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TGTMIHWLTDAGAADPSRSGGKGAKLALLVRAGLPVPAGFVVLTEAYRRFVSDHGLDGLIRQQLGAINTG PDGDPDVVHAVSARLRAAFESAPMSEELRDQVAAAHSTLGAAASAVRSSATAEDLPEASFAGQQDTFLNI VGAEALCEAIKRCWSSLWSARAIAYRRDNDIGHEDISIAVVVQSMVPATVAGVLFTADPISGRRDRIVIE AAAEPGEAVVGGGMTPDRWVLDAVTRRPIDAPERALLTSEQLDSLVDLGARATAAFGIPQDLEWAVDDDG RCWLLQSRPITSLFPIPPATRPGLRVYLPVMLIAQGIAEPMTPSGNAFFRTMVGGWFRYWISGRRPRASD ADPDWMPIVADRLFLDVTPVLQRPRLAARVLSNFGMKDPAGSAALRKWLSQNSGRLPRPDRAAPPRGLLV LLPSLLAGTVASIAAPTRARRRIVAGADAELARLEQQAEMLSAPDEQLRFVERELPAATCDMVLRQLAAA YGEWLLRVVIERLVRRWLGSSTGFAPVLRWLPHDPTIAMGAALARLAREHAAAGIEPGPESAGVSEFLAT FGHRAPDREVDLGLPRLSDDPTYVVELINGYLRSGALDTFETGVHEARAASDGLITGVRRVKGPVRAAVL RNLLARHLALGGLRERPKFDMVRAMALGRRTLRRCGAALVERGLLDDADDVFFLDGADVRAALAGRACDL RARAAADHRSFRRELRRRRVPRVLTSEGEAVYGFDTATPGAETDVLIGTALSPGVHVGTVRVLDSPVGAN LQPGEVIVAASTDPGWTPLFLLAGALVMEVGGVMSHGALVAREYGLPAVAGIGNAMTRLRSGQRVRVDGT AGSVTLLDSVAPDGAAEDPAPTADRAAGSGPRPAPRPRPVSPDSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2632 | - | - | 100% (886) | pyruvate, water dikinase |
| M. vanbaalenii PYR-1 | Mvan_1818 | - | 1e-59 | 28.92% (868) | pyruvate, water dikinase |
| M. vanbaalenii PYR-1 | Mvan_4106 | - | 4e-37 | 33.82% (340) | phosphoenolpyruvate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2073c | - | 1e-27 | 31.04% (422) | hypothetical protein Mb2073c |
| M. gilvum PYR-GCK | Mflv_0493 | - | 5e-63 | 31.19% (872) | pyruvate, water dikinase |
| M. tuberculosis H37Rv | Rv2047c | - | 1e-27 | 31.04% (422) | hypothetical protein Rv2047c |
| M. leprae Br4923 | MLBr_00955 | ppdK | 4e-06 | 34.34% (99) | pyruvate phosphate dikinase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3410 | - | 1e-35 | 30.00% (430) | pyruvate dikinase |
| M. avium 104 | MAV_5056 | - | 3e-31 | 29.59% (419) | PEP-utilizing protein |
| M. smegmatis MC2 155 | MSMEG_3934 | - | 1e-43 | 38.06% (310) | phosphoenolpyruvate synthase |
| M. thermoresistible (build 8) | TH_4555 | - | 6e-52 | 39.10% (312) | PUTATIVE putative phosphoenolpyruvate synthase |
| M. ulcerans Agy99 | MUL_2265 | - | 2e-26 | 32.06% (315) | hypothetical protein MUL_2265 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3410|M.marinum_M ---------------MSSFSYVRFFEEFGIED---------VPLVGGKNA
MSMEG_3934|M.smegmatis_MC2_155 -------------MDIMSDRYVRTLDILTIAD---------AEEAGGKGA
