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ADVVVVGAGFAGLSAARELTRLGHEVVVVEGRDRVGGRSYTGTIAGVPVDLGATFVGPTQDAVLKLADEL GCEREPTFGRGKNLIRWRGSVRSYRSTVPRLSIIELLDVSRIQWRFERVCRKVSVDQPWRSPVAAELDAV SLDGWLRSVHAGASTRDLMAIVARVTWGAEPDAVSMLHAVRYVKAAGGLSRMLDVKGGAQQDRFLAGTQQ IALRMAEQLGDRVVLGAPVRRIARHPDHSLTVGTDRAEYTAAAVVVAIPPAHRGAVEFDPPLPADYGELN RHWPQGHLSKAYAAYQTPFWRTNGCSGEALSDEGPVFITFDCSPGDGGPGVLLGFTDARTFDPLPPEQRR EVALAGFTALFGEAASRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRAPVDGIFWAGTETADRW TGFLDGAVRSGLRAATDVHQELTRRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1866 | - | - | 100% (447) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 3e-68 | 34.39% (442) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | 5e-66 | 35.25% (451) | amine oxidase (flavin-containing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 1e-167 | 65.90% (437) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_4501 | - | 0.0 | 79.78% (445) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 1e-167 | 65.90% (437) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_00062 | gltD | 2e-06 | 62.86% (35) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_2659 | - | 1e-116 | 47.39% (441) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1389 | aofH | 1e-167 | 64.46% (439) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. avium 104 | MAV_4062 | - | 1e-173 | 67.20% (439) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 0.0 | 73.98% (442) | amine oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 0.0 | 72.22% (450) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_2487 | aofH | 1e-164 | 63.33% (439) | flavin-containing monoamine oxidase AofH (amine oxidase) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
Rv3170|M.tuberculosis_H37Rv ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
MMAR_1389|M.marinum_M ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MUL_2487|M.ulcerans_Agy99 ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MAV_4062|M.avium_104 ------MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGG
Mvan_1866|M.vanbaalenii_PYR-1 ------------MADVVVVGAGFAGLSAARELTRLGHEVVVVEGRDRVGG
Mflv_4501|M.gilvum_PYR-GCK ------------MAEVVVVGAGFAGLAAARELSRLGRDVVVVEGRDRVGG
MSMEG_2035|M.smegmatis_MC2_155 -------MSIPTSADVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGG
TH_0685|M.thermoresistible__bu ------------VVDVVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGG
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
MLBr_00062|M.leprae_Br4923 --------MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRN
: . :. .. .: :: : .
Mb3195|M.bovis_AF2122/97 RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
Rv3170|M.tuberculosis_H37Rv RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
MMAR_1389|M.marinum_M RSFTGSIAGLPADMGGSFVGPTQDAVLALAAELGVP-TVPTFHDGKNVIR
MUL_2487|M.ulcerans_Agy99 RSFTGSIAGLPADMGGSFVGPSQDAVLALAAELGVP-TVPTFHDGKNVIR
MAV_4062|M.avium_104 RSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP-TTPTHHEGKNLIH
Mvan_1866|M.vanbaalenii_PYR-1 RSYTGTIAGVPVDLGATFVGPTQDAVLKLADELGCE-REPTFGRGKNLIR
Mflv_4501|M.gilvum_PYR-GCK RSYTGSVGGVPVDFGATFVGPTQDAVLALAAELGVE-SVPTYGEGKNLIR
MSMEG_2035|M.smegmatis_MC2_155 RSSTATIAGVPVDLGGTFVGPTQDAVLGLAAELGCA-TVPTYNRGKNLIR
TH_0685|M.thermoresistible__bu RSYTATLAGVPVDLGATFVGPGQTAVTGLAAELGCP-TVGTYHQGNNLIL
MAB_2659|M.abscessus_ATCC_1997 RSFTGEVAGVKVDLGATWVAKRHTAIRDLMDRLGCS-LTPQYDEGVNLLW
MLBr_00062|M.leprae_Br4923 QASRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPD
:: *: .. :. * . *.
