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MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVSAGIAALMSTHAQEYQLLGGQLA TYHDQLVQALDRTAGWYADAETGNAALLRNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSG GRSVLVVGSTGTPRPSYRFMREVYDLFVAPHYFGDSLFGVQTPAQFQPFTGIPNLTFDESAATGASYLHA AITQQLADGNRVVVAGFSQGASVATLEMRHLQSLPIDSRPSPEDLSFVLLGNPNNPNGGILARFPGLYIQ SVGLTFNGATPVTEYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHSLYYGLTPDQVAAGVVLPV SSPDVNTTYILIPNEHLPLLQPLRGIVPDSVLDGIEPGLRDVVELGYDRTGYADVPTPASLFPANVNPNV VAGAFVEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSAIAVPPQLGGAIAGPLD HLYRTLDSVINGQINPAITSGIYQYGADLSAEAARHGASSELLNAIYVGRQVLPILIEGPGVILTADTYY SINAIKDLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2235 | - | - | 100% (612) | PE-PGRS family protein, PE16 |
M. marinum M | MMAR_0372 | - | 3e-88 | 40.51% (506) | PE family protein |
M. marinum M | MMAR_0383 | - | 8e-87 | 43.25% (467) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1465 | PE16 | 0.0 | 57.52% (612) | PE family protein |
M. gilvum PYR-GCK | Mflv_1918 | - | 1e-33 | 34.16% (363) | hypothetical protein Mflv_1918 |
M. tuberculosis H37Rv | Rv1430 | PE16 | 0.0 | 57.52% (612) | PE family protein |
M. leprae Br4923 | MLBr_01232 | - | 6e-16 | 26.88% (320) | hypothetical protein MLBr_01232 |
M. abscessus ATCC 19977 | MAB_4141 | - | 2e-34 | 34.06% (320) | PE/PPE family protein |
M. avium 104 | MAV_1346 | - | 2e-19 | 40.85% (164) | PE family protein |
M. smegmatis MC2 155 | MSMEG_5455 | - | 5e-39 | 33.76% (311) | PE family protein |
M. thermoresistible (build 8) | TH_3724 | - | 3e-47 | 43.88% (237) | PUTATIVE putative PE-PPE, C-terminal domain protein |
M. ulcerans Agy99 | MUL_1034 | - | 5e-85 | 39.70% (461) | PE family protein |
M. vanbaalenii PYR-1 | Mvan_4726 | - | 2e-36 | 33.14% (353) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1918|M.gilvum_PYR-GCK -----MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVG MSMEG_5455|M.smegmatis_MC2_155 -----MGRLLHSLSTAFLVFVAVVVLCVSTS------------------- TH_3724|M.thermoresistible__bu ---------VVAVGALTWGGXGVASPAGQPE------------------- Mb1465|M.bovis_AF2122/97 MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAA Rv1430|M.tuberculosis_H37Rv MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAA MMAR_2235|M.marinum_M MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVSAG MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA Mvan_4726|M.vanbaalenii_PYR-1 -----MRRRLRSAAWGLLSLVIAVLFAWGS-------------------- MAV_1346|M.avium_104 MSFVTTRPEALLAVASMLEGLGSSMDAQNAA------------------- MAB_4141|M.abscessus_ATCC_1997 ----MAGQYSVPGKRHSLRRYVATITAVAAT------------------- MLBr_01232|M.leprae_Br4923 -MKRLLATTLAALTVGTVSGFGSTVASSEPGE------------------ Mflv_1918|M.gilvum_PYR-GCK TWAWVFAR----SSRSFPRSRRCWRYPRGVPTPVAVLVANTTA------- MSMEG_5455|M.smegmatis_MC2_155 -----------------------------MPTAAHLLLNHPHA------- TH_3724|M.thermoresistible__bu ------------------------------RAAALRLTATADA------- Mb1465|M.bovis_AF2122/97 IAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD- Rv1430|M.tuberculosis_H37Rv IAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD- MMAR_2235|M.marinum_M IAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALLRN MUL_1034|M.ulcerans_Agy99 IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANASLITA Mvan_4726|M.vanbaalenii_PYR-1 -------------------------------VVTSTSAGAGTA------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 -------------------------------CTVLAPLAMESR------- MLBr_01232|M.leprae_Br4923 ------------------------------PWLPPSPVPVREN------- Mflv_1918|M.gilvum_PYR-GCK ---------------------------------------LVMGGTFHPLT MSMEG_5455|M.smegmatis_MC2_155 ---------------------------------------LVIGGTGTPVP TH_3724|M.thermoresistible__bu ---------------------------------------IIMPGTKIGYI Mb1465|M.bovis_AF2122/97 -----------------------TAATGAS--------ELGSGGRTALIL Rv1430|M.tuberculosis_H37Rv -----------------------TAATGAS--------ELGSGGRTALIL MMAR_2235|M.marinum_M VQQELLTGLTAPGRAWS---GAGAASAGASGVDALMSSALLSGGRSVLVV MUL_1034|M.ulcerans_Agy99 GVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVVALIM Mvan_4726|M.vanbaalenii_PYR-1 ---------------------------------------LVMGGNGHPLS MAV_1346|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 ---------------------------------------TIASTLASYVI MLBr_01232|M.leprae_Br4923 -----------------------------------------SPAKIVYAL Mflv_1918|M.gilvum_PYR-GCK GPRDSPEFVTAYLDNAVDNQISAAYGYAVTNAVA--VYTPEEFFPLG-G- MSMEG_5455|M.smegmatis_MC2_155 ----PPEYVNGQTDNYIGAEFPGEYRYAVH--------TPQNFWPVY-GS TH_3724|M.thermoresistible__bu P---SQDEFTAYATAVIGATAGAPGAVDYLG-------VPGEFWPAT-GL Mb1465|M.bovis_AF2122/97 GSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSG----LYTPAQFQPWT-GI Rv1430|M.tuberculosis_H37Rv GSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSG----LYTPAQFQPWT-GI MMAR_2235|M.marinum_M GSTGTPRPSYRFMREVYDLFVAPHYFGDSLFG----VQTPAQFQPFT-GI MUL_1034|M.ulcerans_Agy99 GGTSVPLPGPGYVSDINNNYIQPLFSGAIPQA----LFTPEQFWPVTPGL Mvan_4726|M.vanbaalenii_PYR-1 VPQDTPDYINKYVTAADDAFIAPSGLCGPQCSLV--ATYTPAQIRFVNGI MAV_1346|M.avium_104 ----AAAPTTSIAPAAADEVSALQAAQFSAYG------------------ MAB_4141|M.abscessus_ATCC_1997 GIGGNNDGASANIPRKLGGAYSVDYHPVSYPG---------AIWPVS-GL MLBr_01232|M.leprae_Br4923 GGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPFRYVPTFLVPGPR . Mflv_1918|M.gilvum_PYR-GCK --LTFDDSVAEGLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHDDTFV MSMEG_5455|M.smegmatis_MC2_155 --MSFDESTVAGLAALQAEMAKEG-------------------HFGSPLV TH_3724|M.thermoresistible__bu DSLTFDASVAXGQAMLTPMVDGAIES-------------------DTPIV Mb1465|M.bovis_AF2122/97 PSLTYDQSVAEGAGYLHTAIMQQVAA-------------------GNDVV Rv1430|M.tuberculosis_H37Rv PSLTYDQSVAEGAGYLHTAIMQQVAA-------------------GNDVV MMAR_2235|M.marinum_M PNLTFDESAATGASYLHAAITQQLAD-------------------GNRVV