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MAEVVVVGAGFAGLAAARELSRLGRDVVVVEGRDRVGGRSYTGSVGGVPVDFGATFVGPTQDAVLALAAE LGVESVPTYGEGKNLIRWRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASPLAGQLDD ISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVSMLHAVRYVNAAGGLNRMLDVEGGAQQDRFPAGTQ KIADLMAAELGDRVVVGAPVRRITRNPDRTVTVTTAGAEYQAGAVIVAVPPEHRSGIEFDPPLPAEHREL SRHWPQGRLSKAYAAYETPFWRADGHSGESLSDEGPVFITFDCSPGDDGPGVLLGFTDPRSFDPLPGEQR REIALAGFSALFGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGIFWAGTETADS WTGFLDGAVRSGLRAADEAHRELARA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4501 | - | - | 100% (446) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_1230 | - | 3e-67 | 35.07% (442) | amine oxidase (flavin-containing) |
| M. gilvum PYR-GCK | Mflv_2278 | - | 2e-22 | 29.24% (448) | amine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 1e-169 | 65.14% (436) | flavin-containing monoamine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 1e-169 | 65.14% (436) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 4e-07 | 29.43% (299) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2659 | - | 1e-113 | 47.39% (441) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1389 | aofH | 1e-172 | 65.53% (438) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. avium 104 | MAV_4062 | - | 1e-176 | 68.26% (438) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 0.0 | 70.81% (442) | amine oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 0.0 | 71.78% (450) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_2487 | aofH | 1e-168 | 64.16% (438) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. vanbaalenii PYR-1 | Mvan_1866 | - | 0.0 | 79.78% (445) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 ------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
Rv3170|M.tuberculosis_H37Rv ------MTNPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
MMAR_1389|M.marinum_M ------MTNPSWIVDVVIVGAGFAGLAAARDLARQG---HDVLVLEGRDR
MUL_2487|M.ulcerans_Agy99 ------MTNPSWIVDVVIVGAGFAGLAAARDLARQG---HDVLVLEGRDR
MAV_4062|M.avium_104 ------MSGPPRIVDVVVVGAGFAGLAAARELNRQG---HDVVVFEGRDR
Mflv_4501|M.gilvum_PYR-GCK ------------MAEVVVVGAGFAGLAAARELSRLG---RDVVVVEGRDR
Mvan_1866|M.vanbaalenii_PYR-1 ------------MADVVVVGAGFAGLSAARELTRLG---HEVVVVEGRDR
TH_0685|M.thermoresistible__bu ------------VVDVVVVGAGFAGLTAARELTGLG---YEVVVFEGRDR
MSMEG_2035|M.smegmatis_MC2_155 -------MSIPTSADVVVVGAGFAGLTAARRLVQLG---YDVVVLEGRDR
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMG---VSVLVIDARER
MLBr_01044|M.leprae_Br4923 ----------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDR
. :**.*::**:** * : :.: :*
Mb3195|M.bovis_AF2122/97 VGGRSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRN
Rv3170|M.tuberculosis_H37Rv VGGRSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRN
MMAR_1389|M.marinum_M VGGRSFTGSIAGLPADMGGSFVGPTQDAVLALAAELGVP-TVPTFHDGKN
MUL_2487|M.ulcerans_Agy99 VGGRSFTGSIAGLPADMGGSFVGPSQDAVLALAAELGVP-TVPTFHDGKN
MAV_4062|M.avium_104 VGGRSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP-TTPTHHEGKN
Mflv_4501|M.gilvum_PYR-GCK VGGRSYTGSVGGVPVDFGATFVGPTQDAVLALAAELGVE-SVPTYGEGKN
Mvan_1866|M.vanbaalenii_PYR-1 VGGRSYTGTIAGVPVDLGATFVGPTQDAVLKLADELGCE-REPTFGRGKN
TH_0685|M.thermoresistible__bu VGGRSYTATLAGVPVDLGATFVGPGQTAVTGLAAELGCP-TVGTYHQGNN
MSMEG_2035|M.smegmatis_MC2_155 VGGRSSTATIAGVPVDLGGTFVGPTQDAVLGLAAELGCA-TVPTYNRGKN
MAB_2659|M.abscessus_ATCC_1997 VGGRSFTGEVAGVKVDLGATWVAKRHTAIRDLMDRLGCS-LTPQYDEGVN
MLBr_01044|M.leprae_Br4923 LGGVLRTECVGGQPMDLGAEAFLLRRPEVPALLAELGLSERQRATTDARP
:** * :.* *:*. . : : * .* .
