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VSTAVDETALRDLIPGVLAALVHRGADFATAEDAVQEALIRAVQTWPRRHPDDPRGWLITTAWRRFVDLV RADAARRDRELKSFDEPPPGPAEHADDTLYLYFLCAHPSLTPSSAVALTLRAVGGLTTRQIAQAYLVPES TMAQRISRAKRTVSDVRLDRPGDVRTVLRVLYLVFNEGYSGDVDLAAEAIRLARQLAAVVDDPEVSGLLA LFLLHHARRPARMRGDGSLVPLAEQNRGLWRTDLIAEGVTVLQAALARDRLGEYQAQAAIAALHADAQTA EETDWVQIVEWYDELVRLTDSPVVRLNRAVAVGEADGPRAGLTALANLDPTLPRYTASKAYLCEKAGDTE AAAALYAEAAAQAYNVAERNHLTLRAATLRQALPHDSD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2612 | - | - | 100% (388) | RNA polymerase ECF-subfamily sigma factor |
| M. vanbaalenii PYR-1 | Mvan_3355 | - | 2e-61 | 41.39% (389) | RNA polymerase ECF-subfamily sigma factor |
| M. vanbaalenii PYR-1 | Mvan_4496 | - | 4e-06 | 29.01% (131) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 1e-10 | 31.07% (177) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_2200 | - | 3e-07 | 30.71% (140) | RNA polymerase sigma factor SigE |
| M. tuberculosis H37Rv | Rv1189 | sigI | 1e-10 | 31.07% (177) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | MLBr_01076 | sigE | 2e-07 | 30.60% (134) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4459c | - | 3e-73 | 45.62% (388) | ECF subfamily RNA polymerase sigma factor |
| M. marinum M | MMAR_0975 | - | 2e-58 | 39.95% (393) | RNA polymerase sigma factor |
| M. avium 104 | MAV_4519 | - | 4e-57 | 40.86% (394) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_0405 | - | 1e-166 | 78.44% (385) | extra cytoplasmic sigma factor |
| M. thermoresistible (build 8) | TH_3917 | - | 1e-165 | 77.84% (379) | PUTATIVE putative RNA polymerase, sigma-24 subunit, ECF |
| M. ulcerans Agy99 | MUL_4519 | sigE | 2e-06 | 28.47% (137) | RNA polymerase sigma factor SigE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1221|M.bovis_AF2122/97 MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLR--APV
Rv1189|M.tuberculosis_H37Rv MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLR--APV
Mvan_2612|M.vanbaalenii_PYR-1 -MSTAVDETALRDLIPGVLAALVHRGADFATAEDAVQEALIRAVQTWPR-
MSMEG_0405|M.smegmatis_MC2_155 -----MDPAALRDLIPGVLAALVRRGVDFATAEDAVQEALIKALETWSTG
TH_3917|M.thermoresistible__bu ----VIDGRRLRELIPGVLGTLVRRGADFASAEDAVQEALVRALTTWAG-
MMAR_0975|M.marinum_M -MAN--LDGVFRREWGSAVAALARWSGDLTIAEDAVQEACAEALRAWPRD
MAV_4519|M.avium_104 -MAD--LDGVFRREWGPAVAALARWSGDLTVAEDAVQEACAEALRAWPRD
MAB_4459c|M.abscessus_ATCC_199 -MAHDEISRIFRAEYGRTVATLIRYFGSIDLAEDAVQEAFEVAIARWPED
MLBr_01076|M.leprae_Br4923 --------------MGDGIGMEREGRW----TGNTQCPLRVVPGDESPTL
MUL_4519|M.ulcerans_Agy99 --------------------MERGGRG----LGNTAWQLRVAAGDELPMS
Mflv_2200|M.gilvum_PYR-GCK ------------MTEGARTDTVRTARIDSARSRNENASARVAEHDGSPQG
: .
Mb1221|M.bovis_AF2122/97 GDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDP
Rv1189|M.tuberculosis_H37Rv GDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDP
Mvan_2612|M.vanbaalenii_PYR-1 RHPDDPRGWLITTAWRRFVDLVRADAARRDRELK---------SFDEPPP
MSMEG_0405|M.smegmatis_MC2_155 RAPDDPKAWLITTAWRRFIDVARAEAARRSRELR---------TAVEDPQ
TH_3917|M.thermoresistible__bu KPPRDPKGWLITTAWRCFVDATRSDAARRRREEL---------IATRPPP
MMAR_0975|M.marinum_M GVPDSPGGWLVTVARNRARDRLRRESARPAKELAYVVNDIGAIRARTEHS
MAV_4519|M.avium_104 GMPANPGGWLVTVARNRARDRLRRESARPGKELAAVLDDI---RARTDAA
MAB_4459c|M.abscessus_ATCC_199 GIPPNPGAWITTTARNRGIDKLRRDRRR--DELSREAGAFA--EPQQEPE
MLBr_01076|M.leprae_Br4923 DGRASPEDLIITN---------------------------------LLSP
MUL_4519|M.ulcerans_Agy99 DGREKPEEHTIT----------------------------------TLST
Mflv_2200|M.gilvum_PYR-GCK GPHHHLEDPTTTTQAPTSSVSAAA-----------------PVAAPVAAP
.
