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PTRFLERVVRSPARPLGLGIAVAAGFLAAEVLAVFALKKIAPENAFGALLLLGVLVVSAGWGFGLSIATS LASAAVYAYLHLEGRDSLAPALIIFLTLALLTNALVGQARLRAAEAEQRRREADLSADLARVMLRAPALG PALEDAGRRFADVLGLPYATLTVGGGATGADEMAIDLVDGAEHTGTLLVPRDLPLASVRRIHRMVPSLQA LLAAACDREDITAELEASRRELERFFAVASDLLFIGTYVDGVAQLTRVNPAFERALGYSAAELAARPLTE FIHPDDRDGTAAALDSVPQTDGATQFENRSLRRDGGVRWLEWNVVSDRGVLLGGARDVTERRREQDRLRM ARTQQAALRRVATLVARGAPLSEVYDVAVTELAHSLGVNHVTLLAFEADDHAVVRAALKSAHQPGFAVGD RLSLDGGSISEQVHRTGLPARIDDYSEVPGRIATRLRELGIRSAAGSPLTVDGGTRGVLVVGSHAVQGVP DGTEAHIGDFADLISTAIANAETRAELTASRARIVAAADEARRGFERDLHDGAQQRIVSLSLQLREAEAA VEGDEALRTQLSTVVNGLAGLHSDLQELSRGLHPAVLSRGGLKPAMRNLARRSTVPVELTVDIDRRLPEP VEVAAYYVVAESLTNVAKHAQADSVTVEIGLDDAPDGGTLLRLSVTDDGTGGASADGGSGLVGLRDRVEA LSGQLTVTSRPGDGTSISATIPVD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | - | 100% (725) | multi-sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 1e-29 | 34.14% (290) | GAF sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_0262 | - | 1e-29 | 36.97% (211) | putative signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 8e-18 | 29.66% (236) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_2281 | - | 7e-30 | 37.00% (227) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 2e-18 | 30.08% (236) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-67 | 41.12% (394) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4781 | - | 3e-17 | 28.46% (246) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 1e-17 | 31.98% (222) | hypothetical protein MAV_0874 |
| M. smegmatis MC2 155 | MSMEG_2248 | - | 0.0 | 58.67% (721) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 4e-31 | 38.03% (213) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 2e-17 | 28.46% (246) | two component sensor kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0868|M.bovis_AF2122/97 -----------------------------------------------MPS
Rv0845|M.tuberculosis_H37Rv -----------------------------------------------MPS
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 ---------MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPS
MAV_0874|M.avium_104 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 MPTRFLERVVRSPARPLGLGIAVAAGFLAAEVLAVFALKKIAPENAFGAL
MSMEG_2248|M.smegmatis_MC2_155 ----------------MHWGIVVATAFIVAEIVLVHLFKRVAPENAFGAI
MAB_4499|M.abscessus_ATCC_1997 -------------------------------------MQQAAQASSPRPI
Mflv_2281|M.gilvum_PYR-GCK ----------------------------------MSAVTDTDTGADTAPV
TH_1533|M.thermoresistible__bu ----------------------------------MVAVT-----AETAPA
Mb0868|M.bovis_AF2122/97 YGNLGRLGG-RHEYGVLVAMTSSAELDR----------------VRWAHQ
Rv0845|M.tuberculosis_H37Rv YGNLGRLGG-RHEYGVLVAMTSSAELDR----------------VRWAHQ
MMAR_4781|M.marinum_M ------------------MVTSDAELAR----------------VRRTHQ
MUL_0350|M.ulcerans_Agy99 CANYGQLVGSCRLYGVPVVVTSDAELAR----------------VRRTHQ
MAV_0874|M.avium_104 -----------------MAVAGDAELER----------------VRAVHQ
Mvan_2071|M.vanbaalenii_PYR-1 LLLGVLVVSAGWGFGLSIATSLASAAVYAYLHLEGRDSLAPALIIFLTLA
MSMEG_2248|M.smegmatis_MC2_155 FLMGVLVVSAGWSMPLAVATSLASTLAYIYIHLEGADSLAPAMFVFLPIA
MAB_4499|M.abscessus_ATCC_1997 LMP---DYISGWRTQLFGSTPPSARLG-----------IVAAVVLLVAES
Mflv_2281|M.gilvum_PYR-GCK DVPDQSGAPSGRTRTLSVAASASMLVG----------GAAASVWFWIPLA
TH_1533|M.thermoresistible__bu PAPT-------RTARLGVVPTASMVTG----------AAIALVWFWIPLT
. .
