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MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAGGMLACAAILGDGIASADTAL IVPGTAPSPYGPLRSLYHFNPAMQPQIGANYYNPTATRHVVSYPGSFWPVTGLNSPTVGSSVSAGTNNLD AAIRSTDGPIFVAGLSQGTLVLDREQARLANDPTAPPPGQLTFIKAGDPNNLLWRAFRPGTHVPIIDYTV PAPAESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATAFSDPARVAPRDITTTTNSLGA TTTTYFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNPRDLVQGIRGIPAIAPA IAIPIGSTTGASAATSTAAATAAATNALRGANVGPGANKALSMVRGLLPKGKKH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3822 | - | - | 100% (404) | hypothetical protein Rv3822 |
| M. tuberculosis H37Rv | Rv1184c | - | 1e-51 | 38.64% (352) | hypothetical protein Rv1184c |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 6e-41 | 38.08% (281) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3852 | - | 0.0 | 99.26% (404) | hypothetical protein Mb3852 |
| M. gilvum PYR-GCK | Mflv_0401 | - | 5e-46 | 36.43% (398) | hypothetical protein Mflv_0401 |
| M. leprae Br4923 | MLBr_01232 | - | 3e-47 | 36.69% (338) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 4e-44 | 42.91% (275) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 1e-33 | 32.70% (315) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 9e-47 | 38.04% (347) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 8e-43 | 36.36% (363) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3724 | - | 8e-30 | 34.04% (332) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 3e-21 | 30.25% (314) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0276 | - | 4e-47 | 36.94% (360) | hypothetical protein Mvan_0276 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3822|M.tuberculosis_H37Rv ------------------------------------MKCPGVSDCVATVR
Mb3852|M.bovis_AF2122/97 ------------------------------------MKCPGVSDCVATVR
MAB_0936c|M.abscessus_ATCC_199 -----------------------------------MRNLLAGTAVLVVAC
MAV_1760|M.avium_104 -----------------------------------MKQLLAGVTALLSVS
Mflv_0401|M.gilvum_PYR-GCK -----------------------------------MRRHLAFATAITTLG
MSMEG_0412|M.smegmatis_MC2_155 ----------------------------------MRRRLLAFGTAFTTIG
Mvan_0276|M.vanbaalenii_PYR-1 -----------------------MQPSRSGWCVKAMKRLLAFGTALTTIG
MLBr_01232|M.leprae_Br4923 -----------------------------------MKRLLATTLAALTVG
MMAR_4939|M.marinum_M MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVSTH
TH_3724|M.thermoresistible__bu ---------------------------------------------VVAVG
MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA
Rv3822|M.tuberculosis_H37Rv HDNVFAIA-------------------AGLRWSAAVPPLHKGDAVTKLLV
Mb3852|M.bovis_AF2122/97 HDNVFAIA-------------------AGLRWSAAVPPLHKGDAVTKLLV
MAB_0936c|M.abscessus_ATCC_199 VTGCFGIP-------------------SAVADDPQ-VPGPPIPGIAPDGT
MAV_1760|M.avium_104 TAGYFGIG-------------------TAAADGGP-IGGPPTPG-APG--
Mflv_0401|M.gilvum_PYR-GCK ATGILGLG-------------------IAAAQPAPAPPPPPAPGAAAGAP
MSMEG_0412|M.smegmatis_MC2_155 TAGFLGFG-------------------VAAADDT--KPVDPAPGGAHAEA
Mvan_0276|M.vanbaalenii_PYR-1 AAGCLGFG-------------------IAAADEAPAVPPSPTP---ADAP
MLBr_01232|M.leprae_Br4923 TVSGFGST-------------------VASSEPGE-PWLPPSPVPVRENS
MMAR_4939|M.marinum_M IAALFSTHGLQYQLASAQAAEFHERFVLTLAADANTYLTTEIANAQRCLA
TH_3724|M.thermoresistible__bu ALTWGGXG-------------------VASPAGQP---------------
MUL_1034|M.ulcerans_Agy99 IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANASLITA
.
