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KRLNGVDAMMLYSETPEIHMHTLKIGVLDVSGIGGYDFEFFRRAALPRLHALAPLRYQLVDIPWKLHHPM WIQNAEIDVDYHLRRAKVAAPGGRRELDQLIGEIAGTPLDRTRPLWEMYIADGLADNKIAVIHKVHHVLA DGVASANQLAMAIQPREPAVGGQLEAVPADSMGRANLLAGAGRDHWRQVRRLPKLVGETASGVSRVRRKA RERGANPDLAKNFAPPPTFFNHVVTPGRRFATAPLSLADVKETARHLGVTLNDIVLATAAGALRQLQLTY DGHANSPLIAGVPVSFNSSPDRLMGNEFTYMTPSLPVHIEDPLERVKLTATATAIAKENHNLLGPTLLPS WLTYLPPGTTPQVFRSQARRVESAMVMNLTISNVPGPRERGCMEGAVIDEIYSVGPIVAGSGMNITVWSY VDQLSISVLTDDRTLKDPHEATDALLASFVEIRRAAGLPEELTPVEKSMPPAPAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4091 | - | - | 100% (476) | hypothetical protein Mflv_4091 |
| M. gilvum PYR-GCK | Mflv_2428 | - | e-158 | 58.09% (482) | hypothetical protein Mflv_2428 |
| M. gilvum PYR-GCK | Mflv_0439 | - | e-148 | 56.00% (475) | hypothetical protein Mflv_0439 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1460 | - | 2e-65 | 34.26% (470) | hypothetical protein Mb1460 |
| M. tuberculosis H37Rv | Rv0221 | - | 1e-140 | 53.78% (476) | hypothetical protein Rv0221 |
| M. leprae Br4923 | MLBr_01244 | - | 2e-23 | 25.66% (417) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_1917 | - | 2e-65 | 33.55% (465) | hypothetical protein MAB_1917 |
| M. marinum M | MMAR_0464 | - | 1e-142 | 53.25% (477) | hypothetical protein MMAR_0464 |
| M. avium 104 | MAV_4952 | - | 1e-144 | 55.25% (476) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_0290 | - | 1e-150 | 54.97% (473) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_3760 | - | 1e-143 | 53.70% (473) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_1818 | - | 3e-65 | 33.69% (472) | hypothetical protein MUL_1818 |
| M. vanbaalenii PYR-1 | Mvan_2253 | - | 0.0 | 84.66% (476) | hypothetical protein Mvan_2253 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1460|M.bovis_AF2122/97 ----------MKRLSSVDAAFWSAET-AGWHMHVGALAICDPSDAP---E
MUL_1818|M.ulcerans_Agy99 ----------MRRLSSVDAAFWSAET-AGWHMHVGALAICDPTDAP---D
MAB_1917|M.abscessus_ATCC_1997 ----------MQRLSGLDASFLYLET-PTQPMHVCGVLELDTTTIPG--G
Mflv_4091|M.gilvum_PYR-GCK ----------MKRLNGVDAMMLYSET-PEIHMHTLKIGVLDVSGI---GG
Mvan_2253|M.vanbaalenii_PYR-1 ----------MRRLNGVDAMMLYSET-PEIHMHTLKIGVLDVSDV---EG
Rv0221|M.tuberculosis_H37Rv ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDSD--RQE
MMAR_0464|M.marinum_M ----------MKRLSGWDAVLLYSET-PNVHMHTLKVAVIELDPD--RRA
MAV_4952|M.avium_104 ----------MKRLSGWDSVLLYSEA-PNVHMHTIKAAVIELDAD--RRS
TH_3760|M.thermoresistible__bu ----------VKRLQGWDAVLLYSET-PNVHMHTLKVAVIDLSDV--THP
MSMEG_0290|M.smegmatis_MC2_155 ----------MQRLSGWDAFLLYSET-PNVHMHTLKIAIIDLEGIG-DRT
MLBr_01244|M.leprae_Br4923 MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD-----
. .* . * : *: . :
