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MDPAALRDLIPGVLAALVRRGVDFATAEDAVQEALIKALETWSTGRAPDDPKAWLITTAWRRFIDVARAE AARRSRELRTAVEDPQGPTVPVDDTLQLYFLCAHPSLSPASAVALTLRAVGGLTTRQIARAYLVPESTMA QRISRAKRTVSEVRLNRLGNLGTVLRVLYLVFNEGYTGDVDLSAEAIRLARQLAAATDAPEVAGLLALFL LHDARRPARTRADGTLVPLAEQDRTLWRHDLITEGVAVLQAALAADRLGEYQAQAAIAALHADARTADET DWVQIVEWYDELVALTDSPVARLNRAVAVGEADGPRAGLAALAELDPALPRHTASAAYLHERAGDIARAA QLYVEAADQAHTVPERNHLLLKAATLHQRLGSPGDAKRLPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0405 | - | - | 100% (391) | extra cytoplasmic sigma factor |
| M. smegmatis MC2 155 | MSMEG_1348 | - | 1e-58 | 41.73% (393) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_1486 | - | 3e-06 | 32.03% (153) | RNA polymerase sigma factor SigL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 1e-09 | 29.69% (192) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_5019 | - | 1e-06 | 32.50% (160) | RNA polymerase sigma factor SigL |
| M. tuberculosis H37Rv | Rv1189 | sigI | 1e-09 | 29.69% (192) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4459c | - | 8e-72 | 46.72% (381) | ECF subfamily RNA polymerase sigma factor |
| M. marinum M | MMAR_0975 | - | 1e-62 | 42.20% (391) | RNA polymerase sigma factor |
| M. avium 104 | MAV_4519 | - | 4e-62 | 43.50% (400) | RNA polymerase ECF-subfamily protein sigma factor |
| M. thermoresistible (build 8) | TH_3917 | - | 1e-161 | 76.32% (380) | PUTATIVE putative RNA polymerase, sigma-24 subunit, ECF |
| M. ulcerans Agy99 | MUL_1400 | sigK | 4e-05 | 28.57% (147) | RNA polymerase sigma factor SigK |
| M. vanbaalenii PYR-1 | Mvan_2612 | - | 1e-166 | 78.44% (385) | RNA polymerase ECF-subfamily sigma factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1221|M.bovis_AF2122/97 -------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGV
Rv1189|M.tuberculosis_H37Rv -------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGV
TH_3917|M.thermoresistible__bu -----------------------VIDGRRLRELIPGVLGTLVRRGADFAS
Mvan_2612|M.vanbaalenii_PYR-1 --------------------MSTAVDETALRDLIPGVLAALVHRGADFAT
MSMEG_0405|M.smegmatis_MC2_155 ------------------------MDPAALRDLIPGVLAALVRRGVDFAT
MMAR_0975|M.marinum_M --------------------MAN--LDGVFRREWGSAVAALARWSGDLTI
MAV_4519|M.avium_104 --------------------MAD--LDGVFRREWGPAVAALARWSGDLTV
MAB_4459c|M.abscessus_ATCC_199 --------------------MAHDEISRIFRAEYGRTVATLIRYFGSIDL
Mflv_5019|M.gilvum_PYR-GCK -----------------MEDADAAMMRVLYDEHAAALWRYALRLTGDRAR
MUL_1400|M.ulcerans_Agy99 MTGPPGRSDDLNALLRQIARGERDAFAMFYDHTCTRVYGLVARVLRDAGY
: .
