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TNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGGRSFTGSIAGLPADMGGSFVGPTQDAVL ALAAELGVPTVPTFHDGKNVIRWRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANRA ADLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVENGAQQELI PGGTQQIAELAAAELGTHVVLDAPVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRAAIEFNPPLPTG YQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDIGPVFITFDASPHDDGPGILMGFVDAREFDSLS ADQRRDRTLRCFASLFGDDALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAGTE TADEWTGYFDGAVRSGQRAAAEVAALL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1389 | aofH | - | 100% (448) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. marinum M | MMAR_3362 | aofH_1 | 2e-84 | 39.64% (444) | flavin-containing monoamine oxidase AofH_1 |
| M. marinum M | MMAR_1387 | - | 3e-18 | 25.39% (445) | monoamine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 0.0 | 80.36% (448) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_4501 | - | 1e-172 | 65.53% (438) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 0.0 | 80.36% (448) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_00062 | gltD | 1e-05 | 60.00% (35) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_2659 | - | 1e-116 | 46.26% (441) | putative flavin-containing monoamine oxidase AofH |
| M. avium 104 | MAV_4062 | - | 0.0 | 79.24% (448) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 1e-170 | 65.76% (441) | amine oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 1e-168 | 64.94% (445) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_2487 | aofH | 0.0 | 98.21% (448) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. vanbaalenii PYR-1 | Mvan_1866 | - | 1e-167 | 64.46% (439) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1389|M.marinum_M ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MUL_2487|M.ulcerans_Agy99 ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
Mb3195|M.bovis_AF2122/97 ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
Rv3170|M.tuberculosis_H37Rv ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
MAV_4062|M.avium_104 ------MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGG
MSMEG_2035|M.smegmatis_MC2_155 -------MSIPTSADVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGG
TH_0685|M.thermoresistible__bu ------------VVDVVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGG
Mflv_4501|M.gilvum_PYR-GCK ------------MAEVVVVGAGFAGLAAARELSRLGRDVVVVEGRDRVGG
Mvan_1866|M.vanbaalenii_PYR-1 ------------MADVVVVGAGFAGLSAARELTRLGHEVVVVEGRDRVGG
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
MLBr_00062|M.leprae_Br4923 --------MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRN
: . :. .. .: :: : .
MMAR_1389|M.marinum_M RSFTGSIAGLPADMGGSFVGPTQDAVLALAAELGVP-TVPTFHDGKNVIR
MUL_2487|M.ulcerans_Agy99 RSFTGSIAGLPADMGGSFVGPSQDAVLALAAELGVP-TVPTFHDGKNVIR
Mb3195|M.bovis_AF2122/97 RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
Rv3170|M.tuberculosis_H37Rv RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
MAV_4062|M.avium_104 RSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP-TTPTHHEGKNLIH
MSMEG_2035|M.smegmatis_MC2_155 RSSTATIAGVPVDLGGTFVGPTQDAVLGLAAELGCA-TVPTYNRGKNLIR
TH_0685|M.thermoresistible__bu RSYTATLAGVPVDLGATFVGPGQTAVTGLAAELGCP-TVGTYHQGNNLIL
Mflv_4501|M.gilvum_PYR-GCK RSYTGSVGGVPVDFGATFVGPTQDAVLALAAELGVE-SVPTYGEGKNLIR
Mvan_1866|M.vanbaalenii_PYR-1 RSYTGTIAGVPVDLGATFVGPTQDAVLKLADELGCE-REPTFGRGKNLIR
MAB_2659|M.abscessus_ATCC_1997 RSFTGEVAGVKVDLGATWVAKRHTAIRDLMDRLGCS-LTPQYDEGVNLLW
MLBr_00062|M.leprae_Br4923 QASRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPD
:: *: .. :. * . *.
MMAR_1389|M.marinum_M WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
MUL_2487|M.ulcerans_Agy99 WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
Mb3195|M.bovis_AF2122/97 WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
Rv3170|M.tuberculosis_H37Rv WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
MAV_4062|M.avium_104 WRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARR-AA
MSMEG_2035|M.smegmatis_MC2_155 WHGRVRSYRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSL-AH
TH_0685|M.thermoresistible__bu WRGRLKSYRSTIPTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPA-AH
Mflv_4501|M.gilvum_PYR-GCK WRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASPL-AG
Mvan_1866|M.vanbaalenii_PYR-1 WRGSVRSYRSTVPRLSIIELLDVSRIQWRFERVCRKVSVDQPWRSPV-AA
MAB_2659|M.abscessus_ATCC_1997 MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPN-AD
MLBr_00062|M.leprae_Br4923 VTGRLCPAPCESACVLGINQDPVTIKQIELEIIDK--AFDEGWVQPLPPQ
* . . : : .: : . . * .
