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SAVTDTDTGADTAPVDVPDQSGAPSGRTRTLSVAASASMLVGGAAASVWFWIPLAILVIGISSIPSVIGF LVAAVVFVYLMRGVDHVERVRNEAVFGMGIAVPPRRLSHYTGFQRWAHQLWLDISSARFWKAVAHHYVRL TYDALATALAAGLLAFAFLAPAAAVATGHSDPEAGLSFLPTPLAWLLAVVALAAAVAVVVFGPALDARID RWLLPPSETAALQHEVSALADARAGAVTSAQTERHRIERDLHDSVQPRLVSLAMTIGLAQTKLDSDPPTA RALIAEAHDEAKNALVELRNVVRGIAPTILADRGLDAALSSVVQRANNSGVSTTLSVHLPRRLPDEVEAC AYFVVAEALTNVSRHSSASNAAVTVRLDEAANQLHVSVFDDGRGGARVVDGDDTVDATGLRGLDERVRAA RGTFTVSSPPTGPTIVTAVLPCGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2281 | - | - | 100% (445) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_0967 | - | 2e-34 | 38.71% (248) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 2e-20 | 29.07% (258) | GAF sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2052c | - | 1e-16 | 32.14% (196) | histidine kinase response regulator |
| M. tuberculosis H37Rv | Rv2027c | - | 1e-16 | 32.14% (196) | histidine kinase response regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 2e-27 | 35.21% (213) | putative two-component system sensor kinase |
| M. marinum M | MMAR_1517 | devS | 4e-16 | 30.25% (238) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 1e-12 | 30.36% (224) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 1e-174 | 75.37% (406) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 1e-178 | 73.10% (435) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 4e-16 | 30.25% (238) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_4385 | - | 0.0 | 82.92% (445) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4385|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb2052c|M.bovis_AF2122/97 MT---HPDRANVNPGSP------PVRETLSQLRLRELLLEVQDRIEQIVE
Rv2027c|M.tuberculosis_H37Rv MT---HPDRANVNPGSP------PLRETLSQLRLRELLLEVQDRIEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MAB_4499|M.abscessus_ATCC_1997 -----------------------------------MQQAAQASSPRPILM
Mflv_2281|M.gilvum_PYR-GCK -----------MSAVTDTDTGADTAPVDVPDQSGAPSGRTRTLSVAAS--
Mvan_4385|M.vanbaalenii_PYR-1 -----------MTAVTHADAATDRVPVSSHDHAGAAPPRPRTLGVAAS--
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu -----------------------MVAVTAETAPAPAPTRTARLGVVPT--
Mb2052c|M.bovis_AF2122/97 GRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDH
Rv2027c|M.tuberculosis_H37Rv GRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDH
MMAR_1517|M.marinum_M GRDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRDK
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAV_4108|M.avium_104 ARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWHA
MAB_4499|M.abscessus_ATCC_1997 PDYISGWRTQLFGSTPPSARLGIVAAVVLLVAESMLTIFLRTIAPTEHLA
Mflv_2281|M.gilvum_PYR-GCK ------------------ASMLVGGAAASVWFWIPLAILVIGISSIPSVI
Mvan_4385|M.vanbaalenii_PYR-1 ------------------ASLLVGGAIASVWFWVPLGILVIAVSSIPSVI
MSMEG_4968|M.smegmatis_MC2_155 --------------------MVTGAAIATVWFWIPLAIMIIGVSSIPSVI
TH_1533|M.thermoresistible__bu ------------------ASMVTGAAIALVWFWIPLTILIVGISSIPSVI
Mb2052c|M.bovis_AF2122/97 RLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASV
Rv2027c|M.tuberculosis_H37Rv RLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASV
MMAR_1517|M.marinum_M RVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MAV_4108|M.avium_104 NLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAA
MAB_4499|M.abscessus_ATCC_1997 AVYLIG---ILVISVIWRLRLALAMSIASAIVFDCIRNWPKANPLSTESH
. . . . .
