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VKPARTPAAALFRRVFLINGLIFALGTLILAVSPATVSPRIRLTEIPVLVVGLAVMLTANALLLRSSLAP LNRLAESMQRVDPPRRTDRVDGRGTGDLHHLIESFNAMLDRLETERSTASASALAAQENERQRIARELHD EIGQTLTVALLALKRAVDRAPESIRGELSDAKEIVRSSLDEVREIARRLRPDALEDLGLHSALNALCSDF AQASGISVVKHISPQLDRLKPDVELVCYRIVQESLTNVARHSGARKVWLDLHISTDELTLRIADDGRGGV LEEGAGINGMRERALLVNGTFTISSPEDGGTEVRLVIPMRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0854 | - | - | 100% (322) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 1e-22 | 31.60% (231) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_2804 | - | 6e-22 | 33.33% (210) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 1e-14 | 27.60% (279) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_2281 | - | 1e-25 | 34.21% (228) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 1e-14 | 27.60% (279) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | MLBr_00175 | - | 5e-06 | 26.47% (170) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_1521 | - | 6e-19 | 31.60% (212) | hypothetical protein MAB_1521 |
| M. marinum M | MMAR_0133 | - | 3e-17 | 33.01% (209) | two-component sensor histidine kinase |
| M. avium 104 | MAV_5281 | - | 5e-16 | 27.52% (327) | histidine kinase domain-containing protein |
| M. thermoresistible (build 8) | TH_1533 | - | 3e-24 | 33.02% (212) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 2e-14 | 28.24% (255) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1647 | - | 1e-109 | 66.23% (308) | histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0854|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1647|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------MSAVTD
TH_1533|M.thermoresistible__bu --------------------------------------------MVAVT-
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5281|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
MLBr_00175|M.leprae_Br4923 -------------------------------------MVRFAWRRRASLR
MSMEG_0854|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1647|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK TDTGADTAPVDVPDQSGAPSGRTRTLSVAASASMLVGGAAASVWFWIPLA
TH_1533|M.thermoresistible__bu ----AETAPAPAPT-------RTARLGVVPTASMVTGAAIALVWFWIPLT
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAB_1521|M.abscessus_ATCC_1997 -------------------MDRFRETALRRRALVPYEFPWTVPVVMYGST
MAV_5281|M.avium_104 --------------MLRAAICHLREQLRRRGELIPVGLTWASLIAVDAAL
MMAR_0133|M.marinum_M ---------------------------------MLALLDRTAALRHGADV
MLBr_00175|M.leprae_Br4923 ATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRA
MSMEG_0854|M.smegmatis_MC2_155 -------------MKPARTPAAALFRRVFLINGLIFALGT-------LIL
Mvan_1647|M.vanbaalenii_PYR-1 ---------------------------MFLINGLIFTLGT-------LAL
Mflv_2281|M.gilvum_PYR-GCK ILVIGISS-----IPSVIGFLVAAVVFVYLMRGVDHVERVRNEAVFGMGI
TH_1533|M.thermoresistible__bu ILIVGISS-----IPSVIGFLLAGVVFIYLIRGVEWVERIRSEAVFGMGI
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MAB_1521|M.abscessus_ATCC_1997 LLIVGCAVAQRGFTRPWVLLLAAGLALAPILIFIIAGRKLN--TFWTVAC
MAV_5281|M.avium_104 LLGGTIGTLQRPAADLPVSLTAFAIALSPTVAFFVFNMKMTPGPLWATWT
MMAR_0133|M.marinum_M VHRRLGADLAAGANRIAEDDTMEVVAVVGGRTEELNGLVIGPQEGLGGQA
MLBr_00175|M.leprae_Br4923 QLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGT
MSMEG_0854|M.smegmatis_MC2_155 AVSPATVSPRIRLT--------------------------EIPVLVVGLA
Mvan_1647|M.vanbaalenii_PYR-1 ALSPASVSSRIQLT--------------------------EVPVLAVGLV
Mflv_2281|M.gilvum_PYR-GCK AVPPRRLSHYTGFQRWAHQLWLDISSARFWKAVAHHYVRLTYDALATALA
TH_1533|M.thermoresistible__bu PIPPRRLSPHTGFQRWAHQLWLDISSARFWKAAAHHYLRMSYDMLAVGVA
Mb3156c|M.bovis_AF2122/97 GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
Rv3132c|M.tuberculosis_H37Rv GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MAB_1521|M.abscessus_ATCC_1997 GLSAVALFLTWPPNV-----------------VDAAP---FLLMFTVGEV
MAV_5281|M.avium_104 ASTALTLFVTSTPIR-----------------ADFAP---ALLVLMVLVV
MMAR_0133|M.marinum_M AVLRRTVAVHDYCMS---------------------------RDITHDFD
MLBr_00175|M.leprae_Br4923 AEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKLR
.