Mb2073c|M.bovis_AF2122/97 MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIR
Rv2047c|M.tuberculosis_H37Rv MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIR
MUL_2265|M.ulcerans_Agy99 MRVAVTGAGGVLGRGLASRLLSQGHEVVGMSRRRPDSWPSQADFVAGDIR
TH_4555|M.thermoresistible__bu --------MMTDMSAVTSPNTVEAEHTVSNVIRFADPGATDPRLVGGKGM
Mvan_2632|M.vanbaalenii_PYR-1 ----------------MTGTMIHWLTDAGAAD---------PSRSGGKGA
Mflv_0493|M.gilvum_PYR-GCK ----------------MFDASSRIVDLADVLD----------DSFGGKAL
MAV_5056|M.avium_104 --------------------------------------------------
MLBr_00955|M.leprae_Br4923 --------------------------------------------------
MMAR_3410|M.marinum_M SLGEMFQKLSQQGVRVPHGFATTA------DAYKHMLDRAGAWDALHAEL
MSMEG_3934|M.smegmatis_MC2_155 NLGELVA----ADLPVPHGFVVMR------SAYLDSVRMGGVEAELAALH
Mb2073c|M.bovis_AF2122/97 DATAVESAMTGADVVAHCAWVRGR------NDHINIDGTANVLKAMAETG
Rv2047c|M.tuberculosis_H37Rv DATAVESAMTGADVVAHCAWVRGR------NDHINIDGTANVLKAMAETG
MUL_2265|M.ulcerans_Agy99 DAAAVRRAITGADVVAHCAWARNPGPDGRISQQINIDGTRNVLDAMAACG
TH_4555|M.thermoresistible__bu NLGELVA----AGFRVPNGFTVST------EAYAATLADSGAADRIFELL
Mvan_2632|M.vanbaalenii_PYR-1 KLALLVR----AGLPVPAGFVVLT------EAYRRFVSDHGLDGLIRQQL
Mflv_0493|M.gilvum_PYR-GCK GLAELTR----LGLPVPPGFVIAD--------------------------
MAV_5056|M.avium_104 --------------------------------------------------
MLBr_00955|M.leprae_Br4923 --------------------------------------------------
MMAR_3410|M.marinum_M DD--LDADD-------------------------------VTALARKGKR
MSMEG_3934|M.smegmatis_MC2_155 TEALTHAAD-------------------------------TARLSELCRR
Mb2073c|M.bovis_AF2122/97 TGRIVFTSS-------------------------GHQPRVEQMLADCGLE
Rv2047c|M.tuberculosis_H37Rv TGRIVFTSS-------------------------GHQPRVEQMLADCGLE
MUL_2265|M.ulcerans_Agy99 TGRIVFPSSPHVYRPGLPMPATEHGAVAPASAEGRHKAGVEQMLQESGAQ
TH_4555|M.thermoresistible__bu KGLDVAD---------------------------------LARLESTAAA
Mvan_2632|M.vanbaalenii_PYR-1 GAINTGPDG------------------------------DPDVVHAVSAR
Mflv_0493|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5056|M.avium_104 --------------------------------------------------
MLBr_00955|M.leprae_Br4923 --------------------------------------------------
MMAR_3410|M.marinum_M AREIVYGAGLPEDLASEIVAAYRI--MQEEYGEDVSLAVRSSATA---ED
MSMEG_3934|M.smegmatis_MC2_155 MQSLVNKAGLSPSVRDATLAAYR------ALGTDVVVAVRSSATG---ED