Mb1460|M.bovis_AF2122/97 YSFQRLRELIIERLPEIPQLRWRVTGAPLGLDRPWFVEDEELDIDFHIRR
MUL_1818|M.ulcerans_Agy99 YSFQRLRELLIERLPEIPQLRWRVTGAPLGLDRPWFVEDQDLDVDFHVRR
MAB_1917|M.abscessus_ATCC_1997 YSFEKLRTKLAERVEGIPSFREKLADSRLNLDHPVWVDDDDFDIDRHLHH
Mflv_4091|M.gilvum_PYR-GCK YDFEFFRRAALPRLHALAPLRYQLVDIPWKLHHPMWIQNAEIDVDYHLRR
Mvan_2253|M.vanbaalenii_PYR-1 YDFDLFRRAALPRLHALAPLRYQLVDIPLKFHHPMWVQNAEIDVDYHLRR
Rv0221|M.tuberculosis_H37Rv FGVDAFREVIAGRLHKLEPLGYQLVDVPLKFHHPMWREHCQVDLNYHIRP
MMAR_0464|M.marinum_M FGVDAFRAVIGERMAKLEPFGYQLVDIPFKFHHPMWREHCEVDLDYHIRP
MAV_4952|M.avium_104 LDVAAFRQVIAGRLNKLDPFCYQLVEVPFSFHHPMWRENCEIDLDYHIRP
TH_3760|M.thermoresistible__bu FGLEDFRKVIASRLYKLDPFRYQLVEIPFKFHHPMWRENCEVDLDHHIRG
MSMEG_0290|M.smegmatis_MC2_155 FGVEDFRKVLRGRLHKLDPFRFQLVDIPFKFHHPMWRENCDVDLEYHVRP
MLBr_01244|M.leprae_Br4923 --WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRR
:* : : ::. * : . :.::: *::
Mb1460|M.bovis_AF2122/97 IGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLTKM
MUL_1818|M.ulcerans_Agy99 IGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLTKM
MAB_1917|M.abscessus_ATCC_1997 VGLPAPGGKAEIADMCGHIASLPLDRARPLWEMWVIETGDTNRLVVMTKM
Mflv_4091|M.gilvum_PYR-GCK AKVAAPGGRRELDQLIGEIAGTPLDRTRPLWEMYIADGLADNKIAVIHKV
Mvan_2253|M.vanbaalenii_PYR-1 ARVPAPGGRRELDQLIGEIASTPLDRDHPLWEMYIAEGLADNKIAVIHKV
Rv0221|M.tuberculosis_H37Rv WRLRAPGGRRELDEAVGEIASTPLNRDHPLWEMYFVEGLANHRIAVVAKI
MMAR_0464|M.marinum_M WQLRPPGGRRELDEAIGEIASTPLDRRYPLWEMYFVEGLANHRVAVVGKI
MAV_4952|M.avium_104 WRVSPPGGRRELDEAIGQIASTPLDRSRPLWEMYFVEGLANNRIAVVGKI
TH_3760|M.thermoresistible__bu MRVDPPGGRRELDEAVGRIASTPLDRRYPLWEMYFVEGLANGRVAVVGKI
MSMEG_0290|M.smegmatis_MC2_155 WQVRAPGGRRELDEAIGEIAGTPLDRSRPLWEMYFVEGLAGGRIAVVNKI
MLBr_01244|M.leprae_Br4923 VRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQI
: ** *: : : :: *** . : : . : ::
Mb1460|M.bovis_AF2122/97 HHAIVDGVSGAGLGEILLDITPEPRPPQQETVGFVGFQIPG-LERRAIGA
MUL_1818|M.ulcerans_Agy99 HHAIVDGVSGAGLGEILLDVTPEPRPPQEETVGFVGFQIPR-LERRAVGA
MAB_1917|M.abscessus_ATCC_1997 HHASVDGVTGANLMSALCGLEPDAEAP-EPAPGVGGANS---LEIAVTGA
Mflv_4091|M.gilvum_PYR-GCK HHVLADGVASANQLAMAIQPREPAVGGQLEAVPAD---------SMGRAN
Mvan_2253|M.vanbaalenii_PYR-1 HHVLADGVASANQLAMAIQPREPEVGGQLAESSAD---------SRAPRN
Rv0221|M.tuberculosis_H37Rv HHALADGVASANMMARGMDLLPGPEVGR--YVPDP---------APTKRQ
MMAR_0464|M.marinum_M HHALADGVASANLMARGMDLLPGPEGDP--YVSDP---------APTKRE
MAV_4952|M.avium_104 HHALADGVASANLLARGMDLQPGPEAGP--YVCDP---------PPTTRQ
TH_3760|M.thermoresistible__bu HHALADGVASGNLMARGMDLQPGPQRDHTFYRTDP---------PPGRSH
MSMEG_0290|M.smegmatis_MC2_155 HHALADGIASANLLARGMDLREGPQRDRDSYVTDP---------EPSKGE
MLBr_01244|M.leprae_Br4923 SHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINH
*. .**: .