MUL_1034|M.ulcerans_Agy99 GNLTFNQSVAQGVTLLNDAINTQLAL-------------------GNKVV Mvan_4726|M.vanbaalenii_PYR-1 FDMTYDESVAVGQANLNDCIQGSDCTATLAPYSETG----PHTVADSTYV MAV_1346|M.avium_104 ---TWYQQVSAQAKAIHQTLVQNLDT---------------------NAD MAB_4141|M.abscessus_ATCC_1997 TAPTFKTSVAQGRTNLNDEIVTAGNQ---------------------PIT MLBr_01232|M.leprae_Br4923 DEVTIGEAIAVATKNLNQAIHRGTEP----------------------AA : : : Mflv_1918|M.gilvum_PYR-GCK VFGYSQSAAVASLLKRQLIDAP---GPEPAATTFMLAANPMRPNGG---- MSMEG_5455|M.smegmatis_MC2_155 ILGYSSSTRILTADKNRRIAD----GDYAVDINYVLVSDVAKGNGG---- TH_3724|M.thermoresistible__bu VFGHSQSAVIATKEKQRLLAEYPD-PDTAPDVTFVMVANPNRPNGG---- Mb1465|M.bovis_AF2122/97 VLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG---- Rv1430|M.tuberculosis_H37Rv VLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGG---- MMAR_2235|M.marinum_M VAGFSQGASVATLEMRHLQSLPIDSRPSPEDLSFVLLGNPNNPNGG---- MUL_1034|M.ulcerans_Agy99 AFGYSQSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNPDGG---- Mvan_4726|M.vanbaalenii_PYR-1 IYAYSQSATVAANQKLQLIAHP-----VASTVSFLLVANPNRPDGG---- MAV_1346|M.avium_104 SYGATEAANRVN----------------TSAAALQGLAPNVIPNAA---- MAB_4141|M.abscessus_ATCC_1997 IVGYSLGAVVVSKSHSDLLQRYPG---GNPNIQFVLMGSANTPNGG---- MLBr_01232|M.leprae_Br4923 VVGLSQGSLALDTEQEQLATDP--TAPPPDQLTFNTFGDPSGYHGFGKSV . : .: . .. Mflv_1918|M.gilvum_PYR-GCK VLGRF-PALTIPILGITFHGATPTA-GVDGAYRTVDVVRQYDGLGGDFPV MSMEG_5455|M.smegmatis_MC2_155 VMARF-PGWHIPILGVTFDGATRTD-SDGYAFDTKSISFVHDGWS-DFPV TH_3724|M.thermoresistible__bu LLARF-PGLYIPILGVTFNGATPAP-ADG-PFDSYDVAREFDGWA-DFPR Mb1465|M.bovis_AF2122/97 ILARF-PGLYLQSLGLTFNGAT----PDT-DYATTIYTTQYDGFA-DFPK Rv1430|M.tuberculosis_H37Rv ILARF-PGLYLQSLGLTFNGAT----PDT-DYATTIYTTQYDGFA-DFPK MMAR_2235|M.marinum_M ILARF-PGLYIQSVGLTFNGAT----PVT-EYPTTVYTTQYDGFA-DFPQ MUL_1034|M.ulcerans_Agy99 LLARF-PGFYIPFLDVSFNGAT----PAANPYPTSIFTAQYDGIA-HAPQ Mvan_4726|M.vanbaalenii_PYR-1 ILERF-VGAYIPLLGITFNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPT MAV_1346|M.avium_104 PAADP-PPAGTTSLGTSIG-----------------WAQNVGAAASDFIT MAB_4141|M.abscessus_ATCC_1997 IFARF-PWLKIPLADIESNGAWEPD-----QFKTKVINTEYDTYG-DFPA MLBr_01232|M.leprae_Br4923 LASIFRPGDYIPLIDYTMPQRMDS------QYDSNRVVAAYDGLS-EFPD . . . . Mflv_1918|M.gilvum_PYR-GCK RPLNLLATVNALLGYGIMHG-ETVDVPF--------AQARFQGREGDTDY MSMEG_5455|M.smegmatis_MC2_155 YPLNVLALANAVAGIAVLHP-TYPELDR--------PDLVPVGSTGDTEY TH_3724|M.thermoresistible__bu YPLNLVATANAILGIYYLHG-GYYELLTENPDILDDPERTIVQQYGDTTY Mb1465|M.bovis_AF2122/97 YPLNILADVNALLGIYYSHS-LYYGLTP-EQVASGIVLPVSSPDT-NTTY Rv1430|M.tuberculosis_H37Rv YPLNILADVNALLGIYYSHS-LYYGLTP-EQVASGIVLPVSSPDT-NTTY MMAR_2235|M.marinum_M YPLNVVADVNALLGISYSHS-LYYGLTP-DQVAAGVVLPVSSPDV-NTTY MUL_1034|M.ulcerans_Agy99 YRLNILSDINAIMGYFYVHG-NYPDLMS-GQAIQ---LPTSPGYTGNTDY Mvan_4726|M.vanbaalenii_PYR-1 NPLNLLADLNAIMGTILLHP-NYSDAGT----------PQLQGQYQDSTY MAV_1346|M.avium_104 