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MPPGADTAELRWAMPDEPLSQVELRAVAHLTRVLGSTDDVTAVAQGLAEAIQAGRVNRDVYSYVYDTEAK ELVLTGATESPAAEHVGALRVAYGDGVTGWVAATKQSYLVPDEPARDPRFLAYPGIGEERYGAIFSVPIV SPRGEPLGCITVWATTGHRFDSGEVAFVERMAALVAPVFGTARQRQTSSRLLLVGSGLTELASMVASATP TGPTMDYAVEFLTEAAGLDVAVAFVTDPSGVDRMHMKVSTESDRARPELDGQQLLLVEQGVRNGITDWRT ASQLVNRALDGVAGAVTSAPMRVGPEEFGVIACYRLKPVRFTSEESAMVTAVANHAAVAIRLAVLSDELA ARNRLNWFLRDLSSGRLGAEELRRRAAAVGLDTANRHVFVVGSVSTKSMPHPESGPVSVALGELLAERAV LPQGTLYASTPHQTVAVVPWHGDNESIDTLRVPLLEVCTRLRAAGRAVTFGVSQPVSAPAELAGALAEAR EAMAIGSGLDNPNGVFTLDDVGHHLLLMRVSGVDSIRDRYATAIARIAEYDRVKGTELLETLSVFLHYRS QSAASRELYVHRNTLNQRLTRASTLSDVDVLEPSEWFPLQLALKVHQSRAGMPTGEPRRPQTYPEPRDGS G
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1604 | - | - | 100% (631) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 9e-20 | 24.71% (603) | transcriptional regulator, CdaR |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 5e-13 | 25.29% (261) | GAF sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1464 | - | 1e-05 | 30.83% (120) | hypothetical protein Mb1464 |
| M. gilvum PYR-GCK | Mflv_5015 | - | 8e-12 | 27.22% (169) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1429 | - | 1e-05 | 30.83% (120) | hypothetical protein Rv1429 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1391 | - | 8e-11 | 31.97% (147) | putative transcriptional regulator |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2195 | - | 3e-05 | 25.39% (256) | hypothetical protein MAV_2195 |
| M. smegmatis MC2 155 | MSMEG_6492 | - | 3e-17 | 24.56% (566) | GAF domain-containing protein |
| M. thermoresistible (build 8) | TH_4203 | - | 2e-11 | 22.60% (292) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1464|M.bovis_AF2122/97 -------------------------MAEAGGGPISVIARHMQLIRDDFIS
Rv1429|M.tuberculosis_H37Rv -------------------------MAEAGGGPISVIARHMQLIRDDFIS
Mflv_5015|M.gilvum_PYR-GCK -------------------------------------MTRPLLTADRELA
TH_4203|M.thermoresistible__bu -------------------------VTSGPHPDPVRDLSEQLLTADRELV
Mvan_1604|M.vanbaalenii_PYR-1 -------------------------MPPGADTAELRWAMPDEPLSQVELR
MSMEG_6492|M.smegmatis_MC2_155 MTWLGALRRLSASATAEEDLSHVLAEIAETARSLLGFDFCGVLLPDEQSR
MAV_2195|M.avium_104 ------------------------MNDNPFAGPFAKHPRSPLETLDTVPE
MAB_1391|M.abscessus_ATCC_1997 ------------------------MTASLSDRFMRRLPETARRAVDCFAA
:
Mb1464|M.bovis_AF2122/97 ELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAP
Rv1429|M.tuberculosis_H37Rv ELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAP
Mflv_5015|M.gilvum_PYR-GCK LLRELIQAASSGPGVEPLAAASARMITASTDSDVCFVHVLDDTERSLTLA
TH_4203|M.thermoresistible__bu LLRELIQAASRGPGVEPLAAAAARMITAATASDVCFVHVLDDTERSLTLA
Mvan_1604|M.vanbaalenii_PYR-1 AVAHLTRVLGSTDDVTAVAQGLAEAIQAGRVNRDVYSYVYDTEAKELVLT
MSMEG_6492|M.smegmatis_MC2_155 HLRVRGASGLSSDYVDRVNSDRPLVLHGGSPSSRAFHTAEAVAIRDVTAE
MAV_2195|M.avium_104 SVLRRLKQYSGRLATEAVSVMQDRLPFFADLEASQRASVSLVVQTAVVNF