MSMEG_0854|M.smegmatis_MC2_155 VML----------------------------------TANALLLRSSLAP
Mvan_1647|M.vanbaalenii_PYR-1 IIL----------------------------------TANAVLVRSSLDP
Mflv_2281|M.gilvum_PYR-GCK AGL----------------------------------LAFAFLAPAAAVA
TH_1533|M.thermoresistible__bu FAL----------------------------------LAFAFLGPAGAIA
Mb3156c|M.bovis_AF2122/97 AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
Rv3132c|M.tuberculosis_H37Rv AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEA
MAB_1521|M.abscessus_ATCC_1997 GAMAS--------------------------------VRVGLAATSACAA
MAV_5281|M.avium_104 ATLAS--------------------------------VVGGLLAAASAAA
MMAR_0133|M.marinum_M HAVR-----------------------------------AEGLRAAMVAP
MLBr_00175|M.leprae_Br4923 WVLLIVG-------------------------------SLGVAVAAVAGG
MSMEG_0854|M.smegmatis_MC2_155 LNRLAESMQRVDPPRRTDR-------------------------------
Mvan_1647|M.vanbaalenii_PYR-1 LDELTTSMQRVDPPQRSDR-------------------------------
Mflv_2281|M.gilvum_PYR-GCK TGHSDPEAGLSFLPTPLAW-------------------------------
TH_1533|M.thermoresistible__bu VRNSDDNAGLTFLPPALAV-------------------------------
Mb3156c|M.bovis_AF2122/97 LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGA
Rv3132c|M.tuberculosis_H37Rv LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGA
MUL_2422|M.ulcerans_Agy99 LKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGT
MAB_1521|M.abscessus_ATCC_1997 LLVVAEQLHHLGIFSLYMM-------------------------------
MAV_5281|M.avium_104 LLLTAAALHRLDAIVLYLG-------------------------------
MMAR_0133|M.marinum_M IVRAHRLYGLLYAARRSPV-------------------------------
MLBr_00175|M.leprae_Br4923 MVTRAGLRPVGRLTEAAER-------------------------------
MSMEG_0854|M.smegmatis_MC2_155 -----------------------------------VDG------------
Mvan_1647|M.vanbaalenii_PYR-1 -----------------------------------LDD------------
Mflv_2281|M.gilvum_PYR-GCK -----------------------------------LLAVVALAAAVAVVV
TH_1533|M.thermoresistible__bu -----------------------------------VLAVIAVAAAAAILF
Mb3156c|M.bovis_AF2122/97 VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
Rv3132c|M.tuberculosis_H37Rv VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
MUL_2422|M.ulcerans_Agy99 ALAEVLLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVLLH
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5281|M.avium_104 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MSMEG_0854|M.smegmatis_MC2_155 -----RGTGDLHHLIESFNAMLDRLETERSTASASALAAQENERQRIARE
Mvan_1647|M.vanbaalenii_PYR-1 -----QGNGDLRDLITSFNSMLDRMEAERASSSAAILAAQESERQRIARE
Mflv_2281|M.gilvum_PYR-GCK FGPALDARIDRWLLPPSETAALQHEVSALADARAGAVTSAQTERHRIERD
TH_1533|M.thermoresistible__bu FAPAVDARIDRWLLPPSSTEALQHQVSALSDARAGAVSSAQTERHRIERD
Mb3156c|M.bovis_AF2122/97 QGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARD
Rv3132c|M.tuberculosis_H37Rv QGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARD
MUL_2422|M.ulcerans_Agy99 PSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDRIARD
MAB_1521|M.abscessus_ATCC_1997 -----FFVLCGWMMGHILQLQQRLILQERAQQARIQEQAASDERRRIARE
MAV_5281|M.avium_104 -----FIVVA-WLLGYLMRTQRLLVAEQIEAQQMLAEHAAADERRRIARE
MMAR_0133|M.marinum_M -----AWTDRDRAELLSLARQAAVAMEVADSAREMAEVAAFGERQRLAIR
MLBr_00175|M.leprae_Br4923 -----VARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTD
: *:
MSMEG_0854|M.smegmatis_MC2_155 LHDEIG---QTLTVALLALKRAVDRAP--ESIRGELSDAKEIVRSSLDEV
Mvan_1647|M.vanbaalenii_PYR-1 LHDEIG---QSLTVALLTLKRAIDRAP--AGPQPELEYTQQTIRACLGEV
Mflv_2281|M.gilvum_PYR-GCK LHDSVQPRLVSLAMTIGLAQTKLDSDP--PTARALIAEAHDEAKNALVEL
TH_1533|M.thermoresistible__bu LHDSVQPRLVSLAMTIGLAQTKLDTDL--PAAKKLIAEAHEDAKSALAEL
Mb3156c|M.bovis_AF2122/97 LHDHVIQR--LFAIGLALQGAVPHERN--PEVQQRLSDVVDDLQDVIQEI
Rv3132c|M.tuberculosis_H37Rv LHDHVIQR--LFAIGLALQGAVPHERN--PEVQQRLSDVVDDLQDVIQEI
MUL_2422|M.ulcerans_Agy99 LHDHVIQR--LFAIGLALQGSVPRTRE--PKVQQRLSEVIDDLQGVIQEI
MAB_1521|M.abscessus_ATCC_1997 IHDVIAHSLSVTMLHLTGARRALQEDHDVDDAVAGLVDAERLGRQAMSDI
MAV_5281|M.avium_104 VHDVIAHSLSITLLHVTGARRALQQDRDVDDAVEALEQAERLGRQAMADI
MMAR_0133|M.marinum_M LHDSVGATLFSLRVALMSAQEETEPGR----REELLSDALVLTERATSEL
MLBr_00175|M.leprae_Br4923 AGHELRTPLTSLRTNVELLIASMAPEAP-RLPDQEMADLRADVLAQIEEL
. : : : ::
MSMEG_0854|M.smegmatis_MC2_155 REIARRLRPDALEDLGLHSALNALCSDF------AQASGISVVKHISPQL
Mvan_1647|M.vanbaalenii_PYR-1 RDIARRLRPDALD-LGLAHALTALCNEY------ARATGVSVVTHVGHLP
Mflv_2281|M.gilvum_PYR-GCK RNVVRGIAPTILADRGLDAALSSVVQR-------ANNSGVSTTLSV-HLP
TH_1533|M.thermoresistible__bu RDVVRGIAPTILTDRGLDAALSAVVQR-------AETSGVPTTLNL-HLP
Mb3156c|M.bovis_AF2122/97 RTTIYDLHGASQGITRLRQRIDAAVAQ-------FADSGLRTSVQFVGPL
Rv3132c|M.tuberculosis_H37Rv RTTIYDLHGASQGITRLRQRIDAAVAQ-------FADSGLRTSVQFVGPL
MUL_2422|M.ulcerans_Agy99 RTTIFDLHGSSQGVTRLRQRIDAAVAA-------FGSSGLRTTVQFIGPL
MAB_1521|M.abscessus_ATCC_1997 RGTVGLLSAGPGGVEPMRLAPEPGIADIPGLVADFTAAGMSVESHIYGSG
MAV_5281|M.avium_104 RRTVGLLDNWPTKAAPT--TPEPGLDDVASLVDGFRRAGLAVTLCVEGPA
MMAR_0133|M.marinum_M RAQTLSLH-DLPEDKALAVTLEGDCRDF------ATRTGTAAELVVLGDL
MLBr_00175|M.leprae_Br4923 STLVGDLVDLTRDDAGQVVHEPIDMSEVLYRSLERVRRRRNDIHFDVQAI
:
MSMEG_0854|M.smegmatis_MC2_155 DRLKPDVELVCYRIVQESLTNVARHSGA--RKVWLDLHISTDELTLRIAD
Mvan_1647|M.vanbaalenii_PYR-1 AQLDPQIELVCYRIAQESLTNVARHARP--RKVWVEAHAASDELVMRIAD
Mflv_2281|M.gilvum_PYR-GCK RRLPDEVEACAYFVVAEALTNVSRHSSASNAAVTVRLDEAANQLHVSVFD
TH_1533|M.thermoresistible__bu RRLPEEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNETDNTLQVSVFD
Mb3156c|M.bovis_AF2122/97 SVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKV---DDDLCIEVTD
Rv3132c|M.tuberculosis_H37Rv SVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKV---DDDLCIEVTD