LGEGQFAPVPGAAGIPNFN------------------------------- MAB_4141|M.abscessus_ATCC_1997 Y-FNPLALANSIAAIQYAHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTY MLBr_01232|M.leprae_Br4923 RADNLLAQLNCFAGGAISHT--PSGFFNPEDVPPQNIRTTVNSRGAKTTT . .: . : Mflv_1918|M.gilvum_PYR-GCK YLIGTDLLPLLQPLLLF----VPRPILSALDAPLRVLVEDAYDRDAG--- MSMEG_5455|M.smegmatis_MC2_155 FVIGTDIMPLLMPLETIG---VPRPILLAVDEPLRVLVEAGYRRDIA--- TH_3724|M.thermoresistible__bu YLIRTEQLPLLRPLRDLG---VPEEFVDALEPYVRRIVDLGYDRNTP--- Mb1465|M.bovis_AF2122/97 ILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIELGYDRTG---- Rv1430|M.tuberculosis_H37Rv ILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIELGYDRTG---- MMAR_2235|M.marinum_M ILIPNEHLPLLQPLRGI----VPDSVLDGIEPGLRDVVELGYDRTG---- MUL_1034|M.ulcerans_Agy99 YMYLTQDLPLVQPIRDIPY--AGPPLADLIQPQLRVLVDLGYSDYGPGLS Mvan_4726|M.vanbaalenii_PYR-1 YLIPAPITPVLVPLTWVPI--VGKPLAIALDPAVRVLVEMGYDRTVN--- MAV_1346|M.avium_104 --------PGLTAATTAG---PPAPAAPAAAAGAPVLASMGRGPSIGGLS MAB_4141|M.abscessus_ATCC_1997 YLVRAEHLPLLQPLRDLTNPIGASFVLDAIEPTLRVFIDMAYDRDTG--- MLBr_01232|M.leprae_Br4923 YLIPVNHLPLTLPLRYLG---WSDALVDQIDAVLQPKIDAAYAYNDN--- * . . . Mflv_1918|M.gilvum_PYR-GCK -PGDPTTARWWPVKDFAGTAAKLIASVPVAVDN----------------- MSMEG_5455|M.smegmatis_MC2_155 -PGAPTPARLIPIVNPITLTRNFIAAIPVGVDD----------------- TH_3724|M.thermoresistible__bu -YGEPAPVRVLPPLTPAPG--------PATQHN----------------- Mb1465|M.bovis_AF2122/97 YADVPTPAALFPVHIDP--------------------------------- Rv1430|M.tuberculosis_H37Rv YADVPTPAALFPVHIDP--------------------------------- MMAR_2235|M.marinum_M YADVPTPASLFPANVNPNVVAGAFVEGAVRGIDNGLAGMGLPPLPDLPAA MUL_1034|M.ulcerans_Agy99 YADVPTPAGLL--------------------------------------- Mvan_4726|M.vanbaalenii_PYR-1 -PGQPTPARYLYVPNLIKAALNFAMAIPTGWDDAIS-------------- MAV_1346|M.avium_104 VPPSWAPG------------------------------------------ MAB_4141|M.abscessus_ATCC_1997 -PGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENG------------ MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK -----------------------LTEGFGLGRVLGTPVPGVFGVGG---- MSMEG_5455|M.smegmatis_MC2_155 -----------------------AMEELGHGRPLGTQPSGVFGVGGEDTE TH_3724|M.thermoresistible__bu -----------------------AGQGITVASATSTP------------- Mb1465|M.bovis_AF2122/97 -----------------------IAVPPQIGAAIGGPLTALDG------- Rv1430|M.tuberculosis_H37Rv -----------------------IAVPPQIGAAIGGPLTALDG------- MMAR_2235|M.marinum_M PLLPEIWSNAPPIPGWPASVPSAIAVPPQLGGAIAGPLDHLYR------- MUL_1034|M.ulcerans_Agy99 --------------------------------SVPNPFAVSYY------- Mvan_4726|M.vanbaalenii_PYR-1 ----------------------YLTGDPDCRPFHTTVPASPFGVGGPPVY MAV_1346|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 ----------------------LAGATPKQSASPEKPASPPVPQPGPTNP MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK --------------PDLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAPA MSMEG_5455|M.smegmatis_MC2_155 