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SQAFGAIDTTDGDTSMRQRILAATAEVLARSGKTKLSLSEVAAQAGVSRPTLYRWFASKEELLATFSRYE RQVFESGLSKATAGLKGVDKLDAALRFIVDYQYSYSGVRMVDIEPELVISQMSSVIPEMREGLQRLLPGP NAAVKAATAIRIAISHYIVRSDDADQFLAQLRHAVGLKGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1039 | - | - | 100% (181) | putative regulatory protein |
| M. ulcerans Agy99 | MUL_4837 | - | 3e-08 | 29.19% (161) | transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_4876 | - | 9e-08 | 34.95% (103) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3860c | - | 4e-07 | 28.78% (139) | transcriptional regulatory protein TetR-family |
| M. gilvum PYR-GCK | Mflv_4118 | - | 1e-65 | 71.01% (169) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3830c | - | 4e-07 | 28.78% (139) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_00815 | - | 4e-06 | 28.87% (97) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 2e-08 | 30.77% (91) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0389 | - | 1e-95 | 98.90% (181) | putative regulatory protein |
| M. avium 104 | MAV_5134 | - | 4e-78 | 82.68% (179) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2553 | - | 1e-68 | 77.11% (166) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0275 | - | 2e-69 | 77.71% (166) | transcriptional regulator, TetR family protein |
| M. vanbaalenii PYR-1 | Mvan_2227 | - | 3e-67 | 73.49% (166) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3860c|M.bovis_AF2122/97 -----------------------MVRPPQTARSERTREALRQAALVR---
Rv3830c|M.tuberculosis_H37Rv -----------------------MVRPPQTARSERTREALRQAALVR---
MUL_1039|M.ulcerans_Agy99 -----------------------MSQAFGAIDTTDGDTSMRQRILAATAE
MMAR_0389|M.marinum_M -----------------------MSQAFGAIDTTDGDTSTRQRILAATAE
MAV_5134|M.avium_104 -----------------------MSHPVRATAIADTDTSTRQRILAATAE
Mflv_4118|M.gilvum_PYR-GCK -----------------------MNQPADDAQTPDD-VSTRQRILAATAE
Mvan_2227|M.vanbaalenii_PYR-1 -----------------------MNEPASDAAAAED-TSTRHRILVATAE
MSMEG_2553|M.smegmatis_MC2_155 -----------------------MNEALP-AGAGAD-TSTRHRILVATAE
TH_0275|M.thermoresistible__bu -----------------------VNQPTDQQAAPEEEASTRHRILEATAE
MAB_4541|M.abscessus_ATCC_1997 -------------------MTNLIPESETPNKRERAKADRRDQLLRAAAR
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
. * *
Mb3860c|M.bovis_AF2122/97 -FLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLLFADY-DAGLHWFR
Rv3830c|M.tuberculosis_H37Rv -FLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLLFADY-DAGLHWFR
MUL_1039|M.ulcerans_Agy99 VLARSGKTKLSLSEVAAQAGVSRPTLYRWFASKEELLATFS-RYERQVFE
MMAR_0389|M.marinum_M VLARSGKTKLSLSEVAAQAGVSRPTLYRWFASKEELLATFS-RYERQVFE
MAV_5134|M.avium_104 VLGRNGKTKLSLSDVATQAGVSRPTLYRWFASKEELLSAFS-AYERQIFE
Mflv_4118|M.gilvum_PYR-GCK VLGRSGQTKLSLSEVALQAGVSRPTLYRWFADKQALLEAFG-VHEREMFE
Mvan_2227|M.vanbaalenii_PYR-1 VLSRSGQTKLSLSEVALQAGVSRPTLYRWFADKPALLEAFG-IYEREMFE
MSMEG_2553|M.smegmatis_MC2_155 VLARSGQTKLSLSEVALQAGVSRPTLYRWFADKQELLEAFG-NYEREMFD
TH_0275|M.thermoresistible__bu VLSRAGKRKLSLSEVALQAGVSRPTLYRWFASKEDLLDAFG-AYERQLFD
MAB_4541|M.abscessus_ATCC_1997 LLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLTDVSRRLLE
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
: * .::. .*:* .:*: * .* * . .