Mb0868|M.bovis_AF2122/97 LRSYRIASVLR---------------------------------------
Rv0845|M.tuberculosis_H37Rv LRSYRIASVLR---------------------------------------
MMAR_4781|M.marinum_M LRAYRIGSVLR---------------------------------------
MUL_0350|M.ulcerans_Agy99 LRAYRIGSVLR---------------------------------------
MAV_0874|M.avium_104 MRSYRIGSVLR---------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 LLTNALVGQARLRAAEAEQRRREADLSADLARVMLRAPALGPALEDAGRR
MSMEG_2248|M.smegmatis_MC2_155 LLTNLLAGQARSQTQEAEQRRREADLSAELARLMLGAGDLPHALERAGQR
MAB_4499|M.abscessus_ATCC_1997 MLTIFLRTIAP---------------TEHLAAVYL---------------
Mflv_2281|M.gilvum_PYR-GCK ILVIGIS-------------------------------------------
TH_1533|M.thermoresistible__bu ILIVGIS-------------------------------------------
: :
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 FADVLGLPYATLTVGGGATGADEMAIDLVDGAEHTGTLLVPRDLPLASVR
MSMEG_2248|M.smegmatis_MC2_155 MARVLDVPEVTLTTGRLEPDGDHHAIPLRSGDERIGTLLVPAQLPLNTLR
MAB_4499|M.abscessus_ATCC_1997 ----------------------------------IGILVIS---------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb0868|M.bovis_AF2122/97 ------IGVVGLMVAAMVVGTSRSEWPQQIVLIG----------------
Rv0845|M.tuberculosis_H37Rv ------IGVVGLMVAAMVVGTSRSEWPQQIVLIG----------------
MMAR_4781|M.marinum_M ------IGVVLFMVAAMLVGTPRREWGAQTALIC----------------
MUL_0350|M.ulcerans_Agy99 ------IGVVLFMVAAMLVGTPRREWGAQTALIC----------------
MAV_0874|M.avium_104 ------VGVVGLMVAAMIIGTARSEWPQESVLIL----------------
Mvan_2071|M.vanbaalenii_PYR-1 RIHRMVPSLQALLAAACDREDITAELEASRRELERFFAVASDLLFIGTYV
MSMEG_2248|M.smegmatis_MC2_155 RWQRMVPAIEALLTAAMDREHITAELETSRKELERFFDVASESLFISDHH
MAB_4499|M.abscessus_ATCC_1997 VIWRLRLALAMSIASAIVFDCIRNWPKANP--------------------
Mflv_2281|M.gilvum_PYR-GCK ----SIPSVIGFLVAAVVFVYLMRGVDHVER-------------------
TH_1533|M.thermoresistible__bu ----SIPSVIGFLLAGVVFIYLIRGVEWVER-------------------
.: : :.
Mb0868|M.bovis_AF2122/97 -----VYAVAALWALLLAYSASRRFFA-----------------------
Rv0845|M.tuberculosis_H37Rv -----VYAVAALWALLLAYSASRRFFA-----------------------
MMAR_4781|M.marinum_M -----VYAFAALWALALAFRRSRPMVS-----------------------
MUL_0350|M.ulcerans_Agy99 -----VYAFAALWALALAFRRSRPMVS-----------------------
MAV_0874|M.avium_104 -----LYGIIALGAVALAFAPFRRWIG-----------------------
Mvan_2071|M.vanbaalenii_PYR-1 DGVAQLTRVNPAFERALGYSAAELAARPLTEFIHPDDRDGTAAALDSVPQ
