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KRVIAGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPVGDASTAKVVYALGGARMPGIPWYEYTN QAGSQYFPNAKHDLIDYPAGAAFSWWPTMLLPPGSHQDNMTVGVAVKDGTNSLDNAIHHGTDPAAAVGLS QGSLVLDQEQARLANDPTAPAPDKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQ YDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGPGDVPPQNIRTTVNSRGATTTTYLVP VNHLPLTLPLRYLGMSDAEVDQIDSVLQPQIDAAYARNDNWFTRPVSVDPVRGLDPLTAPGSIVEGARGL LGSPAFGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1184c | - | - | 100% (359) | POSSIBLE EXPORTED PROTEIN |
| M. tuberculosis H37Rv | Rv3822 | - | 1e-51 | 38.64% (352) | hypothetical protein Rv3822 |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 3e-32 | 34.28% (283) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 0.0 | 100.00% (359) | hypothetical protein Mb1216c |
| M. gilvum PYR-GCK | Mflv_0401 | - | 1e-86 | 47.35% (359) | hypothetical protein Mflv_0401 |
| M. leprae Br4923 | MLBr_01232 | - | 1e-120 | 62.72% (338) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 3e-79 | 43.21% (361) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 2e-27 | 31.97% (319) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 2e-89 | 47.18% (354) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 9e-85 | 45.20% (354) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3724 | - | 3e-21 | 32.48% (274) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-13 | 26.30% (346) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0276 | - | 9e-88 | 46.45% (366) | hypothetical protein Mvan_0276 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M ------------------------------------------------MS
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 MLAAAAAWDGTGQELAAAASAFSSLTSDLAGAAWQGPSAAAMASVATSYV
Rv1184c|M.tuberculosis_H37Rv ---------------------------------MKRVIAGAFAVWLVGWA
Mb1216c|M.bovis_AF2122/97 ---------------------------------MKRVIAGAFAVWLVGWA
MLBr_01232|M.leprae_Br4923 ---------------------------------MKRLLATTLAALTVGTV
Mflv_0401|M.gilvum_PYR-GCK ---------------------------------MRRHLAFATAITTLGAT
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------MRRRLLAFGTAFTTIGTA
Mvan_0276|M.vanbaalenii_PYR-1 ---------------------MQPSRSGWCVKAMKRLLAFGTALTTIGAA
MAV_1760|M.avium_104 ---------------------------------MKQLLAGVTALLSVSTA
MAB_0936c|M.abscessus_ATCC_199 ---------------------------------MRNLLAGTAVLVVACVT
MMAR_4939|M.marinum_M YVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVSTHIA
TH_3724|M.thermoresistible__bu -------------------------------------------VVAVGAL
MUL_2440|M.ulcerans_Agy99 RWLGSAASGAVQTARQVATSAAVFEAARTATVPLELVAANRSALMSMVAA
Rv1184c|M.tuberculosis_H37Rv GGFGTA--------------------IAASEPAY----PWAPGPPPSPSP
Mb1216c|M.bovis_AF2122/97 GGFGTA--------------------IAASEPAY----PWAPGPPPSPSP
MLBr_01232|M.leprae_Br4923 SGFGST--------------------VASSEPGE----PWLP---PSPVP
Mflv_0401|M.gilvum_PYR-GCK GILGLG--------------------IAAAQPAPAPPPPPAPGAAAGAPT
MSMEG_0412|M.smegmatis_MC2_155 GFLGFG--------------------VAAADDT--KPVDPAPGGAHAEAP
Mvan_0276|M.vanbaalenii_PYR-1 GCLGFG--------------------IAAADEAPAVPPSPTP---ADAPP
MAV_1760|M.avium_104 GYFGIG--------------------TAAADGGP-----------IGGPP
MAB_0936c|M.abscessus_ATCC_199 GCFGIP--------------------SAVADDPQVPGPPIPGIAPDGTVK
MMAR_4939|M.marinum_M ALFSTHGLQYQLASAQAAEFHERFVLTLAADANTYLTTEIANAQRCLAGA
TH_3724|M.thermoresistible__bu TWGGXG----------------------------------------VASP
MUL_2440|M.ulcerans_Agy99 NVFGLNAPAIAAIEAQYEQMWAQN--VGAMFGYHVGVSEALSGLAPWQEV
.
