvan_2882|M.vanbaalenii_PYR-1 PNPHIDDDQLIRLMYTSGTESHPKGAQHSSRSLMGNYVSTIIAGSMES-A
TH_2591|M.thermoresistible__bu PHPYVADDQMIRLMYTSGTESRPKGAMHSSRSLMGNYVSTIIAGSMES-G
Mflv_4559|M.gilvum_PYR-GCK PAVEIADDDVLRLMYTSGTESRPKGVMHTSRSLMWQYISSIVAGSMSG-E
Mb0172|M.bovis_AF2122/97 EPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANINS
Rv0166|M.tuberculosis_H37Rv EPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANINS
MMAR_0409|M.marinum_M EPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANINS
MAB_4569c|M.abscessus_ATCC_199 AEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDLNS
MUL_4126|M.ulcerans_Agy99 RAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITA-D
MAV_2610|M.avium_104 ERRDITPDDVAFILYTSGTTGRAKGVMHTHRALLYQAADTNLVTEANR-S
MLBr_02546|M.leprae_Br4923 APAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRA-H
. :: *:** . .**.
MSMEG_2883|M.smegmatis_MC2_155 DIEIHSLPLYHCAQMDNFFITDIYLGATSIILPR--PEPELVLRTIEKYG
Mvan_2882|M.vanbaalenii_PYR-1 DIEIHSLPLYHCAQLDNFLITDVYLGATSIIVSR--PDPELVLRTIEKHE
TH_2591|M.thermoresistible__bu DVEIHSLPLYHCAQLDNFLITDVYLGATSIILPR--PDPELVLRTIERHR
Mflv_4559|M.gilvum_PYR-GCK DVEIHSMPLYHCAQLDNFLITDVYLGATSIILPG--PDPEAILRTIEAEQ
Mb0172|M.bovis_AF2122/97 DVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
Rv0166|M.tuberculosis_H37Rv DVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
MMAR_0409|M.marinum_M DVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAER
MAB_4569c|M.abscessus_ATCC_199 DVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLESEG
MUL_4126|M.ulcerans_Agy99 DRHLCINPFFHNFGYKAGILACLQTGAT--LFPHLTFDPLRTLQAIERHR
MAV_2610|M.avium_104 DVMLATTPFFTAGGMV-RTVSWLYLGQTMVIHQR--FDPQAVIDEIERSA
MLBr_02546|M.leprae_Br4923 EVTLLPAPMFHALGYLHATLA-MFLGSTLVLRRR--FKPATVLEDIEKHQ
: : *:: :: : * . : .* : :*
MSMEG_2883|M.smegmatis_MC2_155 VTNYFAPPTVWISLLRSPV-FDQ-VDLTSLRKGYYGASAMPVEILAEMRE
Mvan_2882|M.vanbaalenii_PYR-1 VTNYFAPPTVWISLLRSPV-FDQ-VDLSSLRKGYYGASAMPVEILAEMRE
TH_2591|M.thermoresistible__bu VTNYFAPPTVWISLLRSPV-FDT-VDLSSLRKGYYGASAMPAEILAEIRD
Mflv_4559|M.gilvum_PYR-GCK VTNFFAPPTVWIALLRCPA-FDR-YDLTSLRKGYYGASAMPREILHELRD
Mb0172|M.bovis_AF2122/97 VTGIFLVPAQWQAVCTEQQ-ARP-RDLR-LRVLSWGAAPAPDALLRQMSA
Rv0166|M.tuberculosis_H37Rv VTGIFLVPAQWQAVCTEQQ-ARP-RDLR-LRVLSWGAAPAPDALLRQMSA
MMAR_0409|M.marinum_M VSGIFLVPAQWQAVCAEQQ-ARP-RELS-LRVMSWGAAPAPDALLRQMSE
MAB_4569c|M.abscessus_ATCC_199 VTGIFLVPAQWQAVCAAQQ-ANP-RKVR-LKTLSWGAAPATDVLLRTMSE
MUL_4126|M.ulcerans_Agy99 ITVLPGPPTIYQTLLDHPA-RDD-YDLSSLRFAVTGAATVPVVLVERMQS
MAV_2610|M.avium_104 ITFTTFIPTMLHRTLAILE-DGPPRDMSSLRRISYGSAPVPPGLARKAMD
MLBr_02546|M.leprae_Br4923 ATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALE
: *. .: *: ..: :
MSMEG_2883|M.smegmatis_MC2_155 RLPNLRLWNFYGQTEMAPLASALGPDE-------QDAHAGAAGRPVINVE
Mvan_2882|M.vanbaalenii_PYR-1 RLPNLRLWNFYGQTEMAPLASALGPDE-------QDAHAGSAGRPVINVE
TH_2591|M.thermoresistible__bu RLPGLRLWNFYGQTEMAPLATALGPDE-------QDAHAGAAGRPVTNVE
Mflv_4559|M.gilvum_PYR-GCK RLPNVSLWNFYGQTEIAPLASSLGPDE-------QDRHGGAAGRPAVNVE
Mb0172|M.bovis_AF2122/97 TFPETQILAAFGQTEMSPVTCMLLGED-------AIAKRGSVGRVIPTVA
Rv0166|M.tuberculosis_H37Rv TFPETQILAAFGQTEMSPVTCMLLGED-------AIAKRGSVGRVIPTVA
MMAR_0409|M.marinum_M VFPGTQIMAAFGQTEMSPVTCMLLGED-------AIRKRGSVGKVIPTVS
MAB_4569c|M.abscessus_ATCC_199 TFPDARILAAFGQTEMSPVTCMLMGDD-------AIRKMGSVGRVIPTVS
MUL_4126|M.ulcerans_Agy99 ELDIDIVLTAYGLTEANGMGTMCRADDD------ALTVATTCGRPFADFE
MAV_2610|M.avium_104 LLG-CELQQRYGLTECGGQATILTPQDHRDIVAGKTSIATSCGQETPMCV
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIA-FATIAGPKD-------LQINSATVGPVVKGVK
: : :* ** .: : *