MSMEG_2248|M.smegmatis_MC2_155 T----LTRVNPAFTRTLGFTATELAQRPFMDLVHPDDRDNTRLALEELRT
MAB_4499|M.abscessus_ATCC_1997 -----LSTESHNLITHLSFLAVTLTASALAALAR----------------
Mflv_2281|M.gilvum_PYR-GCK ------VRNEAVFGMGIAVPPRRLSH------------------------
TH_1533|M.thermoresistible__bu ------IRSEAVFGMGIPIPPRRLSP------------------------
:
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 TDGATQFENRSLRRDGGVRWLEWNVVSDRGVLLGGARDVTERRREQDRLR
MSMEG_2248|M.smegmatis_MC2_155 DHREVQFENRCIRNDGETRWFQWSVVSDHGLLFGAGRDVTERRREQDRLR
MAB_4499|M.abscessus_ATCC_1997 -----------------------------------AGTIEAERRRREAAA
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb0868|M.bovis_AF2122/97 -------------------LRRFRSMGRLEPFAFTAVDVLILTGFQLLST
Rv0845|M.tuberculosis_H37Rv -------------------LRRFRSMGRLEPFAFTAVDVLILTGFQLLST
MMAR_4781|M.marinum_M -------------------LDRFANIARYEPLAFTAVDVLALTGFQLLST
MUL_0350|M.ulcerans_Agy99 -------------------LDRFANIARYEPLAFTAVDVLALTGFQLLST
MAV_0874|M.avium_104 -------------------IGRLAGVGRLEPFAFTVVDILALTIFQLLST
Mvan_2071|M.vanbaalenii_PYR-1 MAR--------------TQQAALRRVATLVARGAPLSEVYDVAVTELAHS
MSMEG_2248|M.smegmatis_MC2_155 EAQRQIEASHQEVSALATQQTALRRVATQVARGAKPDEVYPLAVGELSVG
MAB_4499|M.abscessus_ATCC_1997 IAQ---------------QQAALRRTATLVASNVSPVELYAKVVEEAARC
Mflv_2281|M.gilvum_PYR-GCK -------------------YTGFQRWAHQLWLDISSARFWKAVAHHYVRL
TH_1533|M.thermoresistible__bu -------------------HTGFQRWAHQLWLDISSARFWKAAAHHYLRM
: . . . .
Mb0868|M.bovis_AF2122/97 DGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVG---------------
Rv0845|M.tuberculosis_H37Rv DGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVG---------------
MMAR_4781|M.marinum_M DGIYSLLIMTLLPVLVALDISSRRAAVVLALTLVG---------------
MUL_0350|M.ulcerans_Agy99 DGIYSLLIMTLLPVLVALDISSRRAAVVLALTLVG---------------
MAV_0874|M.avium_104 NGIYPLLIMAMLPVLLGLDVSSRRAAVVLIFSMLG---------------
Mvan_2071|M.vanbaalenii_PYR-1 LGVNHVTLLAFEADDHAVVRAALKSAHQPGFAVGDRLSLDGGSISEQVHR
MSMEG_2248|M.smegmatis_MC2_155 IGVSHSTLLRYESESTAVVVAALDTESVERLQVGDKVPLEGDSLAVRILR
MAB_4499|M.abscessus_ATCC_1997 FASPTAVLVQLMPGDEGTIVAGHGTEESRTPPAGKRFPLLD---------
Mflv_2281|M.gilvum_PYR-GCK TYDALATALAAGLLAFAFLAPAAAVATGHSDPE-----------------
TH_1533|M.thermoresistible__bu SYDMLAVGVAFALLAFAFLGPAGAIAVRNSDDN-----------------
: . .