Mb1221|M.bovis_AF2122/97 ADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQA
Rv1189|M.tuberculosis_H37Rv ADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQA
Mvan_2612|M.vanbaalenii_PYR-1 GPAEHADDTLYLYFLCAHPSLTPSSAVALTLRAVGGLTTRQIAQAYLVPE
MSMEG_0405|M.smegmatis_MC2_155 GPTVPVDDTLQLYFLCAHPSLSPASAVALTLRAVGGLTTRQIARAYLVPE
TH_3917|M.thermoresistible__bu GPVPAVDDTLALYFLCAHPRLSPASAVALTLRAVGGLTTRQIAQAYLVPE
MMAR_0975|M.marinum_M DPHPVRDDELRMMFTCAHPALDRQSQLALTLRLVSGLTVTEIARALLQTD
MAV_4519|M.avium_104 DPHPVRDDELRMMFTCAHPALDRPSQLALTLRLVSGLTVAEIARALLQSE
MAB_4459c|M.abscessus_ATCC_199 DVGPVRDDRLRLIFTCCHPALSQEAQVALTLRLLGGLTTPEIAGAYLVSE
MLBr_01076|M.leprae_Br4923 TIMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARV
MUL_4519|M.ulcerans_Agy99 TTMSHPQLVRDDEWAETSDGLLGTAVFDATGDKAAMPSWDELVRQHADRV
Mflv_2200|M.gilvum_PYR-GCK VSMAHREQFTEAEWVEPTDELTGTAVFDATGDKAAMPSWDELVRQHADRV
* . . . ::.
Mb1221|M.bovis_AF2122/97 STCRQLAHRARRKINESRIAAS---------VEPAQHRVVTRAFIEACSN
Rv1189|M.tuberculosis_H37Rv STCRQLAHRARRKINESRIAAS---------VEPAQHRVVTRAFIEACSN
Mvan_2612|M.vanbaalenii_PYR-1 STMAQRISRAKRTVSDVRLDR--------PGDVRTVLRVLYLVFNEGYSG
MSMEG_0405|M.smegmatis_MC2_155 STMAQRISRAKRTVSEVRLNR--------LGNLGTVLRVLYLVFNEGYTG
TH_3917|M.thermoresistible__bu STMAQRISRAKHTIADVQPGR--------PGDLRTVLRVLYLVFNEGYTG
MMAR_0975|M.marinum_M AAIGQRITRAKNKIRHANIPLRVPPAELLPERTPHVLGCIYSVFTEGYWA
MAV_4519|M.avium_104 AAISQRITRAKNKVRHANIPLRVPPAELLGERTPHVLGCVYSVFTEGYWS
MAB_4459c|M.abscessus_ATCC_199 STMAARITRAKKKIAAAGIPYRIPAAHDLPDRLSSVLSVLYLIYNEGYAA
MLBr_01076|M.leprae_Br4923 YWLAYRLSGNQHDAEDLTQET-----------FIRVFRSVQNYQPGTFEG
MUL_4519|M.ulcerans_Agy99 YRLAYRLSGNQQDAEDLTQET-----------FIRVFRSVQNYQPGTFEG
Mflv_2200|M.gilvum_PYR-GCK YRLAYRLSGNQHDAEDLTQET-----------FIRVFRSVQNYQPGTFEG
:. :
Mb1221|M.bovis_AF2122/97 --------------------------------GDLDTLLEVLDPGVAGEI
Rv1189|M.tuberculosis_H37Rv --------------------------------GDLDTLLEVLDPGVAGEI
Mvan_2612|M.vanbaalenii_PYR-1 -------DVDLAAEAIRLARQLAAVVD-DPEVSGLLALFLLHHARRPARM
MSMEG_0405|M.smegmatis_MC2_155 -------DVDLSAEAIRLARQLAAATD-APEVAGLLALFLLHDARRPART
TH_3917|M.thermoresistible__bu -------EVDLAEEAIRLARRLVAVTD-DPEVAGLLALFLLHHARRPART
MMAR_0975|M.marinum_M TGGPSAIRDELCDEGVRLAQELCALMPQEPETHALAALVLLHDSRRATRV
MAV_4519|M.avium_104 TAGPSAIRDDLCDEGIRLGAELCALLPHEREAHALSALMLLHDSRRATRV
MAB_4459c|M.abscessus_ATCC_199 SSGARLTRTDLSAEAIRLSRLLADLMPDEPEALGLLALVLLTEARRPART
MLBr_01076|M.leprae_Br4923 ------------------------------WLHRITTNLFLDMVRRRARI
MUL_4519|M.ulcerans_Agy99 ------------------------------WLHRITTNLFLDMVRRRSRI
Mflv_2200|M.gilvum_PYR-GCK ------------------------------WLHRITTNLFLDMVRRRGRI
: : . : .
