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AHDEISRIFRAEYGRTVATLIRYFGSIDLAEDAVQEAFEVAIARWPEDGIPPNPGAWITTTARNRGIDKL RRDRRRDELSREAGAFAEPQQEPEDVGPVRDDRLRLIFTCCHPALSQEAQVALTLRLLGGLTTPEIAGAY LVSESTMAARITRAKKKIAAAGIPYRIPAAHDLPDRLSSVLSVLYLIYNEGYAASSGARLTRTDLSAEAI RLSRLLADLMPDEPEALGLLALVLLTEARRPARTGDDGALVLLADQDRTRWNRQMITEGHQLVRRCLRRN VPGPYQIQAAINAVHDDAPSAAGTDWRQIVTLYDQLMRFTPTTVVALNRAVAVAERDGAQAGLDAMEPLR ADLDRYYPLHAARADLLTRLHRDSEAADAYRKALELTENEVFRRYLGDRLARLEPGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4459c | - | - | 100% (408) | ECF subfamily RNA polymerase sigma factor |
| M. abscessus ATCC 19977 | MAB_3888 | - | 7e-86 | 46.15% (403) | putative RNA polymerase sigma-70 factor |
| M. abscessus ATCC 19977 | MAB_4733 | - | 6e-05 | 27.45% (153) | putative RNA polymerase sigma factor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 2e-08 | 26.79% (209) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_5019 | - | 2e-05 | 26.22% (164) | RNA polymerase sigma factor SigL |
| M. tuberculosis H37Rv | Rv1189 | sigI | 2e-08 | 26.79% (209) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0975 | - | 8e-88 | 45.79% (404) | RNA polymerase sigma factor |
| M. avium 104 | MAV_4519 | - | 9e-84 | 44.61% (408) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_1348 | - | 3e-87 | 46.80% (406) | RNA polymerase ECF-subfamily protein sigma factor |
| M. thermoresistible (build 8) | TH_3917 | - | 5e-70 | 46.17% (392) | PUTATIVE putative RNA polymerase, sigma-24 subunit, ECF |
| M. ulcerans Agy99 | MUL_0831 | sigL | 1e-05 | 27.67% (159) | RNA polymerase sigma factor SigL |
| M. vanbaalenii PYR-1 | Mvan_3355 | - | 9e-87 | 46.73% (398) | RNA polymerase ECF-subfamily sigma factor |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0975|M.marinum_M ----------MANLDGVFRREWGS-AVAALARWSGDLTIAEDAVQEACAE
MAV_4519|M.avium_104 ----------MADLDGVFRREWGP-AVAALARWSGDLTVAEDAVQEACAE
Mvan_3355|M.vanbaalenii_PYR-1 ----------MQSLDGVFRREWGR-TVAAIARWCGDLTVAEDAVQEACAD
MSMEG_1348|M.smegmatis_MC2_155 ----------MAELDSVFRREWGP-TVATIARWSGDLALAEDAVQEACAH
MAB_4459c|M.abscessus_ATCC_199 --------MAHDEISRIFRAEYGR-TVATLIRYFGSIDLAEDAVQEAFEV
TH_3917|M.thermoresistible__bu ------------VIDGRRLRELIPGVLGTLVRRGADFASAEDAVQEALVR
Mflv_5019|M.gilvum_PYR-GCK ------MEDADAAMMRVLYDEHAAALWRYALRLTGDRARSEDVVQETLLR
MUL_0831|M.ulcerans_Agy99 MARVAGGGAAEAALMQALYDEHAAVLWRYTMRLTSDASYADDIVQETLLR
Mb1221|M.bovis_AF2122/97 --------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSR
Rv1189|M.tuberculosis_H37Rv --------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSR
* .. ::* ***:
MMAR_0975|M.marinum_M ALR-AWPRDGVPDSPGGWLVTVARNRARDRLRRESARPAKELAYVVNDIG
MAV_4519|M.avium_104 ALR-AWPRDGMPANPGGWLVTVARNRARDRLRRESARPGKELAAVLDDI-
Mvan_3355|M.vanbaalenii_PYR-1 ALR-SWPRDGVPEVPGAWLVTTARNRARDRLRRESARPGKELAAVLDDI-
MSMEG_1348|M.smegmatis_MC2_155 AVQ-AWA-DGLPDNPGAWLTTVARNRALDRLRRESQRTGREYAAVYEDM-
