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SRPLLTADRELALLRELIQAASSGPGVEPLAAAAARMITAATDSDVCFVHVLDDTERSLTLAGATPPFDS EVGKIRLPLGQGISGWVASNREPVVIRRDKESDPRYLPFRSLRGRDFTSMVSVPMETDPGGLVGVLNVHT VAERDFGDRDVGLLLVIGRLIAGAMHQARLHRQLVARERAHEHFVEQVIEAQELERRRLAGDIHDGISQR LVTLSYRLDAAAQAATSPGDPDALHEQLDRARELAELTLQEARAAISGLRPPVLDDLGLSGGLASLARTI PQVTIDVDLVDTRLPDHIELALYRIAQECLQNVVKHARASRARLTFALDRGDHGDLARLEIADDGIGFDT LEHPLGGDEMGGYGLLSMAERAEIVGGRLNIRSRPGAGTTVTATIPLPANRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | - | 100% (403) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 6e-30 | 34.14% (290) | multi-sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5907 | - | 2e-19 | 33.79% (219) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2052c | - | 5e-17 | 27.24% (301) | histidine kinase response regulator |
| M. gilvum PYR-GCK | Mflv_5015 | - | 0.0 | 90.95% (398) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv2027c | - | 5e-17 | 27.24% (301) | histidine kinase response regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-23 | 31.72% (268) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4781 | - | 8e-16 | 29.83% (238) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 6e-16 | 30.08% (236) | hypothetical protein MAV_0874 |
| M. smegmatis MC2 155 | MSMEG_1493 | - | 0.0 | 84.71% (399) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_4203 | - | 0.0 | 83.87% (403) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 5e-16 | 29.83% (238) | two component sensor kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2052c|M.bovis_AF2122/97 -----------------------------------------MTHPDRANV
Rv2027c|M.tuberculosis_H37Rv -----------------------------------------MTHPDRANV
Mvan_1357|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1493|M.smegmatis_MC2_155 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
MAV_0874|M.avium_104 --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 ------------MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSARLGI
Mb2052c|M.bovis_AF2122/97 NPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSG
Rv2027c|M.tuberculosis_H37Rv NPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSG
Mvan_1357|M.vanbaalenii_PYR-1 -------------------------MSRPLLTADRELALLRELIQAASSG
Mflv_5015|M.gilvum_PYR-GCK -------------------------MTRPLLTADRELALLRELIQAASSG
MSMEG_1493|M.smegmatis_MC2_155 ------------MNAAKRAVKPVRDL----VDADRELALLRELIQAASSG
TH_4203|M.thermoresistible__bu -------------VTSGPHPDPVRDLSEQLLTADRELVLLRELIQAASRG
MMAR_4781|M.marinum_M ---------MVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MAV_0874|M.avium_104 --------MAVAGDAELERVRAVHQMRSYRIGSVLRVGVVGLMVAAMIIG
MAB_4499|M.abscessus_ATCC_1997 VAAVVLLVAESMLTIFLRTIAPTEHLAAVYLIGILVISVIWRLRLALAMS
: . : : * .
