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FAGLDEPALLAAIERAACEESRAGARKSAAIAALVHESVTFDDVRDQWVWDSWAETACELGAALNTSHRR ASAQMRIAVALHDRLPKVAALFAAGRLSTRLIGQITWRTRLVQDPHLLALLDTAMADKATRWEPLSDDKL TAALDAVIERYDPDAVIRAREHVSGLDFRVGASDDPDALVTVWGKILGCDAAVLAARIAELLKGLCDNDP RSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTAAAVVPGSSNVVISVLADPAALDAVRQLIADQDRDQQDK LADKHAQAKGKAEPEPEAGASEVGEDEESETAEPVREDEELRPEPQTEPRASEVDEDEEPESESEPAAET TPATPAVEPVPSPSPVNRGRCVRDSGVALLPGVKILPIVALAEAIRAGAAIKTLWLPGPDPEPHYRPSAK LAAFVRARDLFCRYPGCDVPAEHCDLDHVVPYPYGPTHPSNLNCKCRTHHLGKTFADGWHEEQLPDGTVV WTTPAGQRNTTVPGSRLFFPAWDTTTAELPPMTAPPPDPNRLAKMPKRRRTRAADTAARIKTEREHNATQ RALESERATAVEHDRQAGRPPPTDYGDEPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2144 | - | - | 100% (593) | hypothetical protein Mvan_2144 |
| M. vanbaalenii PYR-1 | Mvan_2714 | - | 0.0 | 93.32% (599) | hypothetical protein Mvan_2714 |
| M. vanbaalenii PYR-1 | Mvan_5188 | - | 0.0 | 82.51% (606) | hypothetical protein Mvan_5188 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-119 | 44.46% (560) | hypothetical protein Mb3805 |
| M. gilvum PYR-GCK | Mflv_1272 | - | 0.0 | 74.20% (593) | HNH endonuclease |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-119 | 44.46% (560) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 5e-38 | 38.46% (260) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 7e-48 | 45.53% (246) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 2e-50 | 46.03% (252) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5583 | - | 1e-105 | 38.12% (606) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-38 | 34.96% (266) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 3e-39 | 37.31% (260) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3457|M.avium_104 ---------MVEHMFEYVVAS--------RSTPEAVALLDRAREAARAEA
MUL_2679|M.ulcerans_Agy99 ---------MDQHIIEYVFDT--------DDS----APLTRITAAARAEA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERR----QLRTPTAESARWVQRIGAAARAEN
MAB_4752|M.abscessus_ATCC_1997 -------------MFDELGDV---------------ELIDLIASAQRAEA
TH_0334|M.thermoresistible__bu -------------MFESLDDG---------------AVVDSIAAASREQS
Mvan_2144|M.vanbaalenii_PYR-1 ----------------MFAG------------LDEPALLAAIERAACEES
Mflv_1272|M.gilvum_PYR-GCK ------------MFDSGLAG------------LDKPALISAIEQAACEEV
Mb3805|M.bovis_AF2122/97 ------------MFEISLSDP------VELRDADDAALLAAIEDCARAEV
Rv3776|M.tuberculosis_H37Rv ------------MFEISLSDP------VELRDADDAALLAAIEDCARAEV
MSMEG_5583|M.smegmatis_MC2_155 ----------MCLLVVPVCDTGCMPFEHTFDDLDDAALVAGIEGCERAQN
. : . :
MAV_3457|M.avium_104 RAAAARLVAVAELLVLR--CRETGERADWAADAWEAVAAQVGAALGCSVA
MUL_2679|M.ulcerans_Agy99 RAAAERLAAIGDLFRLR--LSQHGNREDWVADTCDAVAAEVAAALNTSVA
MMAR_5187|M.marinum_M RAAAAQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVAAEVAAGLRISQG
MAB_4752|M.abscessus_ATCC_1997 QACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHA
TH_0334|M.thermoresistible__bu AACGREMLAIGELYARR-APEDDTERANWAIDGHANVVAEISAALNISRG
Mvan_2144|M.vanbaalenii_PYR-1 RAGARKSAAIAALVHES--VTFDDVRDQWVWDSWAETACELGAALNTSHR
Mflv_1272|M.gilvum_PYR-GCK RAGARKTAAIAALVHDH--VTYDDVRDEWVWDSWIETACELGAVLNTSHR
Mb3805|M.bovis_AF2122/97 AAGARRLSAIAELTSR---RTGNDQRADWACDGWDCAAAEVAAALTVSHR
Rv3776|M.tuberculosis_H37Rv AAGARRLSAIAELTSR---RTGNDQRADWACDGWDCAAAEVAAALTVSHR
MSMEG_5583|M.smegmatis_MC2_155 AAAARKLALVARFTARRA-ADSEDEVLRWAGDDWAATAAEVGAALNVGPA
* . . :. : . * ...::.*
MAV_3457|M.avium_104 MGHSYLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLA
MUL_2679|M.ulcerans_Agy99 MGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALA
MMAR_5187|M.marinum_M LAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMA
MAB_4752|M.abscessus_ATCC_1997 LASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVA
TH_0334|M.thermoresistible__bu RAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLA
Mvan_2144|M.vanbaalenii_PYR-1 RASAQMRIAVALHDRLPKVAALFAAGRLSTRLIGQITWRTRLVQDPHLLA
Mflv_1272|M.gilvum_PYR-GCK RASAQMRIAVALRDRLPGVAALHAQGRLSARLIGQITWRTRLVQDPQALA
Mb3805|M.bovis_AF2122/97 KASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALS
Rv3776|M.tuberculosis_H37Rv KASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALS
MSMEG_5583|M.smegmatis_MC2_155 VASKWMRVAQEVGERLPRVQEMFAAGWLSAQVVATLTWATHLVGDEQVLA
. :: : : ** . * :. : . : : : : ::
MAV_3457|M.avium_104 RVDATLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLD
MUL_2679|M.ulcerans_Agy99 AVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVD
MMAR_5187|M.marinum_M AVDALVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIW
MAB_4752|M.abscessus_ATCC_1997 RVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLE
TH_0334|M.thermoresistible__bu RLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVV
Mvan_2144|M.vanbaalenii_PYR-1 LLDTAMADKATRWEPLSDDKLTAALDAVIERYDPDAVIRAREHVSGLDFR
Mflv_1272|M.gilvum_PYR-GCK LIDAAIAEKATRWEPLSEDNLTAALDAVIERFDPDAVIRTREQLKGVDFR
Mb3805|M.bovis_AF2122/97 LLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLC
Rv3776|M.tuberculosis_H37Rv LLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLC
MSMEG_5583|M.smegmatis_MC2_155 IVDAQLAARAREFGPMTVDGVKAAVASLLEKYDPAAVRRSREASRDRDVR
:*: :. : : : : * .: . : .
MAV_3457|M.avium_104 VRANESG--MAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRAD
MUL_2679|M.ulcerans_Agy99 CAPLEPG--MALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRAD
MMAR_5187|M.marinum_M IGQDADG--ISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRAD
MAB_4752|M.abscessus_ATCC_1997 IRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRAD
TH_0334|M.thermoresistible__bu VTPAGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRAD
Mvan_2144|M.vanbaalenii_PYR-1 VGASDDPDALVTVWGKILGCDAAVLAARIAELLKGLCDNDPRSVCVRRSH
Mflv_1272|M.gilvum_PYR-GCK IGASDDPDALVTVWGKILGCDAVVLAARIAELLKGLCDADPRGIGERRSC
Mb3805|M.bovis_AF2122/97 IGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRAD
Rv3776|M.tuberculosis_H37Rv IGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRAD
MSMEG_5583|M.smegmatis_MC2_155 FGKPDDVTGTVSISGRVNTADAVAYQKRSAHLTGGVCGDDPRTAGQRRAD
: : . * : :* *** **:
MAV_3457|M.avium_104 ALGALAAGAGRLACGCGSPDCPSAAAPA-PRSTVVIHVVAEQATVAGRGA
MUL_2679|M.ulcerans_Agy99 ALGTLAAGQDRLICDCGRTDCPAAGAPQ-QPSRVVIHVVAGCQTVDGAGE
MMAR_5187|M.marinum_M ALGVLAAGGDRLGCRCGLPDCAAGARPA-AQP-VVIHVIAERATLDGDGG
MAB_4752|M.abscessus_ATCC_1997 AVGALTQGLNRMRCACGHPDCS--GRDT-ADVPVVVNVVINQSTLAGSDD
TH_0334|M.thermoresistible__bu AMAAMSEGQNRLVCGCGSEDCPADPADT-AATRLVINVIAEQATVEGRSD
Mvan_2144|M.vanbaalenii_PYR-1 AVGAIVRGQDHLRCRCGSPDCTAAAVVP-GSSNVVISVLADPAALDAVRQ
Mflv_1272|M.gilvum_PYR-GCK AVGAIVRGQDHLPCRCGSPDCAAAPVVP-GSSNVVISVLADPAALEAVRS
Mb3805|M.bovis_AF2122/97 ALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP-
Rv3776|M.tuberculosis_H37Rv ALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP-
MSMEG_5583|M.smegmatis_MC2_155 AFGVIAVQGDRLVCLCGDPQCPWAGVDP-RAANTMVHIFAEPSVVDAKPD
*...: .:: * ** :*. :: :. .: .