MAB_1391|M.abscessus_ATCC_1997 EVPYYGMLPREVLDGEITEFTKQHFRIFARVMLESRAPTDDEFAVSILAA
: :
Mb1464|M.bovis_AF2122/97 A--------AAL-AYARAAAQRDIPL----SGLVRAHR--LGHARFLEVA
Rv1429|M.tuberculosis_H37Rv A--------AAL-AYARAAAQRDIPL----SGLVRAHR--LGHARFLEVA
Mflv_5015|M.gilvum_PYR-GCK G--------ATP-PFDSEVGKIRLPLGQGISGWVASHRQPVVIRRDKESD
TH_4203|M.thermoresistible__bu G--------ATP-PFDKEVGKIRLPLGQGISGWVASHREPVVITENKEAD
Mvan_1604|M.vanbaalenii_PYR-1 G--------ATESPAAEHVGALRVAYGDGVTGWVAATKQSYLVPDEPARD
MSMEG_6492|M.smegmatis_MC2_155 PGFELWAGIANEQGYRSMIAVPLVARGEVLGTLNGYYGAVHTYTRFEVER
MAV_2195|M.avium_104 AEWMQ-----DPKSNVRHTAQAFELVPQDLARRIALRHSVEMVRVTMEFF
MAB_1391|M.abscessus_ATCC_1997 S-----------RRAQEDIPLPAVLAVYNVAARVGIETLRELATPDEVDE
Mb1464|M.bovis_AF2122/97 MQYVS----LLEPADRVSTIIELVNRSARLVD------------------
Rv1429|M.tuberculosis_H37Rv MQYVS----LLEPADRVSTIIELVNRSARLVD------------------
Mflv_5015|M.gilvum_PYR-GCK PRYLP----FQSLRGRDFTSMVSVPMETDPGG------------------
TH_4203|M.thermoresistible__bu PRYLP----FQSLRGRDFTSMVSVPMETDPGG------------------
Mvan_1604|M.vanbaalenii_PYR-1 PRFLA----YPGIGEERYGAIFSVPIVSPRGEPLGCITVWATTGHRFDSG
MSMEG_6492|M.smegmatis_MC2_155 MTLLANHAAIAVSSARRLDELRALTASLRRQRDALTRSEQIHDRLLAVTL
MAV_2195|M.avium_104 EEVVP----LLARSEEQLTALTVGVLKYSRDLAFT---------------
MAB_1391|M.abscessus_ATCC_1997 VLAVS-------VQLQRYLQLMLPAVTAAYLE------------------
:. . :
Mb1464|M.bovis_AF2122/97 -----------------------------LVAD-----------------
Rv1429|M.tuberculosis_H37Rv -----------------------------LVAD-----------------
Mflv_5015|M.gilvum_PYR-GCK -----------------------------LVG------------------
TH_4203|M.thermoresistible__bu -----------------------------LVG------------------
Mvan_1604|M.vanbaalenii_PYR-1 EVAFVERMAALVAPVFGTARQRQTSSRLLLVGSGLTELASMVASATPTGP
MSMEG_6492|M.smegmatis_MC2_155 RSGGLDGIAAVLQGLIG---------RPILIDDIQHEVLACSVVTTDFPD
MAV_2195|M.avium_104 --------------------------------------------------
MAB_1391|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1464|M.bovis_AF2122/97 -----------------------------QLIVAYEHEHDRWLSRRSGLQ
Rv1429|M.tuberculosis_H37Rv -----------------------------QLIVAYEHEHDRWLSRRSGLQ
Mflv_5015|M.gilvum_PYR-GCK -------------------------------VLNVHTVAERDFTDRDVEL
TH_4203|M.thermoresistible__bu -------------------------------VLNVHTVERREFTRRDVDL
Mvan_1604|M.vanbaalenii_PYR-1 TMDYAVEFLTEAAGLDVAVAFVTDPSGVDRMHMKVSTESDRARPELDGQQ
MSMEG_6492|M.smegmatis_MC2_155 TTWRAAAEAGTGSSPVPVGQFDGTTYLASAVHLGDEVAARIWFPETSIDL
MAV_2195|M.avium_104 -------------------------------AATAYADAAEARGTWDSRM
MAB_1391|M.abscessus_ATCC_1997 -------------------------------------ERQGVYGAAADAR
Mb1464|M.bovis_AF2122/97 QQWVSELLADTPVDVPRAERALGYRLDGVH--------------------
Rv1429|M.tuberculosis_H37Rv QQWVSELLADTPVDVPRAERALGYRLDGVH--------------------
Mflv_5015|M.gilvum_PYR-GCK LLVIGRLIAGAMHQARLHRQLVARERAHEN--------------------
TH_4203|M.thermoresistible__bu LLVIGRLIAGGLHQARLHRQLVARERAHEI--------------------
Mvan_1604|M.vanbaalenii_PYR-1 LLLVEQGVRNGITDWRTASQLVNRALDGVAGAVTSAPMRVGPEEFGVIAC