L-KGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVEDEPA TH_3724|M.thermoresistible__bu -------------------DKRTPVVEAPVEE---PPVQTGRSTLKREKP Mb1465|M.bovis_AF2122/97 -------------------LLDTVINDQLNPVVTSGIYQAGAELSVAAAG Rv1430|M.tuberculosis_H37Rv -------------------LLDTVINDQLNPVVTSGIYQAGAELSVAAAG MMAR_2235|M.marinum_M -------------------TLDSVINGQINPAITSGIYQYGADLSAEAAR MUL_1034|M.ulcerans_Agy99 -------------------LLKGSLQAP---------YGAAVEIGVEAG- Mvan_4726|M.vanbaalenii_PYR-1 TGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVTFSPTT MAV_1346|M.avium_104 -------------------GVAPAANATPAQLVGAGFTSAAPDTAPVTAV MAB_4141|M.abscessus_ATCC_1997 G--SATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGAS MLBr_01232|M.leprae_Br4923 ---------------------------------PLNKPISVDPVNGMDPI Mflv_1918|M.gilvum_PYR-GCK EESRSAVGGADSDGRDDVVDPEPAAPEAETS-----------EAETVTET MSMEG_5455|M.smegmatis_MC2_155 VEDETPVADTKKASPKPLRPKVRGPISFDAP-----------KLPTIRKA TH_3724|M.thermoresistible__bu VSARHLVRNSLRAVPGLRRGEPAATPTPDVT-----------PDVTPDAP Mb1465|M.bovis_AF2122/97 YGAPAGVTNAIFIGQQVLPILVEGPGALVTA-----------DTHYLVDA Rv1430|M.tuberculosis_H37Rv YGAPAGVTNAIFIGQQVLPILVEGPGALVTA-----------DTHYLVDA MMAR_2235|M.marinum_M HGASSELLNAIYVGRQVLPILIEGPGVILTA-----------DTYYSINA MUL_1034|M.ulcerans_Agy99 -----------LLGPESFPDTYPWVPSLNPG-----------LNFYLGQP Mvan_4726|M.vanbaalenii_PYR-1 ESTPSTLLPETPAESEDMPPDFVENDTPDSD-----------EVSPTEDD MAV_1346|M.avium_104 PGGVPSMATAGRGGYGLGAPRYGVKPTVMPK-----------PAI----- MAB_4141|M.abscessus_ATCC_1997 TARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQP MLBr_01232|M.leprae_Br4923 AGIDAELRDSILNVFAQLRSILPPPPG----------------------- Mflv_1918|M.gilvum_PYR-GCK EADD---------ADDADDGADADDEDIDADGADADGEDTAGNTAEAA-- MSMEG_5455|M.smegmatis_MC2_155 TGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA- TH_3724|M.thermoresistible__bu AGQP--------------EPAEPNESAAPPAAAEADDASE---------- Mb1465|M.bovis_AF2122/97 IQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV- Rv1430|M.tuberculosis_H37Rv IQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV- MMAR_2235|M.marinum_M IKDLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP-- MUL_1034|M.ulcerans_Agy99 SVTLLSLLSGGLGDIFHLIPPP-----VFP-------------------- Mvan_4726|M.vanbaalenii_PYR-1 ALKDTETINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAPA MAV_1346|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 GTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKT MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK ------------ MSMEG_5455|M.smegmatis_MC2_155 ------------ TH_3724|M.thermoresistible__bu ------------ Mb1465|M.bovis_AF2122/97 ------------ Rv1430|M.tuberculosis_H37Rv ------------ MMAR_2235|M.marinum_M ------------ MUL_1034|M.ulcerans_Agy99 ------------ Mvan_4726|M.vanbaalenii_PYR-1 DAAAADTAA--- MAV_1346|M.avium_104 ------------ MAB_4141|M.abscessus_ATCC_1997 SDHASETGRGAA MLBr_01232|M.leprae_Br4923 ------------