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NVTGWCSLSGKIPGRGPSPGDAKDDEVARLLALESFDILDTPPEESFDGLTALAAYVCDVPMALIGFLDA ERQWLKSRQGVGHSEIARELSFCASTMGDGDTLIEIPDTRLDSRLAGHPMVTGDPHLRFYAGMPIRTAEG HALGTICVMDVEPRTLSDAQRSHLRTLADQVMNLLDLRRRARQYAVEMTRRLEIDEALRQQQRLLSGVLD HTDVLVYTKDVEGRFVMANNAVQHVTQADRSMIGATDYDFFDATVADSYRRNDRRIMETREWQVFSEDVV HPDGSVHTYRSTKFPLISDSGEVLGVGGLSTDVTELAAARAAHEAAEERWRALVEQSPAPVIVVDAEGAL AYVNPEGLALLGVARGADVSLLPAEDFIPPQLRRATQKLLDETMAGTRVVRGERGVLRRRDGTEITVEIN ATVVSHSGERSVQLEIRDVSEVAAAHAALEHSASTDPLTGVLNRKAWDARVATLLPEVSDTSPMTIAVID LDNFKTYNDTRGHTAGDALLQQFAGAAAACLGADDVFARWGGEEFIVALPGADPDRAEPILDRLRGHVPS EQTCSIGYTGHVPPEALTDTVIRADKALYQAKRRGKNRIARL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4251 | - | - | 100% (603) | diguanylate cyclase with PAS/PAC sensor |
| M. gilvum PYR-GCK | Mflv_2883 | - | 2e-23 | 29.33% (358) | diguanylate cyclase with PAS/PAC sensor |
| M. gilvum PYR-GCK | Mflv_3822 | - | 3e-21 | 41.14% (158) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-15 | 30.28% (218) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-15 | 30.28% (218) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 2e-21 | 28.97% (290) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_1839 | - | 6e-13 | 32.93% (164) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_4127 | - | 7e-22 | 41.67% (156) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 1e-14 | 32.41% (216) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 1e-16 | 31.20% (250) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2109 | - | 0.0 | 66.89% (601) | diguanylate cyclase with PAS/PAC sensor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
MSMEG_2196|M.smegmatis_MC2_155 -----MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu -----VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
Mflv_4251|M.gilvum_PYR-GCK -----------MNVTGWCSLSGKIPGRGPSPGDAK-DDEVARLLALESFD
Mvan_2109|M.vanbaalenii_PYR-1 ---------MSAGFTGLMLLAGKLSSRG---ADCRPDGESARLLALESFE
MAV_4127|M.avium_104 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 -----------------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRI
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
Mflv_4251|M.gilvum_PYR-GCK ILDTPPEESFDGLTALAAYVCDVP----MALIGFLDAERQWLKSRQGVGH
Mvan_2109|M.vanbaalenii_PYR-1 ILDTVPETPFDGLTALAAYVCGAP----MALLSFVDATRQWIKSRHGVDV
MAV_4127|M.avium_104 --------------------------------------------------
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 ESINPAATRILGLRAHD--------------------------VVDMKHG
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
Mflv_4251|M.gilvum_PYR-GCK SEIARELSFCASTMGDGDTLIEIPDTRLDSRLAGHPMVTGDPHLRFYAGM
Mvan_2109|M.vanbaalenii_PYR-1 AEIDREVSFCARTLA-AASLLEIPDTHLDPRFAPHPMVTGDPHVRFYAGV
MAV_4127|M.avium_104 ---------------------------MSGRLASQPSAG-----------
MAB_1839|M.abscessus_ATCC_1997 -------------------MVTTYPGRNGFGSESNRCSTGAQVYGANNDI
MLBr_00397|M.leprae_Br4923 HPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVGIDQHSGQRLWLSVNV
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNR---RA
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNR---RA
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNR---RA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNR---RA
Mflv_4251|M.gilvum_PYR-GCK PIRTAEGHALGTICVMDVEPRTLSDAQRSHLRTLADQVMNLLDLRRRARQ
Mvan_2109|M.vanbaalenii_PYR-1 PIVTGDGHALGALCVMDREPRTLSDPQRVHLQTLADQVLTLLQLRSRTRQ
MAV_4127|M.avium_104 -----RWHAIGLIAFLWLVG------------------------------
MAB_1839|M.abscessus_ATCC_1997 LERVGLRRPVSRANAVFITAVG----------------------------
MLBr_00397|M.leprae_Br4923 SLLAYKAPPHSALVVSFSDISAHHLSIERLTYEATHDCLTGLANRR--FA
.