Mb2073c|M.bovis_AF2122/97 WVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVR
Rv2047c|M.tuberculosis_H37Rv WVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVR
MUL_2265|M.ulcerans_Agy99 WVAVRSALIVGRNIDNWVRRLFALPAFPDGSADDVLQVVHLDDVLRLLTR
TH_4555|M.thermoresistible__bu IRDVVTAVELPDKLAHDIERAYT------ELGADVYVAVRSSGTA---ED
Mvan_2632|M.vanbaalenii_PYR-1 LRAAFESAPMSEELRDQVAAAHS-------TLGAAASAVRSSATA---ED
Mflv_0493|M.gilvum_PYR-GCK ----ASGTSLGDAVTERFSRMRA--------AGQTPVAVRSSAAG---ED
MAV_5056|M.avium_104 ------MTPRACETRRMLMASMP-------SASAILTAARTTASR-----
MLBr_00955|M.leprae_Br4923 ------------------------------MPGQSHKEPHRRATS----T
:
MMAR_3410|M.marinum_M LPTASFAGQQETFLNIKGEESLLDACRRCFASLFTDRAIHYRVDQGFDHF
MSMEG_3934|M.smegmatis_MC2_155 GRDASFAGMNRTITNVMGEVALLDAVTQCWMSLFSPRVITYRASRGFT-A
Mb2073c|M.bovis_AF2122/97 ALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAEL
Rv2047c|M.tuberculosis_H37Rv ALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAEL
MUL_2265|M.ulcerans_Agy99 AVSDVGAGTGPVNLAAPGLPTLREIATALRRPILPVG-AALRRIGSVAEF
TH_4555|M.thermoresistible__bu TAEASFAGMHDTYLDIRGTGEVLDAVRRCWASMWTARAVAYREEHGFDHR
Mvan_2632|M.vanbaalenii_PYR-1 LPEASFAGQQDTFLNIVGAEALCEAIKRCWSSLWSARAIAYRRDNDIGHE
Mflv_0493|M.gilvum_PYR-GCK GAEHSFAGQYDTVLGVGSVDELTAAVEKCVRSAGSERAAAYQD----GGA
MAV_5056|M.avium_104 LSPARLIRRHHLPRLAWTRPCGAATIRRRLHFLSHVQKVTGVSMRSHSAP
MLBr_00955|M.leprae_Br4923 PRSLKQATSELRWALSLAAPESPAFMRHLLGNAHDKVDITTSSEHVAAFT
MMAR_3410|M.marinum_M KVALSIGIMKMVRSDLASSGVMFTLDTESGFNDVVFVTGAYGLGENVVQG
MSMEG_3934|M.smegmatis_MC2_155 APAMAVVVQQMLSADRA--GVAFTSDPSTGDADHIVIEAAFGQGEVVVSG
Mb2073c|M.bovis_AF2122/97 ELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSL
Rv2047c|M.tuberculosis_H37Rv ELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSL
MUL_2265|M.ulcerans_Agy99 QLVQGVPVMDTARLHDEWKFQPAFTAEESVEDFALAVRGRVSLGRRVVSL
TH_4555|M.thermoresistible__bu EAKIAVVVQTMAEADVS--GVMYTANPLNNRTDEIVINSAYGLGESIVSG
Mvan_2632|M.vanbaalenii_PYR-1 DISIAVVVQSMVPATVA--GVLFTADPISGRRDRIVIEAAAEPGEAVVGG
Mflv_0493|M.gilvum_PYR-GCK AARMHLVVQQMVDARAA--GVVFTADPTSGRRDLLVIDAVRGLGESLVDG
MAV_5056|M.avium_104 EHNAANALHSMSPPGATWSSVNLAEAVPGVMTPLCASVWVPASELGLREP
MLBr_00955|M.leprae_Br4923 EHAIVLLNGNAHQTRELLGGKGYNIN--AMRRHQLAVPPAFCITTEVGVR
MMAR_3410|M.marinum_M AVDPDEFYVHKP-TYQAGHRAVLRRLIGDKAVKMVFVEGGTKQTTRNIPT