Rv3822|M.tuberculosis_H37Rv G--AIAGGMLACAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAM
Mb3852|M.bovis_AF2122/97 G--AIAGGMLAYAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAM
MAB_0936c|M.abscessus_ATCC_199 VKAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAG
MAV_1760|M.avium_104 --------DQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAG
Mflv_0401|M.gilvum_PYR-GCK T---PLGTPGRGYALGGAHVLGIPYDEYIMRTGADWFPGLDREIVDYPAG
MSMEG_0412|M.smegmatis_MC2_155 P---SMGTPGRGYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG
Mvan_0276|M.vanbaalenii_PYR-1 P---PLGTPGRAYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG
MLBr_01232|M.leprae_Br4923 P-------AKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPAR
MMAR_4939|M.marinum_M GAINAPATALLGHPLLGADPTASASTAATPAGGASMAPAAAGTRITVPGA
TH_3724|M.thermoresistible__bu ------ERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGATAG
MUL_1034|M.ulcerans_Agy99 G----VSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVV
. .
Rv3822|M.tuberculosis_H37Rv QPQIG-------------------ANYYNPTATRHVVSYPGSFWPVTG--
Mb3852|M.bovis_AF2122/97 QPQIG-------------------ANYYTPTATRHVVSYPGSFWPVTG--
MAB_0936c|M.abscessus_ATCC_199 QVQG----------------------HTLERFFPGIGPIGEKILPGLG--
MAV_1760|M.avium_104 QVQG----------------------HVLERLFPGIGKLDES-FPGLG--
Mflv_0401|M.gilvum_PYR-GCK QVQG----------------------HTLERLFPGIGAFGDRIAPGLG--
MSMEG_0412|M.smegmatis_MC2_155 QVQG----------------------HTLERLFPGIGALGERFMPGLG--
Mvan_0276|M.vanbaalenii_PYR-1 QVQG----------------------HTLERLFPGIGRLDDSF-PGIG--
MLBr_01232|M.leprae_Br4923 APFR----------------------YVPTFLVPGP--------------
MMAR_4939|M.marinum_M GPLYY-------------------PRFLTELPYLGQALLLGIPGPSSASI
TH_3724|M.thermoresistible__bu APGA-----------------------------VDYLGVPGEFWPATG--
MUL_1034|M.ulcerans_Agy99 ALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVTPG-
Rv3822|M.tuberculosis_H37Rv ------------------------------------LNSPTVGSSVSAGT
Mb3852|M.bovis_AF2122/97 ------------------------------------LNSPTVGSSVSAGT
MAB_0936c|M.abscessus_ATCC_199 ------------------------------------LDGPSIGESIDIGE
MAV_1760|M.avium_104 ------------------------------------MDGPSVGESVAEGI
Mflv_0401|M.gilvum_PYR-GCK ------------------------------------LDGPSYGESIDVGA
MSMEG_0412|M.smegmatis_MC2_155 ------------------------------------LDGPSYGESIDVGA
Mvan_0276|M.vanbaalenii_PYR-1 ------------------------------------IDGPSVGESVDVGT
MLBr_01232|M.leprae_Br4923 ------------------------------------RDEVTIGEAIAVAT
MMAR_4939|M.marinum_M LQGYDLINHAIGENWFPDTIASVINYPASIGILSGSLAAPDTNTAVAIGA
TH_3724|M.thermoresistible__bu ------------------------------------LDSLTFDASVAXGQ
MUL_1034|M.ulcerans_Agy99 ------------------------------------LGNLTFNQSVAQGV
. :: .
Rv3822|M.tuberculosis_H37Rv NNLDAAIR-----STDGPIFVAGLSQGTLVLDREQARLANDPTAP-PPGQ
Mb3852|M.bovis_AF2122/97 NNLDAAIR-----STDGPIFVAGLSQGTLVLDREQARLANDPTAP-PPGQ
MAB_0936c|M.abscessus_ATCC_199 PNLENAIR-----SGG-PGTAMGLSEGALVLNAVKNALATDPTAP-EPES
MAV_1760|M.avium_104 DNLDAAIR-----TTGRPGTAIGLSEGAFVVDGEQARLANDPTAP-PPNT
Mflv_0401|M.gilvum_PYR-GCK PNLIGAIR-----RGG-PGTAIGLSEGASVLDEVQARLAYDPAAP-PPDQ
MSMEG_0412|M.smegmatis_MC2_155 PNLINAIR-----QGG-PGTVIGLSEGASVLDEVQARLAYDPAAP-PPDS
Mvan_0276|M.vanbaalenii_PYR-1 PNVITAIR-----EGG-RGTAIGLSEGAMVLNDVQAKLAYDPAAP-PPDQ
MLBr_01232|M.leprae_Br4923 KNLNQAIH-----RGTEPAAVVGLSQGSLALDTEQEQLATDPTAP-PPDQ
MMAR_4939|M.marinum_M RMLHEQIMSAVTNGSGLPVHVATLSQGTIVANRELAYLATDPNAP-PAHA
TH_3724|M.thermoresistible__bu AMLTPMVDG--AIESDTPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAPD
MUL_1034|M.ulcerans_Agy99 TLLNDAIN--TQLALGNKVVAFGYSQSATIVNNEILALMAMGTGAPDPGD
: : . *:.: * . .