Mb3195|M.bovis_AF2122/97 WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
Rv3170|M.tuberculosis_H37Rv WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
MMAR_1389|M.marinum_M WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
MUL_2487|M.ulcerans_Agy99 WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
MAV_4062|M.avium_104 WRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARR-AA
Mvan_1866|M.vanbaalenii_PYR-1 WRGSVRSYRSTVPRLSIIELLDVSRIQWRFERVCRKVSVDQPWRSPV-AA
Mflv_4501|M.gilvum_PYR-GCK WRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASPL-AG
MSMEG_2035|M.smegmatis_MC2_155 WHGRVRSYRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSL-AH
TH_0685|M.thermoresistible__bu WRGRLKSYRSTIPTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPA-AH
MAB_2659|M.abscessus_ATCC_1997 MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPN-AD
MLBr_00062|M.leprae_Br4923 VTGRLCPAPCESACVLGINQDPVTIKQIELEIIDK--AFDEGWVQPLPPQ
* . . : : .: : . . * .
Mb3195|M.bovis_AF2122/97 ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
Rv3170|M.tuberculosis_H37Rv ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
MMAR_1389|M.marinum_M DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVS---MLHAARY
MUL_2487|M.ulcerans_Agy99 DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWECEPDDVS---MLHAARS
MAV_4062|M.avium_104 ELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVS---MLHAARY
Mvan_1866|M.vanbaalenii_PYR-1 ELDAVSLDGWLRSVHAGASTRDLMAIVARVTWGAEPDAVS---MLHAVRY
Mflv_4501|M.gilvum_PYR-GCK QLDDISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVS---MLHAVRY
MSMEG_2035|M.smegmatis_MC2_155 KLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVS---MLHAVRY
TH_0685|M.thermoresistible__bu RLDTMSLDRWLRSVYASASTRDLMAIMARVTWGCEPHQVS---MLHAARY
MAB_2659|M.abscessus_ATCC_1997 QLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVS---LLHVLRY
MLBr_00062|M.leprae_Br4923 QLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTVFERDDRIGGLLRYGIPEF
* :. . :::. * ** :. .
Mb3195|M.bovis_AF2122/97 VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG-----ARVL
Rv3170|M.tuberculosis_H37Rv VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG-----ARVL
MMAR_1389|M.marinum_M VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG-----THVV
MUL_2487|M.ulcerans_Agy99 VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG-----IHVV
MAV_4062|M.avium_104 AHAAGGLDR---LLDVEDGAQQDRFPGGTQQIAAAAAAELG-----ARVV
Mvan_1866|M.vanbaalenii_PYR-1 VKAAGGLSR---MLDVKGGAQQDRFLAGTQQIALRMAEQLG-----DRVV
Mflv_4501|M.gilvum_PYR-GCK VNAAGGLNR---MLDVEGGAQQDRFPAGTQKIADLMAAELG-----DRVV
MSMEG_2035|M.smegmatis_MC2_155 VKAAGGLTR---LLDVEGGAQQDRLVEGTQQIALRMADELG-----QRIA
