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MQSLDGVFRREWGRTVAAIARWCGDLTVAEDAVQEACADALRSWPRDGVPEVPGAWLVTTARNRARDRLR RESARPGKELAAVLDDIIARTDGPEVPHRVRDDELRMMFTCAHPALERPSQLALTLRLVSGLTVAEIARA LLQSEAAVGQRITRAKAKIRHANIPLRVPPGELLAQRTPHVLACIYSVFTEGYWSTAGPSAIRDELCDEA VRLTGELCVAMPEEPEGHALAALVLLHDSRRATRTDGRGTLVPLEEQDRRRWDRGKIARGLEQLRRAGGS PGPYLPQAVIAAVHATAPCWEQTDWVTICAAYDRLLGIADSPVVRANRAMAVGFRDGPDAGLAALETVAD DPRLARSPLVATVRADLLRRAGRDDEAVVSYRHALAANGSIPGREFLARRIAECGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3355 | - | - | 100% (406) | RNA polymerase ECF-subfamily sigma factor |
| M. vanbaalenii PYR-1 | Mvan_2612 | - | 2e-61 | 41.39% (389) | RNA polymerase ECF-subfamily sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 5e-07 | 25.90% (166) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_5063 | - | 1e-05 | 26.80% (153) | ECF subfamily RNA polymerase sigma-24 factor |
| M. tuberculosis H37Rv | Rv1189 | sigI | 5e-07 | 25.90% (166) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3888 | - | 0.0 | 79.70% (404) | putative RNA polymerase sigma-70 factor |
| M. marinum M | MMAR_0975 | - | 0.0 | 78.00% (409) | RNA polymerase sigma factor |
| M. avium 104 | MAV_4519 | - | 1e-180 | 77.97% (404) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_1348 | - | 1e-164 | 73.09% (405) | RNA polymerase ECF-subfamily protein sigma factor |
| M. thermoresistible (build 8) | TH_3917 | - | 2e-57 | 43.00% (393) | PUTATIVE putative RNA polymerase, sigma-24 subunit, ECF |
| M. ulcerans Agy99 | MUL_1400 | sigK | 9e-06 | 26.45% (155) | RNA polymerase sigma factor SigK |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1221|M.bovis_AF2122/97 -------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGV
Rv1189|M.tuberculosis_H37Rv -------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGV
Mvan_3355|M.vanbaalenii_PYR-1 -------------------MQSLD--GVFRREWGR-TVAAIARWCGDLTV
MAB_3888|M.abscessus_ATCC_1997 -------------------MIELE--GVFRREWGP-TVAAIARWSGDLTV
MMAR_0975|M.marinum_M -------------------MANLD--GVFRREWGS-AVAALARWSGDLTI
MAV_4519|M.avium_104 -------------------MADLD--GVFRREWGP-AVAALARWSGDLTV
MSMEG_1348|M.smegmatis_MC2_155 -------------------MAELD--SVFRREWGP-TVATIARWSGDLAL
TH_3917|M.thermoresistible__bu ---------------------VID--GRRLRELIPGVLGTLVRRGADFAS
Mflv_5063|M.gilvum_PYR-GCK --MSADSEGAASEGAVPEGLDAPSALLALYDEALPAVYGYFVRRCGDRGT
MUL_1400|M.ulcerans_Agy99 MTGPPGRSDDLNALLRQIARGERDAFAMFYDHTCTRVYGLVARVLRDAGY
. * *
Mb1221|M.bovis_AF2122/97 AEDMVQEAFSRLLR-APVGDIDDE--RGWLIVVTSRLCLDHIKSASTRRE
Rv1189|M.tuberculosis_H37Rv AEDMVQEAFSRLLR-APVGDIDDE--RGWLIVVTSRLCLDHIKSASTRRE
Mvan_3355|M.vanbaalenii_PYR-1 AEDAVQEACADALR-SWPRDGVPEVPGAWLVTTARNRARDRLRRESARPG
MAB_3888|M.abscessus_ATCC_1997 AEDAVQEACADALR-TWPRDGIPDTPGGWLLTAARNRARDRLRRETLRPG
MMAR_0975|M.marinum_M AEDAVQEACAEALR-AWPRDGVPDSPGGWLVTVARNRARDRLRRESARPA