Mb1221|M.bovis_AF2122/97 DARKGVVVVGADR----------VGPTILR---------HWSHPATVLVA
Rv1189|M.tuberculosis_H37Rv DARKGVVVVGADR----------VGPTILR---------HWSHPATVLVA
Mvan_2612|M.vanbaalenii_PYR-1 RGDGSLVPLAEQNRGLWRTDLIAEGVTVLQAALARDRLGEYQAQAAIAAL
MSMEG_0405|M.smegmatis_MC2_155 RADGTLVPLAEQDRTLWRHDLITEGVAVLQAALAADRLGEYQAQAAIAAL
TH_3917|M.thermoresistible__bu RADGSLVPLAEQDRSVWRRDLIAEGVGILQAALARDRLGEYQAQAAIAAL
MMAR_0975|M.marinum_M DEAGALVPLDEQDRSRWDHGRIARGLDRLRRASGS--RGPYLPQAVIAAL
MAV_4519|M.avium_104 DAHGVPVPLEEQDRTRWDRRRITAGLDRLRYAEGS--SGAYLPQAVIAAL
MAB_4459c|M.abscessus_ATCC_199 GDDGALVLLADQDRTRWNRQMITEGHQLVRRCLRRNVPGPYQIQAAINAV
MLBr_01076|M.leprae_Br4923 RMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLC
MUL_4519|M.ulcerans_Agy99 RMEALPEDYDRVPADDPNPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLC
Mflv_2200|M.gilvum_PYR-GCK RMEALPEDYDRVPADEPNPEQIYHDSRLGADLQAALDSLAPEFRAAVVLC
. *.:
Mb1221|M.bovis_AF2122/97 QPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELG
Rv1189|M.tuberculosis_H37Rv QPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELG
Mvan_2612|M.vanbaalenii_PYR-1 HADAQTAEETDWVQIVEWYDELVRLTDSPVVRLNRAVAVGEADGPRAGLT
MSMEG_0405|M.smegmatis_MC2_155 HADARTADETDWVQIVEWYDELVALTDSPVARLNRAVAVGEADGPRAGLA
TH_3917|M.thermoresistible__bu HADAQRVEDTDWVQIVEWYDELVALTGSPVVRLNRAVAVGAAAGPRAGLA
MMAR_0975|M.marinum_M HASAPSWEHTDWTTICAAYDRLLQLTDSPVVLANRALAVGFRDGPDAGLA
MAV_4519|M.avium_104 HATAPSWEETDWVTICAAYDRLWQLTRSPVVAANRALAIGLRDGPDAGLA
MAB_4459c|M.abscessus_ATCC_199 HDDAPSAAGTDWRQIVTLYDQLMRFTPTTVVALNRAVAVAERDGAQAGLD
MLBr_01076|M.leprae_Br4923 DIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLLTAHPRDGATTDAT
MUL_4519|M.ulcerans_Agy99 DIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDY-LAAHP-EHSELSPR
Mflv_2200|M.gilvum_PYR-GCK DIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDH-LARHSDVGAGRDT-
. : . . :
Mb1221|M.bovis_AF2122/97 GG------------------------------------------------
Rv1189|M.tuberculosis_H37Rv GG------------------------------------------------
Mvan_2612|M.vanbaalenii_PYR-1 ALANLD--PTLPRY---TASKAYLCEKAGDTEAAAALYAEAAAQAYNVAE
MSMEG_0405|M.smegmatis_MC2_155 ALAELD--PALPRH---TASAAYLHERAGDIARAAQLYVEAADQAHTVPE
TH_3917|M.thermoresistible__bu ALAELD--PELPRH---TAAAAYLHEQAGDIATAADLYAEAAAKADNLAE
MMAR_0975|M.marinum_M ALEEVAHDPRLSHSNLVASARADLLRRAGRGADALRWYRVALDSNGSEPS
MAV_4519|M.avium_104 ALEEVD-EPKLERSNLIATLRADLLRRAGRPAEALPWYRIASQSNGSEPG
MAB_4459c|M.abscessus_ATCC_199 AMEPLR--ADLDRYYPLHAARADLLTRLHRDSEAADAYRKALELTENEVF
MLBr_01076|M.leprae_Br4923 HVKSA---------------------------------------------
MUL_4519|M.ulcerans_Agy99 LVGTAR--------------------------------------------
Mflv_2200|M.gilvum_PYR-GCK -AKSA---------------------------------------------
Mb1221|M.bovis_AF2122/97 -----------------------------
Rv1189|M.tuberculosis_H37Rv -----------------------------
Mvan_2612|M.vanbaalenii_PYR-1 RNHLTLRAATLRQALPHDSD---------
MSMEG_0405|M.smegmatis_MC2_155 RNHLLLKAATLHQRLGSPGDAKRLPG---
TH_3917|M.thermoresistible__bu RNHLTLRAATLRRRI--------------
MMAR_0975|M.marinum_M RGFLQRRIAECQG----------------
MAV_4519|M.avium_104 REFLRRRIAECTSAAESATGDAFPENGRR
MAB_4459c|M.abscessus_ATCC_199 RRYLGDRLARLEPGA--------------
MLBr_01076|M.leprae_Br4923 -----------------------------
MUL_4519|M.ulcerans_Agy99 -----------------------------
Mflv_2200|M.gilvum_PYR-GCK -----------------------------