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M. thermoresistible (build 8) TH_3500 (-)

annotation: cytochrome P450
coordinates: 4416538 - 4417740
length: 401

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3500--100% (401)cytochrome P450
M. thermoresistible (build 8)TH_2649-7e-7440.62% (384) PUTATIVE cytochrome P450 superfamily protein
M. thermoresistible (build 8)TH_4556-7e-6336.95% (406) PUTATIVE putative cytochrome P450

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3547ccyp142b5e-8274.48% (192) cytochrome P450 monooxygenase
M. gilvum PYR-GCKMflv_1541-0.077.31% (401) cytochrome P450
M. tuberculosis H37RvRv3518ccyp1421e-17173.42% (395) cytochrome P450 monooxygenase 142
M. leprae Br4923MLBr_02088-4e-4835.96% (317) putative cytochrome p450
M. abscessus ATCC 19977MAB_3825-2e-6235.54% (408) cytochrome P450
M. marinum MMMAR_5003cyp142A31e-16972.66% (395) cytochrome P450 142A3 Cyp142A3
M. avium 104MAV_0641-0.078.22% (404) P450 heme-thiolate protein
M. smegmatis MC2 155MSMEG_5918-0.078.59% (397) P450 heme-thiolate protein
M. ulcerans Agy99MUL_4077cyp142A31e-16872.59% (394) cytochrome P450 142A3 Cyp142A3
M. vanbaalenii PYR-1Mvan_5217-0.078.11% (402) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1541|M.gilvum_PYR-GCK          ------------------------MTSTVET-GLDVDLADGNFYADGTAA
Mvan_5217|M.vanbaalenii_PYR-1       ------------------------MTSTLP--ALDVDLADGNFYADGRAA
MSMEG_5918|M.smegmatis_MC2_155      ------------------------MTQMLT--RPDVDLVNGMFYADG-GA
MAV_0641|M.avium_104                ------------------------MTSTIPEAIANIDLADGNFYADRRAS
Mb3547c|M.bovis_AF2122/97           --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv        --------------------------MTE---APDVDLADGNFYASR-EA
MMAR_5003|M.marinum_M               --------------------------MTKPLIKPDVDLTDGNFYASR-QA
MUL_4077|M.ulcerans_Agy99           ------------------------MAMTKPLIKPDVDLTDGNFYASR-QA
TH_3500|M.thermoresistible__bu      ------------------------MTSTAP----DIDLTDGRFYADSASA
MAB_3825|M.abscessus_ATCC_1997      -----------------------MATALSEIEEAGRVLADPAAYADELRL
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                                                                      

Mflv_1541|M.gilvum_PYR-GCK          RAAYAWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
Mvan_5217|M.vanbaalenii_PYR-1       REAYKWMRANQPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MSMEG_5918|M.smegmatis_MC2_155      REAYRWMRANEPVFR----DRNGLAAATTYQAVLDAERNPELFSSTGG--
MAV_0641|M.avium_104                REAYRWMRANQPVFR----DRNGLAGATTYQAIQDAERNPELFSSTGG--
Mb3547c|M.bovis_AF2122/97           --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv        RAAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MMAR_5003|M.marinum_M               REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
MUL_4077|M.ulcerans_Agy99           REAYRWMRANQPVFR----DRNGLAAASTYQAVIDAERQPELFSNAGG--
TH_3500|M.thermoresistible__bu      RAAYRWMRQNQPVFR----DRNGLAAAATYQAIIESERNPELFSNTGG--
MAB_3825|M.abscessus_ATCC_1997      HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLP----GMPLTVFSSFSDCDEALRHPLSASDRLKAT
                                                                                      

Mflv_1541|M.gilvum_PYR-GCK          ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
Mvan_5217|M.vanbaalenii_PYR-1       ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDK
MSMEG_5918|M.smegmatis_MC2_155      ------------IRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDK
MAV_0641|M.avium_104                ------------IRPDQPGMPYMIDMDDPAHLLRRKLVNAGFTRKRVKEK
Mb3547c|M.bovis_AF2122/97           --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv        ------------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MMAR_5003|M.marinum_M               ------------IRPDQDALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
MUL_4077|M.ulcerans_Agy99           ------------IRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDK
TH_3500|M.thermoresistible__bu      ------------IRPEHPGMPYMIDMDDPEHLVRRKLVNHGFTRKRVRDR
MAB_3825|M.abscessus_ATCC_1997      LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MLBr_02088|M.leprae_Br4923          LAQQAIAAG---AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
                                                                                      