MSMEG_3934|M.smegmatis_MC2_155 KVEPDTYVIDKR-TLEV--RDVR---IGFKAIKIVRGDDGADSMVQLERS
Mb2073c|M.bovis_AF2122/97 PWRLANIQDLPA-VDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLAT
Rv2047c|M.tuberculosis_H37Rv PWRLANIQDLPA-VDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLAT
MUL_2265|M.ulcerans_Agy99 PWRLANIQDLPA-IDASAQDGVVPRLAGPEGVNGEFDTPIDPRFPTFLAT
TH_4555|M.thermoresistible__bu AINPDEFTVDLG-TLKIKQANVG-----NKKEKIVRAPDKPSGTVTLAVS
Mvan_2632|M.vanbaalenii_PYR-1 GMTPDRWVLDAV-TRRPIDAPERALLTSEQLDSLVDLGARATAAFGIPQD
Mflv_0493|M.gilvum_PYR-GCK STASDHFVLTHAGDTVTTEASSQPALADDEIDRIRTGALLAAAHWGRPLD
MAV_5056|M.avium_104 FVAMGALPVDRGGIPADPAERITNAFFGRMAVRVDFLCEMGDLIPGQS--
MLBr_00955|M.leprae_Br4923 YLAAPTPTMEAIWN--------------DVLDQMRWLEAETSRTFGWGPR
MMAR_3410|M.marinum_M PKADRAH----FCITDEDVLELAGYALAIEQHYGRPMDIEWAKDGLDGKL
MSMEG_3934|M.smegmatis_MC2_155 QAEAR-------VLDDDALRKIATLAVATETHNGCPQDIEWVIA--DGAV
Mb2073c|M.bovis_AF2122/97 NLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAV
Rv2047c|M.tuberculosis_H37Rv NLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAV
MUL_2265|M.ulcerans_Agy99 NLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPGGVIQREIAMRTVAV
TH_4555|M.thermoresistible__bu EEDAG-----RLSLTDEQVAELAALGRQVMDHYG-GLPQDIEWACVDGEF
Mvan_2632|M.vanbaalenii_PYR-1 LEWAVDDDGRCWLLQSRPITSLFPIPPATRPGLRVYLPVMLIAQGIAEPM
Mflv_0493|M.gilvum_PYR-GCK LEWAIDRDGLLWWLQARPITTLPGDPNEMDTPVTGPTHVYTRCNIGEMMP
MAV_5056|M.avium_104 -------------------------GEALSRDFFGFVPADFRSRPSARRL
MLBr_00955|M.leprae_Br4923 P-----------LLVSIRSGAVQSMPGMMDTILNLGINDPVEQALAAASP
MMAR_3410|M.marinum_M YIVQARPETAASQRSMTTVETYVLEG----------------SGEQREIL
MSMEG_3934|M.smegmatis_MC2_155 WLVQARPITTLGSAGST-------------------------AGDEPSVL
Mb2073c|M.bovis_AF2122/97 FAHRLYGAITSAHFMAATVP----------------------FAKPATIV
Rv2047c|M.tuberculosis_H37Rv FAHRLYGAITSAHFMAATVP----------------------FAKPATIV
MUL_2265|M.ulcerans_Agy99 FAHRLYGAITSAHFMAETVP----------------------FAKPAMIV
TH_4555|M.thermoresistible__bu FLLQTRPITGAKFTWPEGFNDWQNGPEDPDTLWTFKYAEQYWTGGITPLF
Mvan_2632|M.vanbaalenii_PYR-1 TPSGNAFFRTMVGGWFRYWISGRRPRASDADPDWMPIVADRLFLDVTPVL
Mflv_0493|M.gilvum_PYR-GCK GAFCPLTASVSGHAIDYAMQMVQVAGGVQERYEDRARQVGYFFGHMFLNM
MAV_5056|M.avium_104 PFILARYPRTFAG-----------------------------IGRRIARL
MLBr_00955|M.leprae_Br4923 SPIPQTFARDTRLRFIRTYR------------------------RIVDPL
.