Rv1184c|M.tuberculosis_H37Rv VGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAG--
Mb1216c|M.bovis_AF2122/97 VGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAG--
MLBr_01232|M.leprae_Br4923 VRENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPAR--
Mflv_0401|M.gilvum_PYR-GCK PLGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDREIVDYPAG--
MSMEG_0412|M.smegmatis_MC2_155 SMGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG--
Mvan_0276|M.vanbaalenii_PYR-1 PLGTPG--RAYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG--
MAV_1760|M.avium_104 TPGAPGDQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAG--
MAB_0936c|M.abscessus_ATCC_199 AAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAG--
MMAR_4939|M.marinum_M INAPATALLGHPLLGADPTASASTAATPAGGASMAPAAAGTRITVPGAGP
TH_3724|M.thermoresistible__bu AGQPERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGATAG--
MUL_2440|M.ulcerans_Agy99 LSGVSGRVASALEGTSAAAAAALGPTALTAAGSALPAAATDVTLVIGGSG
: . . . .
Rv1184c|M.tuberculosis_H37Rv -------------------AAFSWWPTMLLPPGSHQDNMT----------
Mb1216c|M.bovis_AF2122/97 -------------------AAFSWWPTMLLPPGSHQDNMT----------
MLBr_01232|M.leprae_Br4923 -------------------APFRYVPTFLVP--GPRDEVT----------
Mflv_0401|M.gilvum_PYR-GCK -------------------QVQGHTLERLFPGIGAFGDRIAP--------
MSMEG_0412|M.smegmatis_MC2_155 -------------------QVQGHTLERLFPGIGALGERFMP--------
Mvan_0276|M.vanbaalenii_PYR-1 -------------------QVQGHTLERLFPGIGRLDDSF-P--------
MAV_1760|M.avium_104 -------------------QVQGHVLERLFPGIGKLDESF-P--------
MAB_0936c|M.abscessus_ATCC_199 -------------------QVQGHTLERFFPGIGPIGEKILP--------
MMAR_4939|M.marinum_M LYYPRFLTELPYLGQALLLGIPGPSSASILQGYDLINHAIGENWFPDTIA
TH_3724|M.thermoresistible__bu --------------------APGAVDYLGVPGEFWPATGLDS--------
MUL_2440|M.ulcerans_Agy99 FPIPSQSYVDNVVNNFVTPNFPSFTVSNAISLFTPAESYWITG-------
.
Rv1184c|M.tuberculosis_H37Rv --------------------VGVAVKDGTNSLDNAIH-----HGTDPAAA
Mb1216c|M.bovis_AF2122/97 --------------------VGVAVKDGTNSLDNAIH-----HGTDPAAA
MLBr_01232|M.leprae_Br4923 --------------------IGEAIAVATKNLNQAIH-----RGTEPAAV
Mflv_0401|M.gilvum_PYR-GCK ------------GLGLDGPSYGESIDVGAPNLIGAIR-----RGG-PGTA
MSMEG_0412|M.smegmatis_MC2_155 ------------GLGLDGPSYGESIDVGAPNLINAIR-----QGG-PGTV
Mvan_0276|M.vanbaalenii_PYR-1 ------------GIGIDGPSVGESVDVGTPNVITAIR-----EGG-RGTA
MAV_1760|M.avium_104 ------------GLGMDGPSVGESVAEGIDNLDAAIR-----TTGRPGTA
MAB_0936c|M.abscessus_ATCC_199 ------------GLGLDGPSIGESIDIGEPNLENAIR-----SGG-PGTA
MMAR_4939|M.marinum_M SVINYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSGLPVHV
TH_3724|M.thermoresistible__bu ------------------LTFDASVAXGQAMLTPMVDG--AIESDTPIVV
MUL_2440|M.ulcerans_Agy99 ---------------IKTMTEDASWAEGLTILDTAIK--AQLAAGNNVVV
. : . : : .
