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MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSARLGIVAAVVLLVAESMLTIFLRTIAPTEHLAAVYLI GILVISVIWRLRLALAMSIASAIVFDCIRNWPKANPLSTESHNLITHLSFLAVTLTASALAALARAGTIE AERRRREAAAIAQQQAALRRTATLVASNVSPVELYAKVVEEAARCFASPTAVLVQLMPGDEGTIVAGHGT EESRTPPAGKRFPLLDSNNVARELRLTPAVCAPIVVDAKHWGTLIVGSHTPAQRDQDIRAGVRDFADLVA TAIANAATREELAASRARIVSASDTARRRLERDLHDGAQQRLAYLRLKLGMVRAAVPATDAELTQELNNL DTDLTAVTRELQEFSRGLHPAILSKGLAPALRTLARRSLIPVRTELELDQKYGESIEIAAYYVVAEALAN TAKHSQASEVVIRAHEADDQIHITISDDGIGGAKPRKGTGLIGLTDRVTALGGRLDVHSASGRGTTMTAI IPLHQSD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4499 | - | - | 100% (497) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-11 | 25.75% (400) | histidine kinase response regulator |
| M. abscessus ATCC 19977 | MAB_0061 | - | 2e-11 | 27.65% (217) | two component sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 6e-17 | 31.82% (220) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 2e-28 | 33.08% (263) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 3e-16 | 31.36% (220) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1517 | devS | 2e-15 | 26.18% (401) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_0874 | - | 2e-15 | 32.67% (202) | hypothetical protein MAV_0874 |
| M. smegmatis MC2 155 | MSMEG_0980 | - | 2e-97 | 43.19% (514) | signal transduction histidine kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 5e-29 | 36.19% (210) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 4e-16 | 26.05% (403) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 9e-68 | 41.12% (394) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0980|M.smegmatis_MC2_155 MNVTGAADRPFEHRRESVGARLLGFVLRPTAPPLKIGIAVALGCIAAESL
Mvan_2071|M.vanbaalenii_PYR-1 -----------------MPTRFLERVVRSPARPLGLGIAVAAGFLAAEVL
MAB_4499|M.abscessus_ATCC_1997 MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSARLGIVAAVVLLVAESM
MMAR_1517|M.marinum_M -----MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERV
MUL_2422|M.ulcerans_Agy99 -----MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERV
Mb0868|M.bovis_AF2122/97 ----------------------MPSYGNLGRLGGRHEYGVLVAMTSSAEL
Rv0845|M.tuberculosis_H37Rv ----------------------MPSYGNLGRLGGRHEYGVLVAMTSSAEL
MAV_0874|M.avium_104 -----------------------------------------MAVAGDAEL
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------MTRPLL
TH_1533|M.thermoresistible__bu ----------------------MVAVTAETAPAPAPTRTARLGVVPTASM
:
MSMEG_0980|M.smegmatis_MC2_155 LVHFLQKVAPESTFGTVFLLGVLVVSAGWDMRLSVATSLLTALVYVHFHM
Mvan_2071|M.vanbaalenii_PYR-1 AVFALKKIAPENAFGALLLLGVLVVSAGWGFGLSIATSLASAAVYAYLHL
MAB_4499|M.abscessus_ATCC_1997 LTIFLRTIAPTEHLAAVYLIGILVISVIWRLRLALAMSIASAIVFDCIRN
MMAR_1517|M.marinum_M EQIVEGRDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEV
MUL_2422|M.ulcerans_Agy99 EQIVEGRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEV
Mb0868|M.bovis_AF2122/97 DRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYA
Rv0845|M.tuberculosis_H37Rv DRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYA
MAV_0874|M.avium_104 ERVRAVHQMRSYRIGSVLRVGVVGLMVAAMIIGTARSEWPQESVLILLYG
Mflv_5015|M.gilvum_PYR-GCK TADRELALLRELIQAASSGPGVEPLAAASARMITASTDSDVCFVHVLDDT
TH_1533|M.thermoresistible__bu VTGAAIALVWFWIPLTILIVGISSIPSVIGFLLAGVVFIYLIRGVEWVER
:
MSMEG_0980|M.smegmatis_MC2_155 ETHGALMPIYSEDIASIAVFIPVALLANILVGQARLRTAEAEQRTVEADR
Mvan_2071|M.vanbaalenii_PYR-1 EGRDSLAP-------ALIIFLTLALLTNALVGQARLRAAEAEQRRREADL
MAB_4499|M.abscessus_ATCC_1997 WPKANPLSTESHNLITHLSFLAVTLTASALAALARAGTIEAERRRREAAA
