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TTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAI VHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPA SIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKA RQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVA SIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFT DEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEV QQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALAD QAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLAS VPGASGTVLRWSAPLSQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3132c | devS | - | 100% (578) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. tuberculosis H37Rv | Rv2027c | - | 0.0 | 62.50% (560) | histidine kinase response regulator |
| M. tuberculosis H37Rv | Rv0845 | - | 1e-10 | 27.96% (186) | two component sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 0.0 | 99.83% (578) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 0.0 | 63.95% (577) | GAF sensor signal transduction histidine kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-147 | 50.96% (575) | histidine kinase response regulator |
| M. marinum M | MMAR_1517 | devS | 0.0 | 79.01% (567) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 1e-120 | 43.88% (547) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 0.0 | 66.96% (560) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 7e-81 | 65.56% (241) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 0.0 | 78.48% (567) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1395 | - | 0.0 | 64.77% (562) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
Mflv_3844|M.gilvum_PYR-GCK ----MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQIIR
Mvan_1395|M.vanbaalenii_PYR-1 ---------------------MRPLRDTLSQLRLRELLNEVQDRVEQIVE
MSMEG_5241|M.smegmatis_MC2_155 ------MGGVNGHHPRRDDDQRTPLRDTLSQLRLRELLSEVQDRVEQIVE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVGAQPNRVTAELAHLQLRELLAEVQGRIEQIVD
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
Rv3132c|M.tuberculosis_H37Rv G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
Mb3156c|M.bovis_AF2122/97 G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
MMAR_1517|M.marinum_M G-RDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRD
MUL_2422|M.ulcerans_Agy99 G-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRD
Mflv_3844|M.gilvum_PYR-GCK G-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRGHD
Mvan_1395|M.vanbaalenii_PYR-1 G-RDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYGALGVRGHD
MSMEG_5241|M.smegmatis_MC2_155 G-RDRLDGLVEAMLVVTSGLELDVTLRTIVHTAIELVDARYGALGVRGED
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSD
MAV_4108|M.avium_104 A-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWH
Rv3132c|M.tuberculosis_H37Rv HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
Mb3156c|M.bovis_AF2122/97 HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
MMAR_1517|M.marinum_M KRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPAS
MUL_2422|M.ulcerans_Agy99 KRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPAS
Mflv_3844|M.gilvum_PYR-GCK QELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHADS
Mvan_1395|M.vanbaalenii_PYR-1 HELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPAS
MSMEG_5241|M.smegmatis_MC2_155 HHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDIRLHPAS
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 EKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPAS
MAV_4108|M.avium_104 ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAA
Rv3132c|M.tuberculosis_H37Rv IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
Mb3156c|M.bovis_AF2122/97 IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
MMAR_1517|M.marinum_M IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MUL_2422|M.ulcerans_Agy99 IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
Mflv_3844|M.gilvum_PYR-GCK VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQAL
Mvan_1395|M.vanbaalenii_PYR-1 VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQAL
MSMEG_5241|M.smegmatis_MC2_155 VGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQAL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRAL
MAV_4108|M.avium_104 AGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
Rv3132c|M.tuberculosis_H37Rv AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
Mb3156c|M.bovis_AF2122/97 AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
MMAR_1517|M.marinum_M AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MUL_2422|M.ulcerans_Agy99 AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
Mflv_3844|M.gilvum_PYR-GCK AAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAG-VFRRVAD
Mvan_1395|M.vanbaalenii_PYR-1 AAAAGIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSK-VFRLVAD
MSMEG_5241|M.smegmatis_MC2_155 AAAAGIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPAT-VFRLVAA
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 AGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGK-ALHLVAS
MAV_4108|M.avium_104 AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAE
Rv3132c|M.tuberculosis_H37Rv EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASIVGRTIPV
Mb3156c|M.bovis_AF2122/97 EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASTVGRTIPV
MMAR_1517|M.marinum_M EALKLTSADAALVAVPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
Mflv_3844|M.gilvum_PYR-GCK RAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIA-AAHDPIPV
Mvan_1395|M.vanbaalenii_PYR-1 QSRLLSGAQSTLVAVRSDLDELDG-RVDELVVVATAGDGPG-VSLSAIPT