MMAR_1389|M.marinum_M DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVS---MLHAARY
MUL_2487|M.ulcerans_Agy99 DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWECEPDDVS---MLHAARS
Mb3195|M.bovis_AF2122/97 ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
Rv3170|M.tuberculosis_H37Rv ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
MAV_4062|M.avium_104 ELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVS---MLHAARY
MSMEG_2035|M.smegmatis_MC2_155 KLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVS---MLHAVRY
TH_0685|M.thermoresistible__bu RLDTMSLDRWLRSVYASASTRDLMAIMARVTWGCEPHQVS---MLHAARY
Mflv_4501|M.gilvum_PYR-GCK QLDDISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVS---MLHAVRY
Mvan_1866|M.vanbaalenii_PYR-1 ELDAVSLDGWLRSVHAGASTRDLMAIVARVTWGAEPDAVS---MLHAVRY
MAB_2659|M.abscessus_ATCC_1997 QLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVS---LLHVLRY
MLBr_00062|M.leprae_Br4923 QLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTVFERDDRIGGLLRYGIPEF
* :. . :::. * ** :. .
MMAR_1389|M.marinum_M VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG---------
MUL_2487|M.ulcerans_Agy99 VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG---------
Mb3195|M.bovis_AF2122/97 VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG---------
Rv3170|M.tuberculosis_H37Rv VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG---------
MAV_4062|M.avium_104 AHAAGGLDR---LLDVEDGAQQDRFPGGTQQIAAAAAAELG---------
MSMEG_2035|M.smegmatis_MC2_155 VKAAGGLTR---LLDVEGGAQQDRLVEGTQQIALRMADELG---------
TH_0685|M.thermoresistible__bu VKAAGGLGR---MLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPG----
Mflv_4501|M.gilvum_PYR-GCK VNAAGGLNR---MLDVEGGAQQDRFPAGTQKIADLMAAELG---------
Mvan_1866|M.vanbaalenii_PYR-1 VKAAGGLSR---MLDVKGGAQQDRFLAGTQQIALRMAEQLG---------
MAB_2659|M.abscessus_ATCC_1997 VQAVGGLDH---MLAVEHGQQEYRVTETTQEIAKRLAAQIG---------
MLBr_00062|M.leprae_Br4923 KMEKRFLERRLDQLRAEGTEFRSGVNVGVDITADQLCADFDAVVLAGGAA
* : * .: . . .: * . ::.
MMAR_1389|M.marinum_M THVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN
MUL_2487|M.ulcerans_Agy99 IHVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN
Mb3195|M.bovis_AF2122/97 ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD
Rv3170|M.tuberculosis_H37Rv ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD
MAV_4062|M.avium_104 ARVVLGAPVRRIERHGAG-VTVRTDLG-DTEAGFVIVAIPPAHRAAIEFA
MSMEG_2035|M.smegmatis_MC2_155 QRIALDAPVQRIERHSGGDIGVTFTTG-HVRARAVVIAIAPQHRGDIEFD
TH_0685|M.thermoresistible__bu SRVRLGAPVRRITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFD
Mflv_4501|M.gilvum_PYR-GCK DRVVVGAPVRRITRNPDRTVTVTTAGA-EYQAGAVIVAVPPEHRSGIEFD
Mvan_1866|M.vanbaalenii_PYR-1 DRVVLGAPVRRIARHPDHSLTVGTDRA-EYTAAAVVVAIPPAHRGAVEFD
MAB_2659|M.abscessus_ATCC_1997 DQIVLNTRVRQISQDDNG-VTVSTDSG-VINAKYAIVTAAPEHRAYIEYQ
MLBr_00062|M.leprae_Br4923 TWRELPIPGRELDGVHQAMEFLPWVNR-VQEGDDVLGDDGQPPITAKDKK
: :.: : . .: :
MMAR_1389|M.marinum_M PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDIGPVFIT
MUL_2487|M.ulcerans_Agy99 PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDMGPVFIT
Mb3195|M.bovis_AF2122/97 PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT
Rv3170|M.tuberculosis_H37Rv PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT
MAV_4062|M.avium_104 PPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEGPVFIT
MSMEG_2035|M.smegmatis_MC2_155 PPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANGCSGEALSDEGPVFIT
TH_0685|M.thermoresistible__bu PALPPRHTALPGHWPQGMLSKAYAAYDTPFWRADGRSGEALSDDGPVFIT
