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ANLDGVFRREWGSAVAALARWSGDLTIAEDAVQEACAEALRAWPRDGVPDSPGGWLVTVARNRARDRLRR ESARPAKELAYVVNDIGAIRARTEHSDPHPVRDDELRMMFTCAHPALDRQSQLALTLRLVSGLTVTEIAR ALLQTDAAIGQRITRAKNKIRHANIPLRVPPAELLPERTPHVLGCIYSVFTEGYWATGGPSAIRDELCDE GVRLAQELCALMPQEPETHALAALVLLHDSRRATRVDEAGALVPLDEQDRSRWDHGRIARGLDRLRRASG SRGPYLPQAVIAALHASAPSWEHTDWTTICAAYDRLLQLTDSPVVLANRALAVGFRDGPDAGLAALEEVA HDPRLSHSNLVASARADLLRRAGRGADALRWYRVALDSNGSEPSRGFLQRRIAECQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0975 | - | - | 100% (408) | RNA polymerase sigma factor |
| M. marinum M | MMAR_0766 | sigK | 2e-07 | 29.45% (146) | alternative RNA polymerase sigma factor SigK |
| M. marinum M | MMAR_1073 | sigL | 3e-05 | 31.51% (146) | alternative RNA polymerase sigma factor (RpoE), SigL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1221 | sigI | 2e-08 | 27.27% (154) | RNA polymerase sigma factor SigI |
| M. gilvum PYR-GCK | Mflv_1818 | - | 2e-06 | 27.69% (130) | RNA polymerase sigma factor SigK |
| M. tuberculosis H37Rv | Rv1189 | sigI | 2e-08 | 27.27% (154) | RNA polymerase sigma factor SigI |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3888 | - | 0.0 | 79.56% (406) | putative RNA polymerase sigma-70 factor |
| M. avium 104 | MAV_4519 | - | 0.0 | 81.28% (406) | RNA polymerase ECF-subfamily protein sigma factor |
| M. smegmatis MC2 155 | MSMEG_1348 | - | 1e-172 | 73.77% (408) | RNA polymerase ECF-subfamily protein sigma factor |
| M. thermoresistible (build 8) | TH_3917 | - | 3e-56 | 42.20% (391) | PUTATIVE putative RNA polymerase, sigma-24 subunit, ECF |
| M. ulcerans Agy99 | MUL_1400 | sigK | 2e-07 | 29.45% (146) | RNA polymerase sigma factor SigK |
| M. vanbaalenii PYR-1 | Mvan_3355 | - | 0.0 | 78.00% (409) | RNA polymerase ECF-subfamily sigma factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1221|M.bovis_AF2122/97 --------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIG
Rv1189|M.tuberculosis_H37Rv --------------------MSQHDPVSAAWRAHRAYLVDLAFRMVGDIG
MMAR_0975|M.marinum_M --------------------MANLD--GVFRREWGS-AVAALARWSGDLT
MAV_4519|M.avium_104 --------------------MADLD--GVFRREWGP-AVAALARWSGDLT
MAB_3888|M.abscessus_ATCC_1997 --------------------MIELE--GVFRREWGP-TVAAIARWSGDLT
Mvan_3355|M.vanbaalenii_PYR-1 --------------------MQSLD--GVFRREWGR-TVAAIARWCGDLT
MSMEG_1348|M.smegmatis_MC2_155 --------------------MAELD--SVFRREWGP-TVATIARWSGDLA
TH_3917|M.thermoresistible__bu ----------------------VID--GRRLRELIPGVLGTLVRRGADFA
Mflv_1818|M.gilvum_PYR-GCK MADRVLLVTAELDALLRQVARRDADAFAAFYDQTRSRVFGLVTRVLRDPG
MUL_1400|M.ulcerans_Agy99 MTG-PPGRSDDLNALLRQIARGERDAFAMFYDHTCTRVYGLVARVLRDAG
: . * *
Mb1221|M.bovis_AF2122/97 VAEDMVQEAFSRLLR-APVGDIDDE--RGWLIVVTSRLCLDHIKSASTRR
Rv1189|M.tuberculosis_H37Rv VAEDMVQEAFSRLLR-APVGDIDDE--RGWLIVVTSRLCLDHIKSASTRR
MMAR_0975|M.marinum_M IAEDAVQEACAEALR-AWPRDGVPDSPGGWLVTVARNRARDRLRRESARP