Mb3860c|M.bovis_AF2122/97 AALDARPADESIIDSVQAAIFSFPYDVDAVTKIASLRRG-----ELEPSR
Rv3830c|M.tuberculosis_H37Rv AALDARPADESIIDSVQAAIFSFPYDVDAVTKIASLRRG-----ELEPSR
MUL_1039|M.ulcerans_Agy99 SGLSKATAGLKGVDKLDAALR---FIVDYQYSYSGVRMV-----DIEPEL
MMAR_0389|M.marinum_M SGLSKATAGLKGVDKLDAALR---FIVDYQYSYSGVRMV-----DIEPEL
MAV_5134|M.avium_104 SGLVKATAGLKGVDKLDAVLR---FIVDYQHSYSGVRMV-----DVEPEH
Mflv_4118|M.gilvum_PYR-GCK TGILKATAGLRGTERVDAAMR---FIVEYQQSYSGVRLV-----DIEPEV
Mvan_2227|M.vanbaalenii_PYR-1 TGIAKATAGLRGNDRVDAAMR---FIVDYQQSYSGVRLV-----DIEPEV
MSMEG_2553|M.smegmatis_MC2_155 NGIGRATAGLRGNEKLDAALR---FIVQYQQSYSGVRLV-----DIEPEV
TH_0275|M.thermoresistible__bu TGISKATAGLRGNEKLDAALR---FIVEYQHSYSGVRLV-----DIEPEV
MAB_4541|M.abscessus_ATCC_1997 GGMTVAAAASSPAEALDGLID---FHLDFALNESDLIRVQDRDLDSLPEN
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNRQRLHAAVQ---AFFDFIEHDGQGYRLIFENDNITEPR
: : :.. : .: . :
Mb3860c|M.bovis_AF2122/97 IVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFG
Rv3830c|M.tuberculosis_H37Rv IVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFG
MUL_1039|M.ulcerans_Agy99 VISQMSSVIPEMREGLQRLLPGPNAAVKAATAIRIAISH-----------
MMAR_0389|M.marinum_M VISQMSGVIPEMREGLQRLLPGPNAAVKAATAIRIAISH-----------
MAV_5134|M.avium_104 TIAQFSWVIPQMREGLQRHLPGPNAAVKAATVIRIAISH-----------
Mflv_4118|M.gilvum_PYR-GCK VISRLAHIIPLMRAQLEKLLPGANGAVKAATAVRVAVCH-----------
Mvan_2227|M.vanbaalenii_PYR-1 VIGRLAHIIPAMRAQLEKLLPGPNGAVKAATAIRVAVSH-----------
MSMEG_2553|M.smegmatis_MC2_155 VIAQLAHVIPIMRARLLKLLSGPNAAVKAATAIRVAISH-----------
TH_0275|M.thermoresistible__bu VIAQLSQVIPVMRARLQRLLPGANGAVKAATAIRVAVSH-----------
MAB_4541|M.abscessus_ATCC_1997 ARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFG---------
MLBr_00815|M.leprae_Br4923 VAAQVRVATESCIDAVFALIS-ADSRLDPHRARMVAVGLVGISVDCARYW
:. : : :
Mb3860c|M.bovis_AF2122/97 AMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS
Rv3830c|M.tuberculosis_H37Rv AMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS
MUL_1039|M.ulcerans_Agy99 ----YIVRSDDADQFLAQLRHA------VGLKGG--------
MMAR_0389|M.marinum_M ----YIVRSDDADQFLAQLRHA------VGLKGG--------
MAV_5134|M.avium_104 ----YIVRSDDADQFLAQLRHA------VGIKAPTD------
Mflv_4118|M.gilvum_PYR-GCK ----YIVRADDDDQFLAQLRHA------VGLRATD-------
Mvan_2227|M.vanbaalenii_PYR-1 ----YIVRADDDDQFLAQLRHS------VGIKPS--------
MSMEG_2553|M.smegmatis_MC2_155 ----YIVRSDDADQFLAQLRHA------VGIRQTDTN-----
TH_0275|M.thermoresistible__bu ----YIVRSDDDDQFLAQLRHA------VGIKAPAGEPAPAR
MAB_4541|M.abscessus_ATCC_1997 ----LMNSTPYSAGRSAPSQTR------TVLRQMVVAALRS-
MLBr_00815|M.leprae_Br4923 LDTNRPISKSDAVEGTVQFAWG-------GLSHVPLTRL---
. :