Rv3822|M.tuberculosis_H37Rv LTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP----APAESQYD
Mb3852|M.bovis_AF2122/97 LTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP----APVESQYD
MAB_0936c|M.abscessus_ATCC_199 LTFATFGDPIAKSPFSESFLTQNFAPGSVVPFMDYPVP----ARVDSQYH
MAV_1760|M.avium_104 LNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMP----PPYESQYD
Mflv_0401|M.gilvum_PYR-GCK LSFATYGNPVGKHAFGESFLTQNFPVGSVVPSLDYRIP----APVESQYD
MSMEG_0412|M.smegmatis_MC2_155 LSFATYGNPVGKHAFGESFLTQMFPVGSVVPSLDYRIP----APVESQYD
Mvan_0276|M.vanbaalenii_PYR-1 LSFAMYGDPVARHAFGESFLTQNFPVGSVVPSLDYRIP----PPVESQYD
MLBr_01232|M.leprae_Br4923 LTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMP----QRMDSQYD
MMAR_4939|M.marinum_M LEFALFGSP------ELGLAHIYLPDGLTVPLINYTVH----GLSNTQYD
TH_3724|M.thermoresistible__bu VTFVMVANPNR----PNGGLLARFP-GLYIPILGVTFNGATPAPADGPFD
MUL_1034|M.ulcerans_Agy99 LSFIMVGAPNN----PDGGLLARFP-GFYIPFLDVSFNG--ATPAANPYP
: * . * . : * :* :. . :
Rv3822|M.tuberculosis_H37Rv TINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATAFSDPARVAPR
Mb3852|M.bovis_AF2122/97 TINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATAFSDPARVAPR
MAB_0936c|M.abscessus_ATCC_199 TDQFISAYDSIADWPDRPDNLFALANAIAG-LATGHTAVAFTNPKMVPAR
MAV_1760|M.avium_104 TNRFVAAYDSIADFPDRPDNMFALANTLMG-LATGHTAVAFTNPSMVPPQ
Mflv_0401|M.gilvum_PYR-GCK TYKFVSAYDSIADWPDRPDNWLSVANAIVG-LATGHTAVAFTDPSMVPER
MSMEG_0412|M.smegmatis_MC2_155 TYQFVSAYDSIADWPDRPDNWISVANAIVG-LATGHTAVAFTNPSMVPPQ
Mvan_0276|M.vanbaalenii_PYR-1 TYQFVSAYDSIADWPDRPDNWISVANAIVG-LATGHTAVAFTEPSMVPPQ
MLBr_01232|M.leprae_Br4923 SNRVVAAYDGLSEFPDRADNLLAQLNCFAG-GAISHTPSGFFNPEDVPPQ
MMAR_4939|M.marinum_M VSVVNGQYDFWGNPPDRPWNLPAWVNSLFG-AAYYHNTSSFASLS--DAV
TH_3724|M.thermoresistible__bu SYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYELLTENPDILD
MUL_1034|M.ulcerans_Agy99 TSIFTAQYDGIAHAPQYRLNILSDINAIMGYFYVHGNYPDLMSGQAIQLP
. :* .. * * : * : . :
Rv3822|M.tuberculosis_H37Rv DITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPI
Mb3852|M.bovis_AF2122/97 DITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPI
MAB_0936c|M.abscessus_ATCC_199 NIVTETNSRGGTTTTYFIPEQHLPLVMGFKYLG-VPEETLNRLDAILQPR
MAV_1760|M.avium_104 NIRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG-IDENTLNKLDAILTPR
Mflv_0401|M.gilvum_PYR-GCK NIRTTVNSRGATTTTYMIPEEHLPLVLPFKYLG-VPKDTLMELDKVLLPY
MSMEG_0412|M.smegmatis_MC2_155 NIRTTVNSRGAKDTTIMIPEEHLPLVLPFKYLG-VDKDTLNKLDGVLKPY
Mvan_0276|M.vanbaalenii_PYR-1 NIRTTVNSRGAKTTTYMIPEEHLPLVLPFKYLG-VPTETLIELDAVLKPF