Mb3195|M.bovis_AF2122/97 VIQWRGSARSYRGTIPKLSLTGLIDIGRLR--WQFERIARGVPVAAPWDA
Rv3170|M.tuberculosis_H37Rv VIQWRGSARSYRGTIPKLSLTGLIDIGRLR--WQFERIARGVPVAAPWDA
MMAR_1389|M.marinum_M VIRWRGGVRPYSGTIPRLSLTGLLDIARLR--WQFERLARSIPISAPWAA
MUL_2487|M.ulcerans_Agy99 VIRWRGGVRPYSGTIPRLSLTGLLDIARLR--WQFERLARSIPISAPWAA
MAV_4062|M.avium_104 LIHWRGWTHAYHGTIPKLSLTGLLDIGRLR--WQFDRIARSIPLAAPWEA
Mflv_4501|M.gilvum_PYR-GCK LIRWRGRVRSYRSTIPRLSILELLDVSRIQ--WRFDRISKRVPVDQPWAS
Mvan_1866|M.vanbaalenii_PYR-1 LIRWRGSVRSYRSTVPRLSIIELLDVSRIQ--WRFERVCRKVSVDQPWRS
TH_0685|M.thermoresistible__bu LILWRGRLKSYRSTIPTLSILELLDVSRIQ--WRFERLCRQIPVGEPWRA
MSMEG_2035|M.smegmatis_MC2_155 LIRWHGRVRSYRSTIPRLSIIELLDVSRIQ--WRFERLFRHVDVAEPWNG
MAB_2659|M.abscessus_ATCC_1997 LLWMAGKRKTWTGTLPTVDPVDLEDLGRIT--IEMGKLLETINVDAAWKS
MLBr_01044|M.leprae_Br4923 LIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAVRPLSWEP
:: :. .:. : . :: .*
Mb3195|M.bovis_AF2122/97 RRARELDDVSLGEWLRLVRATSSSRNLMAIMTR-----VTWGCEPDDVSM
Rv3170|M.tuberculosis_H37Rv RRARELDDVSLGEWLRLVRATSSSRNLMAIMTR-----VTWGCEPDDVSM
MMAR_1389|M.marinum_M NRAADLDGVSLRQWLRSVRASASSHDLMAIMTR-----VTWGCEPDDVSM
MUL_2487|M.ulcerans_Agy99 NRAADLDGVSLRQWLRSVRASASSHDLMAIMTR-----VTWECEPDDVSM
MAV_4062|M.avium_104 RRAAELDGLSLGGWLRSVRATASSHALLAMVAR-----VTWGCEPDEVSM
Mflv_4501|M.gilvum_PYR-GCK PLAGQLDDISLDAWLRSVHAGASTRDLMAIMAR-----VTWGAEPGDVSM
Mvan_1866|M.vanbaalenii_PYR-1 PVAAELDAVSLDGWLRSVHAGASTRDLMAIVAR-----VTWGAEPDAVSM
TH_0685|M.thermoresistible__bu PAAHRLDTMSLDRWLRSVYASASTRDLMAIMAR-----VTWGCEPHQVSM
MSMEG_2035|M.smegmatis_MC2_155 SLAHKLDQYSMERWLRYVHANASTRNLMAIMSR-----VTWGAEPDQVSM
MAB_2659|M.abscessus_ATCC_1997 PNADQLDSISFGEWLSQQQAVTSTNALMYIVTR-----VQWGCSPLDVSL
MLBr_01044|M.leprae_Br4923 GSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAGAPSVAAA
: : * * : : * .:
Mb3195|M.bovis_AF2122/97 LHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQIAQAAAAQLG-----A
Rv3170|M.tuberculosis_H37Rv LHAARYVRAAGGLDRLLDVKNGAQQDRVPGGTQQIAQAAAAQLG-----A
MMAR_1389|M.marinum_M LHAARYVRAAGGLDRLLDVENGAQQELIPGGTQQIAELAAAELG-----T
MUL_2487|M.ulcerans_Agy99 LHAARSVRAAGGLDRLLDVENGAQQELIPGGTQQIAELAAAELG-----I
MAV_4062|M.avium_104 LHAARYAHAAGGLDRLLDVEDGAQQDRFPGGTQQIAAAAAAELG-----A
Mflv_4501|M.gilvum_PYR-GCK LHAVRYVNAAGGLNRMLDVEGGAQQDRFPAGTQKIADLMAAELG-----D
Mvan_1866|M.vanbaalenii_PYR-1 LHAVRYVKAAGGLSRMLDVKGGAQQDRFLAGTQQIALRMAEQLG-----D
TH_0685|M.thermoresistible__bu LHAARYVKAAGGLGRMLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPGS
MSMEG_2035|M.smegmatis_MC2_155 LHAVRYVKAAGGLTRLLDVEGGAQQDRLVEGTQQIALRMADELG-----Q
MAB_2659|M.abscessus_ATCC_1997 LHVLRYVQAVGGLDHMLAVEHGQQEYRVTETTQEIAKRLAAQIG-----D
MLBr_01044|M.leprae_Br4923 LDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRSR------
*. . : * * . * : . .