Mflv_4501|M.gilvum_PYR-GCK PPLPAEHRELSRHWPQGRLSKAYAAYETPFWRADGHSGESLSDEGPVFIT
Mvan_1866|M.vanbaalenii_PYR-1 PPLPADYGELNRHWPQGHLSKAYAAYQTPFWRTNGCSGEALSDEGPVFIT
MAB_2659|M.abscessus_ATCC_1997 PALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDTAPVFIT
MLBr_00062|M.leprae_Br4923 VVIIGGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWPTYPLM
: . * .:. : : : : . :
MMAR_1389|M.marinum_M FDASPHDDGPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS
MUL_2487|M.ulcerans_Agy99 FDASPHDDAPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS
Mb3195|M.bovis_AF2122/97 FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS
Rv3170|M.tuberculosis_H37Rv FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS
MAV_4062|M.avium_104 FDVSPHPDGPGILMGFVDARAFDSLPA----------DQRRRDALRCFAT
MSMEG_2035|M.smegmatis_MC2_155 FDVSPGDEGPGILLGFTDARTFDALPP----------EQRRQRALGGFAT
TH_0685|M.thermoresistible__bu FDVSPDENGPGILLGFTDARTFDPLSP----------DRRRDKALHGFAK
Mflv_4501|M.gilvum_PYR-GCK FDCSPGDDGPGVLLGFTDPRSFDPLPG----------EQRREIALAGFSA
Mvan_1866|M.vanbaalenii_PYR-1 FDCSPGDGGPGVLLGFTDARTFDPLPP----------EQRREVALAGFTA
MAB_2659|M.abscessus_ATCC_1997 FDVSPSDDGPGILMVFCTARVYDGFGP----------EVRRKLVLKQLVD
MLBr_00062|M.leprae_Br4923 YRVSPAHEEGGERVFSVNTEEFVGKNGRVHALKAHEVTMQDGRFVKVENS
: ** * : .. : : :
MMAR_1389|M.marinum_M LFGDDALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI
MUL_2487|M.ulcerans_Agy99 LFGDDALEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI
Mb3195|M.bovis_AF2122/97 LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI
Rv3170|M.tuberculosis_H37Rv LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI
MAV_4062|M.avium_104 LFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPI
MSMEG_2035|M.smegmatis_MC2_155 FFGDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGI
TH_0685|M.thermoresistible__bu LFGDAALKPIDYLDFCWGCDDFAPGGPTAAVPPGSWTEFGPWLREPVDQI
Mflv_4501|M.gilvum_PYR-GCK LFGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGI
Mvan_1866|M.vanbaalenii_PYR-1 LFGEAASRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRAPVDGI
MAB_2659|M.abscessus_ATCC_1997 LYGEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRI
MLBr_00062|M.leprae_Br4923 VFELEADLVLLAMGFVGPEKPGLLTDLGVKFTDRGNVARGADFDTSVPGV
.: * : .. . . . . . * : . :
MMAR_1389|M.marinum_M HWAGTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
MUL_2487|M.ulcerans_Agy99 HWAGTETADEWTGYFDGAVRAGQRAAAEVAALL-----------------
Mb3195|M.bovis_AF2122/97 HWASTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
Rv3170|M.tuberculosis_H37Rv HWASTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
MAV_4062|M.avium_104 HWAGTETADEWTGFLDGAIRSGRRAAAEVTALL-----------------
MSMEG_2035|M.smegmatis_MC2_155 HWAGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG----------
TH_0685|M.thermoresistible__bu YWAGTETADQWTGFLDGAVRSGQRAAAEVHRRLSSGG-------------
Mflv_4501|M.gilvum_PYR-GCK FWAGTETADSWTGFLDGAVRSGLRAADEAHRELARA--------------
Mvan_1866|M.vanbaalenii_PYR-1 FWAGTETADRWTGFLDGAVRSGLRAATDVHQELTRRS-------------
MAB_2659|M.abscessus_ATCC_1997 HWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK---------
MLBr_00062|M.leprae_Br4923 FVAG--DMGRGQSLIVWAIAEGRAAAAAVDRFLMGATALPAPVKPSSLPL
. *. . . : *: * :* *
MMAR_1389|M.marinum_M -
MUL_2487|M.ulcerans_Agy99 -
Mb3195|M.bovis_AF2122/97 -
Rv3170|M.tuberculosis_H37Rv -
MAV_4062|M.avium_104 -
MSMEG_2035|M.smegmatis_MC2_155 -
TH_0685|M.thermoresistible__bu -
Mflv_4501|M.gilvum_PYR-GCK -
Mvan_1866|M.vanbaalenii_PYR-1 -
MAB_2659|M.abscessus_ATCC_1997 -
MLBr_00062|M.leprae_Br4923 Q