MAV_3457|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5187|M.marinum_M --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mvan_2144|M.vanbaalenii_PYR-1 LIAD---------------------QDRDQQDKLADKHAQAKGKAEPEPE
Mflv_1272|M.gilvum_PYR-GCK LIAD---------------------EDRHQQDALAEK-------------
Mb3805|M.bovis_AF2122/97 --------------------------------------------------
Rv3776|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5583|M.smegmatis_MC2_155 PYVHGDYASNPVPFVDPEFDPWPVYPERDSTPPPEPPSEPQWAPQWWSEI
MAV_3457|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5187|M.marinum_M --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Mvan_2144|M.vanbaalenii_PYR-1 AGASEVGEDEESETAEPVREDEELRPEPQTEPRASEVDEDEEPESESEPA
Mflv_1272|M.gilvum_PYR-GCK ------------------------------QPHAVKAKEQGEP-------
Mb3805|M.bovis_AF2122/97 ------------------------------DPRLSGPE------------
Rv3776|M.tuberculosis_H37Rv ------------------------------DPRLSGPE------------
MSMEG_5583|M.smegmatis_MC2_155 PLPPEPEPEPEPEPEPEPEPEPEPELRFESEPQTASAPQPEPEPEARPEP
MAV_3457|M.avium_104 ------------------------------------------------TP
MUL_2679|M.ulcerans_Agy99 ------------------------------------------------AP
MMAR_5187|M.marinum_M ------------------------------------------------AP
MAB_4752|M.abscessus_ATCC_1997 ------------------------------------------------CP
TH_0334|M.thermoresistible__bu ------------------------------------------------NP
Mvan_2144|M.vanbaalenii_PYR-1 AETTPATPAVEPVPSPSPVNRGRCVR--------------------DSGV
Mflv_1272|M.gilvum_PYR-GCK -------------AAPAPSNRGRCVR--------------------DSGT
Mb3805|M.bovis_AF2122/97 -------------PALAPEAPATPAV--------------------KPPA
Rv3776|M.tuberculosis_H37Rv -------------PALAPEAPATPAV--------------------KPPA
MSMEG_5583|M.smegmatis_MC2_155 QPKTGPEPEPVSTPKPQPQDPPAAAESWGGGGVNPLVVAPAPVVSPQRAT
MAV_3457|M.avium_104 AVVAGLDGLIPAQVIAELAAS-ARLVPVAVPE-GGPEPGYTPSARLADFI
MUL_2679|M.ulcerans_Agy99 GVLPG-DGIIPAEIVRELAKS-AKLQPMSTP--ILAETGYVPSPALMDFV
MMAR_5187|M.marinum_M AWEVGADGLVTPELVAELAKS-AKLVPLRHPGDVPPEPGYVPSKALADFV
MAB_4752|M.abscessus_ATCC_1997 AHVPG-FGVLAAESARAAVAG-TPTRNLTDSR----STGYRPSAKLAAFV
TH_0334|M.thermoresistible__bu GYLPG-YGAVPASILRAKAAT-ATLRPVALPQ-PCAEAGYRPSAALTRFI
Mvan_2144|M.vanbaalenii_PYR-1 ALLPG-VKILPIVALAEAIRAGAAIKTLWLPG-PDPEPHYRPSAKLAAFV
Mflv_1272|M.gilvum_PYR-GCK ALLPG-VKILPIVALAEAIRAGAAIKQLWLPG-PDPEPHYRPSAKLAAFV
Mb3805|M.bovis_AF2122/97 ALISG-GGVVPAPLLAELIRGGAALSRVRHPGDLRSEPHYRPSAKLAEFV
Rv3776|M.tuberculosis_H37Rv ALISG-GGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFV
MSMEG_5583|M.smegmatis_MC2_155 AVIVG-GGLVPASYVAQMIASGAKVKQGRVPL-EDPESGYRPSVGLAEFV
. * :. : . .. * ** * *:
MAV_3457|M.avium_104 RCRDLTCRAPGCDRPAVDCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLKT
MUL_2679|M.ulcerans_Agy99 RARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKT
MMAR_5187|M.marinum_M RCRDLTCRWPGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKT
MAB_4752|M.abscessus_ATCC_1997 RSRDQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKT
TH_0334|M.thermoresistible__bu RCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAE
Mvan_2144|M.vanbaalenii_PYR-1 RARDLFCRYPGCDVPAEHCDLDHVVPYPYG-PTHPSNLNCKCRTHHLGKT
Mflv_1272|M.gilvum_PYR-GCK RARDLFCRYPGCNVPAEQCDIDHVVPWPYG-PTHPSNLNCKCRTHHLGKT
Mb3805|M.bovis_AF2122/97 RIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKT
Rv3776|M.tuberculosis_H37Rv RIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKT
MSMEG_5583|M.smegmatis_MC2_155 RMRDLTCRFPGCGRPAECCDIDHTEPFPGG-VTHASNIKCLCRFHHLIKT
* ** ** *** : .::**. *:. * * :*:: * *
MAV_3457|M.avium_104 FWG-WRDRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLCTPTGAVSPAKP
MUL_2679|M.ulcerans_Agy99 FWG-WHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPP-
MMAR_5187|M.marinum_M FWG-WHDQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEA
MAB_4752|M.abscessus_ATCC_1997 FGQ-WTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTR----------
TH_0334|M.thermoresistible__bu LRF-THDQHKHQSSCLP------AYFQRPHG----PATRRP---------
Mvan_2144|M.vanbaalenii_PYR-1 FADGWHEEQLPDGTVVWTTPAGQRNTTVPGSRLFFPAWDTTTAELPPMTA
Mflv_1272|M.gilvum_PYR-GCK FAEGWHEEQLPDGTVIWTTPAGQRYSTVPGSRLFFPGWDTTTAELPPMAQ
Mb3805|M.bovis_AF2122/97 FWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPS
Rv3776|M.tuberculosis_H37Rv FWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPS
MSMEG_5583|M.smegmatis_MC2_155 FWAGFVDTQLPDGQVVWTMPSGRTYTTVPGSRWVFPQWDTTTTTLPPPP-
: : : :. : * . *
MAV_3457|M.avium_104 DT-EHRCGERTAMMPLRRHTRAHNRAHRITTER---NHNRRTRLTTHPAT
MUL_2679|M.ulcerans_Agy99 -----RSEATGSLRKPRRDDAQTRPNSRPKLGR---THCDRT--------
MMAR_5187|M.marinum_M DPPSDHCDQRSAMMPRRQRTRAQDRARRVATERRQNHHARSTQPGGQPRS
MAB_4752|M.abscessus_ATCC_1997 -----HHTRQQARDRRRRTERNLNREQRLQREAALAALAAKD--------
TH_0334|M.thermoresistible__bu ---------PSARGLREAVPRQGVDPRRVSGQ------------------
Mvan_2144|M.vanbaalenii_PYR-1 --PPPD-PNRLAKMPKRRRTRAADTAARIKTEREHNATQR-ALESERATA
Mflv_1272|M.gilvum_PYR-GCK --PPPD-PDRLAKMPKRRRTRAADHAARIKAEREDNAHQR-ALETERAAA
Mb3805|M.bovis_AF2122/97 --PPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTA
Rv3776|M.tuberculosis_H37Rv --PPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTA
MSMEG_5583|M.smegmatis_MC2_155 --PRATSPARGVMMPQRKLTRAEQRARQIRAERARNEKYL----SERNKP
. :
MAV_3457|M.avium_104 PGPAPPPDPDDE--PPPF-----
MUL_2679|M.ulcerans_Agy99 -----QPQHD-------------
MMAR_5187|M.marinum_M AAPPTPPQSEPQSHPPPF-----
MAB_4752|M.abscessus_ATCC_1997 --------------PPPF-----
TH_0334|M.thermoresistible__bu -----------------------
Mvan_2144|M.vanbaalenii_PYR-1 VEHDRQAGRPPPTDYGDEPPPF-
Mflv_1272|M.gilvum_PYR-GCK RRSGLPP--PAPPDYGDDPPPF-
Mb3805|M.bovis_AF2122/97 VAEGFEP--PDGVSRLSLSRRVH
Rv3776|M.tuberculosis_H37Rv VAEGFEP--PDGVSRLSLSRRVH
MSMEG_5583|M.smegmatis_MC2_155 PPQ--------------------