MAV_4519|M.avium_104 AEDAVQEACAEALR-AWPRDGMPANPGGWLVTVARNRARDRLRRESARPG
MSMEG_1348|M.smegmatis_MC2_155 AEDAVQEACAHAVQ-AWA-DGLPDNPGAWLTTVARNRALDRLRRESQRTG
TH_3917|M.thermoresistible__bu AEDAVQEALVRALT-TWA-GKPPRDPKGWLITTAWRCFVDATRSDAARRR
Mflv_5063|M.gilvum_PYR-GCK AEDLTSETFLAAMD-AARKPSPPDLSVRWLIGVARHKLADHYRRRWDRFA
MUL_1400|M.ulcerans_Agy99 SEETTQEIYLEVWRTASDYDATKGSPLAWLLTMAHRRAVDRVRAEQAGSQ
:*: ..* : ** : . * :
Mb1221|M.bovis_AF2122/97 RPQDIAAWHDG-DASVSSVDPADRVTLDDEVR-LALLIMLERLGPAERVV
Rv1189|M.tuberculosis_H37Rv RPQDIAAWHDG-DASVSSVDPADRVTLDDEVR-LALLIMLERLGPAERVV
Mvan_3355|M.vanbaalenii_PYR-1 KELAAVLDDI---IARTDGPEVPHRVRDDELR-MMFTCAHPALERPSQLA
MAB_3888|M.abscessus_ATCC_1997 KELAAVVDDI---TARTD-VADPHPVRDDELR-MMFTCAHPALERTSQLA
MMAR_0975|M.marinum_M KELAYVVNDIGAIRARTE-HSDPHPVRDDELR-MMFTCAHPALDRQSQLA
MAV_4519|M.avium_104 KELAAVLDDI---RARTD-AADPHPVRDDELR-MMFTCAHPALDRPSQLA
MSMEG_1348|M.smegmatis_MC2_155 REYAAVYEDM---TARAD--TELHPVRDDQLR-MMFTCAHPALDRASQLA
TH_3917|M.thermoresistible__bu REELIATRPP----------PGPVPAVDDTLA-LYFLCAHPRLSPASAVA
Mflv_5063|M.gilvum_PYR-GCK TPVAELPEPA-----------DPADEWDAELDRIVAEQVLTRLSDPHRAV
MUL_1400|M.ulcerans_Agy99 RESRYGAANVD---LASDVVADSAIAGDERRR---VVECLDGLTDTQRQC
* *
Mb1221|M.bovis_AF2122/97 FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQH
Rv1189|M.tuberculosis_H37Rv FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQH
Mvan_3355|M.vanbaalenii_PYR-1 LTLRLVSGLTVAEIARALLQSEAAVGQRITRAKAKIRHANIPLRVPPGEL
MAB_3888|M.abscessus_ATCC_1997 LTLRLVSGLTVAEIARALLHSEAAIGQRITRAKAKIRTANIPLRVPPAEL
MMAR_0975|M.marinum_M LTLRLVSGLTVTEIARALLQTDAAIGQRITRAKNKIRHANIPLRVPPAEL
MAV_4519|M.avium_104 LTLRLVSGLTVAEIARALLQSEAAISQRITRAKNKVRHANIPLRVPPAEL
MSMEG_1348|M.smegmatis_MC2_155 LTLRLISGLTAAEIARALLQSETAVRQRITRAKNKIRKANIPLRVPPAEL
TH_3917|M.thermoresistible__bu LTLRAVGGLTTRQIAQAYLVPESTMAQRISRAKHTIADVQPGR---PGDL
Mflv_5063|M.gilvum_PYR-GCK LVLRYMDGCSVPECAELIGRTVHATEALLVRARRAFR-------------
MUL_1400|M.ulcerans_Agy99 IELAYYGGLTYAEVSQRLATNLSTIKSRMRDALRGLRN------------
: * * . : : : * .
Mb1221|M.bovis_AF2122/97 R---------VVTRAFIEACSN----------------------------
Rv1189|M.tuberculosis_H37Rv R---------VVTRAFIEACSN----------------------------
Mvan_3355|M.vanbaalenii_PYR-1 LAQRTPHVLACIYSVFTEGYWSTAGPSAIRDELCDEAVRLTGELCVAMPE
MAB_3888|M.abscessus_ATCC_1997 LPERTPHVLSCIYSVFTEGYWSTGGPSAIRDELCDEGVRLAGELCRLMPQ
MMAR_0975|M.marinum_M LPERTPHVLGCIYSVFTEGYWATGGPSAIRDELCDEGVRLAQELCALMPQ
MAV_4519|M.avium_104 LGERTPHVLGCVYSVFTEGYWSTAGPSAIRDDLCDEGIRLGAELCALLPH
MSMEG_1348|M.smegmatis_MC2_155 LPERTPHVLACIYSVFTEGYWSTAGPSAIRDELCDEGVRLAAELCALLPD
TH_3917|M.thermoresistible__bu R-----TVLRVLYLVFNEGYTG-------EVDLAEEAIRLARRLVAVT-D
Mflv_5063|M.gilvum_PYR-GCK ----------AMYPEPEGGLS-----------------------------
MUL_1400|M.ulcerans_Agy99 ----------CLDAS-----------------------------------
:
Mb1221|M.bovis_AF2122/97 ----GDLDTLLEVLDPGVAGEIDAR---------------KGVVVVGADR