Mb3195|M.bovis_AF2122/97 RVLLNAAVRRIDRHGAG-VTVTS-DQGQAEAGFVIVAIPPAHRVAIEFDP
Rv3170|M.tuberculosis_H37Rv RVLLNAAVRRIDRHGAG-VTVTS-DQGQAEAGFVIVAIPPAHRVAIEFDP
MMAR_1389|M.marinum_M HVVLDAPVRRIDRHGAG-VTVTS-DQGQAEAGFVIVAIPPAHRAAIEFNP
MUL_2487|M.ulcerans_Agy99 HVVLDAPVRRIDRHGAG-VTVTS-DQGQAEAGFVIVAIPPAHRAAIEFNP
MAV_4062|M.avium_104 RVVLGAPVRRIERHGAG-VTVRT-DLGDTEAGFVIVAIPPAHRAAIEFAP
Mflv_4501|M.gilvum_PYR-GCK RVVVGAPVRRITRNPDRTVTVTT-AGAEYQAGAVIVAVPPEHRSGIEFDP
Mvan_1866|M.vanbaalenii_PYR-1 RVVLGAPVRRIARHPDHSLTVGT-DRAEYTAAAVVVAIPPAHRGAVEFDP
TH_0685|M.thermoresistible__bu RVRLGAPVRRITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFDP
MSMEG_2035|M.smegmatis_MC2_155 RIALDAPVQRIERHSGGDIGVTF-TTGHVRARAVVIAIAPQHRGDIEFDP
MAB_2659|M.abscessus_ATCC_1997 QIVLNTRVRQISQDDNG-VTVST-DSGVINAKYAIVTAAPEHRAYIEYQP
MLBr_01044|M.leprae_Br4923 LQWVAATVVGLDRGTCGWTLVDD-TGACWSADGVILAVPAPRLVRLLQQI
: : * : : * * .::: .. : :
Mb3195|M.bovis_AF2122/97 PLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGY---SGQALSDEAPVF
Rv3170|M.tuberculosis_H37Rv PLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGY---SGQALSDEAPVF
MMAR_1389|M.marinum_M PLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGF---TGQSLSDIGPVF
MUL_2487|M.ulcerans_Agy99 PLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGF---TGQSLSDMGPVF
MAV_4062|M.avium_104 PLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGF---SGQALSDEGPVF
Mflv_4501|M.gilvum_PYR-GCK PLPAEHRELSRHWPQGRLSKAYAAYETPFWRADGH---SGESLSDEGPVF
Mvan_1866|M.vanbaalenii_PYR-1 PLPADYGELNRHWPQGHLSKAYAAYQTPFWRTNGC---SGEALSDEGPVF
TH_0685|M.thermoresistible__bu ALPPRHTALPGHWPQGMLSKAYAAYDTPFWRADGR---SGEALSDDGPVF
MSMEG_2035|M.smegmatis_MC2_155 PLPPEYTELAARWPQGRLSKAYAAYDRPFWRANGC---SGEALSDEGPVF
MAB_2659|M.abscessus_ATCC_1997 ALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEGL---SGEALTDTAPVF
MLBr_01044|M.leprae_Br4923 APRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKAVTL
. . . . : .. . .* : .* :*: * . .:
Mb3195|M.bovis_AF2122/97 ITFDVSPHADGPGILMGFVDA--RGFDSLPIEERRRDALRCFASLFGDEA
Rv3170|M.tuberculosis_H37Rv ITFDVSPHADGPGILMGFVDA--RGFDSLPIEERRRDALRCFASLFGDEA
MMAR_1389|M.marinum_M ITFDASPHDDGPGILMGFVDA--REFDSLSADQRRDRTLRCFASLFGDDA
MUL_2487|M.ulcerans_Agy99 ITFDASPHDDAPGILMGFVDA--REFDSLSADQRRDRTLRCFASLFGDDA