Mflv_2281|M.gilvum_PYR-GCK G----------FLVAAVVFVYLMRGVDHVERVRNEAVFGMGIAVPPRRLS
Mvan_4385|M.vanbaalenii_PYR-1 G----------FLLAGVVFIYLIRGVDHVERVRSEAVFGMGIPVPPRALS
MSMEG_4968|M.smegmatis_MC2_155 G----------FLLAGVVFIYLMRGVEWVERARSEAVFALNISIPPRPRT
TH_1533|M.thermoresistible__bu G----------FLLAGVVFIYLIRGVEWVERIRSEAVFGMGIPIPPRRLS
Mb2052c|M.bovis_AF2122/97 GFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA
Rv2027c|M.tuberculosis_H37Rv GFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA
MMAR_1517|M.marinum_M GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MAV_4108|M.avium_104 GFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALA
MAB_4499|M.abscessus_ATCC_1997 NLITHLSFLAVTLTASALAALARAGTIEAERRRREAAAIAQQQAALRRTA
. * . * : :
Mflv_2281|M.gilvum_PYR-GCK HYTGFQRWAHQLWLDISSARFWKAVAHHYVRLTYDALAT----ALAAGLL
Mvan_4385|M.vanbaalenii_PYR-1 HYTGFQRWAHQLWLDLSSARFWKTVAHHYLRMAYDALVT----GLAFALT
MSMEG_4968|M.smegmatis_MC2_155 HHSGFQGWAHQLWLDVSSTRFWKGVAHHYLRMIYDLLAA----GIAFALL
TH_1533|M.thermoresistible__bu PHTGFQRWAHQLWLDISSARFWKAAAHHYLRMSYDMLAV----GVAFALL
Mb2052c|M.bovis_AF2122/97 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADP-AMVFRLIAEE
Rv2027c|M.tuberculosis_H37Rv AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADP-AMVFRLIAEE
MMAR_1517|M.marinum_M AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRLVAEE
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRLVAEE
MAV_4108|M.avium_104 FAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAER
MAB_4499|M.abscessus_ATCC_1997 TLVASNVSPVELYAKVVEEAARCFASPTAVLVQLMPGDE---GTIVAGHG
. .:: .: .
Mflv_2281|M.gilvum_PYR-GCK AFAFLAPAAAVATGHSDPEAGLS-----------FLPTPLAWLLAVVALA
Mvan_4385|M.vanbaalenii_PYR-1 VFAFLAPAAAIAIGHSDPEAGLS-----------FLPTPLAWLLALVALA
MSMEG_4968|M.smegmatis_MC2_155 AFAFIGPAASMAIRDSDDDAGLV-----------FLSPPIAWLLAVIAVA
TH_1533|M.thermoresistible__bu AFAFLGPAGAIAVRNSDDNAGLT-----------FLPPALAVVLAVIAVA
Mb2052c|M.bovis_AF2122/97 ALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTVAVS
Rv2027c|M.tuberculosis_H37Rv ALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTVAVS
MMAR_1517|M.marinum_M ALKLTSADAALVAVPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAVA
MUL_2422|M.ulcerans_Agy99 ALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAVA
MAV_4108|M.avium_104 ACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPVR
MAB_4499|M.abscessus_ATCC_1997 TEESRTPPAGKRFPLLDSNNVAR-----------ELRLTPAVCAPIVVDA
. * : :
Mflv_2281|M.gilvum_PYR-GCK AAVAVVVFGPALDARIDRWLLP----------------------------
Mvan_4385|M.vanbaalenii_PYR-1 AAAALVAFAPTLDAMIDRWLLP----------------------------
MSMEG_4968|M.smegmatis_MC2_155 AAAAILVFAPALDAAIDRWLLS----------------------------
TH_1533|M.thermoresistible__bu AAAAILFFAPAVDARIDRWLLP----------------------------
Mb2052c|M.bovis_AF2122/97 GTSIGGVFHDRTPRRFDRLDLA-VDGPVEPG--PALVLPLRAADTVAGVL
Rv2027c|M.tuberculosis_H37Rv GTSIGGVFHDRTPRRFDRLDLA-VDGPVEPG--PALVLPLRAADTVAGVL
MMAR_1517|M.marinum_M GTALAEVLLDSAPRQVDKIAVEGVDELGDTG--PALVLPLRATDAVAGVV
MUL_2422|M.ulcerans_Agy99 GTALAEVLLDSAPRQVDKIAVEDVDELGDMG--PALVLPLRATDAVAGVV
MAV_4108|M.avium_104 GSTSGAVFKSGEPLITDEFRYP-IQAFTDAGRRPAIVMPLRARDEVVGVI
MAB_4499|M.abscessus_ATCC_1997 KHWGTLIVGSHTPAQRDQDIRAG---------------------------
. *.