Mb1221|M.bovis_AF2122/97 AEDMVQEAFSRLLR--APVGDIDDER-GWLIVVTSRLCLDHIKSASTRRE
Rv1189|M.tuberculosis_H37Rv AEDMVQEAFSRLLR--APVGDIDDER-GWLIVVTSRLCLDHIKSASTRRE
TH_3917|M.thermoresistible__bu AEDAVQEALVRALTTWAG-KPPRDPK-GWLITTAWRCFVDATRSDAARRR
Mvan_2612|M.vanbaalenii_PYR-1 AEDAVQEALIRAVQTWPR-RHPDDPR-GWLITTAWRRFVDLVRADAARRD
MSMEG_0405|M.smegmatis_MC2_155 AEDAVQEALIKALETWSTGRAPDDPK-AWLITTAWRRFIDVARAEAARRS
MMAR_0975|M.marinum_M AEDAVQEACAEALRAWPRDGVPDSPG-GWLVTVARNRARDRLRRESARPA
MAV_4519|M.avium_104 AEDAVQEACAEALRAWPRDGMPANPG-GWLVTVARNRARDRLRRESARPG
MAB_4459c|M.abscessus_ATCC_199 AEDAVQEAFEVAIARWPEDGIPPNPG-AWITTTARNRGIDKLRRDRRR--
Mflv_5019|M.gilvum_PYR-GCK SEDVVQETLLRAWRHPGVIADVDRPARAWLFTVARNMIIDERRSARFRHE
MUL_1400|M.ulcerans_Agy99 SEETTQEIYLEVWRTASDYDATKGSPLAWLLTMAHRRAVDRVRAEQAGSQ
:*: .** .*: . : . * :
Mb1221|M.bovis_AF2122/97 RPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFV
Rv1189|M.tuberculosis_H37Rv RPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFV
TH_3917|M.thermoresistible__bu REEL---------IATRPPPGPVPAVDDTLALYFLCAHPRLSPASAVALT
Mvan_2612|M.vanbaalenii_PYR-1 RELK---------SFDEPPPGPAEHADDTLYLYFLCAHPSLTPSSAVALT
MSMEG_0405|M.smegmatis_MC2_155 RELR---------TAVEDPQGPTVPVDDTLQLYFLCAHPSLSPASAVALT
MMAR_0975|M.marinum_M KELAYVVNDIGAIRARTEHSDPHPVRDDELRMMFTCAHPALDRQSQLALT
MAV_4519|M.avium_104 KELAAVLDDI---RARTDAADPHPVRDDELRMMFTCAHPALDRPSQLALT
MAB_4459c|M.abscessus_ATCC_199 DELSREAGAFA--EPQQEPEDVGPVRDDRLRLIFTCCHPALSQEAQVALT
Mflv_5019|M.gilvum_PYR-GCK TGVPDP-------EHVAEPASPDEADPTLDRILLGTALRQLSDEHRAVVR
MUL_1400|M.ulcerans_Agy99 RESRYGAAN----VDLASDVVADSAIAGDERRRVVECLDGLTDTQRQCIE
. * .
Mb1221|M.bovis_AF2122/97 LHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRI---------AA
Rv1189|M.tuberculosis_H37Rv LHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRI---------AA
TH_3917|M.thermoresistible__bu LRAVGGLTTRQIAQAYLVPESTMAQRISRAKHTIADVQP--------GRP
Mvan_2612|M.vanbaalenii_PYR-1 LRAVGGLTTRQIAQAYLVPESTMAQRISRAKRTVSDVRL--------DRP
MSMEG_0405|M.smegmatis_MC2_155 LRAVGGLTTRQIARAYLVPESTMAQRISRAKRTVSEVRL--------NRL
MMAR_0975|M.marinum_M LRLVSGLTVTEIARALLQTDAAIGQRITRAKNKIRHANIPLRVPPAELLP
MAV_4519|M.avium_104 LRLVSGLTVAEIARALLQSEAAISQRITRAKNKVRHANIPLRVPPAELLG
MAB_4459c|M.abscessus_ATCC_199 LRLLGGLTTPEIAGAYLVSESTMAARITRAKKKIAAAGIPYRIPAAHDLP
Mflv_5019|M.gilvum_PYR-GCK RAYYQGWTTGQIAADLQIPEGTVKSRLHYAVRALK---------------
MUL_1400|M.ulcerans_Agy99 LAYYGGLTYAEVSQRLATNLSTIKSRMRDALRGLRNCLDAS---------
* . ::: .: * . :
Mb1221|M.bovis_AF2122/97 SVEPAQHRVVTRAFIEACSN------------------------------
Rv1189|M.tuberculosis_H37Rv SVEPAQHRVVTRAFIEACSN------------------------------
TH_3917|M.thermoresistible__bu GDLRTVLRVLYLVFNEGYTG-------EVDLAEEAIRLARRLVAVTD-DP
Mvan_2612|M.vanbaalenii_PYR-1 GDVRTVLRVLYLVFNEGYSG-------DVDLAAEAIRLARQLAAVVD-DP
MSMEG_0405|M.smegmatis_MC2_155 GNLGTVLRVLYLVFNEGYTG-------DVDLSAEAIRLARQLAAATD-AP
MMAR_0975|M.marinum_M ERTPHVLGCIYSVFTEGYWATGGPSAIRDELCDEGVRLAQELCALMPQEP
MAV_4519|M.avium_104 ERTPHVLGCVYSVFTEGYWSTAGPSAIRDDLCDEGIRLGAELCALLPHER