MAV_4062|M.avium_104 ITFDVSPHPDGPGILMGFVDA--RAFDSLPADQRRRDALRCFATLFGDDA
Mflv_4501|M.gilvum_PYR-GCK ITFDCSPGDDGPGVLLGFTDP--RSFDPLPGEQRREIALAGFSALFGAAA
Mvan_1866|M.vanbaalenii_PYR-1 ITFDCSPGDGGPGVLLGFTDA--RTFDPLPPEQRREVALAGFTALFGEAA
TH_0685|M.thermoresistible__bu ITFDVSPDENGPGILLGFTDA--RTFDPLSPDRRRDKALHGFAKLFGDAA
MSMEG_2035|M.smegmatis_MC2_155 ITFDVSPGDEGPGILLGFTDA--RTFDALPPEQRRQRALGGFATFFGDAA
MAB_2659|M.abscessus_ATCC_1997 ITFDVSPSDDGPGILMVFCTA--RVYDGFGPEVRRKLVLKQLVDLYGEQA
MLBr_01044|M.leprae_Br4923 SSRKWGLQGDTQLVRLSFGKFGDQVASTASDDELLAWAVSDLAAVF-DVT
: . . : : * : . : .: : .: :
Mb3195|M.bovis_AF2122/97 LDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTE
Rv3170|M.tuberculosis_H37Rv LDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWASTE
MMAR_1389|M.marinum_M LEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAGTE
MUL_2487|M.ulcerans_Agy99 LEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAGTE
MAV_4062|M.avium_104 LKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAGTE
Mflv_4501|M.gilvum_PYR-GCK AHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGIFWAGTE
Mvan_1866|M.vanbaalenii_PYR-1 SRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRAPVDGIFWAGTE
TH_0685|M.thermoresistible__bu LKPIDYLDFCWGCDDFAPGGPTAAVPPGSWTEFGPWLREPVDQIYWAGTE
MSMEG_2035|M.smegmatis_MC2_155 RDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGIHWAGTE
MAB_2659|M.abscessus_ATCC_1997 NTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRIHWAGTE
MLBr_01044|M.leprae_Br4923 VDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIG--
*:* * * . . . * . . : .
Mb3195|M.bovis_AF2122/97 TADEWTGYFDGAVRSGQRAAAEVAALL--------
Rv3170|M.tuberculosis_H37Rv TADEWTGYFDGAVRSGQRAAAEVAALL--------
MMAR_1389|M.marinum_M TADEWTGYFDGAVRSGQRAAAEVAALL--------
MUL_2487|M.ulcerans_Agy99 TADEWTGYFDGAVRAGQRAAAEVAALL--------
MAV_4062|M.avium_104 TADEWTGFLDGAIRSGRRAAAEVTALL--------
Mflv_4501|M.gilvum_PYR-GCK TADSWTGFLDGAVRSGLRAADEAHRELARA-----
Mvan_1866|M.vanbaalenii_PYR-1 TADRWTGFLDGAVRSGLRAATDVHQELTRRS----
TH_0685|M.thermoresistible__bu TADQWTGFLDGAVRSGQRAAAEVHRRLSSGG----
MSMEG_2035|M.smegmatis_MC2_155 TADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 TAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK
MLBr_01044|M.leprae_Br4923 --------VPACISAAGRAIEALQAEVAR------
. ..: . :: :