Mb0868|M.bovis_AF2122/97 ------------------------FAVAVLGDPVMLRAIGWPETIFRFAL
Rv0845|M.tuberculosis_H37Rv ------------------------FAVAVLGDPVMLRAIGWPETIFRFAL
MMAR_4781|M.marinum_M ------------------------FALALAQDPVVIRMNGWPEAIFRFGL
MUL_0350|M.ulcerans_Agy99 ------------------------FGLALAQDPVVIRMNGWPEAIFRFGL
MAV_0874|M.avium_104 ------------------------FAIAVLQDPVMSSSVRLPEAGFRFLL
Mvan_2071|M.vanbaalenii_PYR-1 TGLPARIDDYSEVPGRIATRLRELGIRSAAGSPLTVDGGTRGVLVVGSHA
MSMEG_2248|M.smegmatis_MC2_155 TGAPARIDSYAGLDSEIAMRLRGFGVRAGVAAPIIVDGHTWGALIAGTSG
MAB_4499|M.abscessus_ATCC_1997 -------------SNNVARELR---LTPAVCAPIVVDAKHWGTLIVGSHT
Mflv_2281|M.gilvum_PYR-GCK --------------------------AGLSFLPTPLAWLLAVVALAAAVA
TH_1533|M.thermoresistible__bu --------------------------AGLTFLPPALAVVLAVIAVAAAAA
*
Mb0868|M.bovis_AF2122/97 YAFLCATALMVVRIEERHTRSVAGLSALREELLAQ---TMTASEVLQRRI
Rv0845|M.tuberculosis_H37Rv YAFLCATALMVVRIEERHTRSVAGLSALRAELLAQ---TMTASEVLQRRI
MMAR_4781|M.marinum_M YAFLCATALMVVRSEERHARSVATLSVIREELLAQ---TMTASEVLQRRI
MUL_0350|M.ulcerans_Agy99 YAFLCATALMVVRSEERHARSVATLSVIREELLAQ---TMTASEVLQRRI
MAV_0874|M.avium_104 YGFLCCAAFLVVRIEERHTRSVAGLSALREELLAQ---TMNASDVSQRRI
Mvan_2071|M.vanbaalenii_PYR-1 VQGVPDGTEAHIGDFADLISTAIANAETRAELTASRARIVAAADEARRGF
MSMEG_2248|M.smegmatis_MC2_155 DEPLPPGTEERVGDFADLVSTAIFNAESRAEITASRARIVAAADQARRRF
MAB_4499|M.abscessus_ATCC_1997 PAQRDQDIRAGVRDFADLVATAIANAATREELAASRARIVSASDTARRRL
Mflv_2281|M.gilvum_PYR-GCK VVVFGPALDARIDRWLLPPSETAALQHEVSALADARAGAVTSAQTERHRI
TH_1533|M.thermoresistible__bu ILFFAPAVDARIDRWLLPPSSTEALQHQVSALSDARAGAVSSAQTERHRI
: . : : ::: :: :
Mb0868|M.bovis_AF2122/97 AEAIHDGPLQDVLAARQELIELDAVTPGD-----ERVGRALAGLQSASER
Rv0845|M.tuberculosis_H37Rv AEAIHDGPLQDVLAARQELIELDAVTPGD-----ERVGRALAGLQSASER
MMAR_4781|M.marinum_M SESIHDGPLQDVLAARQELIELRAAAPHD-----QRVSTALAGLQSASDL
MUL_0350|M.ulcerans_Agy99 SESIHDGPLQDVLAARQELIELRAAAPHD-----QRVSTALAGLQSASDL
MAV_0874|M.avium_104 SEFIHDGPLQDILAVRQELVELDAAVPDD-----ERIGRALAGLQLASER
Mvan_2071|M.vanbaalenii_PYR-1 ERDLHDGAQQRIVSLSLQLREAEAAVEGD-EALRTQLSTVVNGLAGLHSD
MSMEG_2248|M.smegmatis_MC2_155 ERDLHDGAQQRIVSLGLELRAVQASVPDENTALQDQMSHVVDGLAGLYAD
MAB_4499|M.abscessus_ATCC_1997 ERDLHDGAQQRLAYLRLKLGMVRAAVPATDAELTQELNNLDTDLTAVTRE
Mflv_2281|M.gilvum_PYR-GCK ERDLHDSVQPRLVSLAMTIGLAQTKLDSDPPTARALIAEAHDEAKNALVE
TH_1533|M.thermoresistible__bu ERDLHDSVQPRLVSLAMTIGLAQTKLDTDLPAAKKLIAEAHEDAKSALAE
. :**. : : : :
Mb0868|M.bovis_AF2122/97 LRQATFELHPAVLEQVGLGPAVKQLAASTAQR-SGIKISTDIDYPIRSGI
Rv0845|M.tuberculosis_H37Rv LRQATFELHPAVLEQVGLGPAVKQLAASTAQR-SGIKISTDIDYPIRSGI
MMAR_4781|M.marinum_M LRQATFELHPAVLEQVGLGAAVEQLASFHAQR-SGIRITDDVDYPIRDEI