Mflv_1541|M.gilvum_PYR-GCK          VPSIEKLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPEERDM
Mvan_5217|M.vanbaalenii_PYR-1       VPSIENLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPDERDM
MSMEG_5918|M.smegmatis_MC2_155      VDSIGRLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERDM
MAV_0641|M.avium_104                EPSIGTLCDTLIDAVCERG-ECDFVRDIAAPLPMAVIGDMLGVLPTERGM
Mb3547c|M.bovis_AF2122/97           --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv        EASIAALCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVRPEQRDM
MMAR_5003|M.marinum_M               ERSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
MUL_4077|M.ulcerans_Agy99           EHSIAQLCDTLIDAVCERG-ECDFVRDLAAPLPMAVIGDMLGVLPEQREM
TH_3500|M.thermoresistible__bu      EDSIARLCDTLIDNVCERG-ECDFVRDIAAPLPMAVIGDMLGVAPEDRGQ
MAB_3825|M.abscessus_ATCC_1997      KLRTDELANRYVNKLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDR
MLBr_02088|M.leprae_Br4923          EGDIAALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPE
                                                                                      

Mflv_1541|M.gilvum_PYR-GCK          LLTWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTMEVIADRRAN
Mvan_5217|M.vanbaalenii_PYR-1       LLKWSDDLVCGLSSTVD-----EQTIQKLMDTFAAYTAFTTEVIADRRAN
MSMEG_5918|M.smegmatis_MC2_155      LLKWSDDLVCGLSSHVD-----EAAIQKLMDTFAAYTEFTKDVITKRRAE
MAV_0641|M.avium_104                LLKWSDDLVCGLSSHIDPT---SAEFQTVMDAFAAYTAFTMDIIAKRRAE
Mb3547c|M.bovis_AF2122/97           --------------------------------------------------
Rv3518c|M.tuberculosis_H37Rv        FLRWSDDLVTFLSSHVS-----QEDFQITMDAFAAYNDFTRATIAARRAD
MMAR_5003|M.marinum_M               FLRWSDDLVTFLSSHVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
MUL_4077|M.ulcerans_Agy99           FLRWSDDLVTFLSSQVS-----QEDFQVTIDAFAAYNDFTRATIAARRAE
TH_3500|M.thermoresistible__bu      LLKWSDDLVTGLSTTAD-----EATVQAVMDAFAGYTAYTMEIIGKRRAE
MAB_3825|M.abscessus_ATCC_1997      MLKLTQELFGGDDSEFQR----GTTPEEQLMALLDFFGYFSGLTASRRQH
MLBr_02088|M.leprae_Br4923          FGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGT
                                                                                      

Mflv_1541|M.gilvum_PYR-GCK          PRDDLFSILVNAEVEGSRMSDDEIVFETLLILIGGDETTRHTLSGGTEQI
Mvan_5217|M.vanbaalenii_PYR-1       PRDDLFSVLVNAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MSMEG_5918|M.smegmatis_MC2_155      PTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQL
MAV_0641|M.avium_104                PTDDLFSILVNAEVEGQRMSDDEIVMETLLILIGGDETTRHTLSGGTEQL
Mb3547c|M.bovis_AF2122/97           ---------MSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
Rv3518c|M.tuberculosis_H37Rv        PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQL
MMAR_5003|M.marinum_M               PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
MUL_4077|M.ulcerans_Agy99           PTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGSEQL
TH_3500|M.thermoresistible__bu      PTDDLFSILINAEVEGQRMSDEEIVFETLLILIGGDETTRHTLSGGVEQL
MAB_3825|M.abscessus_ATCC_1997      PTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEAL
MLBr_02088|M.leprae_Br4923          PGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
                                              .   .*. ::: :      ::  .*.:**   ::..   :