Mb1389c|M.bovis_AF2122/97 LLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRI
Rv1354c|M.tuberculosis_H37Rv LLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRI
MSMEG_2196|M.smegmatis_MC2_155 LMAHLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRL
TH_0811|M.thermoresistible__bu LLAHLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERL
Mflv_4251|M.gilvum_PYR-GCK YAVEMTRRLEIDEALRQQQRLLSGVLDHTDVLVYTKDVEGRFVMANNAVQ
Mvan_2109|M.vanbaalenii_PYR-1 TASEIDRRLAADAALRQQQRMLEAVLEHTDVLIFAKDVDGRFVMANRALE
MAV_4127|M.avium_104 -IYSVKARLG--------------------------GAGDPRLYGLLGGA
MAB_1839|M.abscessus_ATCC_1997 ------------------------------------AAAILLAATGMSTI
MLBr_00397|M.leprae_Br4923 EDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHDVGDAVLQTVAQRL
.
Mb1389c|M.bovis_AF2122/97 GDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG
Rv1354c|M.tuberculosis_H37Rv GDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG
MSMEG_2196|M.smegmatis_MC2_155 QRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDG
TH_0811|M.thermoresistible__bu REGAGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDG
Mflv_4251|M.gilvum_PYR-GCK HVTQADRSMIGATDYDFFDATVADSYRRNDRRIMETREWQVFSEDVVHP-
Mvan_2109|M.vanbaalenii_PYR-1 HVTRAESTLIGFTDHDFFDAEIADDYRRNDRRIMAGREWQVFSEEVVHP-
MAV_4127|M.avium_104 ALAAVAAALVGRLRG-----------RQESRVLLAGWPVASLLLTTVVG-
MAB_1839|M.abscessus_ATCC_1997 PLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTT-
MLBr_00397|M.leprae_Br4923 RSAVRPDDVVARLGGDEFIVLLRGPLSDMNANDVAKRLHTTLSESLVVDQ
: . : :
Mb1389c|M.bovis_AF2122/97 EVLTRTVSIGVASGTPGQH-TPSDLLRRADQAALAAKHAGGDSVA-----
Rv1354c|M.tuberculosis_H37Rv EVLTRTVSIGVASGTPGQH-TPSDLLRRADQAALAAKHAGGDSVA-----
MSMEG_2196|M.smegmatis_MC2_155 EMLTRTVSIGIAQGIPGKD-STSDVLNRADHAVLTAKGSGGNRVA-----
TH_0811|M.thermoresistible__bu EMLTRTASIGVAQGTPGRD-TTSDLLRRADQAVLTAKSAGGNQIT-----
Mflv_4251|M.gilvum_PYR-GCK ---DGSVHTYRSTKFPLIS-DSGEVLGVGGLSTDVTELAAAR--------
Mvan_2109|M.vanbaalenii_PYR-1 ---DGSVHTYRSTKFPLFD-DGGEVIGTGGVSTDVTELVAAR--------
MAV_4127|M.avium_104 -----AVDPPVTRDFPG---TITITFAYIGLTCPRWR-------------
MAB_1839|M.abscessus_ATCC_1997 ---TGVAFVKLAWLLAVSA-YVSLVHGRVAVA------------------
MLBr_00397|M.leprae_Br4923 LTVPIGASVGILEVRPDDRRRAADILRDADSAMYAAKNKKQCAVTPQQLV
. . :
Mb1389c|M.bovis_AF2122/97 ---------IFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
Rv1354c|M.tuberculosis_H37Rv ---------IFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
MSMEG_2196|M.smegmatis_MC2_155 ---------VFSDAMAMEIDFRNDIELHLQSVIEGGALVLHYLPEIDMRT
TH_0811|M.thermoresistible__bu ---------VFTDDMSLEAEFRNDIELHLQSVIQDEALLLHFLPEVDMRT
Mflv_4251|M.gilvum_PYR-GCK -----------AAHEAAEERWRALVEQSPAPVIVVDAE--GALAYVNPEG
Mvan_2109|M.vanbaalenii_PYR-1 -----------AAHAAAEQRWRALVEQSPAAVIVIDRD--GGLSYVNPEA
MAV_4127|M.avium_104 -----------------------------------------SLAFVPLGV
MAB_1839|M.abscessus_ATCC_1997 ------------------------------------------MQSLVTTA
MLBr_00397|M.leprae_Br4923 PFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVVLAIVGYGMTFVIMAG
: :
Mb1389c|M.bovis_AF2122/97 GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
Rv1354c|M.tuberculosis_H37Rv GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
MSMEG_2196|M.smegmatis_MC2_155 GEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEF
TH_0811|M.thermoresistible__bu GEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEF
Mflv_4251|M.gilvum_PYR-GCK LALLGVARGADVSLLPAEDFIPPQLRRATQKLLDETMAGTRVVRGERGVL
Mvan_2109|M.vanbaalenii_PYR-1 VTLLGGETAEQITAQPGLDFVPAHLRAAAQTLLEVALSGGTPARSQRGLL
MAV_4127|M.avium_104 AAFVVGGAKALPDGSTSVLLAAAMWVIVAEVP------------------
MAB_1839|M.abscessus_ATCC_1997 GTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAG---------------
MLBr_00397|M.leprae_Br4923 SVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLVGLAAGMVNGIVFAYG
: . . .