Rv1189|M.tuberculosis_H37Rv ----GDLDTLLEVLDPGVAGEIDAR---------------KGVVVVGADR
Mvan_3355|M.vanbaalenii_PYR-1 EPEGHALAALVLLHDSRRATRTDGRGTLVPLEEQDRRRWDRGKIARGLEQ
MAB_3888|M.abscessus_ATCC_1997 EREANALAALVLLHDSRRLERMDSAGALVPLEEQDRTRWDHGRISRGLSQ
MMAR_0975|M.marinum_M EPETHALAALVLLHDSRRATRVDEAGALVPLDEQDRSRWDHGRIARGLDR
MAV_4519|M.avium_104 EREAHALSALMLLHDSRRATRVDAHGVPVPLEEQDRTRWDRRRITAGLDR
MSMEG_1348|M.smegmatis_MC2_155 DRDAHALSALVLLHDSRRSTRTDHTGALIPLDEQDRTRWDRGRIARGLDQ
TH_3917|M.thermoresistible__bu DPEVAGLLALFLLHHARRPARTRADGSLVPLAEQDRSVWRRDLIAEGVGI
Mflv_5063|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 VGPTILRH----WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAG
Rv1189|M.tuberculosis_H37Rv VGPTILRH----WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAG
Mvan_3355|M.vanbaalenii_PYR-1 LRRAGGSP--GPYLPQAVIAAVHATAPCWEQTDWVTICAAYDRLLGIADS
MAB_3888|M.abscessus_ATCC_1997 LRLAAGST--GPYLPQAVIAALHATAASWEETDWHAICLAYDRLLTMTDS
MMAR_0975|M.marinum_M LRRASGSR--GPYLPQAVIAALHASAPSWEHTDWTTICAAYDRLLQLTDS
MAV_4519|M.avium_104 LRYAEGSS--GAYLPQAVIAALHATAPSWEETDWVTICAAYDRLWQLTRS
MSMEG_1348|M.smegmatis_MC2_155 LRLAEGAT--GPYLPQAVIAAVHATAPGWQATDWSTICLAYDRLLQQADS
TH_3917|M.thermoresistible__bu LQAALARDRLGEYQAQAAIAALHADAQRVEDTDWVQIVEWYDELVALTGS
Mflv_5063|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 KITKIHVLVQPSTLDPLRAELGGG--------------------------
Rv1189|M.tuberculosis_H37Rv KITKIHVLVQPSTLDPLRAELGGG--------------------------
Mvan_3355|M.vanbaalenii_PYR-1 PVVRANRAMAVGFRDGPDAGLAALETVADDPRLARSPLVATVRADLLRRA
MAB_3888|M.abscessus_ATCC_1997 PVVLVNRALAIGLRDAPEAGLAALEKVAHDPRLARSNLAATVRADLLRRA
MMAR_0975|M.marinum_M PVVLANRALAVGFRDGPDAGLAALEEVAHDPRLSHSNLVASARADLLRRA
MAV_4519|M.avium_104 PVVAANRALAIGLRDGPDAGLAALEEVD-EPKLERSNLIATLRADLLRRA
MSMEG_1348|M.smegmatis_MC2_155 PVVRANRALAIGFRDGHAAGLAALDEVADDPLLARSNTVAVIRADLLRRA
TH_3917|M.thermoresistible__bu PVVRLNRAVAVGAAAGPRAGLAALAELD--PELPRHTAAAAY---LHEQA
Mflv_5063|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 --------------------------------------------------
Rv1189|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3355|M.vanbaalenii_PYR-1 GRDDEAVVSYRHALAANGS-IPGREFLARRIAECGG--------------
MAB_3888|M.abscessus_ATCC_1997 GRYDEAIDWYRTALSANGS-DPGRDFLRRRIAECLNNSG-----------
MMAR_0975|M.marinum_M GRGADALRWYRVALDSNGS-EPSRGFLQRRIAECQG--------------
MAV_4519|M.avium_104 GRPAEALPWYRIASQSNGS-EPGREFLRRRIAECTSAAESATGDAFPENG
MSMEG_1348|M.smegmatis_MC2_155 GRTGEAIHWYGVALEHHAINEPAAAFLRRRLAECESATAAN---------
TH_3917|M.thermoresistible__bu GDIATAADLYAEAAAKADN-LAERNHLTLRAATLRRRI------------
Mflv_5063|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 --
Rv1189|M.tuberculosis_H37Rv --
Mvan_3355|M.vanbaalenii_PYR-1 --
MAB_3888|M.abscessus_ATCC_1997 --
MMAR_0975|M.marinum_M --
MAV_4519|M.avium_104 RR
MSMEG_1348|M.smegmatis_MC2_155 --
TH_3917|M.thermoresistible__bu --
Mflv_5063|M.gilvum_PYR-GCK --
MUL_1400|M.ulcerans_Agy99 --