Mb2052c|M.bovis_AF2122/97 LKLDATLRAI-----VHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEE
Rv2027c|M.tuberculosis_H37Rv LKLDATLRAI-----VHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEE
Mvan_1357|M.vanbaalenii_PYR-1 PGVEPLAAAA-----ARMITAATDSDVCFVHVLDDTERSLTLAGATPPFD
Mflv_5015|M.gilvum_PYR-GCK PGVEPLAAAS-----ARMITASTDSDVCFVHVLDDTERSLTLAGATPPFD
MSMEG_1493|M.smegmatis_MC2_155 PGVEPLAAAA-----ARMITAATGTDVCFVHVLDDSDRSLTLAGATPPFD
TH_4203|M.thermoresistible__bu PGVEPLAAAA-----ARMITAATASDVCFVHVLDDTERSLTLAGATPPFD
MMAR_4781|M.marinum_M TPRREWGAQT-----ALICVYAFAALWALALAFRRSRPMVSLDRFANIAR
MUL_0350|M.ulcerans_Agy99 TPRREWGAQT-----ALICVYAFAALWALALAFRRSRPMVSLDRFANIAR
MAV_0874|M.avium_104 TARSEWPQES-----VLILLYGIIALGAVALAFAPFRRWIGIGRLAGVGR
MAB_4499|M.abscessus_ATCC_1997 IASAIVFDCIRNWPKANPLSTESHNLITHLSFLAVTLTASALAALARAGT
. :
Mb2052c|M.bovis_AF2122/97 TRHLIGSLPEGRGVLGALIEEPKPIRLD-DISRHPASVGFP-LHHPPMRT
Rv2027c|M.tuberculosis_H37Rv TRHLIGSLPEGRGVLGALIEEPKPIRLD-DISRHPASVGFP-LHHPPMRT
Mvan_1357|M.vanbaalenii_PYR-1 SEVGKIRLPLGQGISGWVASNREPVVIRRDKESDPRYLPFRSLRGRDFTS
Mflv_5015|M.gilvum_PYR-GCK SEVGKIRLPLGQGISGWVASHRQPVVIRRDKESDPRYLPFQSLRGRDFTS
MSMEG_1493|M.smegmatis_MC2_155 SEVGKIRLPIGQGISGWVADHCEPVVISHDKEADPRYMPFESLRGRDFTS
TH_4203|M.thermoresistible__bu KEVGKIRLPLGQGISGWVASHREPVVITENKEADPRYLPFQSLRGRDFTS
MMAR_4781|M.marinum_M YEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLLPVLVALDISSRRAAVV
MUL_0350|M.ulcerans_Agy99 YEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLLPVLVALDISSRRAAVV
MAV_0874|M.avium_104 LEPFAFTVVDILALTIFQLLSTNGIYPLLIMAMLPVLLGLDVSSRRAAVV
MAB_4499|M.abscessus_ATCC_1997 IEAERRRREAAAIAQQQAALRRTATLVASNVSPVELYAKVVEEAARCFAS
. .
Mb2052c|M.bovis_AF2122/97 FLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAV-DNA
Rv2027c|M.tuberculosis_H37Rv FLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAV-DNA
Mvan_1357|M.vanbaalenii_PYR-1 MVSVPMETDPGGLVGVLNVHTVAERDFGDRDVGLLLVIGRLIAGAM-HQA
Mflv_5015|M.gilvum_PYR-GCK MVSVPMETDPGGLVGVLNVHTVAERDFTDRDVELLLVIGRLIAGAM-HQA
MSMEG_1493|M.smegmatis_MC2_155 MVSVPMEAEPGGLVGVLNVHTVRRREFTPRDVELLVVIGRLIAGAL-HQA
TH_4203|M.thermoresistible__bu MVSVPMETDPGGLVGVLNVHTVERREFTRRDVDLLLVIGRLIAGGL-HQA
MMAR_4781|M.marinum_M LALTLVGFALALAQDPVVIRMNGWPEAIFRFGLYAFLCATALMVVR-SEE
MUL_0350|M.ulcerans_Agy99 LALTLVGFGLALAQDPVVIRMNGWPEAIFRFGLYAFLCATALMVVR-SEE
MAV_0874|M.avium_104 LIFSMLGFAIAVLQDPVMSSSVRLPEAGFRFLLYGFLCCAAFLVVR-IEE
MAB_4499|M.abscessus_ATCC_1997 PTAVLVQLMPGDEGTIVAGHGTEESRTPPAGKRFPLLDSNNVARELRLTP
:
Mb2052c|M.bovis_AF2122/97 RLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL
Rv2027c|M.tuberculosis_H37Rv RLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL
Mvan_1357|M.vanbaalenii_PYR-1 RLHRQLVARERAHEHFVEQ-------------------------------
Mflv_5015|M.gilvum_PYR-GCK RLHRQLVARERAHENFVEQ-------------------------------
MSMEG_1493|M.smegmatis_MC2_155 RLHRQLVARERAHENFVEQ-------------------------------
