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LRAAICHLREQLRRRGELIPVGLTWASLIAVDAALLLGGTIGTLQRPAADLPVSLTAFAIALSPTVAFFV FNMKMTPGPLWATWTASTALTLFVTSTPIRADFAPALLVLMVLVVATLASVVGGLLAAASAAALLLTAAA LHRLDAIVLYLGFIVVAWLLGYLMRTQRLLVAEQIEAQQMLAEHAAADERRRIAREVHDVIAHSLSITLL HVTGARRALQQDRDVDDAVEALEQAERLGRQAMADIRRTVGLLDNWPTKAAPTTPEPGLDDVASLVDGFR RAGLAVTLCVEGPADHVSPAVGLALYRITQESLANIAKHAPESKAGVVLDISPASARLAVTNILPAAVVA ARSPEGRGLRGMRQRVELLGGAIDVGPTRDGWSVCAEIPLQESDGSWRPWWCGKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5281 | - | - | 100% (406) | histidine kinase domain-containing protein |
| M. avium 104 | MAV_2508 | - | 2e-07 | 26.27% (217) | PAS domain-containing protein |
| M. avium 104 | MAV_4108 | - | 3e-06 | 22.73% (220) | GAF family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 7e-08 | 22.35% (358) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 2e-14 | 28.51% (235) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 2e-07 | 22.35% (358) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1521 | - | 1e-84 | 46.55% (391) | hypothetical protein MAB_1521 |
| M. marinum M | MMAR_0133 | - | 6e-13 | 28.29% (258) | two-component sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2813 | - | 6e-28 | 32.53% (292) | sensor kinase |
| M. thermoresistible (build 8) | TH_4203 | - | 1e-11 | 27.00% (237) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 7e-11 | 24.40% (336) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_5523 | - | 1e-110 | 54.88% (379) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------MPSYGNLGRLGG
Rv0845|M.tuberculosis_H37Rv --------------------------------------MPSYGNLGRLGG
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
MAV_5281|M.avium_104 --------------------------------------------------
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2813|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK -------------------------MTRPLLT-ADRELALLRELIQAASS
TH_4203|M.thermoresistible__bu ----------VTSGPHPDPVR---DLSEQLLT-ADRELVLLRELIQAASR
Mb0868|M.bovis_AF2122/97 -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIA-SVLRIGVVGLMVAAMVV
Rv0845|M.tuberculosis_H37Rv -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIA-SVLRIGVVGLMVAAMVV
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIG-SVLRIGVVLFMVAAMLV
MAV_5281|M.avium_104 -------MLRAAICHLREQLRRRGELIPVGLT-WASLIAVDAALLLGGTI
Mvan_5523|M.vanbaalenii_PYR-1 -------------------------MMPGGFS-WPIVVSIDVTLFIVSAV
MAB_1521|M.abscessus_ATCC_1997 ------------MDRFRETALRRRALVPYEFP-WTVPVVMYGSTLLIVGC
MSMEG_2813|M.smegmatis_MC2_155 -------------------------MATGELSGARRSLARQSVVIALLAA
MMAR_0133|M.marinum_M ----------------------------------MLALLDRTAALRHGAD
: .
Mflv_5015|M.gilvum_PYR-GCK GPGVEPLAAASARMITASTDSDVCFVHVLDDTERSLTLAGATPPFDSEVG
TH_4203|M.thermoresistible__bu GPGVEPLAAAAARMITAATASDVCFVHVLDDTERSLTLAGATPPFDKEVG
Mb0868|M.bovis_AF2122/97 GTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPF
Rv0845|M.tuberculosis_H37Rv GTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPF
MUL_0350|M.ulcerans_Agy99 GTPRREWGAQTALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPL
MAV_5281|M.avium_104 GTLQRPAADLPVSLTAFAIALSPTVAFFVFNMKMTPG-------------
Mvan_5523|M.vanbaalenii_PYR-1 AILQRPESQWWIAILGLAVAYSPYLVFFAVDISVSPAVE-----------
MAB_1521|M.abscessus_ATCC_1997 AVAQRGFTRPWVLLLAAGLALAPILIFIIAGRKLN---------------
MSMEG_2813|M.smegmatis_MC2_155 AVDVGIFASSGIFRVAFAAACAMTVLLVLADLALALPAHAT---------
MMAR_0133|M.marinum_M VVHRRLGADLAAGANRIAEDDTMEVVAVVGGRTEELN-------------
. .