MMAR_1517|M.marinum_M HDRDKRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQ
MUL_2422|M.ulcerans_Agy99 HDRDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQ
Mb0868|M.bovis_AF2122/97 -------------------VAALWALLLAYSASRRFFALRR---------
Rv0845|M.tuberculosis_H37Rv -------------------VAALWALLLAYSASRRFFALRR---------
MAV_0874|M.avium_104 -------------------IIALGAVALAFAPFRRWIGIGR---------
Mflv_5015|M.gilvum_PYR-GCK ER-----------------SLTLAGATPPFDSEVGKIRLPLG--------
TH_1533|M.thermoresistible__bu -------------------IRSEAVFGMGIPIPPRRLSPHTG--------
MSMEG_0980|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 SADLARVMLRAPALGPALEDAGRRFADVLGLPYATLTVGGGATGADEMAI
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1517|M.marinum_M HP------------------------------------------------
MUL_2422|M.ulcerans_Agy99 HP------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 --------------------------------------AAAAAQEAQKLI
Mvan_2071|M.vanbaalenii_PYR-1 DLVDGAEHTGTLLVPRDLPLASVRRIHRMVPSLQALLAAACDREDITAEL
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1517|M.marinum_M --------------------------------------ASIGFPSHHPPM
MUL_2422|M.ulcerans_Agy99 --------------------------------------ASIGFPSHHPPM
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 EASHAEVS--------------------------------------ELAA
Mvan_2071|M.vanbaalenii_PYR-1 EASRRELERFFAVASDLLFIGTYVDGVAQLTRVNPAFERALGYSAAELAA
MAB_4499|M.abscessus_ATCC_1997 -----------------------------------------------IAQ
MMAR_1517|M.marinum_M RTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALAAAAGIAIAN
MUL_2422|M.ulcerans_Agy99 RTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALAAAAGIAIAN
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 RPLTEFIHPDDRDGTAAALDSVPQTDGATQFENRSLRRDGGVRWLEWNVV
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1517|M.marinum_M --------------------------------------------------
MUL_2422|M.ulcerans_Agy99 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 ----------------------------QQAALRRVATLVARGSPPEEVY
Mvan_2071|M.vanbaalenii_PYR-1 SDRGVLLGGARDVTERRREQDRLRMARTQQAALRRVATLVARGAPLSEVY
MAB_4499|M.abscessus_ATCC_1997 ----------------------------QQAALRRTATLVASNVSPVELY
MMAR_1517|M.marinum_M ----------------ARLYEQAKARQAWIGATRDIATELLSGTEPASVF
MUL_2422|M.ulcerans_Agy99 ----------------ARLYEQAKARQAWIGATRDIATELLSGTEPASVF
Mb0868|M.bovis_AF2122/97 --------------------------------FRSMGRLEPFAFTAVDVL
Rv0845|M.tuberculosis_H37Rv --------------------------------FRSMGRLEPFAFTAVDVL
MAV_0874|M.avium_104 --------------------------------LAGVGRLEPFAFTVVDIL
Mflv_5015|M.gilvum_PYR-GCK ---------------------------------QGISGWVASHRQP----
TH_1533|M.thermoresistible__bu --------------------------------FQRWAHQLWLDISSARFW
.
MSMEG_0980|M.smegmatis_MC2_155 PAAVDELAAGFGLDHVALLLFPGDGT-----STVLASRDATGAPKFPVGE
Mvan_2071|M.vanbaalenii_PYR-1 DVAVTELAHSLGVNHVTLLAFEADDH-----AVVRAALKSAHQPGFAVGD
MAB_4499|M.abscessus_ATCC_1997 AKVVEEAARCFASPTAVLVQLMPGDE-----GTIVAGHGTEESRTPPAGK
MMAR_1517|M.marinum_M RLVAEEALKLTSADAALVAVPVDEDVPASEVAQLLVIETVGNAVAAAEGC
MUL_2422|M.ulcerans_Agy99 RLVAEEALKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGC
Mb0868|M.bovis_AF2122/97 ILTGFQLLSTDGIYPLLIMILLPVLVG----LDVSTRRAAVVLACTLVGF
Rv0845|M.tuberculosis_H37Rv ILTGFQLLSTDGIYPLLIMILLPVLVG----LDVSTRRAAVVLACTLVGF
MAV_0874|M.avium_104 ALTIFQLLSTNGIYPLLIMAMLPVLLG----LDVSSRRAAVVLIFSMLGF
Mflv_5015|M.gilvum_PYR-GCK --VVIRRDKESDPRYLPFQSLRGRDFT------SMVSVPMETDPGGLVG-
TH_1533|M.thermoresistible__bu KAAAHHYLRMSYDMLAVGVAFALLAFAFLGPAGAIAVRNSDDNAGLTFLP
. .