TH_4203|M.thermoresistible__bu RLHRQLVARERAHEIFVEQ-------------------------------
MMAR_4781|M.marinum_M RHARSVATLSVIREELLAQ-------------------------------
MUL_0350|M.ulcerans_Agy99 RHARSVATLSVIREELLAQ-------------------------------
MAV_0874|M.avium_104 RHTRSVAGLSALREELLAQ-------------------------------
MAB_4499|M.abscessus_ATCC_1997 AVCAPIVVDAKHWGTLIVGSHTPAQRDQDIRAGVRDFADLVATAIANAAT
Mb2052c|M.bovis_AF2122/97 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRT
Rv2027c|M.tuberculosis_H37Rv VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRT
Mvan_1357|M.vanbaalenii_PYR-1 ----------VIEAQELERRRLAGDIHDGISQRLVTLS------------
Mflv_5015|M.gilvum_PYR-GCK ----------VIEAQELERRRLAGDIHDGISQRLVTLS------------
MSMEG_1493|M.smegmatis_MC2_155 ----------VIEAQELERRRLAADIHDGISQRLVTLS------------
TH_4203|M.thermoresistible__bu ----------VIEAQELERRRLAADIHDGISQRLVTLS------------
MMAR_4781|M.marinum_M ----------TMTASEVLQRRISESIHDGPLQDVLAAR------------
MUL_0350|M.ulcerans_Agy99 ----------TMTASEVLQRRISESIHDGPLQDVLAAR------------
MAV_0874|M.avium_104 ----------TMNASDVSQRRISEFIHDGPLQDILAVR------------
MAB_4499|M.abscessus_ATCC_1997 REELAASRARIVSASDTARRRLERDLHDGAQQRLAYLR------------
..: .: : . *
Mb2052c|M.bovis_AF2122/97 PRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQ
Rv2027c|M.tuberculosis_H37Rv PRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQ
Mvan_1357|M.vanbaalenii_PYR-1 -YRLDAAAQAATSPGDPDALHEQLDRARELAELTLQEARAAISG------
Mflv_5015|M.gilvum_PYR-GCK -YRLDAAAQAAKSPADHAALTEQLDRARELADLTLQEARAAISG------
MSMEG_1493|M.smegmatis_MC2_155 -YRLDAAARAAD---DPRAVAEQLGKARELADLTLQEARAAISG------
TH_4203|M.thermoresistible__bu -YRLDAAIRAVD---DPATVTEQLSKARELADLTLEETRAAISG------
MMAR_4781|M.marinum_M -QELIELRAAAPHDQRVSTALAGLQSASDLLRQATFEL------------
MUL_0350|M.ulcerans_Agy99 -QELIELRAAAPHDQRVSTALAGLQSASDLLRQATFEL------------
MAV_0874|M.avium_104 -QELVELDAAVPDDERIGRALAGLQLASERLRQATFEL------------
MAB_4499|M.abscessus_ATCC_1997 -LKLGMVRAAVP--ATDAELTQELNNLDTDLTAVTRELQEFSRG------
.: *. .
Mb2052c|M.bovis_AF2122/97 LDMMAAFADQAALAWRLATAQRQMREVEILT--DRDRIARDLHDHVIQRL
Rv2027c|M.tuberculosis_H37Rv LDMMAAFADQAALAWRLATAQRQMREVEILT--DRDRIARDLHDHVIQRL
Mvan_1357|M.vanbaalenii_PYR-1 --LRPPVLDDLGLSGGLASLARTIPQVTI----DVDLVDTRLPDHIELAL
Mflv_5015|M.gilvum_PYR-GCK --LRPPVLDDLGLAGGLASLARSIPQIGI----ETDLDDTRLADHIELAL
MSMEG_1493|M.smegmatis_MC2_155 --LRPPVLDDLGLSGGLASLARSIPQVDL----DVDLADTRVPDHIELAL
TH_4203|M.thermoresistible__bu --LRPPVLDDLGLSGGLASLAQSVGQLDIGVDIEVDLAETRLPDHIELAL
MMAR_4781|M.marinum_M ---HPAVLEQVGLGAAVEQLASFHAQRSGIR--ITDDVDYPIRDEIDPIV
MUL_0350|M.ulcerans_Agy99 ---HPAVLEQVGLGAAVEQLASFHAQRSGIR--ITDDVDYPIRDEIDPIV
MAV_0874|M.avium_104 ---HPAVLEQVGLGAAVQQLAEFTAQRSGIE--ISTDIDYSGRSAIDAVV
MAB_4499|M.abscessus_ATCC_1997 -------LHPAILSKGLAPALRTLARRSLIPVRTELELDQKYGESIEIAA
. *. : . . :
Mb2052c|M.bovis_AF2122/97 FAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSR
Rv2027c|M.tuberculosis_H37Rv FAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSR
Mvan_1357|M.vanbaalenii_PYR-1 YRI----------------------AQECLQNVVKHAR------------
Mflv_5015|M.gilvum_PYR-GCK YRI----------------------AQECLQNVVKHAR------------
MSMEG_1493|M.smegmatis_MC2_155 YRI----------------------AQECLQNVVKHAR------------
TH_4203|M.thermoresistible__bu YRI----------------------AQECLQNVVKHAR------------
MMAR_4781|M.marinum_M FGV----------------------ARELLSNVVQHSR------------
MUL_0350|M.ulcerans_Agy99 FGV----------------------ARELLSNVVQHSR------------
MAV_0874|M.avium_104 FGV----------------------VRELLSNVVQHSR------------
MAB_4499|M.abscessus_ATCC_1997 YYV----------------------VAEALANTAKHSQ------------
: : : * : :. :
Mb2052c|M.bovis_AF2122/97 ATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVS
Rv2027c|M.tuberculosis_H37Rv ATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVS
Mvan_1357|M.vanbaalenii_PYR-1 -------------------------------------------ASRARLT
Mflv_5015|M.gilvum_PYR-GCK -------------------------------------------ASAARLT
MSMEG_1493|M.smegmatis_MC2_155 -------------------------------------------ATTARLT
TH_4203|M.thermoresistible__bu -------------------------------------------ARTARLT
MMAR_4781|M.marinum_M -------------------------------------------ARNASVA
MUL_0350|M.ulcerans_Agy99 -------------------------------------------ARNASVA
MAV_0874|M.avium_104 -------------------------------------------ARTAAIM
MAB_4499|M.abscessus_ATCC_1997 -------------------------------------------ASEVVIR
. :
Mb2052c|M.bovis_AF2122/97 NAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADD
Rv2027c|M.tuberculosis_H37Rv NAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADD
Mvan_1357|M.vanbaalenii_PYR-1 FALDRGDHGDLARLEIADDGIGFDTLEHPLGGD-EMGGYGLLSMAERAEI
Mflv_5015|M.gilvum_PYR-GCK FAVD----DNTARLEIADDGVGFDTFEHPLGSD-EMGGYGLLSMAERAEI
MSMEG_1493|M.smegmatis_MC2_155 FAVEDG----IARLEIVDDGIGFDTFEHPLGSD-EMSGYGLLSMAERAEI
TH_4203|M.thermoresistible__bu YAVDRGEHGEVARLEIVDDGVGFDTFEHPLGGD-DMSGYGLLSMAERAEI
MMAR_4781|M.marinum_M LGISDG----VCVLDVADDGVGVSGETMARRLG--QGHIGLASHRARVDA
MUL_0350|M.ulcerans_Agy99 LGISDG----VCVLDVADDGVGVSGETMARRLG--QGHIGLASHRARVDA
MAV_0874|M.avium_104 LGRTDG----TCVLHVVDDGVGFNQETVARRLG--EGHIGLASHRARVEA
MAB_4499|M.abscessus_ATCC_1997 -------------AHEADDQIHITISDDGIGGAKPRKGTGLIGLTDRVTA
.:* : . ** . *.
Mb2052c|M.bovis_AF2122/97 AGGEFTVENMPTGGTLLRWSAPLR------------
Rv2027c|M.tuberculosis_H37Rv AGGEFTVENMPTGGTLLRWSAPLR------------
Mvan_1357|M.vanbaalenii_PYR-1 VGGRLNIRSRPGAGTTVTATIPLPANRE--------
Mflv_5015|M.gilvum_PYR-GCK VGGRLNIRSRPGSGTTVTATIPLHQGGA--------
MSMEG_1493|M.smegmatis_MC2_155 VGGRLNIRSRPGAGTAVTATIPLPSHEPAPNLTKLP
TH_4203|M.thermoresistible__bu VGGRLNIRSRPGAGTAVIATIPLP---PATR-----
MMAR_4781|M.marinum_M AGGSLVFLNTP-TGTHVCVRIPLKG-----------
MUL_0350|M.ulcerans_Agy99 AGGSLVFLNTP-TGTHVCVRIPLKG-----------
MAV_0874|M.avium_104 AGGELVFLDVP-VGTHVCVEVPLRN-----------
MAB_4499|M.abscessus_ATCC_1997 LGGRLDVHSASGRGTTMTAIIPLHQSD---------
** : . . . ** : **