Mb1389c|M.bovis_AF2122/97 SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
Rv1354c|M.tuberculosis_H37Rv SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
MSMEG_2196|M.smegmatis_MC2_155 SRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEI
TH_0811|M.thermoresistible__bu AKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEI
Mflv_4251|M.gilvum_PYR-GCK RRRDGTEITVEINATVVSHSGERSVQLEIRDVSEVAAAHAALEHSASTDP
Mvan_2109|M.vanbaalenii_PYR-1 RRVDGTVIAVEFNGTVVDHSDERSVQLEVRDVSADAAAHAALKLSASTDP
MAV_4127|M.avium_104 ----------------------------AWLIARLEEQSALLRKVAHTDA
MAB_1839|M.abscessus_ATCC_1997 ---------------------LVIYVGKAQFSEHADGRDRLARHDVLTGL
MLBr_00397|M.leprae_Br4923 KIPSFVSTLGMLQVCRGITLMISDSSAKPMPFHGILGAMGAMPWILIVCL
Mb1389c|M.bovis_AF2122/97 TENVVVQDLHTARATLAR---LKEVGVHIAIDDFGTGYSAISLLQTLPID
Rv1354c|M.tuberculosis_H37Rv TENVVVQDLHTARATLAR---LKEVGVHIAIDDFGTGYSAISLLQTLPID
MSMEG_2196|M.smegmatis_MC2_155 TESVVVQDIETTRTTLTG---LHNVGVQVAIDDFGTGYSVLSLLKSLPVD
TH_0811|M.thermoresistible__bu TESVVVQDIKTTRITLEG---LNEVGVQVAIDDFGTGYSVLSHLKTLPVD
Mflv_4251|M.gilvum_PYR-GCK LTGVLNRKAWDARVATLLPEVSDTSPMTIAVIDLDN------FKTYNDTR
Mvan_2109|M.vanbaalenii_PYR-1 LTGALNRRGWDARVAALL---ADGAAMTVAVLDLDN------FKSYNDAH
MAV_4127|M.avium_104 LTQLLDRSTLGPRLSAHA------SESAVVVIDLDN------FKRYNDTH
MAB_1839|M.abscessus_ATCC_1997 LNRRGLQEAYEATVGVPG------MHVTVVVVDLNL------FKQINDTF
MLBr_00397|M.leprae_Br4923 FVTILAGILFQFTMFGRWVKAIGGNERVATLAGVPTRGIKVAIFAICGLT
.: ..
Mb1389c|M.bovis_AF2122/97 TLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARIL
Rv1354c|M.tuberculosis_H37Rv TLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARIL
MSMEG_2196|M.smegmatis_MC2_155 TLKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTL
TH_0811|M.thermoresistible__bu TLKIDKGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTL
Mflv_4251|M.gilvum_PYR-GCK GHTAGDALLQQFAGAAAACLGADDVFARWGGEEFIVALPGADPDRAEPIL
Mvan_2109|M.vanbaalenii_PYR-1 GHTAGDALLQNFAAAAGASIRDGDVFARWGGEEFIVALPDTTPDQAERIL
MAV_4127|M.avium_104 GHSAGDELLVAFADALRWSVGADDAVFRIGGDEFLIMLVDADREQAERVL
MAB_1839|M.abscessus_ATCC_1997 GHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPHIDYQR
MLBr_00397|M.leprae_Br4923 AGLGGIVLASRLGAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLI
. . . .
Mb1389c|M.bovis_AF2122/97 LDQRCYRAQG----FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS--
Rv1354c|M.tuberculosis_H37Rv LDQRCYRAQG----FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS--
MSMEG_2196|M.smegmatis_MC2_155 LRHGCYRAQG----FLLSKPILGSEMQTLLAKGRVPVHFSAAPRM-----
TH_0811|M.thermoresistible__bu LRHGCHRAQG----FLLSRPIPSNEMRELLARGRIPMRFSATP-------
Mflv_4251|M.gilvum_PYR-GCK DRLRGHVPSEQTCSIGYTGHVPPEALTDTVIRADKALYQAKRRGKNRIAR
Mvan_2109|M.vanbaalenii_PYR-1 NRLRNCVPYGQTCSIGYTAHTPADTLTDTVARADKALYEAKSRGRNQLRL
MAV_4127|M.avium_104 DRLRGRWAELG-EPVGFSAGIAAG-AQDLMRLADEHMYANKRSRDLSAD-
MAB_1839|M.abscessus_ATCC_1997 AVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADG
MLBr_00397|M.leprae_Br4923 GAIIISMLSNG--MVFMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK-
.
Mb1389c|M.bovis_AF2122/97 ---------
Rv1354c|M.tuberculosis_H37Rv ---------
MSMEG_2196|M.smegmatis_MC2_155 ---------
TH_0811|M.thermoresistible__bu ---------
Mflv_4251|M.gilvum_PYR-GCK L--------
Mvan_2109|M.vanbaalenii_PYR-1 L--------
MAV_4127|M.avium_104 ---------
MAB_1839|M.abscessus_ATCC_1997 AMYGAKKAG
MLBr_00397|M.leprae_Br4923 ---------