Mflv_5015|M.gilvum_PYR-GCK KIRLPLGQGISGWVASHRQPVVIRRDKESDPRYLPFQSLRGRDFTSMVSV
TH_4203|M.thermoresistible__bu KIRLPLGQGISGWVASHREPVVITENKEADPRYLPFQSLRGRDFTSMVSV
Mb0868|M.bovis_AF2122/97 AFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACT
Rv0845|M.tuberculosis_H37Rv AFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACT
MUL_0350|M.ulcerans_Agy99 AFTAVDVLALTGFQLLSTDGIYSLLIMTLLPVLVALDISSRRAAVVLALT
MAV_5281|M.avium_104 ----PLWATWTASTALTLFVTSTPIRADFAPALLVLMVL---VVATLASV
Mvan_5523|M.vanbaalenii_PYR-1 --ALALGLAWMLAISIWLFGMSAPIEGDFAPVLLGLVTG---VIGSMTSM
MAB_1521|M.abscessus_ATCC_1997 ----TFWTVACGLSAVALFLTWPPNVVDAAPFLLMFTVG---EVGAMASV
MSMEG_2813|M.smegmatis_MC2_155 -AAVAIVQVVIRLAVCWLLSRHGLAAGIGDVGILVAGYRVGAWLPTRVAL
MMAR_0133|M.marinum_M GLVIGPQEGLGGQAAVLRRTVAVHDYCMSRDITHDFDHAVRAEGLRAAMV
.
Mflv_5015|M.gilvum_PYR-GCK PMETDPGGLVGVLNVHTVAERDFTDRDVELLLVIGRLIAGAMHQARLHRQ
TH_4203|M.thermoresistible__bu PMETDPGGLVGVLNVHTVERREFTRRDVDLLLVIGRLIAGGLHQARLHRQ
Mb0868|M.bovis_AF2122/97 LVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRS
Rv0845|M.tuberculosis_H37Rv LVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRS
MUL_0350|M.ulcerans_Agy99 LVGFGLALAQDPVVIRMNGWPEAIFRFGLYAFLCATALMVVRSEERHARS
MAV_5281|M.avium_104 VGGLLAAASAAALLLTAAALHRLDAIVLYLGFIVVA-WLLGYLMRTQRLL
Mvan_5523|M.vanbaalenii_PYR-1 RGGMLAAVTAAGILGAAVAMDRVDTPWLYLSFIGIG-WLVGYLMRIQQEL
MAB_1521|M.abscessus_ATCC_1997 RVGLAATSACAALLVVAEQLHHLGIFSLYMMFFVLCGWMMGHILQLQQRL
MSMEG_2813|M.smegmatis_MC2_155 LVVPLLAAGVSGAAVINGAGRTWREVVLIAVSNAVVPWLVGRYTAAGRAY
MMAR_0133|M.marinum_M APIVRAHRLYGLLYAARRSPVAWTDRDRAELLSLARQAAVAMEVADSARE
Mflv_5015|M.gilvum_PYR-GCK LVARERAHENFVEQVIEAQELERRRLAGDIHDGISQRLVTLSYRLDAAAQ
TH_4203|M.thermoresistible__bu LVARERAHEIFVEQVIEAQELERRRLAADIHDGISQRLVTLSYRLDAAIR
Mb0868|M.bovis_AF2122/97 VAGLSALREELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDA
Rv0845|M.tuberculosis_H37Rv VAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDA
MUL_0350|M.ulcerans_Agy99 VATLSVIREELLAQTMTASEVLQRRISESIHDGPLQDVLAARQELIELRA