Mb1460|M.bovis_AF2122/97 LINVGIMTPFRIVRLLEQTVRQQIAALGVAGKP----------ARYFEAP
MUL_1818|M.ulcerans_Agy99 LINVGIMTPFRIARLVEQTVRQQIAALGVSARP----------PRYFDAP
MAB_1917|M.abscessus_ATCC_1997 LKWA--SRPLKFAKLLPATIGVIPAWLERSKRGE-------AMSAPFSAP
Mflv_4091|M.gilvum_PYR-GCK LLAGAGRDHWRQVRRLPKLVGETASGVSRVRRKARERGANPDLAKNFAPP
Mvan_2253|M.vanbaalenii_PYR-1 LLKAAARDHLRQLRRLPRLVNDTAAGVSRVRRLARERGGHPDLARNFAPP
Rv0221|M.tuberculosis_H37Rv LLSAAFIDHLRHLGRIPATIRYTTQGLGRVRRSSRKLS--PALTMPFTPP
MMAR_0464|M.marinum_M LMSSAFLDHLRHLGRIPATMRYTAQGLARVRRSSRKLS--PELTRPFTPP
MAV_4952|M.avium_104 LMVSAFADHLRHVGRLPHTIRYTAQGLGRVRRSARKLS--PELTRPFEPP
TH_3760|M.thermoresistible__bu LVRTAFVDHLRQIGRIPSVMRYTYDGLRRVHRSTRKLS--PELTRPFTPP
MSMEG_0290|M.smegmatis_MC2_155 LVRTAFADHMRQIGRIPATIRYTAQGVARVRRSSRKLS--PELTRPFTPP
MLBr_01244|M.leprae_Br4923 LPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAE
* : .
Mb1460|M.bovis_AF2122/97 KTRFNAPVSPHRRVTGTRVELARAKAVKDAFGVKLNDVVLALVAGAARQY
MUL_1818|M.ulcerans_Agy99 KTRFNAHVSPHRRVSGCRIELARAKAVKDAFGVKLNDVVLATVAGAAREY
MAB_1917|M.abscessus_ATCC_1997 RTSFNSTITSRRNVGYAQLDLEDVRTVKNHFGVKVNDVVMAICAGALRKY
Mflv_4091|M.gilvum_PYR-GCK PTFFNHVVTPGRRFATAPLSLADVKETARHLGVTLNDIVLATAAGALRQL
Mvan_2253|M.vanbaalenii_PYR-1 PTFLNHVVTPGRRFATAPLALADVKETARHLGVTLNDVVLATAAGALREL
Rv0221|M.tuberculosis_H37Rv PTFMNHRLTPERRFATATLALIDVKATAKLLGATINDMVLAMSTGALRTL
MMAR_0464|M.marinum_M PTFMNHMLTPQRRFATATLALADVKQTGKQLGATINDMVLAMSTGALRNL
MAV_4952|M.avium_104 PTFMNHKLTPERRFATATLALADVKETGKRLGATINDMVLAMSTGALRTL
TH_3760|M.thermoresistible__bu PTFLNHKIDATRTFATATLALSDVKATSRHLGVTINDLVLALSAGALRKL
MSMEG_0290|M.smegmatis_MC2_155 PSFINHMITSKRKFATATIALADAKETSKKLGITLNDLVLAMSSGALRTL
MLBr_01244|M.leprae_Br4923 PSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRY
: : : * : . . .:** :* ** *