MAB_4459c|M.abscessus_ATCC_199 AIA-RWPEDGIPPNPGAWITTTARNRGIDKLRRDRRR--DELSREAGAF-
TH_3917|M.thermoresistible__bu ALT-TWA-GKPPRDPKGWLITTAWRCFVDATRSDAARRRREELIATRPP-
Mflv_5019|M.gilvum_PYR-GCK AWRHPGVIADVDRPARAWLFTVARNMIIDERRSARFRHETGVPDPEHVA-
MUL_0831|M.ulcerans_Agy99 AWQHPEVIDERGRSARAWLFTVARNMIIDDRRSARYRYVVSSTDADGAP-
Mb1221|M.bovis_AF2122/97 LLR---APVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDG
Rv1189|M.tuberculosis_H37Rv LLR---APVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDG
.*: ..: . * : *
MMAR_0975|M.marinum_M AIRARTEHSD-PHPVRDDELRMMFTCAHPALDRQSQLALTLRLVSGLTVT
MAV_4519|M.avium_104 --RARTDAAD-PHPVRDDELRMMFTCAHPALDRPSQLALTLRLVSGLTVA
Mvan_3355|M.vanbaalenii_PYR-1 --IARTDGPEVPHRVRDDELRMMFTCAHPALERPSQLALTLRLVSGLTVA
MSMEG_1348|M.smegmatis_MC2_155 --TARADTEL--HPVRDDQLRMMFTCAHPALDRASQLALTLRLISGLTAA
MAB_4459c|M.abscessus_ATCC_199 --AEPQQEPEDVGPVRDDRLRLIFTCCHPALSQEAQVALTLRLLGGLTTP
TH_3917|M.thermoresistible__bu ---------PGPVPAVDDTLALYFLCAHPRLSPASAVALTLRAVGGLTTR
Mflv_5019|M.gilvum_PYR-GCK -------EPASPDEADPTLDRILLGTALRQLSDEHRAVVRRAYYQGWTTG
MUL_0831|M.ulcerans_Agy99 -------EQSTPDEVGAALGRLLIADALAQLSGEHRAVIERSYYRGWTTA
Mb1221|M.bovis_AF2122/97 -DASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQ
Rv1189|M.tuberculosis_H37Rv -DASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQ
. : : * .. * .
MMAR_0975|M.marinum_M EIARALLQTDAAIGQRITRAKNKIRHANIPLRVPPAELLPERTPHVLGCI
MAV_4519|M.avium_104 EIARALLQSEAAISQRITRAKNKVRHANIPLRVPPAELLGERTPHVLGCV
Mvan_3355|M.vanbaalenii_PYR-1 EIARALLQSEAAVGQRITRAKAKIRHANIPLRVPPGELLAQRTPHVLACI
MSMEG_1348|M.smegmatis_MC2_155 EIARALLQSETAVRQRITRAKNKIRKANIPLRVPPAELLPERTPHVLACI
MAB_4459c|M.abscessus_ATCC_199 EIAGAYLVSESTMAARITRAKKKIAAAGIPYRIPAAHDLPDRLSSVLSVL
TH_3917|M.thermoresistible__bu QIAQAYLVPESTMAQRISRAKHTIAD------VQPG--RPGDLRTVLRVL
Mflv_5019|M.gilvum_PYR-GCK QIAADLQIPEGTVKSRLHYAVRALKLGLQEMGVTR---------------
MUL_0831|M.ulcerans_Agy99 QIAKDLEIAEGTVKSRLHYAVRALRLTLQELGVTR---------------
Mb1221|M.bovis_AF2122/97 QIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVTRAFIEACS
Rv1189|M.tuberculosis_H37Rv QIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVTRAFIEACS
:** : * : :
MMAR_0975|M.marinum_M YSVFTEGYWATGGPSAIRDELCDEGVRLAQELCALMPQEPETHALAALVL
MAV_4519|M.avium_104 YSVFTEGYWSTAGPSAIRDDLCDEGIRLGAELCALLPHEREAHALSALML
Mvan_3355|M.vanbaalenii_PYR-1 YSVFTEGYWSTAGPSAIRDELCDEAVRLTGELCVAMPEEPEGHALAALVL
MSMEG_1348|M.smegmatis_MC2_155 YSVFTEGYWSTAGPSAIRDELCDEGVRLAAELCALLPDDRDAHALSALVL
MAB_4459c|M.abscessus_ATCC_199 YLIYNEGYAASSGARLTRTDLSAEAIRLSRLLADLMPDEPEALGLLALVL
TH_3917|M.thermoresistible__bu YLVFNEGYTG-------EVDLAEEAIRLARRLVAVT-DDPEVAGLLALFL
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0831|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 N-----------------------------------------GDLDTLLE