MSMEG_0980|M.smegmatis_MC2_155 RIPLDGDTVTTLVARTGAPARVDDYAVVGGAGAARIREVGIRSAVGAPIL
Mvan_2071|M.vanbaalenii_PYR-1 RLSLDGGSISEQVHRTGLPARIDDYSEVPGRIATRLRELGIRSAAGSPLT
MAB_4499|M.abscessus_ATCC_1997 RFPLLD---SNNVAR----------------------ELRLTPAVCAPIV
MMAR_1517|M.marinum_M TIAVAGTALAEVLLDSAP------------RQVDKIAVEGVDELGDTGPA
MUL_2422|M.ulcerans_Agy99 TIAVAGTALAEVLLDSAP------------RQVDKIAVEDVDELGDMGPA
Mb0868|M.bovis_AF2122/97 AVAVLGDP------------------------------VMLRAIGWPETI
Rv0845|M.tuberculosis_H37Rv AVAVLGDP------------------------------VMLRAIGWPETI
MAV_0874|M.avium_104 AIAVLQDP------------------------------VMSSSVRLPEAG
Mflv_5015|M.gilvum_PYR-GCK -------------------------------------VLNVHTVAERDFT
TH_1533|M.thermoresistible__bu PA-----------------------------------LAVVLAVIAVAAA
MSMEG_0980|M.smegmatis_MC2_155 VDGRVYGVLLVGSSQPFEFPADTEVRVGDFADLVGTAITNAETRAALTAS
Mvan_2071|M.vanbaalenii_PYR-1 VDGGTRGVLVVGSHAVQGVPDGTEAHIGDFADLISTAIANAETRAELTAS
MAB_4499|M.abscessus_ATCC_1997 VDAKHWGTLIVGSHTPAQRDQDIRAGVRDFADLVATAIANAATREELAAS
MMAR_1517|M.marinum_M LVLPLRATDAVAGVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATS
MUL_2422|M.ulcerans_Agy99 LVLPLRATDAVAGVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATS
Mb0868|M.bovis_AF2122/97 FRFALYAFLCATALMVVRIEERHTRSVAGLSALREELLAQTMTASEVLQR
Rv0845|M.tuberculosis_H37Rv FRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQR
MAV_0874|M.avium_104 FRFLLYGFLCCAAFLVVRIEERHTRSVAGLSALREELLAQTMNASDVSQR
Mflv_5015|M.gilvum_PYR-GCK DRDVELLLVIGRLIAGAMHQARLHRQLVARERAHENFVEQVIEAQELERR
TH_1533|M.thermoresistible__bu AAILFFAPAVDARIDRWLLPPSSTEALQHQVSALSDARAGAVSSAQTERH
.
MSMEG_0980|M.smegmatis_MC2_155 RARIVTAADQARR-RFERDLHDGAQQRVISLGLGLR--AVEASVPDDQLE
Mvan_2071|M.vanbaalenii_PYR-1 RARIVAAADEARR-GFERDLHDGAQQRIVSLSLQLR--EAEAAVEGDE-A
MAB_4499|M.abscessus_ATCC_1997 RARIVSASDTARR-RLERDLHDGAQQRLAYLRLKLG--MVRAAVPATDAE
MMAR_1517|M.marinum_M QRRMRELDVMTERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQR
MUL_2422|M.ulcerans_Agy99 QRRMRELDVVTERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQR
Mb0868|M.bovis_AF2122/97 R--------------IAEAIHDGPLQDVLAARQELI--ELDAVTPGDE--
Rv0845|M.tuberculosis_H37Rv R--------------IAEAIHDGPLQDVLAARQELI--ELDAVTPGDE--
MAV_0874|M.avium_104 R--------------ISEFIHDGPLQDILAVRQELV--ELDAAVPDDE--
Mflv_5015|M.gilvum_PYR-GCK R--------------LAGDIHDGISQRLVTLSYRLDAAAQAAKSPADHAA
TH_1533|M.thermoresistible__bu R--------------IERDLHDSVQPRLVSLAMTIG--LAQTKLDTDLPA
: : :** : : :
MSMEG_0980|M.smegmatis_MC2_155 LRLQISRVVDGLSSLSTELQEFSRGIHPAILSKGGLGPALRALARRCPVP
Mvan_2071|M.vanbaalenii_PYR-1 LRTQLSTVVNGLAGLHSDLQELSRGLHPAVLSRGGLKPAMRNLARRSTVP
MAB_4499|M.abscessus_ATCC_1997 LTQELNNLDTDLTAVTRELQEFSRGLHPAILSKG-LAPALRTLARRSLIP
MMAR_1517|M.marinum_M LSEVIDDLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRT
MUL_2422|M.ulcerans_Agy99 LSEVIDDLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRT
Mb0868|M.bovis_AF2122/97 ---RVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQR
Rv0845|M.tuberculosis_H37Rv ---RVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQR
MAV_0874|M.avium_104 ---RIGRALAGLQLASERLRQATFELHPAVLEQVGLGAAVQQLAEFTAQR
Mflv_5015|M.gilvum_PYR-GCK LTEQLDRARELADLTLQEARAAISGLRPPVLDDLGLAGGLASLARSIPQI
TH_1533|M.thermoresistible__bu AKKLIAEAHEDAKSALAELRDVVRGIAPTILTDRGLDAALSAVVQRAETS
: : .: .
