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PQPPPGDRGPQSADDPDSPTRQRILAATAEVLGRNGTTKLSLSEVASQAGVSRPTLYRYFADKRELLDVF VVWERQYYERAIARATADLPVSERLDAALRVIVEYQLSYPGLRMVDVEPDQVIKRLTRVLPLMRDRLQRL CTGPDAALAAATAVRVAISQYLVRSDDSEQFLAQLRHAARVKHRDM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2233 | - | - | 100% (187) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2227 | - | 6e-54 | 60.84% (166) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2776 | - | 8e-08 | 38.81% (67) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3860c | - | 2e-07 | 25.79% (190) | transcriptional regulatory protein TetR-family |
| M. gilvum PYR-GCK | Mflv_4112 | - | 1e-85 | 85.33% (184) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3830c | - | 2e-07 | 25.79% (190) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_00717 | - | 3e-06 | 31.46% (89) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2046 | - | 4e-09 | 42.65% (68) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0389 | - | 2e-56 | 63.22% (174) | putative regulatory protein |
| M. avium 104 | MAV_5134 | - | 8e-56 | 63.69% (168) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2557 | - | 9e-68 | 73.81% (168) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0276 | - | 8e-63 | 74.68% (158) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_1039 | - | 4e-56 | 62.64% (174) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3860c|M.bovis_AF2122/97 MVRPPQ--------TARSERTREALRQAALVRFLAQGVEATSAEQIAEDA
Rv3830c|M.tuberculosis_H37Rv MVRPPQ--------TARSERTREALRQAALVRFLAQGVEATSAEQIAEDA
Mvan_2233|M.vanbaalenii_PYR-1 MPQPPPGDRGPQSADDPDSPTRQRILAATAEVLGRNGTTKLSLSEVASQA
Mflv_4112|M.gilvum_PYR-GCK MTMPSP---APGSAD-PDNPTRQRILAATAEVLGRNGTTRLSLSEVAAQA
MSMEG_2557|M.smegmatis_MC2_155 MAGTDA----GTDAGTEASSTRERILAATAKVLGSNGTTKLSLSDVASQA
TH_0276|M.thermoresistible__bu MP------------DRIAASARERILTATAEVLGRAGMTKLSLSDVAQQA
MMAR_0389|M.marinum_M MSQAFG----AIDTTDGDTSTRQRILAATAEVLARSGKTKLSLSEVAAQA
MUL_1039|M.ulcerans_Agy99 MSQAFG----AIDTTDGDTSMRQRILAATAEVLARSGKTKLSLSEVAAQA
MAV_5134|M.avium_104 MSHPVR----ATAIADTDTSTRQRILAATAEVLGRNGKTKLSLSDVATQA
MAB_2046|M.abscessus_ATCC_1997 MPTEPVR-------VSFRRHVREKVLRATRELAIEKGWDQVRMSEVAESV
MLBr_00717|M.leprae_Br4923 MTTARR--------RLSPEDRRAELLALGAEVFGKRPYDEVRIDEIAERA
* * : .::* .
Mb3860c|M.bovis_AF2122/97 GVSLRTFYRHFRSKHDLLFADYDAGLH-WFRAALDARPADESIIDS--VQ
Rv3830c|M.tuberculosis_H37Rv GVSLRTFYRHFRSKHDLLFADYDAGLH-WFRAALDARPADESIIDS--VQ
Mvan_2233|M.vanbaalenii_PYR-1 GVSRPTLYRYFADKRELLDVFVVWERQ-YYERAIARATADLPVSER--LD
Mflv_4112|M.gilvum_PYR-GCK GVSRPTLYRYFADKRELLDVFVVWERQ-YYERAIAKATAELPAHER--LD
MSMEG_2557|M.smegmatis_MC2_155 GVSRPTLYRWFSSKQDLLDAFVVWERR-GYEQAVAQATGALPASER--LD
TH_0276|M.thermoresistible__bu GVSRPTLYRWFSGKEELLDAFAQWERQ-MYERALAEATAGLPAEER--LD
MMAR_0389|M.marinum_M GVSRPTLYRWFASKEELLATFSRYERQ-VFESGLSKATAGLKGVDK--LD
MUL_1039|M.ulcerans_Agy99 GVSRPTLYRWFASKEELLATFSRYERQ-VFESGLSKATAGLKGVDK--LD