MUL_0350|M.ulcerans_Agy99 LRQATFELHPAVLEQVGLGAAVEQLASFHAQR-SGIRITDDVDYPIRDEI
MAV_0874|M.avium_104 LRQATFELHPAVLEQVGLGAAVQQLAEFTAQR-SGIEISTDIDYSGRSAI
Mvan_2071|M.vanbaalenii_PYR-1 LQELSRGLHPAVLSRGGLKPAMRNLARRST---VPVELTVDIDRRLPEPV
MSMEG_2248|M.smegmatis_MC2_155 LQELSRGIHPAILSKGGLGPALRTLARRSS---VPVVLDIDVGHRLPESV
MAB_4499|M.abscessus_ATCC_1997 LQEFSRGLHPAILSKG-LAPALRTLARRSL---IPVRTELELDQKYGESI
Mflv_2281|M.gilvum_PYR-GCK LRNVVRGIAPTILADRGLDAALSSVVQRANNSGVSTTLSVHLPRRLPDEV
TH_1533|M.thermoresistible__bu LRDVVRGIAPTILTDRGLDAALSAVVQRAETSGVPTTLNLHLPRRLPEEV
*:: : *::* * .*: :. .: . :
Mb0868|M.bovis_AF2122/97 DPIVFGVVRELLSNVVRHSGATTASVRLGIT-----DEKCVLDVADDGVG
Rv0845|M.tuberculosis_H37Rv DPIVFGVVRELLSNVVRHSGATTASVRLGIT-----DEKCVLDVADDGVG
MMAR_4781|M.marinum_M DPIVFGVARELLSNVVQHSRARNASVALGIS-----DGVCVLDVADDGVG
MUL_0350|M.ulcerans_Agy99 DPIVFGVARELLSNVVQHSRARNASVALGIS-----DGVCVLDVADDGVG
MAV_0874|M.avium_104 DAVVFGVVRELLSNVVQHSRARTAAIMLGRT-----DGTCVLHVVDDGVG
Mvan_2071|M.vanbaalenii_PYR-1 EVAAYYVVAESLTNVAKHAQADSVTVEIGLDDAPDGGTLLRLSVTDDGTG
MSMEG_2248|M.smegmatis_MC2_155 EVAAYYVVAEALTNAAKHASASEVAVRAAAD-----GDELAVSVSDDGIG
MAB_4499|M.abscessus_ATCC_1997 EIAAYYVVAEALANTAKHSQASEVVIRAHEA-----DDQIHITISDDGIG
Mflv_2281|M.gilvum_PYR-GCK EACAYFVVAEALTNVSRHSSASNAAVTVRLD---EAANQLHVSVFDDGRG
TH_1533|M.thermoresistible__bu ESVAYFVVAEALTNVVKHAQASQAVVTVRLN---ETDNTLQVSVFDDGCG
: .: *. * *:*. :*: * . : : : *** *
Mb0868|M.bovis_AF2122/97 VTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLK
Rv0845|M.tuberculosis_H37Rv VTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLK
MMAR_4781|M.marinum_M VSGETMARRLGQGHIGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLK
MUL_0350|M.ulcerans_Agy99 VSGETMARRLGQGHIGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLK
MAV_0874|M.avium_104 FNQETVARRLGEGHIGLASHRARVEAAGGELVFLDVP-VGTHVCVEVPLR
Mvan_2071|M.vanbaalenii_PYR-1 GASADGGS-------GLVGLRDRVEALSGQLTVTSRPGDGTSISATIPVD
MSMEG_2248|M.smegmatis_MC2_155 GAVSGGGS-------GLIGLKDRVEALSGRLEVSSPPGAGTTLSVRIPLD
MAB_4499|M.abscessus_ATCC_1997 GAKPRKGT-------GLIGLTDRVTALGGRLDVHSASGRGTTMTAIIPLH
Mflv_2281|M.gilvum_PYR-GCK GARVVDGDDT-VDATGLRGLDERVRAARGTFTVSSPPTGPTIVTAVLPCG
TH_1533|M.thermoresistible__bu SAQISDRD----NATGLRGLAERVRAAHGTFTVSSPPTGPTIVTAVLPCG
** . ** * * : . . * : . :*
Mb0868|M.bovis_AF2122/97 R--
Rv0845|M.tuberculosis_H37Rv R--
MMAR_4781|M.marinum_M G--
MUL_0350|M.ulcerans_Agy99 G--
MAV_0874|M.avium_104 N--
Mvan_2071|M.vanbaalenii_PYR-1 ---
MSMEG_2248|M.smegmatis_MC2_155 AA-
MAB_4499|M.abscessus_ATCC_1997 QSD
Mflv_2281|M.gilvum_PYR-GCK S--
TH_1533|M.thermoresistible__bu S--