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FLINGLIFTLGTLALALSPASVSSRIQLTEVPVLAVGLVIILTANAVLVRSSLDPLDELTTSMQRVDPPQ RSDRLDDQGNGDLRDLITSFNSMLDRMEAERASSSAAILAAQESERQRIARELHDEIGQSLTVALLTLKR AIDRAPAGPQPELEYTQQTIRACLGEVRDIARRLRPDALDLGLAHALTALCNEYARATGVSVVTHVGHLP AQLDPQIELVCYRIAQESLTNVARHARPRKVWVEAHAASDELVMRIADDGGGIIREGAGIRGMRERALLV DATVTIASGADGTEVRLRIPLDGGPAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1647 | - | - | 100% (308) | histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 3e-16 | 33.80% (216) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 9e-16 | 29.61% (233) | multi-sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 1e-12 | 29.56% (203) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_2281 | - | 3e-17 | 30.29% (208) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 1e-12 | 29.56% (203) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-20 | 32.23% (242) | putative two-component system sensor kinase |
| M. marinum M | MMAR_0133 | - | 1e-11 | 29.68% (219) | two-component sensor histidine kinase |
| M. avium 104 | MAV_5281 | - | 2e-14 | 31.73% (208) | histidine kinase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0854 | - | 1e-109 | 66.23% (308) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 7e-18 | 26.52% (279) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 3e-11 | 27.83% (212) | two component sensor kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1647|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0854|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDG
Rv3132c|M.tuberculosis_H37Rv MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDG
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 -------------MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSARLG
MMAR_0133|M.marinum_M --------------------------------------------------
MAV_5281|M.avium_104 --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1647|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0854|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 LVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVY
Rv3132c|M.tuberculosis_H37Rv LVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVY
Mflv_2281|M.gilvum_PYR-GCK ----MSAVTDTDTGADTAPVDVPDQSGAPSGRTRTLSVAASAS-------
TH_1533|M.thermoresistible__bu ----MVAVT-----AETAPAPAPT-------RTARLGVVPTAS-------
MAB_4499|M.abscessus_ATCC_1997 IVAAVVLLVAESMLTIFLRTIAPTEHLAAVYLIGILVISVIWR-------
MMAR_0133|M.marinum_M --------------------------------------------------
MAV_5281|M.avium_104 --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCAN------
Mvan_1647|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0854|M.smegmatis_MC2_155 --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 EGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHP
Rv3132c|M.tuberculosis_H37Rv EGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHP
Mflv_2281|M.gilvum_PYR-GCK -------------MLVGGAAASVWFWIPLAILVIGISSIPSVIG------