MMAR_3410|M.marinum_M TEGRSVGEKVASGVVKR---IDDLERLSDFKPGQVLVADTTTPDWEPVMK
MSMEG_3934|M.smegmatis_MC2_155 IRGLPAAPGVASGRVRV---LLAPDDGDKLTDGEILVAPTTNPDWLPTIR
Mb2073c|M.bovis_AF2122/97 SNSGFFGPSMASLPIFG---AQRPPSESSRARRWLRTLRNIGVFGVNLVG
Rv2047c|M.tuberculosis_H37Rv SNSGFFGPSMASLPIFG---AQRPPSESSRARRWLRTLRNIGVFGVNLVG
MUL_2265|M.ulcerans_Agy99 SNSGFFGPSMGSLPIFG---EERPPAESSFVRRQLCTVRNIGVFGVNLVG
TH_4555|M.thermoresistible__bu FSVRARETQVGYDRMNARAGFQDLLGQRLYKDKYGTVYWNVDMDEKRLRY
Mvan_2632|M.vanbaalenii_PYR-1 QRPRLAARVLSNFGMKDPAGSAALRKWLSQNSGRLPRPDRAAPPRGLLVL
Mflv_0493|M.gilvum_PYR-GCK TEGTALSSGILGNSLEQFSLSVCGRVIDELEPGPPKPFVRKLINTVRLST
MAV_5056|M.avium_104 RSETDAWWRHEIAAVSR----------LDLRLAQRLAAEARDRFFTTLAA
MLBr_00955|M.leprae_Br4923 NPPPANTYDQLRAAIES-----IFSSWNSPRAVAYRTHYGLDDQSGTAVI
:
MMAR_3410|M.marinum_M IAAAIVTNRGGRTCHAAIIARELGIPAVVGAG------------------
MSMEG_3934|M.smegmatis_MC2_155 RAAALVTETGGMTCHAAIVARELGVPCVVGAR------------------
Mb2073c|M.bovis_AF2122/97 LSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLS-------------
Rv2047c|M.tuberculosis_H37Rv LSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLS-------------
MUL_2265|M.ulcerans_Agy99 LSAGSALDTNDFIADVDRLEQLAGGDVTTLDDRRLLS-------------
TH_4555|M.thermoresistible__bu VLPRFARPAGANVVPADMQEQMFAEPLDVVRWLKAMISFSVSPIYSLSRW
Mvan_2632|M.vanbaalenii_PYR-1 LPSLLAGTVASIAAPTRARRRIVAGADAELARLEQQAEMLSAP-----DE
Mflv_0493|M.gilvum_PYR-GCK FALSSAPAIRRLPQTIAAFPPITSRDPAVVLRHLEAG-------------
MAV_5056|M.avium_104 QAVISATVIQPVQEQLSTLCKAAGVDPAVLLR------------------
MLBr_00955|M.leprae_Br4923 VQAMVFGNQGAYSGAGTLFSRNPITRESKLFGEWLPG-------------
MMAR_3410|M.marinum_M -----------DATTNVPDGQLVTVSCVEGD--TGRVYRGEVGFHVDRTE
MSMEG_3934|M.smegmatis_MC2_155 -----------SATVALAVGSMVTVDGTRGEVTTGRLPETVRTTTTPQEP
Mb2073c|M.bovis_AF2122/97 --------LILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAA
Rv2047c|M.tuberculosis_H37Rv --------LILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAA
MUL_2265|M.ulcerans_Agy99 --------LILLARDHVVHGWVLASGSFMLCAAFNVLLRAVSGRDTAPAA
TH_4555|M.thermoresistible__bu KKVIREDYLFNEAAVAKANGLSDAELRALSDDELYRYQRDLQEYAIDFMD
Mvan_2632|M.vanbaalenii_PYR-1 QLRFVERELPAATCDMVLRQLAAAYGEWLLRVVIERLVRRWLGSSTGFAP
Mflv_0493|M.gilvum_PYR-GCK --------VDIYREVTLIHVRSSSRSAVAANVLESHLVRRAAKRGASDTA
MAV_5056|M.avium_104 -----------GASHEENAVLHDLWAASRGALEVDEFVKRHGYHGPGEGE