MUL_2422|M.ulcerans_Agy99 SVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKV---DDDLCIEVSD
MAB_1521|M.abscessus_ATCC_1997 EAVSAGVGLALYRVAQESLANIAKHSPRSSAAVLLDITGSAASLTVSNDL
MAV_5281|M.avium_104 DHVSPAVGLALYRITQESLANIAKHAPESKAGVVLDISPASARLAVTNIL
MMAR_0133|M.marinum_M PLLDSARTDALRRTAREALLNVEKHAGA--HSVVVSLYRAEDGVGLTVAD
MLBr_00175|M.leprae_Br4923 GWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSD
. : : * : : * : :
MSMEG_0854|M.smegmatis_MC2_155 DGRGGVLE--------------------EGAGINGMRERALLVNGTFTIS
Mvan_1647|M.vanbaalenii_PYR-1 DG-GGIIR--------------------EGAGIRGMRERALLVDATVTIA
Mflv_2281|M.gilvum_PYR-GCK DGRGGARVVDGDDTV-------------DATGLRGLDERVRAARGTFTVS
TH_1533|M.thermoresistible__bu DGCGSAQISDRD----------------NATGLRGLAERVRAAHGTFTVS
Mb3156c|M.bovis_AF2122/97 NGRGLPDEF-------------------TGSGLTNLRQRAEQAGGEFTLA
Rv3132c|M.tuberculosis_H37Rv NGRGLPDEF-------------------TGSGLTNLRQRAEQAGGEFTLA
MUL_2422|M.ulcerans_Agy99 NGRGMPKTY-------------------TSSGLTNLRRRAQEAGGQFTIE
MAB_1521|M.abscessus_ATCC_1997 AAGLRPDVCS-------------------GGGLTGMRQRIEMLGGVFHAG
MAV_5281|M.avium_104 PAAVVAARSPE------------------GRGLRGMRQRVELLGGAIDVG
MMAR_0133|M.marinum_M DGTAPDIASEHR----------------RGLGLRATVERIERVGGWLSCT
MLBr_00175|M.leprae_Br4923 YGPGIPPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVE
. . *: . . .
MSMEG_0854|M.smegmatis_MC2_155 SPEDGG-TEVRLVIPMRGG-------------------------------
Mvan_1647|M.vanbaalenii_PYR-1 SGADG--TEVRLRIPLDGGPAA----------------------------
Mflv_2281|M.gilvum_PYR-GCK SPPTGP-TIVTAVLPCGS--------------------------------
TH_1533|M.thermoresistible__bu SPPTGP-TIVTAVLPCGS--------------------------------
Mb3156c|M.bovis_AF2122/97 SVPGASGTVLRWSAPLSQ--------------------------------
Rv3132c|M.tuberculosis_H37Rv SVPGASGTVLRWSAPLSQ--------------------------------
MUL_2422|M.ulcerans_Agy99 SPAAGGGTLLRWSAPLIQ--------------------------------
MAB_1521|M.abscessus_ATCC_1997 RAEDGWTVSASVPLESNGTDCRSRRRKVLWRHD-----------------
MAV_5281|M.avium_104 PTRDGWSVCAEIPLQESDGSWRPWWCGKA---------------------
MMAR_0133|M.marinum_M ANEEGGGTVQAWVPAARAFRPVGP--------------------------
MLBr_00175|M.leprae_Br4923 DTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQV
.
MSMEG_0854|M.smegmatis_MC2_155 ------------------------
Mvan_1647|M.vanbaalenii_PYR-1 ------------------------
Mflv_2281|M.gilvum_PYR-GCK ------------------------
TH_1533|M.thermoresistible__bu ------------------------
Mb3156c|M.bovis_AF2122/97 ------------------------
Rv3132c|M.tuberculosis_H37Rv ------------------------
MUL_2422|M.ulcerans_Agy99 ------------------------
MAB_1521|M.abscessus_ATCC_1997 ------------------------
MAV_5281|M.avium_104 ------------------------
MMAR_0133|M.marinum_M ------------------------
MLBr_00175|M.leprae_Br4923 SGKSANFRDSAHVISVDYQSARAR