TH_1533|M.thermoresistible__bu -------------MVTGAAIALVWFWIPLTILIVGISSIPSVIG------
MAB_4499|M.abscessus_ATCC_1997 -----------LRLALAMSIASAIVFDCIRNWPKANPLSTESHNLITHLS
MMAR_0133|M.marinum_M --------------------------------------------------
MAV_5281|M.avium_104 -------------------MLRAAICHLREQLRRRGELIP--VG------
MUL_0350|M.ulcerans_Agy99 ---------------YGQLVGSCRLYGVPVVVTSDAELARVRRTHQLRAY
Mvan_1647|M.vanbaalenii_PYR-1 -----------------------------------------MFLINGLIF
MSMEG_0854|M.smegmatis_MC2_155 ---------------------------MKPARTPAAALFRRVFLINGLIF
Mb3156c|M.bovis_AF2122/97 PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAV
Rv3132c|M.tuberculosis_H37Rv PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAV
Mflv_2281|M.gilvum_PYR-GCK ----FLVAAVVFVYLMRGVDHVERVRNEAVFGMGIAVPPRRLSHYTGFQR
TH_1533|M.thermoresistible__bu ----FLLAGVVFIYLIRGVEWVERIRSEAVFGMGIPIPPRRLSPHTGFQR
MAB_4499|M.abscessus_ATCC_1997 FLAVTLTASALAALARAGTIEAERRRREAAAIAQQQAALRRTATLVASNV
MMAR_0133|M.marinum_M ------------------MLALLDRTAALRHGADVVHRRLGADLAAGANR
MAV_5281|M.avium_104 --LTWASLIAVDAALLLGGTIGTLQRPAADLPVSLTAFAIALSPTVAFFV
MUL_0350|M.ulcerans_Agy99 RIGSVLRIGVVLFMVAAMLVGTPRREWGAQTALICVYAFAALWALALAFR
Mvan_1647|M.vanbaalenii_PYR-1 TLGTLALALSPAS----VSSRIQLTEVPVLAVGLVIILTANAVLVR----
MSMEG_0854|M.smegmatis_MC2_155 ALGTLILAVSPAT----VSPRIRLTEIPVLVVGLAVMLTANALLLR----
Mb3156c|M.bovis_AF2122/97 ANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAAD
Rv3132c|M.tuberculosis_H37Rv ANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAAD
Mflv_2281|M.gilvum_PYR-GCK WAHQLWLDISSARFWKAVAHHYVRLTYDALATALAAGLLAFAFLAP----
TH_1533|M.thermoresistible__bu WAHQLWLDISSARFWKAAAHHYLRMSYDMLAVGVAFALLAFAFLGP----
MAB_4499|M.abscessus_ATCC_1997 SPVELYAKVVEEAARCFASPTAVLVQLMPGDEGTIVAGHGTEESRTPPAG
MMAR_0133|M.marinum_M IAEDDTMEVVAVVGGRTEELNGLVIGPQEGLGGQAAVLRRTVAVHDYCMS
MAV_5281|M.avium_104 FNMKMTPGPLWATWTASTALTLFVTSTPIRADFAPALLVLMVLVVAT---
MUL_0350|M.ulcerans_Agy99 RSRPMVSLDRFANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLL
Mvan_1647|M.vanbaalenii_PYR-1 -----SSLDPLDELTTSMQRVDPPQRSDRLD--------DQGNGDLRDLI
MSMEG_0854|M.smegmatis_MC2_155 -----SSLAPLNRLAESMQRVDPPRRTDRVD--------GRGTGDLHHLI
Mb3156c|M.bovis_AF2122/97 AALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFV
Rv3132c|M.tuberculosis_H37Rv AALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFV
Mflv_2281|M.gilvum_PYR-GCK ----AAAVATGHSDPEAGLSFLPTPLAWLLA-----VVALAAAVAVVVFG
TH_1533|M.thermoresistible__bu ----AGAIAVRNSDDNAGLTFLPPALAVVLA-----VIAVAAAAAILFFA
MAB_4499|M.abscessus_ATCC_1997 ----KRFPLLDSNNVARELRLTPAVCAPIVVDAKHWGTLIVGSHTPAQRD
MMAR_0133|M.marinum_M -----RDITHDFDHAVRAEGLRAAMVAPIVRAHRLYGLLYAARRSPVAWT
MAV_5281|M.avium_104 ---LASVVGGLLAAASAAALLLTAAALHRLD-----AIVLYLGFIVVAWL
MUL_0350|M.ulcerans_Agy99 P----VLVALDISSRRAAVVLALTLVGFGLALAQDPVVIRMNGWPEAIFR
. :
Mvan_1647|M.vanbaalenii_PYR-1 TSFNSMLDR--------------------MEAERASSSAAILAAQ-----
MSMEG_0854|M.smegmatis_MC2_155 ESFNAMLDR--------------------LETERSTASASALAAQ-----
Mb3156c|M.bovis_AF2122/97 NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAF
Rv3132c|M.tuberculosis_H37Rv NGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAF
Mflv_2281|M.gilvum_PYR-GCK PALDARIDR---------------WLLPPSETAALQHEVSALADARAGAV
TH_1533|M.thermoresistible__bu PAVDARIDR---------------WLLPPSSTEALQHQVSALSDARAGAV
MAB_4499|M.abscessus_ATCC_1997 QDIRAGVRD---------------FADLVATAIANAATREELAASRARIV
MMAR_0133|M.marinum_M DRDRAELLS---------------LARQAAVAMEVADSAREMAEVAA---
MAV_5281|M.avium_104 LGYLMRTQR-----------------LLVAEQIEAQQMLAEHAAAD----
MUL_0350|M.ulcerans_Agy99 FGLYAFLCAT--------------ALMVVRSEERHARSVATLSVIREELL
:
Mvan_1647|M.vanbaalenii_PYR-1 ---------------------------------ESERQRIARELHDEIGQ
MSMEG_0854|M.smegmatis_MC2_155 ---------------------------------ENERQRIARELHDEIGQ
Mb3156c|M.bovis_AF2122/97 TDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
Rv3132c|M.tuberculosis_H37Rv TDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQ
Mflv_2281|M.gilvum_PYR-GCK T------------------------------SAQTERHRIERDLHDSVQP
TH_1533|M.thermoresistible__bu S------------------------------SAQTERHRIERDLHDSVQP
MAB_4499|M.abscessus_ATCC_1997 S------------------------------ASDTARRRLERDLHDGAQQ
MMAR_0133|M.marinum_M ---------------------------------FGERQRLAIRLHDSVGA
MAV_5281|M.avium_104 -----------------------------------ERRRIAREVHDVIAH
MUL_0350|M.ulcerans_Agy99 AQTMT--------------------------ASEVLQRRISESIHDGPLQ
: *: :**
Mvan_1647|M.vanbaalenii_PYR-1 SLTVALLTLKRAIDRAPAG-----PQPELEYTQQTIRACLGEVRDIARRL
MSMEG_0854|M.smegmatis_MC2_155 TLTVALLALKRAVDRAPES-----IRGELSDAKEIVRSSLDEVREIARRL
Mb3156c|M.bovis_AF2122/97 RLFAIGLALQGAVPHERN----PEVQQRLSDVVDDLQDVIQEIRTTIYDL
Rv3132c|M.tuberculosis_H37Rv RLFAIGLALQGAVPHERN----PEVQQRLSDVVDDLQDVIQEIRTTIYDL
Mflv_2281|M.gilvum_PYR-GCK RLVSLAMTIGLAQTKLDSDP--PTARALIAEAHDEAKNALVELRNVVRGI
TH_1533|M.thermoresistible__bu RLVSLAMTIGLAQTKLDTDL--PAAKKLIAEAHEDAKSALAELRDVVRGI
MAB_4499|M.abscessus_ATCC_1997 RLAYLRLKLGMVRAAVPATD--AELTQELNNLDTDLTAVTRELQEFSRGL
MMAR_0133|M.marinum_M TLFSLRVALMSAQEETEPG----RREELLSDALVLTERATSELRAQTLSL
MAV_5281|M.avium_104 SLSITLLHVTGARRALQQDRDVDDAVEALEQAERLGRQAMADIRRTVGLL
MUL_0350|M.ulcerans_Agy99 DVLAARQELIELRAAAPHD-------QRVSTALAGLQSASDLLRQATFEL
: : : :: :
Mvan_1647|M.vanbaalenii_PYR-1 RPDALD-LGLAHA-----LTALCNEYARATGVSVVTHVGHLPAQLDPQIE
MSMEG_0854|M.smegmatis_MC2_155 RPDALEDLGLHSA-----LNALCSDFAQASGISVVKHISPQLDRLKPDVE
Mb3156c|M.bovis_AF2122/97 HGASQGITRLRQR-----IDAAVAQFA-DSGLRTSVQFVGPLSVVDSALA
Rv3132c|M.tuberculosis_H37Rv HGASQGITRLRQR-----IDAAVAQFA-DSGLRTSVQFVGPLSVVDSALA
Mflv_2281|M.gilvum_PYR-GCK APTILADRGLDAA-----LSSVVQRAN-NSGVSTTLSVHLPR-RLPDEVE
TH_1533|M.thermoresistible__bu APTILTDRGLDAA-----LSAVVQRAE-TSGVPTTLNLHLPR-RLPEEVE
MAB_4499|M.abscessus_ATCC_1997 HPAILS-KGLAPA-----LRTLARRSL----IPVRTELELDQ-KYGESIE
MMAR_0133|M.marinum_M H-DLPEDKALAVT-----LEGDCRDFATRTGTAAELVVLGDLPLLDSART
MAV_5281|M.avium_104 DNWPTKAAPTTPEPGLDDVASLVDGFR-RAGLAVTLCVEGPADHVSPAVG
MUL_0350|M.ulcerans_Agy99 HPAVLEQVGLGAA-----VEQLASFHAQRSGIRITDDVDYPI---RDEID
: .