MLBr_00955|M.leprae_Br4923 -----------GQGDDVVSGLVEVQPITSLRDEQPTVYDELVDTAGRLER
MMAR_3410|M.marinum_M -----------------VADLARPRT--EVMVNLGNP-DLAFKTSFLPN-
MSMEG_3934|M.smegmatis_MC2_155 -----------------APHITGEATGTKVYVNLAMP-DSAEAVAAQDV-
Mb2073c|M.bovis_AF2122/97 -----------------GPELVSARSVEAVQRLVAAARRDPVVIRLLAE-
Rv2047c|M.tuberculosis_H37Rv -----------------GPELVSARSVEAVQRLVAAARRDPVVIRLLAE-
MUL_2265|M.ulcerans_Agy99 -----------------GPELVSARSVEAVQRLVDAARHDEAVIRLLSE-
TH_4555|M.thermoresistible__bu PLWFGAYTAMSMFFSLHAALLAKYYTGTNELLGQDLISGLPTTLQALENR
Mvan_2632|M.vanbaalenii_PYR-1 -----------------VLRWLPHDPTIAMGAALARLAREHAAAGIEPGP
Mflv_0493|M.gilvum_PYR-GCK G----------------SAEAIRLMTGAGVESALMVEELTAVVSMLRRD-
MAV_5056|M.avium_104 ------------------------------LETRVWREDPGAVAGLVRR-
MLBr_00955|M.leprae_Br4923 ----------------LGSDVQEIEFTTEDSKLWLLQTRVAERSAQVAVR
MMAR_3410|M.marinum_M ---DGVGLARMEFIVGEYIKVHPLALLHPDKVDD----------------
MSMEG_3934|M.smegmatis_MC2_155 ---DGVGLLRAEFMLTEALAG-----------------------------
Mb2073c|M.bovis_AF2122/97 ---PGERLDKLAVEAPEFHSAVLAELTLIG--------------------
Rv2047c|M.tuberculosis_H37Rv ---PGERLDKLAVEAPEFHSAVLAELTLIG--------------------
MUL_2265|M.ulcerans_Agy99 ---PGDRLGKLAVAAPHFYDAVRQELSLIG--------------------
TH_4555|M.thermoresistible__bu AFFELTSMIRHSKVLSDAFEKHQGAAFFAELENSDEGREFLEKYREFLAE
Mvan_2632|M.vanbaalenii_PYR-1 ---ESAGVSEFLATFGHRAPDREVDLGLPRLSDDP---------------
Mflv_0493|M.gilvum_PYR-GCK ---GDAAARFLAAPAGEAVTRLRAAETPSGAALRTFLDRHG---------
MAV_5056|M.avium_104 --------------------------------------------------
MLBr_00955|M.leprae_Br4923 --------------------------------------------------
MMAR_3410|M.marinum_M --PEARRTIERLTRGYSDGAEFFVQRLSEGIGTIAAA-------------
MSMEG_3934|M.smegmatis_MC2_155 -----RHPRDLITKGEQD---TLVDAMAAAVTRIGTA-------------
Mb2073c|M.bovis_AF2122/97 --HRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP-------------
Rv2047c|M.tuberculosis_H37Rv --HRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP-------------
MUL_2265|M.ulcerans_Agy99 --HRGPAEVEMMSTSYADNPELLVGMVAKTLSTSSVP-------------
TH_4555|M.thermoresistible__bu HGHRGHPDRDLIFKRRADDPAVDYEAFKVQLQAPEATPPIELEERVRARR
Mvan_2632|M.vanbaalenii_PYR-1 -TYVVELINGYLRSGALDTFETGVHEARAASDGLITG-------------
Mflv_0493|M.gilvum_PYR-GCK --HRGYRELCMRDPSWADDPDGLGAMMQVMLRGAAPENP-----------
MAV_5056|M.avium_104 -----YSARSDAESPDADAAEHHRRRSEAERDLMSSLG------------