Mflv_2281|M.gilvum_PYR-GCK --------PSETAALQHEVSALADARAGAVTSAQT-----------ERHR
Mvan_4385|M.vanbaalenii_PYR-1 --------PSSTAELQHQVTALADARQGAVTSAQT-----------ERHR
MSMEG_4968|M.smegmatis_MC2_155 --------PSPTAALQHRVNALADAREGAVSSAQT-----------ERHR
TH_1533|M.thermoresistible__bu --------PSSTEALQHQVSALSDARAGAVSSAQT-----------ERHR
Mb2052c|M.bovis_AF2122/97 VALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDR
Rv2027c|M.tuberculosis_H37Rv VALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDR
MMAR_1517|M.marinum_M VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVMTERDR
MUL_2422|M.ulcerans_Agy99 VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDR
MAV_4108|M.avium_104 AIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
MAB_4499|M.abscessus_ATCC_1997 -------VRDFADLVATAIANAATREELAASRARIVS-----ASDTARRR
: : * * * *
Mflv_2281|M.gilvum_PYR-GCK IERDLHDSVQPRLVSLAMTIGLAQTKLDSDPPTARALIAEAHDEAKNALV
Mvan_4385|M.vanbaalenii_PYR-1 IERDLHDSVQPRLVSLAMTIGLAQTKLDSDLPAAKALIAEAHDDAKNALV
MSMEG_4968|M.smegmatis_MC2_155 IERDLHDSVQPRLVSLAMTIGLAQTKLDSDLPAAKELIAEAHDEAKNALV
TH_1533|M.thermoresistible__bu IERDLHDSVQPRLVSLAMTIGLAQTKLDTDLPAAKKLIAEAHEDAKSALA
Mb2052c|M.bovis_AF2122/97 IARDLHDHVIQRLFAVGLTLQGAAPRARV--PAVRESIYSSIDDLQEIIQ
Rv2027c|M.tuberculosis_H37Rv IARDLHDHVIQRLFAVGLTLQGAAPRARV--PAVRESIYSSIDDLQEIIQ
MMAR_1517|M.marinum_M IARDLHDHVIQRLFAIGLALQGSVPRTRE--PKVQQRLSEVIDDLQGVIQ
MUL_2422|M.ulcerans_Agy99 IARDLHDHVIQRLFAIGLALQGSVPRTRE--PKVQQRLSEVIDDLQGVIQ
MAV_4108|M.avium_104 IAHDLHDHVIQRLFAAGMDLQGTLARARS--PEVADRLNRTLDDLQTIIE
MAB_4499|M.abscessus_ATCC_1997 LERDLHDGAQQRLAYLRLKLGMVRAAVPATDAELTQELNNLDTDLTAVTR
: :**** . ** : : . . : :
Mflv_2281|M.gilvum_PYR-GCK ELRNVVRGIAPTILADRGLDAALSSVVQRANNS-GVSTTLSVHLPR-RLP
Mvan_4385|M.vanbaalenii_PYR-1 ELRNVVRGIAPTILSDRGLDAALSSVVQRSANS-GVPTTLSVHLPH-RLP
MSMEG_4968|M.smegmatis_MC2_155 ELRNVVRGIAPTILADRGLDAALSSVAQRAQNS-GVPTTLDVHLPH-RLP
TH_1533|M.thermoresistible__bu ELRDVVRGIAPTILTDRGLDAALSAVVQRAETS-GVPTTLNLHLPR-RLP
Mb2052c|M.bovis_AF2122/97 EIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIP-ALHTTVQYTGPLSVVD
Rv2027c|M.tuberculosis_H37Rv EIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIP-ALHTTVQYTGPLSVVD
MMAR_1517|M.marinum_M EIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSVVD
MUL_2422|M.ulcerans_Agy99 EIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSVVD
MAV_4108|M.avium_104 EIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVG
MAB_4499|M.abscessus_ATCC_1997 ELQEFSRGLHPAILS-KGLAPALRTLARRSLIP--VRTELELDQKY---G
*:: : : : : * :
Mflv_2281|M.gilvum_PYR-GCK DEVEACAYFVVAEALTNVSRHSSASNAAVTVRLDEAANQLHVSVFDDGRG
Mvan_4385|M.vanbaalenii_PYR-1 DEVEACAYFVVAEALTNVSRHSGASHAAVTVRLDESANQLHVSVFDDGRG
MSMEG_4968|M.smegmatis_MC2_155 DEVESVAYFVAAEALTNVIRHAQANQAVVTVRLDEPSATLHVSVFDDGKG
TH_1533|M.thermoresistible__bu EEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNETDNTLQVSVFDDGCG
Mb2052c|M.bovis_AF2122/97 TVLANHAEAVLREAVSNAVRHANATSLAINVSVED---DVRVEVVDDGVG
Rv2027c|M.tuberculosis_H37Rv TVLANHAEAVLREAVSNAVRHANATSLAINVSVED---DVRVEVVDDGVG
MMAR_1517|M.marinum_M NVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD---DLCIEVSDNGRG
MUL_2422|M.ulcerans_Agy99 NVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD---DLCIEVSDNGRG
MAV_4108|M.avium_104 AELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVAD---MFTLDVIDNGRG
MAB_4499|M.abscessus_ATCC_1997 ESIEIAAYYVVAEALANTAKHSQASEVVIRAHEAD--DQIHITISDDGIG
: * * **::*. :*: *. .: : . : : *:* *
Mflv_2281|M.gilvum_PYR-GCK GARVVDGDDTVDATGLRGLDERVRAARGTFTVSSPPTGP-TIVTAVLPCG
Mvan_4385|M.vanbaalenii_PYR-1 GARIVGDDGDMDATGLRGLDERVRAARGTFSVSSPVTGP-TIVTAVLPCG
MSMEG_4968|M.smegmatis_MC2_155 GARIESDA---NATGLRGLAERVRAAGGTFDVSSPATGP-TIVTAVLPCG
TH_1533|M.thermoresistible__bu SAQISDRD---NATGLRGLAERVRAAHGTFTVSSPPTGP-TIVTAVLPCG
Mb2052c|M.bovis_AF2122/97 ---ISGDIT---ESGLRNLRQRADDAGGEFTVENMPTGG-TLLRWSAPLR
Rv2027c|M.tuberculosis_H37Rv ---ISGDIT---ESGLRNLRQRADDAGGEFTVENMPTGG-TLLRWSAPLR
MMAR_1517|M.marinum_M ---MPKTYT---SSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLI
MUL_2422|M.ulcerans_Agy99 ---MPKTYT---SSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLI
MAV_4108|M.avium_104 ---IAAGNTR--RSGLANMTRRAEQLGGSCEISSPPGGG-TRVHWTAPLL
MAB_4499|M.abscessus_ATCC_1997 ------GAKPRKGTGLIGLTDRVTALGGRLDVHSASGRG-TTMTAIIPLH
:** .: *. * : . * : *
Mflv_2281|M.gilvum_PYR-GCK S--
Mvan_4385|M.vanbaalenii_PYR-1 S--
MSMEG_4968|M.smegmatis_MC2_155 S--
TH_1533|M.thermoresistible__bu S--
Mb2052c|M.bovis_AF2122/97 ---
Rv2027c|M.tuberculosis_H37Rv ---
MMAR_1517|M.marinum_M Q--
MUL_2422|M.ulcerans_Agy99 Q--
MAV_4108|M.avium_104 DH-
MAB_4499|M.abscessus_ATCC_1997 QSD