TH_0685|M.thermoresistible__bu VKAAGGLGR---MLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPGSRVR
MAB_2659|M.abscessus_ATCC_1997 VQAVGGLDH---MLAVEHGQQEYRVTETTQEIAKRLAAQIG-----DQIV
MLBr_00062|M.leprae_Br4923 KMEKRFLERRLDQLRAEGTEFRSGVNVGVDITADQLCADFD------AVV
* : * .: . . .: * . ::. :
Mb3195|M.bovis_AF2122/97 LNAAVRRIDRHGAG-VTVT-SDQGQAEAGFVIVAIPPAHRVAIEFDPPLP
Rv3170|M.tuberculosis_H37Rv LNAAVRRIDRHGAG-VTVT-SDQGQAEAGFVIVAIPPAHRVAIEFDPPLP
MMAR_1389|M.marinum_M LDAPVRRIDRHGAG-VTVT-SDQGQAEAGFVIVAIPPAHRAAIEFNPPLP
MUL_2487|M.ulcerans_Agy99 LDAPVRRIDRHGAG-VTVT-SDQGQAEAGFVIVAIPPAHRAAIEFNPPLP
MAV_4062|M.avium_104 LGAPVRRIERHGAG-VTVR-TDLGDTEAGFVIVAIPPAHRAAIEFAPPLP
Mvan_1866|M.vanbaalenii_PYR-1 LGAPVRRIARHPDHSLTVG-TDRAEYTAAAVVVAIPPAHRGAVEFDPPLP
Mflv_4501|M.gilvum_PYR-GCK VGAPVRRITRNPDRTVTVT-TAGAEYQAGAVIVAVPPEHRSGIEFDPPLP
MSMEG_2035|M.smegmatis_MC2_155 LDAPVQRIERHSGGDIGVTFTTG-HVRARAVVIAIAPQHRGDIEFDPPLP
TH_0685|M.thermoresistible__bu LGAPVRRITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFDPALP
MAB_2659|M.abscessus_ATCC_1997 LNTRVRQISQDDNG-VTVS-TDSGVINAKYAIVTAAPEHRAYIEYQPALP
MLBr_00062|M.leprae_Br4923 LAGGAATWRELPIPGRELDGVHQAMEFLPWVNRVQEGDDVLGDDGQPPIT
: . . : . . . : *.:.
Mb3195|M.bovis_AF2122/97 PEYQQLAHHWPQGRLSKAYAAYSTP-----------FWRASGYSGQALSD
Rv3170|M.tuberculosis_H37Rv PEYQQLAHHWPQGRLSKAYAAYSTP-----------FWRASGYSGQALSD
MMAR_1389|M.marinum_M TGYQELADNWPQGRLSKAYAAYSTP-----------FWRINGFTGQSLSD
MUL_2487|M.ulcerans_Agy99 TGYQELADNWPQGRLSKAYAAYSTP-----------FWRINGFTGQSLSD
MAV_4062|M.avium_104 AEYEQLARHWPQGRLSKAYAAYSTP-----------FWRADGFSGQALSD
Mvan_1866|M.vanbaalenii_PYR-1 ADYGELNRHWPQGHLSKAYAAYQTP-----------FWRTNGCSGEALSD
Mflv_4501|M.gilvum_PYR-GCK AEHRELSRHWPQGRLSKAYAAYETP-----------FWRADGHSGESLSD
MSMEG_2035|M.smegmatis_MC2_155 PEYTELAARWPQGRLSKAYAAYDRP-----------FWRANGCSGEALSD
TH_0685|M.thermoresistible__bu PRHTALPGHWPQGMLSKAYAAYDTP-----------FWRADGRSGEALSD
MAB_2659|M.abscessus_ATCC_1997 AKIEGLTTSFPMGALSKAFVAYDKP-----------FWRAEGLSGEALTD
MLBr_00062|M.leprae_Br4923 AKDKKVVIIGGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWP
. : . :.. * .. :..:
Mb3195|M.bovis_AF2122/97 EAPVFITFDVSPHADGPGILMG----FVD----ARGFDSLPIEERRRDAL
Rv3170|M.tuberculosis_H37Rv EAPVFITFDVSPHADGPGILMG----FVD----ARGFDSLPIEERRRDAL
MMAR_1389|M.marinum_M IGPVFITFDASPHDDGPGILMG----FVD----AREFDSLSADQRRDRTL
MUL_2487|M.ulcerans_Agy99 MGPVFITFDASPHDDAPGILMG----FVD----AREFDSLSADQRRDRTL
MAV_4062|M.avium_104 EGPVFITFDVSPHPDGPGILMG----FVD----ARAFDSLPADQRRRDAL
Mvan_1866|M.vanbaalenii_PYR-1 EGPVFITFDCSPGDGGPGVLLG----FTD----ARTFDPLPPEQRREVAL
Mflv_4501|M.gilvum_PYR-GCK EGPVFITFDCSPGDDGPGVLLG----FTD----PRSFDPLPGEQRREIAL