MLBr_00955|M.leprae_Br4923 ------LALQLWQEGLIDDAEALRRVTPVHVETVLLP-------------
*
MMAR_3410|M.marinum_M ---------------FWPKP-VVVRMSDFKSNEYASLIG------GSGFE
MSMEG_3934|M.smegmatis_MC2_155 ---------------FAPRP-VIYRAMDFRTNEFRGLAG------GEQFE
Mb2073c|M.bovis_AF2122/97 ---------------QPPTPVIPLRAKPVALLAARQLRD------REVRR
Rv2047c|M.tuberculosis_H37Rv ---------------QPPTPVIPLRAKPVALLAARQLRD------REVRR
MUL_2265|M.ulcerans_Agy99 ---------------QPPQPSIPLQAKPIAVLAARQLRD------REARR
TH_4555|M.thermoresistible__bu EAAEAEVIENLGRGFLGPVKQQLFKLLQHQIIDFLVLRDDWRHFIDRITY
Mvan_2632|M.vanbaalenii_PYR-1 -----------VRRVKGPVRAAVLRNLLARHLALGGLRERPKFDMVRAMA
Mflv_0493|M.gilvum_PYR-GCK ----------AATAPSDPAQSRTLRVLARLAQAGARGREETKSRMALMAH
MAV_5056|M.avium_104 -----------------PAARVRARLVLRLARNYIPLRGTGKVAYLQSLD
MLBr_00955|M.leprae_Br4923 --------------------------------------------------
MMAR_3410|M.marinum_M PTESNPMIGFRGASRYAHP--AYAEGFALECRAMQRVRDQMGLTNVVIML
MSMEG_3934|M.smegmatis_MC2_155 PVEHNPMIGYRGCYRYIK----EPDLFALELSALARAREHT--PNIHLMI
Mb2073c|M.bovis_AF2122/97 DRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSG
Rv2047c|M.tuberculosis_H37Rv DRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSG
MUL_2265|M.ulcerans_Agy99 DKMVRAIWVLRALLREHGRRLAEAGVLHASDDVFYLLVDEVDALPADVAE
TH_4555|M.thermoresistible__bu AKRKAFLEVARRCVERGRLEKEDDAFFLGETELFEVLNGTAKQPLVQAKI
Mvan_2632|M.vanbaalenii_PYR-1 LGRRTLRRCGAALVERGLLDDADDVFFLDGADVRAALAGRACDLRARAAA
Mflv_0493|M.gilvum_PYR-GCK LLKRGYRHLGEVLHEAGRLPDADLVFFFDRRELPLVVSGDDVTELVHRAR
MAV_5056|M.avium_104 VLRAAARRIGSLLVEQQRLTDPDDAFYLTIDELTGAP---LADAATDLRG
MLBr_00955|M.leprae_Br4923 -VLQPENHLSATLLAKGTPTCPGVISGKAYTEVDEALDAAESAEQVILVR
MMAR_3410|M.marinum_M PFVRRVAEADLVLETMAEHGLRRGENGLKVYAMCEIPNNVILIDQFAKR-
MSMEG_3934|M.smegmatis_MC2_155 PFVRTRWELEECLALVDASPLRRHRN-LHRWVMAEVPSVVHWLPEYVGMG
Mb2073c|M.bovis_AF2122/97 LVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGR
Rv2047c|M.tuberculosis_H37Rv LVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGR
MUL_2265|M.ulcerans_Agy99 LVARRRAEQRRLTAVVPPTVFSGKWEPSTASAAALTAEGTLRGVGVCGGR
TH_4555|M.thermoresistible__bu AARRPDFELFESRTFTPPMFMRGETPVDEAAPAAVAGSGAINGVGTSAGQ
Mvan_2632|M.vanbaalenii_PYR-1 DHRSFRRELR-RRRVPRVLTSEGEAVYGFDTATPGAETDVLIGTALSPGV
Mflv_0493|M.gilvum_PYR-GCK QR-REALPFQAALEFGDVSVGR----PTPIVRAAVSGDGVVAGRPAGHGS
