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FDRMFAGLDEPALLAAIEQAACEESRAGARKSAAIAALVHESVTFDDVRDQWVWDSWAETACELGAALNT SHRRASAQMRIAVALHDRLPKVAALFAAGRLSTRLIGQITWRTRLVQDPHLLALLDTAMADKATRWEPLS DDKLTAALDAVIERYDPDAVIRAREHVSGLDFRVGASDDPDALVTVWGKILGCDAAVLAARIAELLKGLC DNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTAAAVVPGSSNVVISVLADPAALDAVRQLIADQDRD QQDKLADKHAQAKGKAEPEPEPEPAVEAEPEAGASEVGEDEELRPEPQTEPRASEVDEDEEPESESEPAA ETTPATPAVEPVPSPSPVNRVRCVRDSGVALLPGVKILPIVALAEAIRSGAAIKTLWLPGPDPEPHYRPS AKLAAFVRARDLFCRYPGCDVPAEHCDLDHVVPYPYGPTHPSNLNCKCRTHHLGKTFADGWHEEQLPDGT VIWTTPAGQRNTTVPGSRLFFPAWDTTTAELPPMTAPPPDPNRLAKMPKRRRTRAADQAARIKTEREHNA TQRALERQQALDRQPRTEAGRIGCEGLPPPPGYGDDPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2714 | - | - | 100% (601) | hypothetical protein Mvan_2714 |
| M. vanbaalenii PYR-1 | Mvan_2144 | - | 0.0 | 93.32% (599) | hypothetical protein Mvan_2144 |
| M. vanbaalenii PYR-1 | Mvan_5188 | - | 0.0 | 83.03% (607) | hypothetical protein Mvan_5188 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-122 | 43.61% (587) | hypothetical protein Mb3805 |
| M. gilvum PYR-GCK | Mflv_1272 | - | 0.0 | 67.99% (603) | HNH endonuclease |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-122 | 43.61% (587) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 4e-38 | 38.46% (260) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 3e-48 | 45.88% (255) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 3e-48 | 44.96% (258) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5583 | - | 1e-108 | 38.63% (611) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-38 | 34.96% (266) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 3e-39 | 37.31% (260) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3457|M.avium_104 ---------MVEHMFEYVVAS---------RSTPEAVALLDRAREAARAE
MUL_2679|M.ulcerans_Agy99 ---------MDQHIIEYVFDT---------DDS----APLTRITAAARAE
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERR-----QLRTPTAESARWVQRIGAAARAE
MAB_4752|M.abscessus_ATCC_1997 -------------MFDELGDV----------------ELIDLIASAQRAE
TH_0334|M.thermoresistible__bu -------------MFESLDDG----------------AVVDSIAAASREQ
Mvan_2714|M.vanbaalenii_PYR-1 -------------MFDRMFAG------------LDEPALLAAIEQAACEE
Mflv_1272|M.gilvum_PYR-GCK -------------MFDSGLAG------------LDKPALISAIEQAACEE
Mb3805|M.bovis_AF2122/97 -------------MFEISLSDP------VELRDADDAALLAAIEDCARAE
Rv3776|M.tuberculosis_H37Rv -------------MFEISLSDP------VELRDADDAALLAAIEDCARAE
MSMEG_5583|M.smegmatis_MC2_155 -----------MCLLVVPVCDTGCMPFEHTFDDLDDAALVAGIEGCERAQ
: . :
MAV_3457|M.avium_104 ARAAAARLVAVAELLVLR--CRETGERADWAADAWEAVAAQVGAALGCSV
MUL_2679|M.ulcerans_Agy99 ARAAAERLAAIGDLFRLR--LSQHGNREDWVADTCDAVAAEVAAALNTSV
MMAR_5187|M.marinum_M NRAAAAQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVAAEVAAGLRISQ
MAB_4752|M.abscessus_ATCC_1997 AQACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITH
TH_0334|M.thermoresistible__bu SAACGREMLAIGELYARR-APEDDTERANWAIDGHANVVAEISAALNISR
Mvan_2714|M.vanbaalenii_PYR-1 SRAGARKSAAIAALVHES--VTFDDVRDQWVWDSWAETACELGAALNTSH
Mflv_1272|M.gilvum_PYR-GCK VRAGARKTAAIAALVHDH--VTYDDVRDEWVWDSWIETACELGAVLNTSH
Mb3805|M.bovis_AF2122/97 VAAGARRLSAIAELTSR---RTGNDQRADWACDGWDCAAAEVAAALTVSH
Rv3776|M.tuberculosis_H37Rv VAAGARRLSAIAELTSR---RTGNDQRADWACDGWDCAAAEVAAALTVSH
MSMEG_5583|M.smegmatis_MC2_155 NAAAARKLALVARFTARRA-ADSEDEVLRWAGDDWAATAAEVGAALNVGP
* . . :. : . * ...::.*
MAV_3457|M.avium_104 AMGHSYLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVL
MUL_2679|M.ulcerans_Agy99 AMGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDAL
MMAR_5187|M.marinum_M GLAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVM
MAB_4752|M.abscessus_ATCC_1997 ALASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVV
TH_0334|M.thermoresistible__bu GRAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLL
Mvan_2714|M.vanbaalenii_PYR-1 RRASAQMRIAVALHDRLPKVAALFAAGRLSTRLIGQITWRTRLVQDPHLL
Mflv_1272|M.gilvum_PYR-GCK RRASAQMRIAVALRDRLPGVAALHAQGRLSARLIGQITWRTRLVQDPQAL
Mb3805|M.bovis_AF2122/97 RKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEAL
Rv3776|M.tuberculosis_H37Rv RKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEAL
MSMEG_5583|M.smegmatis_MC2_155 AVASKWMRVAQEVGERLPRVQEMFAAGWLSAQVVATLTWATHLVGDEQVL
. :: : : ** . * :. : . : : : : :
MAV_3457|M.avium_104 ARVDATLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYL
MUL_2679|M.ulcerans_Agy99 AAVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYV
MMAR_5187|M.marinum_M AAVDALVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREI
MAB_4752|M.abscessus_ATCC_1997 ARVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHL
TH_0334|M.thermoresistible__bu ARLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYV
Mvan_2714|M.vanbaalenii_PYR-1 ALLDTAMADKATRWEPLSDDKLTAALDAVIERYDPDAVIRAREHVSGLDF
Mflv_1272|M.gilvum_PYR-GCK ALIDAAIAEKATRWEPLSEDNLTAALDAVIERFDPDAVIRTREQLKGVDF
Mb3805|M.bovis_AF2122/97 SLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDL
Rv3776|M.tuberculosis_H37Rv SLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDL
MSMEG_5583|M.smegmatis_MC2_155 AIVDAQLAARAREFGPMTVDGVKAAVASLLEKYDPAAVRRSREASRDRDV
: :*: :. : : : : * .: . : .
MAV_3457|M.avium_104 DVRANESG--MAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRA
MUL_2679|M.ulcerans_Agy99 DCAPLEPG--MALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRA
MMAR_5187|M.marinum_M WIGQDADG--ISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRA
MAB_4752|M.abscessus_ATCC_1997 EIRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRA
TH_0334|M.thermoresistible__bu VVTPAGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRA
Mvan_2714|M.vanbaalenii_PYR-1 RVGASDDPDALVTVWGKILGCDAAVLAARIAELLKGLCDNDPRSVCVRRS
Mflv_1272|M.gilvum_PYR-GCK RIGASDDPDALVTVWGKILGCDAVVLAARIAELLKGLCDADPRGIGERRS
Mb3805|M.bovis_AF2122/97 CIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRA
Rv3776|M.tuberculosis_H37Rv CIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRA
MSMEG_5583|M.smegmatis_MC2_155 RFGKPDDVTGTVSISGRVNTADAVAYQKRSAHLTGGVCGDDPRTAGQRRA
: : . * : :* *** **:
MAV_3457|M.avium_104 DALGALAAGAGRLACGCGSPDCPSAAAPA-PRSTVVIHVVAEQATVAGRG
MUL_2679|M.ulcerans_Agy99 DALGTLAAGQDRLICDCGRTDCPAAGAPQ-QPSRVVIHVVAGCQTVDGAG
MMAR_5187|M.marinum_M DALGVLAAGGDRLGCRCGLPDCAAGARPA-AQP-VVIHVIAERATLDGDG
MAB_4752|M.abscessus_ATCC_1997 DAVGALTQGLNRMRCACGHPDCS--GRDT-ADVPVVVNVVINQSTLAGSD
TH_0334|M.thermoresistible__bu DAMAAMSEGQNRLVCGCGSEDCPADPADT-AATRLVINVIAEQATVEGRS
Mvan_2714|M.vanbaalenii_PYR-1 HAVGAIVRGQDHLRCRCGSPDCTAAAVVP-GSSNVVISVLADPAALDAVR
Mflv_1272|M.gilvum_PYR-GCK CAVGAIVRGQDHLPCRCGSPDCAAAPVVP-GSSNVVISVLADPAALEAVR
Mb3805|M.bovis_AF2122/97 DALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP
Rv3776|M.tuberculosis_H37Rv DALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP
MSMEG_5583|M.smegmatis_MC2_155 DAFGVIAVQGDRLVCLCGDPQCPWAGVDP-RAANTMVHIFAEPSVVDAKP
*...: .:: * ** :*. :: :. .: .