MAV_5281|M.avium_104 VAEQIEAQQMLAEHAAAD---ERRRIAREVHDVIAHSLSITLLHVTGARR
Mvan_5523|M.vanbaalenii_PYR-1 LLEQREAQQKLAEHAAVD---ERRRIAREVHDVIAHSLTVTLLHVTGARR
MAB_1521|M.abscessus_ATCC_1997 ILQERAQQARIQEQAASD---ERRRIAREIHDVIAHSLSVTMLHLTGARR
MSMEG_2813|M.smegmatis_MC2_155 VDQLERHQQQQQAALERALADEREAIARDLHDVISHHVSAVGIHAGAARL
MMAR_0133|M.marinum_M MAEVAAFG-------------ERQRLAIRLHDSVGATLFSLRVALMSAQE
: :. :: :** :
Mflv_5015|M.gilvum_PYR-GCK AAKSPADHAALTEQLDRARELADLTLQEARAAISGLRPPV----------
TH_4203|M.thermoresistible__bu AVDDP---ATVTEQLSKARELADLTLEETRAAISGLRPPV----------
Mb0868|M.bovis_AF2122/97 VTPGD-------ERVGRALAGLQSASERLRQATFELHPAV----------
Rv0845|M.tuberculosis_H37Rv VTPGD-------ERVGRALAGLQSASERLRQATFELHPAV----------
MUL_0350|M.ulcerans_Agy99 AAPHD-------QRVSTALAGLQSASDLLRQATFELHPAV----------
MAV_5281|M.avium_104 ALQQD-------RDVDDAVEALEQAERLGRQAMADIRRTVGLLDNWPTKA
Mvan_5523|M.vanbaalenii_PYR-1 GLQED-------RDVDEAVEALEQAERLGRQAMADIRRTVGLLD---DAV
MAB_1521|M.abscessus_ATCC_1997 ALQED-------HDVDDAVAGLVDAERLGRQAMSDIRGTVGLLSAGPGGV
MSMEG_2813|M.smegmatis_MC2_155 ALGTD---------PDAVARSLAAVESASRSAMMDLRRQLDLLHG-----
MMAR_0133|M.marinum_M ETEPG----RREELLSDALVLTERATSELRAQTLSLHDLP----------
. . . * ::
Mflv_5015|M.gilvum_PYR-GCK -----LDDLGLAGGLASLARSIPQ-IGI----ETDLDDTRLADHIELALY
TH_4203|M.thermoresistible__bu -----LDDLGLSGGLASLAQSVGQ-LDIGVDIEVDLAETRLPDHIELALY
Mb0868|M.bovis_AF2122/97 -----LEQVGLGPAVKQLAASTAQ-RSG-IKISTDIDYP-IRSGIDPIVF
Rv0845|M.tuberculosis_H37Rv -----LEQVGLGPAVKQLAASTAQ-RSG-IKISTDIDYP-IRSGIDPIVF
MUL_0350|M.ulcerans_Agy99 -----LEQVGLGAAVEQLASFHAQ-RSG-IRITDDVDYP-IRDEIDPIVF
MAV_5281|M.avium_104 APT--TPEPGLD-DVASLVDGFRR-AGLAVTLCVEGPADHVSPAVGLALY
Mvan_5523|M.vanbaalenii_PYR-1 GKV--TPEPGVG-DIAMLVDDFVR-AGLAVRFESSGRHDRISGAAGLALY
MAB_1521|M.abscessus_ATCC_1997 EPMRLAPEPGIA-DIPGLVADFTA-AGMSVESHIYGSGEAVSAGVGLALY
MSMEG_2813|M.smegmatis_MC2_155 ADSAGERQPGLA-NVSHLVDTVRQ-AGLSVELELPDAMPALSQSLDVTVY
MMAR_0133|M.marinum_M ------EDKALAVTLEGDCRDFATRTGTAAELVVLGDLPLLDSARTDALR
: .: : . : :
Mflv_5015|M.gilvum_PYR-GCK RIAQECLQNVVKHARASAARLTFAVDDN----TARLEIADDGVGFD--TF