Mvan_1647|M.vanbaalenii_PYR-1 LVCYRIAQESLTNVARHARPRKVWVEAHAAS--DELVMR-IADDG-GGII
MSMEG_0854|M.smegmatis_MC2_155 LVCYRIVQESLTNVARHSGARKVWLDLHIST--DELTLR-IADDGRGGVL
Mb3156c|M.bovis_AF2122/97 DQAEAVVREAVSNAVRHAKASTLTVRVKVDD---DLCIE-VTDNGRGLPD
Rv3132c|M.tuberculosis_H37Rv DQAEAVVREAVSNAVRHAKASTLTVRVKVDD---DLCIE-VTDNGRGLPD
Mflv_2281|M.gilvum_PYR-GCK ACAYFVVAEALTNVSRHSSASNAAVTVRLDEAANQLHVS-VFDDGRGGAR
TH_1533|M.thermoresistible__bu SVAYFVVAEALTNVVKHAQASQAVVTVRLNETDNTLQVS-VFDDGCGSAQ
MAB_4499|M.abscessus_ATCC_1997 IAAYYVVAEALANTAKHSQASEVVIRAHEAD--DQIHIT-ISDDGIGGAK
MMAR_0133|M.marinum_M DALRRTAREALLNVEKHAGAHSVVVSLYRAE--DGVGLT-VADDGTAPDI
MAV_5281|M.avium_104 LALYRITQESLANIAKHAPESKAGVVLDISPASARLAVTNILPAAVVAAR
MUL_0350|M.ulcerans_Agy99 PIVFGVARELLSNVVQHSRARNASVALGISD---GVCVLDVADDGVGVSG
. * : * :*: : : : : .
Mvan_1647|M.vanbaalenii_PYR-1 REGAG--------IRGMRERALLVDATVTIASGADG-TEVRLRIPLDGGP
MSMEG_0854|M.smegmatis_MC2_155 EEGAG--------INGMRERALLVNGTFTISSPEDGGTEVRLVIPMRGG-
Mb3156c|M.bovis_AF2122/97 EFTGS-------GLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv EFTGS-------GLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Mflv_2281|M.gilvum_PYR-GCK VVDGDDTVD-ATGLRGLDERVRAARGTFTVSSPP-TGPTIVTAVLPCGS-
TH_1533|M.thermoresistible__bu ISDRD---N-ATGLRGLAERVRAAHGTFTVSSPP-TGPTIVTAVLPCGS-
MAB_4499|M.abscessus_ATCC_1997 PRKGT-------GLIGLTDRVTALGGRLDVHSASGRGTTMTAIIPLHQSD
MMAR_0133|M.marinum_M ASEHRRG----LGLRATVERIERVGGWLSCTANEEGGGTVQAWVPAARAF
MAV_5281|M.avium_104 SPEGR-------GLRGMRQRVELLGGAIDVGPTRDGWSVCAEIPLQESDG
MUL_0350|M.ulcerans_Agy99 ETMARRLGQGHIGLASHRARVDAAGGSLVFLNTPTGTHVCVRIPLKG---
: * . .
Mvan_1647|M.vanbaalenii_PYR-1 AA--------
MSMEG_0854|M.smegmatis_MC2_155 ----------
Mb3156c|M.bovis_AF2122/97 ----------
Rv3132c|M.tuberculosis_H37Rv ----------
Mflv_2281|M.gilvum_PYR-GCK ----------
TH_1533|M.thermoresistible__bu ----------
MAB_4499|M.abscessus_ATCC_1997 ----------
MMAR_0133|M.marinum_M RPVGP-----
MAV_5281|M.avium_104 SWRPWWCGKA
MUL_0350|M.ulcerans_Agy99 ----------