MLBr_01232|M.leprae_Br4923 NIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG-WSDALVDQIDAVLQPK
MMAR_4939|M.marinum_M EVSSVTTSLGGTITTYLIPSPTLPMLLPLEQIG-VPAPIVAGLNSVLAPI
TH_3724|M.thermoresistible__bu DPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG-VPEEFVDALEPYVRRI
MUL_1034|M.ulcerans_Agy99 TSP----GYTGNTDYYMYLTQDLPLVQPIRDIPYAGPPLADLIQPQLRVL
. : **: : : :: :
Rv3822|M.tuberculosis_H37Rv IDRAYQPGPAPAVNPRDLVQGIRGIPAIAPAIAIPIGSTTGASAATSTAA
Mb3852|M.bovis_AF2122/97 IDRAYQPGPAPAVNPRDLVQGIRGIPAIAPAIAIPIGSTTGASAATSTAA
MAB_0936c|M.abscessus_ATCC_199 VDAGYSRNDDPATAP------------------IAVDPRRGFDPAEVTAP
MAV_1760|M.avium_104 VNAGYSRNDDPATAP------------------VQVDPVHGFDPAEVTAP
Mflv_0401|M.gilvum_PYR-GCK VDAGYSRNDDPATAP------------------ITVDPVNGYDPAEVTAP
MSMEG_0412|M.smegmatis_MC2_155 VDAGYSRNDDPLTAP------------------ITVDPVNGYDPAAVTAP
Mvan_0276|M.vanbaalenii_PYR-1 VDAGYSRNDDPLTAP------------------ITVDPVNGYDPAEVTAP
MLBr_01232|M.leprae_Br4923 IDAAYAYNDNPLNKP------------------ISVDPVNGMDPIAGIDA
MMAR_4939|M.marinum_M VNDGYS-SLTPNAGP------------------------YFSQGALVGLP
TH_3724|M.thermoresistible__bu VDLGYDRNTPYGEPAPVR---------VLPPLTPAPGPATQHNAGQGITV
MUL_1034|M.ulcerans_Agy99 VDLGYSDYGPGLSYADVP---------------TPAGLLSVPNPFAVSYY
:: .* . .
Rv3822|M.tuberculosis_H37Rv ATAAATNALRGANVGPGANKALSMVRGLLPKGKKH---------------
Mb3852|M.bovis_AF2122/97 ATAAATNALRGANVGPGANKALSMVRGLLPKGKKH---------------
MAB_0936c|M.abscessus_ATCC_199 ASQATFGGGSDPISQITSGALAVLGNGTRPTPPN----------------
MAV_1760|M.avium_104 ANQATFGGGADPLSQIMAGAMSVLSHGAGEADH-----------------
Mflv_0401|M.gilvum_PYR-GCK ATQAAFGGGADPVSQLLSGLQYILNNPP----------------------
MSMEG_0412|M.smegmatis_MC2_155 ATQAAFGGGTDPVSQLLAGLQYVVNNQPAPKP------------------
Mvan_0276|M.vanbaalenii_PYR-1 ATQAAFGGAADPVSQLLSGLQYVLNNPP----------------------
MLBr_01232|M.leprae_Br4923 ELR-------DSILNVFAQLRSILPPPPG---------------------
MMAR_4939|M.marinum_M SAADVLGSWPWPALGSVTAHIC----------------------------
TH_3724|M.thermoresistible__bu ASATSTPDKRTPVVEAPVEEPPVQTGRSTLKREKPVSARHLVRNSLRAVP
MUL_1034|M.ulcerans_Agy99 LLKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVPSLNPGLNFYLGQPS
.
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
Mb3852|M.bovis_AF2122/97 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
TH_3724|M.thermoresistible__bu GLRRGEPAATPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE
MUL_1034|M.ulcerans_Agy99 VTLLSLLSGGLGDIFHLIPPPVFP--------------------------