MSMEG_0980|M.smegmatis_MC2_155 ---VDLEVDLPEPVPESVGVAAYYVVAEALTNAAKYAEAQAIVITATLGD
Mvan_2071|M.vanbaalenii_PYR-1 ---VELTVDIDRRLPEPVEVAAYYVVAESLTNVAKHAQADSVTVEIGLDD
MAB_4499|M.abscessus_ATCC_1997 ---VRTELELDQKYGESIEIAAYYVVAEALANTAKHSQASEVVIRAHEAD
MMAR_1517|M.marinum_M ---TVQFIGPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD
MUL_2422|M.ulcerans_Agy99 ---TVQFIGPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD
Mb0868|M.bovis_AF2122/97 SG-IKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITD
Rv0845|M.tuberculosis_H37Rv SG-IKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITD
MAV_0874|M.avium_104 SG-IEISTDIDYSGRSAIDAVVFGVVRELLSNVVQHSRARTAAIMLGRTD
Mflv_5015|M.gilvum_PYR-GCK G--IETDLDDTR-LADHIELALYRIAQECLQNVVKHARASAARLTFAVDD
TH_1533|M.thermoresistible__bu GVPTTLNLHLPRRLPEEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNE
. : :. * : *..::: * : :
MSMEG_0980|M.smegmatis_MC2_155 DT-----LDLMIDDDGVGGAVAGGGS--------GLIGLKDRVEALSGEL
Mvan_2071|M.vanbaalenii_PYR-1 APDGGTLLRLSVTDDGTGGASADGGS--------GLVGLRDRVEALSGQL
MAB_4499|M.abscessus_ATCC_1997 DQ-----IHITISDDGIGGAKPRKGT--------GLIGLTDRVTALGGRL
MMAR_1517|M.marinum_M DL------CIEVSDNGRGMPKTYTSS--------GLTNLRRRAQEAGGQF
MUL_2422|M.ulcerans_Agy99 DL------CIEVSDNGRGMPKTYTSS--------GLTNLRRRAQEAGGQF
Mb0868|M.bovis_AF2122/97 EK-----CVLDVADDGVGVTGDTMARRLGEGH-IGLASHRARVDAAGGVL
Rv0845|M.tuberculosis_H37Rv EK-----CVLDVADDGVGVTGDTMARRLGEGH-IGLASHRARVDAAGGVL
MAV_0874|M.avium_104 GT-----CVLHVVDDGVGFNQETVARRLGEGH-IGLASHRARVEAAGGEL
Mflv_5015|M.gilvum_PYR-GCK NT-----ARLEIADDGVGFDTFEHPLGSDEMGGYGLLSMAERAEIVGGRL
TH_1533|M.thermoresistible__bu TDN---TLQVSVFDDGCGSAQISDRD-----NATGLRGLAERVRAAHGTF
: : *:* * ** . *. * :
MSMEG_0980|M.smegmatis_MC2_155 TITS-PSGVGTTITARIPLHHD--
Mvan_2071|M.vanbaalenii_PYR-1 TVTS-RPGDGTSISATIPVD----
MAB_4499|M.abscessus_ATCC_1997 DVHS-ASGRGTTMTAIIPLHQSD-
MMAR_1517|M.marinum_M TIESPAAGGGTLLRWSAPLIQ---
MUL_2422|M.ulcerans_Agy99 TIESPAAGGGTLLRWSAPLIQ---
Mb0868|M.bovis_AF2122/97 VFLA--TPRGTHVCVELPLKR---
Rv0845|M.tuberculosis_H37Rv VFLA--TPRGTHVCVELPLKR---
MAV_0874|M.avium_104 VFLD--VPVGTHVCVEVPLRN---
Mflv_5015|M.gilvum_PYR-GCK NIRS-RPGSGTTVTATIPLHQGGA
TH_1533|M.thermoresistible__bu TVSS-PPTGPTIVTAVLPCGS---
. * : *