Rv1184c|M.tuberculosis_H37Rv VGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFGASFLA
Mb1216c|M.bovis_AF2122/97 VGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFGASFLA
MLBr_01232|M.leprae_Br4923 VGLSQGSLALDTEQEQLATDPTAP-PPDQLTFNTFGDPSGYHGFGKSVLA
Mflv_0401|M.gilvum_PYR-GCK IGLSEGASVLDEVQARLAYDPAAP-PPDQLSFATYGNPVGKHAFGESFLT
MSMEG_0412|M.smegmatis_MC2_155 IGLSEGASVLDEVQARLAYDPAAP-PPDSLSFATYGNPVGKHAFGESFLT
Mvan_0276|M.vanbaalenii_PYR-1 IGLSEGAMVLNDVQAKLAYDPAAP-PPDQLSFAMYGDPVARHAFGESFLT
MAV_1760|M.avium_104 IGLSEGAFVVDGEQARLANDPTAP-PPNTLNFATFGDPIGRHAFGQSFLT
MAB_0936c|M.abscessus_ATCC_199 MGLSEGALVLNAVKNALATDPTAP-EPESLTFATFGDPIAKSPFSESFLT
MMAR_4939|M.marinum_M ATLSQGTIVANRELAYLATDPNAP-PAHALEFALFGSP------ELGLAH
TH_3724|M.thermoresistible__bu FGHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFP
MUL_2440|M.ulcerans_Agy99 QGYSQGAGIASLEMSNLKAAGVPT---GSVSFSLIGNAMNPNGGLYERFA
*:.: * . : * ...
Rv1184c|M.tuberculosis_H37Rv RIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRPDNLLA
Mb1216c|M.bovis_AF2122/97 RIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRPDNLLA
MLBr_01232|M.leprae_Br4923 SIFRPGDYIPL--IDYTMPQRMDSQYDSNRVVAAYDGLSEFPDRADNLLA
Mflv_0401|M.gilvum_PYR-GCK QNFPVGSVVPS--LDYRIPAPVESQYDTYKFVSAYDSIADWPDRPDNWLS
MSMEG_0412|M.smegmatis_MC2_155 QMFPVGSVVPS--LDYRIPAPVESQYDTYQFVSAYDSIADWPDRPDNWIS
Mvan_0276|M.vanbaalenii_PYR-1 QNFPVGSVVPS--LDYRIPPPVESQYDTYQFVSAYDSIADWPDRPDNWIS
MAV_1760|M.avium_104 AMFGVGSVVPA--LDYTMPPPYESQYDTNRFVAAYDSIADFPDRPDNMFA
MAB_0936c|M.abscessus_ATCC_199 QNFAPGSVVPF--MDYPVPARVDSQYHTDQFISAYDSIADWPDRPDNLFA
MMAR_4939|M.marinum_M IYLPDGLTVPL--INYTVHGLSNTQYDVSVVNGQYDFWGNPPDRPWNLPA
TH_3724|M.thermoresistible__bu GLYIPILGVTF---NGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVA
MUL_2440|M.ulcerans_Agy99 GLVSPSLGKTF------WGATPDNYYTTDVYTLEYDGFADFPRYPPNFVS
. : : :* .: * . * :
Rv1184c|M.tuberculosis_H37Rv VANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYLVPVNH
Mb1216c|M.bovis_AF2122/97 VANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYLVPVNH
MLBr_01232|M.leprae_Br4923 QLNCFAGGAISHT--PSGFFNPEDVPPQNIRTTVNSRGAKTTTYLIPVNH
Mflv_0401|M.gilvum_PYR-GCK VANAIVGLATGHT--AVAFTDPSMVPERNIRTTVNSRGATTTTYMIPEEH
MSMEG_0412|M.smegmatis_MC2_155 VANAIVGLATGHT--AVAFTNPSMVPPQNIRTTVNSRGAKDTTIMIPEEH
Mvan_0276|M.vanbaalenii_PYR-1 VANAIVGLATGHT--AVAFTEPSMVPPQNIRTTVNSRGAKTTTYMIPEEH
MAV_1760|M.avium_104 LANTLMGLATGHT--AVAFTNPSMVPPQNIRTTINSRGAKDTTIMIPEKH
MAB_0936c|M.abscessus_ATCC_199 LANAIAGLATGHT--AVAFTNPKMVPARNIVTETNSRGGTTTTYFIPEQH
MMAR_4939|M.marinum_M WVNSLFGAAYYHN--TSSFASLS--DAVEVSSVTTSLGGTITTYLIPSPT
TH_3724|M.thermoresistible__bu TANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG-DTTYYLIRTEQ