MAV_4519|M.avium_104 VAEDAVQEACAEALR-AWPRDGMPANPGGWLVTVARNRARDRLRRESARP
MAB_3888|M.abscessus_ATCC_1997 VAEDAVQEACADALR-TWPRDGIPDTPGGWLLTAARNRARDRLRRETLRP
Mvan_3355|M.vanbaalenii_PYR-1 VAEDAVQEACADALR-SWPRDGVPEVPGAWLVTTARNRARDRLRRESARP
MSMEG_1348|M.smegmatis_MC2_155 LAEDAVQEACAHAVQ-AWA-DGLPDNPGAWLTTVARNRALDRLRRESQRT
TH_3917|M.thermoresistible__bu SAEDAVQEALVRALT-TWA-GKPPRDPKGWLITTAWRCFVDATRSDAARR
Mflv_1818|M.gilvum_PYR-GCK YSEETTQDVYLQVWRTAHNYDPSAGSPLAWLLTLAHRRAVDRVRSEEAAS
MUL_1400|M.ulcerans_Agy99 YSEETTQEIYLEVWRTASDYDATKGSPLAWLLTMAHRRAVDRVRAEQAGS
:*: .*: : . .** . : . * :
Mb1221|M.bovis_AF2122/97 ERPQDIAAWHDG-DASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVV
Rv1189|M.tuberculosis_H37Rv ERPQDIAAWHDG-DASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVV
MMAR_0975|M.marinum_M AKELAYVVNDIGAIRARTE-HSDPHPVRDDELRMMFTCAHPALDRQSQLA
MAV_4519|M.avium_104 GKELAAVLDDI---RARTD-AADPHPVRDDELRMMFTCAHPALDRPSQLA
MAB_3888|M.abscessus_ATCC_1997 GKELAAVVDDI---TARTD-VADPHPVRDDELRMMFTCAHPALERTSQLA
Mvan_3355|M.vanbaalenii_PYR-1 GKELAAVLDDI---IARTDGPEVPHRVRDDELRMMFTCAHPALERPSQLA
MSMEG_1348|M.smegmatis_MC2_155 GREYAAVYEDM---TARAD--TELHPVRDDQLRMMFTCAHPALDRASQLA
TH_3917|M.thermoresistible__bu RREELIATRPP----------PGPVPAVDDTLALYFLCAHPRLSPASAVA
Mflv_1818|M.gilvum_PYR-GCK SRDSRYGAATIE----TPTDHVSDAAILSDERQRVTDCLG-ALTDTQREC
MUL_1400|M.ulcerans_Agy99 QRESRYGAANVD----LASDVVADSAIAGDERRRVVECLD-GLTDTQRQC
: .* * .
Mb1221|M.bovis_AF2122/97 FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQH
Rv1189|M.tuberculosis_H37Rv FVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQH
MMAR_0975|M.marinum_M LTLRLVSGLTVTEIARALLQTDAAIGQRITRAKNKIRHANIPLRVPPAEL
MAV_4519|M.avium_104 LTLRLVSGLTVAEIARALLQSEAAISQRITRAKNKVRHANIPLRVPPAEL
MAB_3888|M.abscessus_ATCC_1997 LTLRLVSGLTVAEIARALLHSEAAIGQRITRAKAKIRTANIPLRVPPAEL
Mvan_3355|M.vanbaalenii_PYR-1 LTLRLVSGLTVAEIARALLQSEAAVGQRITRAKAKIRHANIPLRVPPGEL
MSMEG_1348|M.smegmatis_MC2_155 LTLRLISGLTAAEIARALLQSETAVRQRITRAKNKIRKANIPLRVPPAEL
TH_3917|M.thermoresistible__bu LTLRAVGGLTTRQIAQAYLVPESTMAQRISRAKHTIADVQPGR---PGDL
Mflv_1818|M.gilvum_PYR-GCK IQLAYYDGLTYAQVSERLATNLATIKSRMRDAIRGLKRCMGVT-------
MUL_1400|M.ulcerans_Agy99 IELAYYGGLTYAEVSQRLATNLSTIKSRMRDALRGLRNCLDAS-------
: * **. ::: :: . * :
Mb1221|M.bovis_AF2122/97 R---------VVTRAFIEACSN----------------------------
Rv1189|M.tuberculosis_H37Rv R---------VVTRAFIEACSN----------------------------
MMAR_0975|M.marinum_M LPERTPHVLGCIYSVFTEGYWATGGPSAIRDELCDEGVRLAQELCALMPQ
MAV_4519|M.avium_104 LGERTPHVLGCVYSVFTEGYWSTAGPSAIRDDLCDEGIRLGAELCALLPH
MAB_3888|M.abscessus_ATCC_1997 LPERTPHVLSCIYSVFTEGYWSTGGPSAIRDELCDEGVRLAGELCRLMPQ
Mvan_3355|M.vanbaalenii_PYR-1 LAQRTPHVLACIYSVFTEGYWSTAGPSAIRDELCDEAVRLTGELCVAMPE
MSMEG_1348|M.smegmatis_MC2_155 LPERTPHVLACIYSVFTEGYWSTAGPSAIRDELCDEGVRLAAELCALLPD
TH_3917|M.thermoresistible__bu R-----TVLRVLYLVFNEGYTG-------EVDLAEEAIRLARRLVAVT-D
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 ----GDLDTLLEVLDPGVAGEIDAR---------------KGVVVVGADR