MSMEG_5241|M.smegmatis_MC2_155 EALTLTGADGTLVAVPADPDASA---AEELVIVEVAGAVPAEVEASAIPV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 SAALLAEADFAFIALPAGD---EE-DTAELVVAVCEGKGAEVLNDKLIPI
MAV_4108|M.avium_104 RACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPV
Rv3132c|M.tuberculosis_H37Rv AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
Mb3156c|M.bovis_AF2122/97 AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
MMAR_1517|M.marinum_M AGTALAEVLLDSAPRQVDKIAVEGVD-ELGDTGPALVLPLRATDAVAGVV
MUL_2422|M.ulcerans_Agy99 AGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVAGVV
Mflv_3844|M.gilvum_PYR-GCK AGTAIGDAFVHRTPGMTDRADIG-I---GATVGPALLLPLRAPDAVPGVL
Mvan_1395|M.vanbaalenii_PYR-1 HGSAIGEVFSTKTPVRFDTLELEPR---HLAPGPALVLPLRATDTVAGVL
MSMEG_5241|M.smegmatis_MC2_155 QDNAIGQAFRDRAPRRLDVLDGP------GLGGPALVLPLRATDTVAGVL
TH_0388|M.thermoresistible__bu ------------------------------------------------VL
MAB_3890c|M.abscessus_ATCC_199 DGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVL
MAV_4108|M.avium_104 RGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVI
*:
Rv3132c|M.tuberculosis_H37Rv VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
Mb3156c|M.bovis_AF2122/97 VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
MMAR_1517|M.marinum_M VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVMTERDR
MUL_2422|M.ulcerans_Agy99 VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDR
Mflv_3844|M.gilvum_PYR-GCK IVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDRDR
Mvan_1395|M.vanbaalenii_PYR-1 VALRPEGAPPFNAEELDMMAAFVDQAALAWQLATTQRQLRELDVLTDRDR
MSMEG_5241|M.smegmatis_MC2_155 VAVQGSGARPFTAEQLEMMTGFADQAAVAWQLASSQRRMSELDILADRDR
TH_0388|M.thermoresistible__bu VVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSDRDR
MAB_3890c|M.abscessus_ATCC_199 ILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLADRDR
MAV_4108|M.avium_104 AIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
.. . *:: *. :** * * : :* ::::*:*
Rv3132c|M.tuberculosis_H37Rv IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
Mb3156c|M.bovis_AF2122/97 IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
MMAR_1517|M.marinum_M IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
MUL_2422|M.ulcerans_Agy99 IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
Mflv_3844|M.gilvum_PYR-GCK IARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVIQEI
Mvan_1395|M.vanbaalenii_PYR-1 IARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQEI
MSMEG_5241|M.smegmatis_MC2_155 IARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAVISEI
TH_0388|M.thermoresistible__bu IARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVIGEI
MAB_3890c|M.abscessus_ATCC_199 IARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVIQEI
MAV_4108|M.avium_104 IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEI
**:************ *: :*.: : * *: :*:*: :* **
Rv3132c|M.tuberculosis_H37Rv RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
Mb3156c|M.bovis_AF2122/97 RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
MMAR_1517|M.marinum_M RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
MUL_2422|M.ulcerans_Agy99 RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
Mflv_3844|M.gilvum_PYR-GCK RTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSVVDAG
Mvan_1395|M.vanbaalenii_PYR-1 RTAIFDLHGGHGGSNRLRQRLDEAIAQFT-ASDVHTTVQFSGPLSVVDPA
MSMEG_5241|M.smegmatis_MC2_155 RTAIFDLHHTAPGGTRLRQRLDEAIAQFS-GAGLHTTSQFVGPLSVVDAE
TH_0388|M.thermoresistible__bu RTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSVISAV
MAB_3890c|M.abscessus_ATCC_199 RTAIFDLHTNDES---LRATLRSTINELTAETGLRVSVRMSGPLDVVPAS
MAV_4108|M.avium_104 RTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAE
**:*: *: :* : . : .: . : **: .:
Rv3132c|M.tuberculosis_H37Rv LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP-DE
Mb3156c|M.bovis_AF2122/97 LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP-DE
MMAR_1517|M.marinum_M LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP-KT
MUL_2422|M.ulcerans_Agy99 LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP-KT
Mflv_3844|M.gilvum_PYR-GCK LADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIA-AD
Mvan_1395|M.vanbaalenii_PYR-1 LSDHAEAVVREAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGMP-AD
MSMEG_5241|M.smegmatis_MC2_155 LADHAEAVLREAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGIS-GP
TH_0388|M.thermoresistible__bu LADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGFPEGE
MAB_3890c|M.abscessus_ATCC_199 TSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIP-DV
MAV_4108|M.avium_104 LAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRGIAAGN
: .**** *****.:**. * : * : . * : : * *:* *:.
Rv3132c|M.tuberculosis_H37Rv FTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Mb3156c|M.bovis_AF2122/97 FTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
MMAR_1517|M.marinum_M YTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MUL_2422|M.ulcerans_Agy99 YTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
Mflv_3844|M.gilvum_PYR-GCK VTGSGLANLARRAQDVGGSFSVRRGAQV-GTTLTWRAPLP--
Mvan_1395|M.vanbaalenii_PYR-1 VTESGLTNLRQRAGDVGGTFTVESGDAG-GTRLRWCAPLR--
MSMEG_5241|M.smegmatis_MC2_155 VTESGLSNLRQRADQCGGELRIIDRPGG-GTILRWTAPLPD-
TH_0388|M.thermoresistible__bu VTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 VARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP--
MAV_4108|M.avium_104 TRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWTAPLLDH
***:.: .** . ** : *: : * .**