MAB_4459c|M.abscessus_ATCC_199 DRLSSVLSVLYLIYNEGYAASSGARLTRTDLSAEAIRLSRLLADLMPDEP
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 --GDLDTLLEVLDPGVAGEIDARKGVVVVGADR----------VGPTILR
Rv1189|M.tuberculosis_H37Rv --GDLDTLLEVLDPGVAGEIDARKGVVVVGADR----------VGPTILR
TH_3917|M.thermoresistible__bu EVAGLLALFLLHHARRPARTRADGSLVPLAEQDRSVWRRDLIAEGVGILQ
Mvan_2612|M.vanbaalenii_PYR-1 EVSGLLALFLLHHARRPARMRGDGSLVPLAEQNRGLWRTDLIAEGVTVLQ
MSMEG_0405|M.smegmatis_MC2_155 EVAGLLALFLLHDARRPARTRADGTLVPLAEQDRTLWRHDLITEGVAVLQ
MMAR_0975|M.marinum_M ETHALAALVLLHDSRRATRVDEAGALVPLDEQDRSRWDHGRIARGLDRLR
MAV_4519|M.avium_104 EAHALSALMLLHDSRRATRVDAHGVPVPLEEQDRTRWDRRRITAGLDRLR
MAB_4459c|M.abscessus_ATCC_199 EALGLLALVLLTEARRPARTGDDGALVLLADQDRTRWNRQMITEGHQLVR
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 ---------HWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKI
Rv1189|M.tuberculosis_H37Rv ---------HWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKI
TH_3917|M.thermoresistible__bu AALARDRLGEYQAQAAIAALHADAQRVEDTDWVQIVEWYDELVALTGSPV
Mvan_2612|M.vanbaalenii_PYR-1 AALARDRLGEYQAQAAIAALHADAQTAEETDWVQIVEWYDELVRLTDSPV
MSMEG_0405|M.smegmatis_MC2_155 AALAADRLGEYQAQAAIAALHADARTADETDWVQIVEWYDELVALTDSPV
MMAR_0975|M.marinum_M RASGS--RGPYLPQAVIAALHASAPSWEHTDWTTICAAYDRLLQLTDSPV
MAV_4519|M.avium_104 YAEGS--SGAYLPQAVIAALHATAPSWEETDWVTICAAYDRLWQLTRSPV
MAB_4459c|M.abscessus_ATCC_199 RCLRRNVPGPYQIQAAINAVHDDAPSAAGTDWRQIVTLYDQLMRFTPTTV
Mflv_5019|M.gilvum_PYR-GCK ------------------------------------------LGLQEMGV
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 TKIHVLVQPSTLDPLRAELGGG----------------------------
Rv1189|M.tuberculosis_H37Rv TKIHVLVQPSTLDPLRAELGGG----------------------------
TH_3917|M.thermoresistible__bu VRLNRAVAVGAAAGPRAGLAALAELD--PELPRH---TAAAAYLHEQAGD
Mvan_2612|M.vanbaalenii_PYR-1 VRLNRAVAVGEADGPRAGLTALANLD--PTLPRY---TASKAYLCEKAGD
MSMEG_0405|M.smegmatis_MC2_155 ARLNRAVAVGEADGPRAGLAALAELD--PALPRH---TASAAYLHERAGD
MMAR_0975|M.marinum_M VLANRALAVGFRDGPDAGLAALEEVAHDPRLSHSNLVASARADLLRRAGR
MAV_4519|M.avium_104 VAANRALAIGLRDGPDAGLAALEEVD-EPKLERSNLIATLRADLLRRAGR
MAB_4459c|M.abscessus_ATCC_199 VALNRAVAVAERDGAQAGLDAMEPLR--ADLDRYYPLHAARADLLTRLHR
Mflv_5019|M.gilvum_PYR-GCK TR------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 -------------------------------------------------
Rv1189|M.tuberculosis_H37Rv -------------------------------------------------
TH_3917|M.thermoresistible__bu IATAADLYAEAAAKADNLAERNHLTLRAATLRRRI--------------
Mvan_2612|M.vanbaalenii_PYR-1 TEAAAALYAEAAAQAYNVAERNHLTLRAATLRQALPHDSD---------
MSMEG_0405|M.smegmatis_MC2_155 IARAAQLYVEAADQAHTVPERNHLLLKAATLHQRLGSPGDAKRLPG---
MMAR_0975|M.marinum_M GADALRWYRVALDSNGSEPSRGFLQRRIAECQG----------------
MAV_4519|M.avium_104 PAEALPWYRIASQSNGSEPGREFLRRRIAECTSAAESATGDAFPENGRR
MAB_4459c|M.abscessus_ATCC_199 DSEAADAYRKALELTENEVFRRYLGDRLARLEPGA--------------
Mflv_5019|M.gilvum_PYR-GCK -------------------------------------------------
MUL_1400|M.ulcerans_Agy99 -------------------------------------------------