MUL_2440|M.ulcerans_Agy99 DLNAIMGIYYVHT----QYPTLTAAQVATAFTLPTEGATMTTYHMIPTEN
* * * : . . * ::
Rv1184c|M.tuberculosis_H37Rv LPLTLPLRYLGMS-DAEVDQIDSVLQPQIDAAY-ARNDNWFTRPVSVDPV
Mb1216c|M.bovis_AF2122/97 LPLTLPLRYLGMS-DAEVDQIDSVLQPQIDAAY-ARNDNWFTRPVSVDPV
MLBr_01232|M.leprae_Br4923 LPLTLPLRYLGWS-DALVDQIDAVLQPKIDAAY-AYNDNPLNKPISVDPV
Mflv_0401|M.gilvum_PYR-GCK LPLVLPFKYLGVP-KDTLMELDKVLLPYVDAGY-SRNDDPATAPITVDPV
MSMEG_0412|M.smegmatis_MC2_155 LPLVLPFKYLGVD-KDTLNKLDGVLKPYVDAGY-SRNDDPLTAPITVDPV
Mvan_0276|M.vanbaalenii_PYR-1 LPLVLPFKYLGVP-TETLIELDAVLKPFVDAGY-SRNDDPLTAPITVDPV
MAV_1760|M.avium_104 LPLVMPLKYIGID-ENTLNKLDAILTPRVNAGY-SRNDDPATAPVQVDPV
MAB_0936c|M.abscessus_ATCC_199 LPLVMGFKYLGVP-EETLNRLDAILQPRVDAGY-SRNDDPATAPIAVDPR
MMAR_4939|M.marinum_M LPMLLPLEQIGVP-APIVAGLNSVLAPIVNDGY-SSLTPNAGPYFSQGAL
TH_3724|M.thermoresistible__bu LPLLRPLRDLGVP-EEFVDALEPYVRRIVDLGY-DRN-TPYGEPAPVRVL
MUL_2440|M.ulcerans_Agy99 LPLLEPLRGVPFIGNTLADLVQPDLKVLVNLGYGDPNYGYSTGPANVPTP
**: :. : :: : :: .*
Rv1184c|M.tuberculosis_H37Rv RGLDPLTAPGSIVEG---------------ARGLLGSPAFGG--------
Mb1216c|M.bovis_AF2122/97 RGLDPLTAPGSIVEG---------------ARGLLGSPAFGG--------
MLBr_01232|M.leprae_Br4923 NGMDPIAGIDAELRDSI-------LNVFAQLRSILPPPPG----------
Mflv_0401|M.gilvum_PYR-GCK NGYDPAEVTAPATQAAFGGGADPVSQLLSGLQYILNNPP-----------
MSMEG_0412|M.smegmatis_MC2_155 NGYDPAAVTAPATQAAFGGGTDPVSQLLAGLQYVVNNQPAPKP-------
Mvan_0276|M.vanbaalenii_PYR-1 NGYDPAEVTAPATQAAFGGAADPVSQLLSGLQYVLNNPP-----------
MAV_1760|M.avium_104 HGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH------
MAB_0936c|M.abscessus_ATCC_199 RGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN-----
MMAR_4939|M.marinum_M VGLPSAADVLGSWPWP-------------ALGSVTAHIC-----------
TH_3724|M.thermoresistible__bu PPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRST
MUL_2440|M.ulcerans_Agy99 FGLFPDVAPATVFDALVAGTQQGISDAAADIGAWQLPSLPDISLSGISNA
.
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
TH_3724|M.thermoresistible__bu LKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQPE
MUL_2440|M.ulcerans_Agy99 LGSDPWSALSNATLPTLSVSTIENAIKGVQTATTDIANTISFDATTAYAT
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
TH_3724|M.thermoresistible__bu PAEPNESAAPPAAAEADDASE-----------------------------
MUL_2440|M.ulcerans_Agy99 LLPTADVVNAMVTTLPAYNLKLFLDGILQVLDGDPAGLIYALGAPIAADT
Rv1184c|M.tuberculosis_H37Rv --------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------
MLBr_01232|M.leprae_Br4923 --------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------
MAV_1760|M.avium_104 --------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------
MMAR_4939|M.marinum_M --------------------------
TH_3724|M.thermoresistible__bu --------------------------
MUL_2440|M.ulcerans_Agy99 ALVTLLAGFNLYAYLYAFNKILPGVL