Mflv_1541|M.gilvum_PYR-GCK          LRHQDQWRQVVAQPDLLPSAIEEMLRWTSPVKNMCRTLTADTEFHGTALK
Mvan_5217|M.vanbaalenii_PYR-1       LRHQDQWRQAVADPELLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTSLK
MSMEG_5918|M.smegmatis_MC2_155      LRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELR
MAV_0641|M.avium_104                LRHRDQWDALVRDPSLLPGAIEEMLRWTSPVKNMCRTLTADTEFHGTELR
Mb3547c|M.bovis_AF2122/97           LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
Rv3518c|M.tuberculosis_H37Rv        LRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALC
MMAR_5003|M.marinum_M               LRNRDQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
MUL_4077|M.ulcerans_Agy99           LRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTALS
TH_3500|M.thermoresistible__bu      LRHPDQWQRLRNDPDLVPGAIEEMLRWTSPVKNMCRTLTADTEFHGTQLR
MAB_3825|M.abscessus_ATCC_1997      LEHPDQLARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPIT
MLBr_02088|M.leprae_Br4923          LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
                                    *.:  *      :    * .::* :*: ..:: : *  : *  :  . : 

Mflv_1541|M.gilvum_PYR-GCK          SGEKIMLMFESANFDESVFENPESFDIHRDPNSHVAFGFGTHFCLGNQLA
Mvan_5217|M.vanbaalenii_PYR-1       AGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA
MSMEG_5918|M.smegmatis_MC2_155      AGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLA
MAV_0641|M.avium_104                AGEKIMLLFESGNFDESVFDDPDSFDIRRNPNSHMAFGFGTHFCLGNQLA
Mb3547c|M.bovis_AF2122/97           AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
Rv3518c|M.tuberculosis_H37Rv        AGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLA
MMAR_5003|M.marinum_M               EGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
MUL_4077|M.ulcerans_Agy99           KGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLA
TH_3500|M.thermoresistible__bu      KGEKMLLLFESANFDETVFENPDDFRIDRDPNPHIAFGFGTHFCLGNQLA
MAB_3825|M.abscessus_ATCC_1997      EGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFGVHFCLGAALA
MLBr_02088|M.leprae_Br4923          EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVGSHFCLGAALA
                                     *:.::*   :.* *  ::  *  *   * .. *:**..* ***:*  **

Mflv_1541|M.gilvum_PYR-GCK          RLELKLMLGKILQRLPDMRLAD-ENMLPLRPANFVSGLESMPVVFTPTAK
Mvan_5217|M.vanbaalenii_PYR-1       RLELRLMLTKILQRLPDLRLAD-ESMLPLRPANFVSGLESMPVVFTPTAP
MSMEG_5918|M.smegmatis_MC2_155      RLELRLMTERVLRRLPDLRLAD-DAPVPLRPANFVSGPESMPVVFTPSAP
MAV_0641|M.avium_104                RLELSMMTERVLKRLPDLRLAD-DGDLPLRPANFVSGLEAMPVVFTPSAP
Mb3547c|M.bovis_AF2122/97           RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
Rv3518c|M.tuberculosis_H37Rv        RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPP
MMAR_5003|M.marinum_M               RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
MUL_4077|M.ulcerans_Agy99           RLELSLMTARVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRP
TH_3500|M.thermoresistible__bu      RLELTLMLRRLLQRLPDLRLAS-DDPLPLRPANFVSGPEAMPVVFTPTEP
MAB_3825|M.abscessus_ATCC_1997      RMEVNSFFSALLPRLESIEVDG---NIERTSTIFVGGIKHLPIRYTLR--
MLBr_02088|M.leprae_Br4923          RLEATVTLSAISARFPQVQLAG---ELVYKPNVAMRGMSALPVQV-----
                                    *:*       :  *: .:.:      :   .   : * . :*:       

Mflv_1541|M.gilvum_PYR-GCK          VLS
Mvan_5217|M.vanbaalenii_PYR-1       VGA
MSMEG_5918|M.smegmatis_MC2_155      VLA
MAV_0641|M.avium_104                LLR
Mb3547c|M.bovis_AF2122/97           LG-
Rv3518c|M.tuberculosis_H37Rv        LG-
MMAR_5003|M.marinum_M               LS-
MUL_4077|M.ulcerans_Agy99           LR-
TH_3500|M.thermoresistible__bu      VSA
MAB_3825|M.abscessus_ATCC_1997      ---
MLBr_02088|M.leprae_Br4923          ---