Rv1189|M.tuberculosis_H37Rv N-----------------------------------------GDLDTLLE
MMAR_0975|M.marinum_M LHDSRRATRVDEAGALVPLDEQDRSRWDHGRIARGLDRLRRAS--GSRGP
MAV_4519|M.avium_104 LHDSRRATRVDAHGVPVPLEEQDRTRWDRRRITAGLDRLRYAE--GSSGA
Mvan_3355|M.vanbaalenii_PYR-1 LHDSRRATRTDGRGTLVPLEEQDRRRWDRGKIARGLEQLRRAG--GSPGP
MSMEG_1348|M.smegmatis_MC2_155 LHDSRRSTRTDHTGALIPLDEQDRTRWDRGRIARGLDQLRLAE--GATGP
MAB_4459c|M.abscessus_ATCC_199 LTEARRPARTGDDGALVLLADQDRTRWNRQMITEGHQLVRRCLRRNVPGP
TH_3917|M.thermoresistible__bu LHHARRPARTRADGSLVPLAEQDRSVWRRDLIAEGVGILQAALARDRLGE
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0831|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 VLDPGVAGEIDARKGVVVVGADRVG-------------------PTILRH
Rv1189|M.tuberculosis_H37Rv VLDPGVAGEIDARKGVVVVGADRVG-------------------PTILRH
MMAR_0975|M.marinum_M YLPQAVIAALHASAPSWEHTDWTTICAAYDRLLQLTDSPVVLANRALAVG
MAV_4519|M.avium_104 YLPQAVIAALHATAPSWEETDWVTICAAYDRLWQLTRSPVVAANRALAIG
Mvan_3355|M.vanbaalenii_PYR-1 YLPQAVIAAVHATAPCWEQTDWVTICAAYDRLLGIADSPVVRANRAMAVG
MSMEG_1348|M.smegmatis_MC2_155 YLPQAVIAAVHATAPGWQATDWSTICLAYDRLLQQADSPVVRANRALAIG
MAB_4459c|M.abscessus_ATCC_199 YQIQAAINAVHDDAPSAAGTDWRQIVTLYDQLMRFTPTTVVALNRAVAVA
TH_3917|M.thermoresistible__bu YQAQAAIAALHADAQRVEDTDWVQIVEWYDELVALTGSPVVRLNRAVAVG
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0831|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPS
Rv1189|M.tuberculosis_H37Rv WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPS
MMAR_0975|M.marinum_M FRDGPDAGLAALEEVAHDPRLSHSNLVASARADLLRRAGRGADALRWYRV
MAV_4519|M.avium_104 LRDGPDAGLAALEEVD-EPKLERSNLIATLRADLLRRAGRPAEALPWYRI
Mvan_3355|M.vanbaalenii_PYR-1 FRDGPDAGLAALETVADDPRLARSPLVATVRADLLRRAGRDDEAVVSYRH
MSMEG_1348|M.smegmatis_MC2_155 FRDGHAAGLAALDEVADDPLLARSNTVAVIRADLLRRAGRTGEAIHWYGV
MAB_4459c|M.abscessus_ATCC_199 ERDGAQAGLDAMEPLR--ADLDRYYPLHAARADLLTRLHRDSEAADAYRK
TH_3917|M.thermoresistible__bu AAAGPRAGLAALAELD--PELPRH---TAAAAYLHEQAGDIATAADLYAE
Mflv_5019|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0831|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 TLDPLRAELGGG--------------------------------------
Rv1189|M.tuberculosis_H37Rv TLDPLRAELGGG--------------------------------------
MMAR_0975|M.marinum_M ALDSNGS-EPSRGFLQRRIAECQG----------------
MAV_4519|M.avium_104 ASQSNGS-EPGREFLRRRIAECTSAAESATGDAFPENGRR
Mvan_3355|M.vanbaalenii_PYR-1 ALAANGS-IPGREFLARRIAECGG----------------
MSMEG_1348|M.smegmatis_MC2_155 ALEHHAINEPAAAFLRRRLAECESATAAN-----------
MAB_4459c|M.abscessus_ATCC_199 ALELTEN-EVFRRYLGDRLARLEPGA--------------
TH_3917|M.thermoresistible__bu AAAKADN-LAERNHLTLRAATLRRRI--------------
Mflv_5019|M.gilvum_PYR-GCK ----------------------------------------
MUL_0831|M.ulcerans_Agy99 ----------------------------------------
Mb1221|M.bovis_AF2122/97 ----------------------------------------
Rv1189|M.tuberculosis_H37Rv ----------------------------------------