TH_4203|M.thermoresistible__bu RIAQECLQNVVKHARARTARLTYAVDRGEHGEVARLEIVDDGVGFD--TF
Mb0868|M.bovis_AF2122/97 GVVRELLSNVVRHSGATTASVRLGITDE----KCVLDVADDGVGVTGDTM
Rv0845|M.tuberculosis_H37Rv GVVRELLSNVVRHSGATTASVRLGITDE----KCVLDVADDGVGVTGDTM
MUL_0350|M.ulcerans_Agy99 GVARELLSNVVQHSRARNASVALGISDG----VCVLDVADDGVGVSGETM
MAV_5281|M.avium_104 RITQESLANIAKHAPESKAGVVLDISPA----SARLAVTNI-------LP
Mvan_5523|M.vanbaalenii_PYR-1 RIAQESLANIAKHAPDAVSELSLTVSPS----EAVLTVTNR-------LP
MAB_1521|M.abscessus_ATCC_1997 RVAQESLANIAKHSPRSSAAVLLDITGS----AASLTVSND-------LA
MSMEG_2813|M.smegmatis_MC2_155 RIVQELLTNALRHG-DGTARLQVRRTIN----EVIIDTSNP--------I
MMAR_0133|M.marinum_M RTAREALLNVEKHAGAHSVVVSLYRAEDG----VGLTVADDG-------T
.:* * * :*. : : :
Mflv_5015|M.gilvum_PYR-GCK EHPLGSDEMGGYGLLSMAERAEIVGGRLNIRSRPGSGTTVTATIPLHQGG
TH_4203|M.thermoresistible__bu EHPLGGDDMSGYGLLSMAERAEIVGGRLNIRSRPGAGTAVIATIPLPPAT
Mb0868|M.bovis_AF2122/97 ARRLG---EGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR--
Rv0845|M.tuberculosis_H37Rv ARRLG---EGHIGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR--
MUL_0350|M.ulcerans_Agy99 ARRLG---QGHIGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG--
MAV_5281|M.avium_104 AAVVAARSPEGRGLRGMRQRVELLGGAIDVGPTR-DGWSVCAEIPLQESD
Mvan_5523|M.vanbaalenii_PYR-1 VPVAAANCADGRGMRGMRQRVQQLGGTVNAGPDG-DGWVVHATIPLDDES
MAB_1521|M.abscessus_ATCC_1997 AGLRPDVCSGG-GLTGMRQRIEMLGGVFHAGRAE-DGWTVSASVPLESNG
MSMEG_2813|M.smegmatis_MC2_155 ADGRFSGESPGRGRAGVRRRAELFGGIMRDGSDDGLRWRTVVSIPVPPS-
MMAR_0133|M.marinum_M APDIASEHRRGLGLRATVERIERVGGWLSCTANEEGGGTVQAWVPAARAF
* . * : ** . . . :*
Mflv_5015|M.gilvum_PYR-GCK A--------------
TH_4203|M.thermoresistible__bu R--------------
Mb0868|M.bovis_AF2122/97 ---------------
Rv0845|M.tuberculosis_H37Rv ---------------
MUL_0350|M.ulcerans_Agy99 ---------------
MAV_5281|M.avium_104 GSWRPWWCGKA----
Mvan_5523|M.vanbaalenii_PYR-1 CVLR--GCGG-----
MAB_1521|M.abscessus_ATCC_1997 TDCRSRRRKVLWRHD
MSMEG_2813|M.smegmatis_MC2_155 ---------------
MMAR_0133|M.marinum_M RPVGP----------