Mb1460|M.bovis_AF2122/97 LQKRDELPAKPLIAQIPVSTRSEETKADVGNQVSSMTASLATHIEDPAKR
MUL_1818|M.ulcerans_Agy99 LKKRDELPAKPLIAQIPVSTRTDQTKEDVGNQISSMTASLATHINDPAER
MAB_1917|M.abscessus_ATCC_1997 LDDRGELPDNSLVAMVPVSVHEKSDRPGR-NQVSGMFSRLETNVDDPVER
Mflv_4091|M.gilvum_PYR-GCK QLTYDGHANSPLIAGVPVSFNSSPD-RLMGNEFTYMTPSLPVHIEDPLER
Mvan_2253|M.vanbaalenii_PYR-1 QLRYDQKADAPLIAGVPVSFSTSPD-RLVGNEFTYMTPSLPVHVADPMAR
Rv0221|M.tuberculosis_H37Rv LLRYDGKA-EPLLASVPVSYDFSPE-RISGNRFTGMLVALPADSDDPLQR
MMAR_0464|M.marinum_M LLRYDGRA-EPLLASVPVSYDFSPD-RISGNYFSGMMVALPTDCADPLER
MAV_4952|M.avium_104 LLRYDGQA-QPLLASVPVSFDFSPE-RISGNRFTGMLVALPVDHDDPLER
TH_3760|M.thermoresistible__bu LLRYDGHADHPLLASVPVSFDFSPD-RICGNYFTGMLVALPVDTAEPLDR
MSMEG_0290|M.smegmatis_MC2_155 QLRYDGRADHPLLASVPMSFDFSPD-RIWGNRFSGVLVALPVDVADTGER
MLBr_01244|M.leprae_Br4923 HEAL-GVSISTLPMAVPVNVRTEAD-VVGSNRFVGVTLAAPLGTNDPAAR
. .* :*:. . * . : :. *
Mb1460|M.bovis_AF2122/97 LAAIHESTLSAKEMAKALSAHQIMGLTETTPPGLLQLAARAYTASGLSHN
MUL_1818|M.ulcerans_Agy99 LKAIHESTQNAKEMAKALSAHQIMGLTETTPPGLLHLAARAYTATGLSHN
MAB_1917|M.abscessus_ATCC_1997 LNAIAAANNIAKDHTAVLGATLLQDWSQFAAPAVFGTAMRVYSRIRLADR
Mflv_4091|M.gilvum_PYR-GCK VKLTATATAIAKENHNLLGPTLLPSWLTYLPP---GTTPQVFRSQARRVE
Mvan_2253|M.vanbaalenii_PYR-1 VRLTATATAIAKENHRLLGPTLLPSWLAYLPP---ATTPRIFRMQARRLE
Rv0221|M.tuberculosis_H37Rv VRVCHENAVSAKESHQLLGPELISRWAAYWPP---AGAEALFRWLSERDG
MMAR_0464|M.marinum_M VQACHENALSAKESHQLLGPELISRWAAYWPP---GATEAAFRWASSRDG
MAV_4952|M.avium_104 VAACHQNAISAKESHQLMGPELVSRWAAYMPP---APTRAFFQWASARDG
TH_3760|M.thermoresistible__bu IRATRDAALLAKESHQLIGPELISRWSQYLPP---APAERLFGWLSRIDG
MSMEG_0290|M.smegmatis_MC2_155 VRRTREAANLAKESHQLIGPELVARWAAYMPP---VPVEALFKRLSSKDG
MLBr_01244|M.leprae_Br4923 MQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPA----------SVLDFIVD
: :: : ..