MAV_3457|M.avium_104 A-------------------------------------------------
MUL_2679|M.ulcerans_Agy99 E-------------------------------------------------
MMAR_5187|M.marinum_M G-------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 D-------------------------------------------------
TH_0334|M.thermoresistible__bu D-------------------------------------------------
Mvan_2714|M.vanbaalenii_PYR-1 Q-----------------------LIADQDRDQQDKLADKHAQAKGKAEP
Mflv_1272|M.gilvum_PYR-GCK S-----------------------LIADEDRHQQDALAEK----------
Mb3805|M.bovis_AF2122/97 --------------------------------------------------
Rv3776|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5583|M.smegmatis_MC2_155 DPYVHGDYASNPVPFVDPEFDPWPVYPERDSTPPPEPPSEPQWAPQWWSE
MAV_3457|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5187|M.marinum_M --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mvan_2714|M.vanbaalenii_PYR-1 EPEPEPAVEAEPEAGASEVGEDEELRPEPQTEPRASEVDEDEEPESESEP
Mflv_1272|M.gilvum_PYR-GCK -------------------------------QPHAVKAKEQGEP------
Mb3805|M.bovis_AF2122/97 -------------------------------DPRLSGPE-----------
Rv3776|M.tuberculosis_H37Rv -------------------------------DPRLSGPE-----------
MSMEG_5583|M.smegmatis_MC2_155 IPLPPEPEPEPEPEPEPEPEPEPEPELRFESEPQTASAPQPEPEPEARPE
MAV_3457|M.avium_104 -------------------------------------------------T
MUL_2679|M.ulcerans_Agy99 -------------------------------------------------A
MMAR_5187|M.marinum_M -------------------------------------------------A
MAB_4752|M.abscessus_ATCC_1997 -------------------------------------------------C
TH_0334|M.thermoresistible__bu -------------------------------------------------N
Mvan_2714|M.vanbaalenii_PYR-1 AAETTPATPAVEPVPSPSPVNRVRCVR--------------------DSG
Mflv_1272|M.gilvum_PYR-GCK --------------AAPAPSNRGRCVR--------------------DSG
Mb3805|M.bovis_AF2122/97 --------------PALAPEAPATPAV--------------------KPP
Rv3776|M.tuberculosis_H37Rv --------------PALAPEAPATPAV--------------------KPP
MSMEG_5583|M.smegmatis_MC2_155 PQPKTGPEPEPVSTPKPQPQDPPAAAESWGGGGVNPLVVAPAPVVSPQRA
MAV_3457|M.avium_104 PAVVAGLDGLIPAQVIAELAAS-ARLVPVAVPE-GGPEPGYTPSARLADF
MUL_2679|M.ulcerans_Agy99 PGVLPG-DGIIPAEIVRELAKS-AKLQPMSTP--ILAETGYVPSPALMDF
MMAR_5187|M.marinum_M PAWEVGADGLVTPELVAELAKS-AKLVPLRHPGDVPPEPGYVPSKALADF
MAB_4752|M.abscessus_ATCC_1997 PAHVPG-FGVLAAESARAAVAG-TPTRNLTDSR----STGYRPSAKLAAF
TH_0334|M.thermoresistible__bu PGYLPG-YGAVPASILRAKAAT-ATLRPVALPQ-PCAEAGYRPSAALTRF
Mvan_2714|M.vanbaalenii_PYR-1 VALLPG-VKILPIVALAEAIRSGAAIKTLWLPG-PDPEPHYRPSAKLAAF
Mflv_1272|M.gilvum_PYR-GCK TALLPG-VKILPIVALAEAIRAGAAIKQLWLPG-PDPEPHYRPSAKLAAF
Mb3805|M.bovis_AF2122/97 AALISG-GGVVPAPLLAELIRGGAALSRVRHPGDLRSEPHYRPSAKLAEF
Rv3776|M.tuberculosis_H37Rv AALISG-GGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEF
MSMEG_5583|M.smegmatis_MC2_155 TAVIVG-GGLVPASYVAQMIASGAKVKQGRVPL-EDPESGYRPSVGLAEF
. * :. : . .. * ** * *
MAV_3457|M.avium_104 IRCRDLTCRAPGCDRPAVDCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLK
MUL_2679|M.ulcerans_Agy99 VRARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLK
MMAR_5187|M.marinum_M VRCRDLTCRWPGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVK
MAB_4752|M.abscessus_ATCC_1997 VRSRDQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLK
TH_0334|M.thermoresistible__bu IRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQA
Mvan_2714|M.vanbaalenii_PYR-1 VRARDLFCRYPGCDVPAEHCDLDHVVPYPYG-PTHPSNLNCKCRTHHLGK
Mflv_1272|M.gilvum_PYR-GCK VRARDLFCRYPGCNVPAEQCDIDHVVPWPYG-PTHPSNLNCKCRTHHLGK
Mb3805|M.bovis_AF2122/97 VRIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLK
Rv3776|M.tuberculosis_H37Rv VRIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLK
MSMEG_5583|M.smegmatis_MC2_155 VRMRDLTCRFPGCGRPAECCDIDHTEPFPGG-VTHASNIKCLCRFHHLIK
:* ** ** *** : .::**. *:. * * :*:: * *
MAV_3457|M.avium_104 TFWG-WRDRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLCTPTGAVSPAK
MUL_2679|M.ulcerans_Agy99 TFWG-WHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPP
MMAR_5187|M.marinum_M TFWG-WHDQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAE
MAB_4752|M.abscessus_ATCC_1997 TFGQ-WTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTR---------
TH_0334|M.thermoresistible__bu ELRF-THDQHKHQSSCLP------AYFQRPHG----PATRRP--------
Mvan_2714|M.vanbaalenii_PYR-1 TFADGWHEEQLPDGTVIWTTPAGQRNTTVPGSRLFFPAWDTTTAELPPMT
Mflv_1272|M.gilvum_PYR-GCK TFAEGWHEEQLPDGTVIWTTPAGQRYSTVPGSRLFFPGWDTTTAELPPMA
Mb3805|M.bovis_AF2122/97 TFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAP
Rv3776|M.tuberculosis_H37Rv TFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAP
MSMEG_5583|M.smegmatis_MC2_155 TFWAGFVDTQLPDGQVVWTMPSGRTYTTVPGSRWVFPQWDTTTTTLPPPP
: : : :. : * . *
MAV_3457|M.avium_104 PDT-EHRCGERTAMMPLRRHTRAHNRAHRITTER---NHNRRTRLTTHPA
MUL_2679|M.ulcerans_Agy99 ------RSEATGSLRKPRRDDAQTRPNSRPKLGR---THCDRT-------
MMAR_5187|M.marinum_M ADPPSDHCDQRSAMMPRRQRTRAQDRARRVATERRQNHHARSTQPGGQPR
MAB_4752|M.abscessus_ATCC_1997 ------HHTRQQARDRRRRTERNLNREQRLQREAALAALAAKD-------
TH_0334|M.thermoresistible__bu ----------PSARGLREAVPRQGVDPRRVSGQ-----------------
Mvan_2714|M.vanbaalenii_PYR-1 A--PPPD-PNRLAKMPKRRRTRAADQAARIKTEREHNATQR-ALERQQAL
Mflv_1272|M.gilvum_PYR-GCK Q--PPPD-PDRLAKMPKRRRTRAADHAARIKAEREDNAHQR-ALETERAA
Mb3805|M.bovis_AF2122/97 S--PPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDT
Rv3776|M.tuberculosis_H37Rv S--PPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDT
MSMEG_5583|M.smegmatis_MC2_155 ---PRATSPARGVMMPQRKLTRAEQRARQIRAERAR-----------NEK
. :
MAV_3457|M.avium_104 TPGPAPPPDPDDE--PPPF-----------
MUL_2679|M.ulcerans_Agy99 ------QPQHD-------------------
MMAR_5187|M.marinum_M SAAPPTPPQSEPQSHPPPF-----------
MAB_4752|M.abscessus_ATCC_1997 ---------------PPPF-----------
TH_0334|M.thermoresistible__bu ------------------------------
Mvan_2714|M.vanbaalenii_PYR-1 DRQPRTEAGRIGCEGLPPPPGYGDDPPPF-
Mflv_1272|M.gilvum_PYR-GCK ARRSGLPP--------PAPPDYGDDPPPF-
Mb3805|M.bovis_AF2122/97 AVAEGFEP--------PDGVSRLSLSRRVH
Rv3776|M.tuberculosis_H37Rv AVAEGFEP--------PDGVSRLSLSRRVH
MSMEG_5583|M.smegmatis_MC2_155 YLSERNKP--------PPQ-----------