Rv1189|M.tuberculosis_H37Rv ----GDLDTLLEVLDPGVAGEIDAR---------------KGVVVVGADR
MMAR_0975|M.marinum_M EPETHALAALVLLHDSRRATRVDEAGALVPLDEQDRSRWDHGRIARGLDR
MAV_4519|M.avium_104 EREAHALSALMLLHDSRRATRVDAHGVPVPLEEQDRTRWDRRRITAGLDR
MAB_3888|M.abscessus_ATCC_1997 EREANALAALVLLHDSRRLERMDSAGALVPLEEQDRTRWDHGRISRGLSQ
Mvan_3355|M.vanbaalenii_PYR-1 EPEGHALAALVLLHDSRRATRTDGRGTLVPLEEQDRRRWDRGKIARGLEQ
MSMEG_1348|M.smegmatis_MC2_155 DRDAHALSALVLLHDSRRSTRTDHTGALIPLDEQDRTRWDRGRIARGLDQ
TH_3917|M.thermoresistible__bu DPEVAGLLALFLLHHARRPARTRADGSLVPLAEQDRSVWRRDLIAEGVGI
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 VGPTILRH----WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAG
Rv1189|M.tuberculosis_H37Rv VGPTILRH----WSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAG
MMAR_0975|M.marinum_M LRRASGSR--GPYLPQAVIAALHASAPSWEHTDWTTICAAYDRLLQLTDS
MAV_4519|M.avium_104 LRYAEGSS--GAYLPQAVIAALHATAPSWEETDWVTICAAYDRLWQLTRS
MAB_3888|M.abscessus_ATCC_1997 LRLAAGST--GPYLPQAVIAALHATAASWEETDWHAICLAYDRLLTMTDS
Mvan_3355|M.vanbaalenii_PYR-1 LRRAGGSP--GPYLPQAVIAAVHATAPCWEQTDWVTICAAYDRLLGIADS
MSMEG_1348|M.smegmatis_MC2_155 LRLAEGAT--GPYLPQAVIAAVHATAPGWQATDWSTICLAYDRLLQQADS
TH_3917|M.thermoresistible__bu LQAALARDRLGEYQAQAAIAALHADAQRVEDTDWVQIVEWYDELVALTGS
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 KITKIHVLVQPSTLDPLRAELGGG--------------------------
Rv1189|M.tuberculosis_H37Rv KITKIHVLVQPSTLDPLRAELGGG--------------------------
MMAR_0975|M.marinum_M PVVLANRALAVGFRDGPDAGLAALEEVAHDPRLSHSNLVASARADLLRRA
MAV_4519|M.avium_104 PVVAANRALAIGLRDGPDAGLAALEEVD-EPKLERSNLIATLRADLLRRA
MAB_3888|M.abscessus_ATCC_1997 PVVLVNRALAIGLRDAPEAGLAALEKVAHDPRLARSNLAATVRADLLRRA
Mvan_3355|M.vanbaalenii_PYR-1 PVVRANRAMAVGFRDGPDAGLAALETVADDPRLARSPLVATVRADLLRRA
MSMEG_1348|M.smegmatis_MC2_155 PVVRANRALAIGFRDGHAAGLAALDEVADDPLLARSNTVAVIRADLLRRA
TH_3917|M.thermoresistible__bu PVVRLNRAVAVGAAAGPRAGLAALAELD--PELPRHTAAAAY---LHEQA
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 --------------------------------------------------
Rv1189|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0975|M.marinum_M GRGADALRWYRVALDSNGS-EPSRGFLQRRIAECQG--------------
MAV_4519|M.avium_104 GRPAEALPWYRIASQSNGS-EPGREFLRRRIAECTSAAESATGDAFPENG
MAB_3888|M.abscessus_ATCC_1997 GRYDEAIDWYRTALSANGS-DPGRDFLRRRIAECLNNSG-----------
Mvan_3355|M.vanbaalenii_PYR-1 GRDDEAVVSYRHALAANGS-IPGREFLARRIAECGG--------------
MSMEG_1348|M.smegmatis_MC2_155 GRTGEAIHWYGVALEHHAINEPAAAFLRRRLAECESATAAN---------
TH_3917|M.thermoresistible__bu GDIATAADLYAEAAAKADN-LAERNHLTLRAATLRRRI------------
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mb1221|M.bovis_AF2122/97 --
Rv1189|M.tuberculosis_H37Rv --
MMAR_0975|M.marinum_M --
MAV_4519|M.avium_104 RR
MAB_3888|M.abscessus_ATCC_1997 --
Mvan_3355|M.vanbaalenii_PYR-1 --
MSMEG_1348|M.smegmatis_MC2_155 --
TH_3917|M.thermoresistible__bu --
Mflv_1818|M.gilvum_PYR-GCK --
MUL_1400|M.ulcerans_Agy99 --