MSMEG_2035|M.smegmatis_MC2_155 EGPVFITFDVSPGDEGPGILLG----FTD----ARTFDALPPEQRRQRAL
TH_0685|M.thermoresistible__bu DGPVFITFDVSPDENGPGILLG----FTD----ARTFDPLSPDRRRDKAL
MAB_2659|M.abscessus_ATCC_1997 TAPVFITFDVSPSDDGPGILMV----FCT----ARVYDGFGPEVRRKLVL
MLBr_00062|M.leprae_Br4923 TYPLMYRVSPAHEEGGERVFSVNTEEFVGKNGRVHALKAHEVTMQDGRFV
*:: .. : . :: * : . : :
Mb3195|M.bovis_AF2122/97 RCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLRE
Rv3170|M.tuberculosis_H37Rv RCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLRE
MMAR_1389|M.marinum_M RCFASLFGDDALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRK
MUL_2487|M.ulcerans_Agy99 RCFASLFGDDALEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRK
MAV_4062|M.avium_104 RCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLRE
Mvan_1866|M.vanbaalenii_PYR-1 AGFTALFGEAASRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRA
Mflv_4501|M.gilvum_PYR-GCK AGFSALFGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRA
MSMEG_2035|M.smegmatis_MC2_155 GGFATFFGDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRK
TH_0685|M.thermoresistible__bu HGFAKLFGDAALKPIDYLDFCWGCDDFAPGGPTAAVPPGSWTEFGPWLRE
MAB_2659|M.abscessus_ATCC_1997 KQLVDLYGEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALRE
MLBr_00062|M.leprae_Br4923 KVENSVFELEADLVLLAMGFVGPEKPGLLTDLGVKFTDRGNVARGADFDT
.: * : .. . . . . . * :
Mb3195|M.bovis_AF2122/97 PVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL------------
Rv3170|M.tuberculosis_H37Rv PVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVAALL------------
MMAR_1389|M.marinum_M PVGPIHWAGTETADEWTGYFDGAVRSGQRAAAEVAALL------------
MUL_2487|M.ulcerans_Agy99 PVGPIHWAGTETADEWTGYFDGAVRAGQRAAAEVAALL------------
MAV_4062|M.avium_104 PVGPIHWAGTETADEWTGFLDGAIRSGRRAAAEVTALL------------
Mvan_1866|M.vanbaalenii_PYR-1 PVDGIFWAGTETADRWTGFLDGAVRSGLRAATDVHQELTRRS--------
Mflv_4501|M.gilvum_PYR-GCK PVDGIFWAGTETADSWTGFLDGAVRSGLRAADEAHRELARA---------
MSMEG_2035|M.smegmatis_MC2_155 PIDGIHWAGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG-----
TH_0685|M.thermoresistible__bu PVDQIYWAGTETADQWTGFLDGAVRSGQRAAAEVHRRLSSGG--------
MAB_2659|M.abscessus_ATCC_1997 PHGRIHWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK----
MLBr_00062|M.leprae_Br4923 SVPGVFVAG--DMGRGQSLIVWAIAEGRAAAAAVDRFLMGATALPAPVKP
. :. *. . . : *: * :* *
Mb3195|M.bovis_AF2122/97 ------
Rv3170|M.tuberculosis_H37Rv ------
MMAR_1389|M.marinum_M ------
MUL_2487|M.ulcerans_Agy99 ------
MAV_4062|M.avium_104 ------
Mvan_1866|M.vanbaalenii_PYR-1 ------
Mflv_4501|M.gilvum_PYR-GCK ------
MSMEG_2035|M.smegmatis_MC2_155 ------
TH_0685|M.thermoresistible__bu ------
MAB_2659|M.abscessus_ATCC_1997 ------
MLBr_00062|M.leprae_Br4923 SSLPLQ