MSMEG_2883|M.smegmatis_MC2_155 TAILDDDNRPVPPGEVGEIAHRSPHLMLGYLDDEAKTAEAFRGG-WFHSG
Mvan_2882|M.vanbaalenii_PYR-1 TAILDDDNSPVAPGVVGEIAHRSPHLMLGYLDDDAKTAESFRGG-WFHSG
TH_2591|M.thermoresistible__bu TVILDDDGAVLPAGTVGEIAHRSPHLMLGYYDDPAKTAEAFRGG-WFHSG
Mflv_4559|M.gilvum_PYR-GCK TAILDDSDNPVPPGTVGEIAHRSPHLMVGYLDDPQRTAEAFRGD-WFHSG
Mb0172|M.bovis_AF2122/97 ARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSG
Rv0166|M.tuberculosis_H37Rv ARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGG-WFHSG
MMAR_0409|M.marinum_M ARVVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGG-WFHSG
MAB_4569c|M.abscessus_ATCC_199 ARVVDDNMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGG-WFHSG
MUL_4126|M.ulcerans_Agy99 LRIGPDT---------GEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTG
MAV_2610|M.avium_104 IRVIDVDGNDAPPGDVGEIVITSPANAIGYWNRPEQTAETFRPD-GLRSG
MLBr_02546|M.leprae_Br4923 VKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG---GGKQIIDG-LLSSG
: *.: . * . . : . : :*
MSMEG_2883|M.smegmatis_MC2_155 DLGYYDEHGLLHVVDRKKDMIKTGGENVASREVEEAVYRHPAVEEVAVFG
Mvan_2882|M.vanbaalenii_PYR-1 DLGYYDGHGLLHVVDRKKDMIKTGGENVASREVEEVIYRHSAVEEVAVFG
TH_2591|M.thermoresistible__bu DLGYFDEHGMLHVVDRKKDMINTGGENVASREVEEVIYRHPAVEEVAVFG
Mflv_4559|M.gilvum_PYR-GCK DLGYYDEFGLLHVVDRKKDMIKSGGENVASREVEEVLYQHDDVQEAAVFG
Mb0172|M.bovis_AF2122/97 DLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIG
Rv0166|M.tuberculosis_H37Rv DLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIG
MMAR_0409|M.marinum_M DLVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIG
MAB_4569c|M.abscessus_ATCC_199 DLVRQDEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIG
MUL_4126|M.ulcerans_Agy99 DIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIG
MAV_2610|M.avium_104 DLGYLDEEGYLHITGRKTDLIISGGFNVYPAEIERVIAQHSDVDMVAVVG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
*: * . : : .* :: ** *: *:* : : .:..*
MSMEG_2883|M.smegmatis_MC2_155 LPHPTWVEAVVAAVVTRDG---AELTEDELLTHCRSCLAGFKTPKQVFFV
Mvan_2882|M.vanbaalenii_PYR-1 LPHPVWVEAVVAAVVVRDG---MEVTEDELASHCRAHLAGFKTPKQVYFV
TH_2591|M.thermoresistible__bu LPHPTWVEAVVAAVVTRNG---MTLGEEELLGHCREHLAGFKTPKQVFFV
Mflv_4559|M.gilvum_PYR-GCK LPHPVWVEAVVAAVVPREG---RVLDPDAVIAHCRSRLAGFKTPKQIFTV
Mb0172|M.bovis_AF2122/97 RADEKWGEVPIAVAAVTN----DDLRIEDLGEFLTDRLARYKHPKALEIV
Rv0166|M.tuberculosis_H37Rv RADEKWGEVPIAVAAVTN----DDLRIEDLGEFLTDRLARYKHPKALEIV
MMAR_0409|M.marinum_M RADEKWGEVPIAVAAVTK----DHLRIEDLDEYLTERLARYKHPKALEIV
MAB_4569c|M.abscessus_ATCC_199 RPHEKWGEVPVAVAAIHG----AALTLAELDGFLTARLARYKHPKDLVIV
MUL_4126|M.ulcerans_Agy99 IPDHRLGEVGRAFIVARPG---FNLDEKSVIDYTREHLANFKAPRSVRFV
MAV_2610|M.avium_104 VPDPEWGETPVAAVIAKSHVGDQDALTAELAALCRAELAGYKQPRRFVFW
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQD---ATIDEDAIKAYVRDHLARYKVPREVIFL
. * : ** :* *: .
MSMEG_2883|M.smegmatis_MC2_155 ESLPKNPSGKLLKRVLRERFARTTTDAI-----------------
Mvan_2882|M.vanbaalenii_PYR-1 DSLPKNPSGKLLKRSLREQFG-VDRGALS----------------
TH_2591|M.thermoresistible__bu DSLPKNPSGKLLKRVLRERYSEKAPH-------------------
Mflv_4559|M.gilvum_PYR-GCK AELPKNPSGKLLKRELRERFASAMN--------------------
Mb0172|M.bovis_AF2122/97 DALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv DALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M DALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAB_4569c|M.abscessus_ATCC_199 DALPRNPSGKVLKTELRQRFGIAD---------------------
MUL_4126|M.ulcerans_Agy99 DTLPRNAGGKVVKPQLRELA-------------------------
MAV_2610|M.avium_104 REFPLGPAGKILKREIANQVNHVSQSGGKMPVSTGSTEERR----
MLBr_02546|M.leprae_Br4923 EELPRNPTGKVLKRELRDFEVH-----------------------
:* .. **::* :