MAV_5134|M.avium_104 GVSRPTLYRWFASKEELLSAFSAYERQ-IFESGLVKATAGLKGVDK--LD
MAB_2046|M.abscessus_ATCC_1997 GVSRPTLYKEFGDKQGLGDALVVSEGQ-RFMEGILAVLAEHVGDVRGGIT
MLBr_00717|M.leprae_Br4923 GVSRALMYHYFPDKRAFFAAVVKDEADRLYAATNIPPPAGLTMFEEVRVG
*** :*: * .*. : . : . :
Mb3860c|M.bovis_AF2122/97 AAIFS-------FPYDVDAVTKIAS------------LRRGELEPSRIVR
Rv3830c|M.tuberculosis_H37Rv AAIFS-------FPYDVDAVTKIAS------------LRRGELEPSRIVR
Mvan_2233|M.vanbaalenii_PYR-1 AALR----------VIVEYQLSYPG------------LRMVDVEPDQVIK
Mflv_4112|M.gilvum_PYR-GCK AALR----------VIVEYQLSYPG------------MRMVDVEPDQVIR
MSMEG_2557|M.smegmatis_MC2_155 AALR----------VIAEYQRSYPG------------LRMVDIEPEHVIR
TH_0276|M.thermoresistible__bu AVLR----------VIVEYQQSYPG------------LRMVDIEPAHLIG
MMAR_0389|M.marinum_M AALR----------FIVDYQYSYSG------------VRMVDIEPELVIS
MUL_1039|M.ulcerans_Agy99 AALR----------FIVDYQYSYSG------------VRMVDIEPELVIS
MAV_5134|M.avium_104 AVLR----------FIVDYQHSYSG------------VRMVDVEPEHTIA
MAB_2046|M.abscessus_ATCC_1997 AAVQFTLCEAEDSPLLKAVLTSNPSGNDRGGSSSTGVLPLLPTSASLLQL
MLBr_00717|M.leprae_Br4923 VLAYMAYHKQNPEAAWAAYVGLGRSD-----------PVLLGIDDEAKNR
. . .
Mb3860c|M.bovis_AF2122/97 HMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAME
Rv3830c|M.tuberculosis_H37Rv HMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAME
Mvan_2233|M.vanbaalenii_PYR-1 RLTRVLPLMRDRLQRLCTGPDAALAAATAVRVAIS---------------
Mflv_4112|M.gilvum_PYR-GCK RMSRVLPLMRERLERLCTGPDAALSAATAVRVAIS---------------
MSMEG_2557|M.smegmatis_MC2_155 RLSQIMPLLRERLQRLTTGPDSDVAAATAVRVAIS---------------
TH_0276|M.thermoresistible__bu RLSAILPVMRDRLERLCTGPTASAAAATAVRVAVS---------------
MMAR_0389|M.marinum_M QMSGVIPEMREGLQRLLPGPNAAVKAATAIRIAIS---------------
MUL_1039|M.ulcerans_Agy99 QMSSVIPEMREGLQRLLPGPNAAVKAATAIRIAIS---------------
MAV_5134|M.avium_104 QFSWVIPQMREGLQRHLPGPNAAVKAATVIRIAIS---------------
MAB_2046|M.abscessus_ATCC_1997 CSAALITWFNDHFDDLDP-EDVEEVADVLVRLTVS---------------
MLBr_00717|M.leprae_Br4923 QMEHIMSRIGDVVS-VVPESKLHPDIERDLRVIVHG---WLAFTFEVCRQ
: . : : .. *: :
Mb3860c|M.bovis_AF2122/97 AWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS-------
Rv3830c|M.tuberculosis_H37Rv AWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS-------
Mvan_2233|M.vanbaalenii_PYR-1 QYLVRSDDSEQFLAQLRHAAR-------------VKHRDM------
Mflv_4112|M.gilvum_PYR-GCK QYLVRSDDSADFLAQLRHAAR-------------VRHPGR------
MSMEG_2557|M.smegmatis_MC2_155 HYLVRSDDADDFLAQLRHVA---------------RPRRRE-----
TH_0276|M.thermoresistible__bu HYLVQSDDAGDFLAQLRHAVGLPIAPGAVSAKTPLQPRRNP-----
MMAR_0389|M.marinum_M HYIVRSDDADQFLAQLRHAVG-------------LKGG--------
MUL_1039|M.ulcerans_Agy99 HYIVRSDDADQFLAQLRHAVG-------------LKGG--------
MAV_5134|M.avium_104 HYIVRSDDADQFLAQLRHAVG-------------IKAPTD------
MAB_2046|M.abscessus_ATCC_1997 HVVLPAADIATTGERISRVALR-----------YLGVVHSL-----
MLBr_00717|M.leprae_Br4923 RIMDPSTDADRLADSCAHALLDAIARVPEISKELADAMAIARQPPQ
: : :.