MAV_5056|M.avium_104 TISERREIRAHYQSLTLPSAWTGQPEPLAPSASAETSVRSLRGIGACAGV
MLBr_00955|M.leprae_Br4923 DHTRPDDVLGMLASQGVVTEVGGAASHAAVVSRELSRVAVVGCGQGTAVS
MMAR_3410|M.marinum_M FDGFS--IGSND-LTQLTLGVDRDSEIVAFDYDERDDGVKEMIRLAVEGC
MSMEG_3934|M.smegmatis_MC2_155 IDGVS--IGSND-LTQLMLGVDRDSETCAELFDESDAAVLDAISRIISTA
Mb2073c|M.bovis_AF2122/97 VRGRVRIVRPET-IDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPM
Rv2047c|M.tuberculosis_H37Rv VRGRVRIVRPET-IDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPM
MUL_2265|M.ulcerans_Agy99 VRGRVRIVRPET-IDELEPGEILVAEVTDVGYTAAFCYAAAVVTELGGPM
TH_4555|M.thermoresistible__bu VEGRARVLASMTEIGTLEQGDVLVCNATDPGWSPVFGVISGLIIETGGML
Mvan_2632|M.vanbaalenii_PYR-1 HVGTVRVLDSPV-GANLQPGEVIVAASTDPGWTPLFLLAGALVMEVGGVM
Mflv_0493|M.gilvum_PYR-GCK VEGVVRVARSVVEARDLQPGEILVAPVTDVGWTPYFAVIAALVTDIGSSV
MAV_5056|M.avium_104 AEGRAVVVTDPT-ETEIADGDILIAQTTDPSWVSLMFLSAALVVDIGGLM
MLBr_00955|M.leprae_Br4923 LAGKQITVDGDK-------GEVRQGNLTLSAWSENETPELRELADIARRI
* * : :
MMAR_3410|M.marinum_M RRNGIHSGLCGQAPSDYPDMAEFLVRAGIDSVSLNPDVVVKTTRQILDLE
MSMEG_3934|M.smegmatis_MC2_155 NRLGITSSLCGQAPSTRPEFAEHLVRMGITSVSVNPDAAGAARRAVAAAE
Mb2073c|M.bovis_AF2122/97 SHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDG
Rv2047c|M.tuberculosis_H37Rv SHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDG
MUL_2265|M.ulcerans_Agy99 SHAAVVAREFGFPCVVDAQGATRFLPPGALIEVDGTTGEIQVLELAAEGD
TH_4555|M.thermoresistible__bu AHGACLSREHGIPAVQIVG-ATQIIPDGAYVRINGTTGLVEVLEPAPAGA
Mvan_2632|M.vanbaalenii_PYR-1 SHGALVAREYGLPAVAGIGNAMTRLRSGQRVRVDGTAGSVTLLDSVAPDG
Mflv_0493|M.gilvum_PYR-GCK SHGAVVAREYGLPCVVNTLVGTQVLRTGDRVRVDGDRGLVTVLDSP----
MAV_5056|M.avium_104 SHAAVMARELGIPCVMNTGTGTTALRTGDTIRVDGAAGTVEILSRNIQQS
MLBr_00955|M.leprae_Br4923 SPLRVHMTEDHTRLDDSSDTAVRLAINTGHADVVSATPLIVMMTTLRLQD
. .
MMAR_3410|M.marinum_M QQVVPLQ------------------------
MSMEG_3934|M.smegmatis_MC2_155 RRLLLDSVRHPRHAPTASPRNPL--------
Mb2073c|M.bovis_AF2122/97 PALPGSDLSR---------------------
Rv2047c|M.tuberculosis_H37Rv PALPGSDLSR---------------------
MUL_2265|M.ulcerans_Agy99 SSVTQSDPADLA-------------------
TH_4555|M.thermoresistible__bu A------------------------------
Mvan_2632|M.vanbaalenii_PYR-1 AAEDPAPTADRAAGSGPRPAPRPRPVSPDSR
Mflv_0493|M.gilvum_PYR-GCK -------------------------------
MAV_5056|M.avium_104 SIPERTH------------------------
MLBr_00955|M.leprae_Br4923 SKDSSAKS-----------------------