Mb1460|M.bovis_AF2122/97 LAPIN-LVVSNVPGPPFPLYMAGARLDSLVPLGPPVMDVALNITCFSYQD
MUL_1818|M.ulcerans_Agy99 LAPIN-LVVSNVPGPQFPLYMAGARLDSLVPLGPPVMDVALNITCFSYQE
MAB_1917|M.abscessus_ATCC_1997 HPVIHNLVVSNVPGPQVPLYFLGAQVIGMYPLGPIFHGAALTVTVMSLDG
Mflv_4091|M.gilvum_PYR-GCK SAMVMNLTISNVPGPRERGCMEGAVIDEIYSVGPIVAGSGMNITVWSYVD
Mvan_2253|M.vanbaalenii_PYR-1 SAMVMNLTVSNVAGPKRRGVIEGAVVDEIYSVGPIVAGSGMNITVWSYVD
Rv0221|M.tuberculosis_H37Rv QNKVLNLNISNVPGPRERGRVGAALVTEIYSVGPLTAGSGLNITVWSYVD
MMAR_0464|M.marinum_M QNKVLNLNISNVPGPREHGRVGGALVTEIYSVGPLTAGSGLNITVWSYVD
MAV_4952|M.avium_104 HNKILNLNISNVPGPRERGRVGGALVTEIYSVGPLTAGSGLNITVWSYVD
TH_3760|M.thermoresistible__bu QNKIQNLTVSNVMGPKERGRVGGALVTEIYSVGPLTAASGLNITVWSYVD
MSMEG_0290|M.smegmatis_MC2_155 QNKVLNLNISNVPGPRERGKVGGATVTELYSVGPITAGSGLNITVWSYVD
MLBr_01244|M.leprae_Br4923 SVASSDVNASNIPAYPGDTYFAGAKILRQYGIGPR-PGVAMMAVLMSRGG
: **: . . .* : :** .: . *
Mb1460|M.bovis_AF2122/97 YLDFGLVTTPEVANDIDEMADAIEPALAELERAAE---------------
MUL_1818|M.ulcerans_Agy99 HLDFGFVTTPEVANDIDEMADLIEPALAELERAAGL--------------
MAB_1917|M.abscessus_ATCC_1997 KLNVGLISCPDLMPDLGTLTDDFGVALEELKARI----------------
Mflv_4091|M.gilvum_PYR-GCK QLSISVLTDDRTLKDPHEATDALLASFVEIRRAAGLPEELTPVEKSMPPA
Mvan_2253|M.vanbaalenii_PYR-1 QLSISVLTDDRTLKDPHEATDALIASFAEIRRAAGLPEELTPVEKALPVA
Rv0221|M.tuberculosis_H37Rv QLNISVLTDGSTVQDPHEVTAGMIADFIEIRRAAGLSVELTVVESAMAQA
MMAR_0464|M.marinum_M QLNISVLTDGATVEDPHEVTEAMMADFVEIRRAAGLSAELTVIEAAMAQA
MAV_4952|M.avium_104 QLNISVLTDGATCKDPHEVTEAMVQDFIEIRRAAGFSEDLTVVEAAMAPA
TH_3760|M.thermoresistible__bu QLNISVLSDGSTFDDPHEVTDAMVGEFIEIRGAAGLPGELTVVETAMAR-
MSMEG_0290|M.smegmatis_MC2_155 QLNISVISDDATVDDPHEVTDAMLDEFREIRRTAGLSEKLTVVETAMPQ-
MLBr_01244|M.leprae_Br4923 FCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAARS
. . . : : : *:
Mb1460|M.bovis_AF2122/97 -----------
MUL_1818|M.ulcerans_Agy99 -----------
MAB_1917|M.abscessus_ATCC_1997 -----------
Mflv_4091|M.gilvum_PYR-GCK PAL--------
Mvan_2253|M.vanbaalenii_PYR-1 PAL--------
Rv0221|M.tuberculosis_H37Rv -----------
MMAR_0464|M.marinum_M RSMNEGAGSA-
MAV_4952|M.avium_104 -----------
TH_3760|M.thermoresistible__bu -----------
MSMEG_0290|M.smegmatis_MC2_155 -----------
MLBr_01244|M.leprae_Br4923 SGSPAGWLSSS