MSMEG_6492|M.smegmatis_MC2_155 DPIMVRAVEHASIVTALELLRCQTAAEVEQR-------------------
MAV_2195|M.avium_104 EASVVDAVVRGDTGPELLSRAAALNWDTTAP-------------------
MAB_1391|M.abscessus_ATCC_1997 RDLFEALVKGMPWEEAAERASVTLALSYH---------------------
. :
Mb1464|M.bovis_AF2122/97 --------------------------IAAVVWVDSAVPIGDVVAQFDQVR
Rv1429|M.tuberculosis_H37Rv --------------------------IAAVVWVDSAVPIGDVVAQFDQVR
Mflv_5015|M.gilvum_PYR-GCK --------------------------FVEQVIEAQELERRRLAGDIHDGI
TH_4203|M.thermoresistible__bu --------------------------FVEQVIEAQELERRRLAADIHDGI
Mvan_1604|M.vanbaalenii_PYR-1 YRLKPVRFTSEESAMVTAVANHAAVAIRLAVLSDELAARNRLNWFLRDLS
MSMEG_6492|M.smegmatis_MC2_155 --------------------------LRGELLSDVLSSGAALSDRLLDRA
MAV_2195|M.avium_104 ----------------------------ATVVVGTPAPGRDGSTGPGDSE
MAB_1391|M.abscessus_ATCC_1997 -----------------------------VLFLYMPEPATNTVVARRRAH
:
Mb1464|M.bovis_AF2122/97 CLL---AGELGPELGPVANSLMVPTDEREARLWFS---------------
Rv1429|M.tuberculosis_H37Rv CLL---AGELGPELGPVANSLMVPTDEREARLWFS---------------
Mflv_5015|M.gilvum_PYR-GCK SQR---LVTLSYRLDAAAQAAKSPADHAALTEQLD---------------
TH_4203|M.thermoresistible__bu SQR---LVTLSYRLDAAIRAVDDP---ATVTEQLS---------------
Mvan_1604|M.vanbaalenii_PYR-1 SGR---LGAEELRRRAAAVGLDTANRHVFVVGSVSTKSMPHPESGPVSVA
MSMEG_6492|M.smegmatis_MC2_155 HRLGHDLTVPHIAIVGAFTGLDPVAERRAYERSLVLLAKESAAHRP----
MAV_2195|M.avium_104 RASQHVRDIAAQHGRAALTDVHGTWLVAIVSGQLS---------------
MAB_1391|M.abscessus_ATCC_1997 RVQ----DIVDEYAREPVLAALDGRGGTILLPAVG---------------
.
Mb1464|M.bovis_AF2122/97 --------------------PAPTRAFAPSRIRAAFESAGIRARLACGR-
Rv1429|M.tuberculosis_H37Rv --------------------PAPTRAFAPSRIRAAFESAGIRARLACGR-
Mflv_5015|M.gilvum_PYR-GCK --------------------RARELADLTLQEARAAISGLRPPVLDDLG-
TH_4203|M.thermoresistible__bu --------------------KARELADLTLEETRAAISGLRPPVLDDLG-
Mvan_1604|M.vanbaalenii_PYR-1 LGELLAERAVLPQGTLYASTPHQTVAVVPWHGDNESIDTLRVPLLEVCTR
MSMEG_6492|M.smegmatis_MC2_155 -------------KPVVAMHAGTIVMLWPAQDAADAAGAGEVVRQAMRAA
MAV_2195|M.avium_104 ----------------------PTDKFLGDLLEAFSDGPVVVG-------
MAB_1391|M.abscessus_ATCC_1997 ----------------------KVESLLPLFSEVAG-GPVTIGLS-----
.
Mb1464|M.bovis_AF2122/97 --------------VGDGLRGFRASLKQAERVKALALAGGARPGGRVMFY
Rv1429|M.tuberculosis_H37Rv --------------VGDGLRGFRASLKQAERVKALALAGGARPGGRVMFY
Mflv_5015|M.gilvum_PYR-GCK --------------LAGGLASLARSIPQIGI----ETDLDDT---RLADH
TH_4203|M.thermoresistible__bu --------------LSGGLASLAQSVGQLDIGVDIEVDLAET---RLPDH
Mvan_1604|M.vanbaalenii_PYR-1 LRAAGRAVTFGVSQPVSAPAELAGALAEAREAMAIGSGLDNPNGVFTLDD
MSMEG_6492|M.smegmatis_MC2_155 SADR----QATVAVGPGDVASHRESYQTAKGALQVAIMSGRTAAVVGLDD
MAV_2195|M.avium_104 ---------------PTAPMLTAAYHSASEAISGMNAVGGWRGAPRPVLA
MAB_1391|M.abscessus_ATCC_1997 --------------EAADPAEIAAAADEARELALLALRLGRAPGAYRLSD
Mb1464|M.bovis_AF2122/97 DDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRS
Rv1429|M.tuberculosis_H37Rv DDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRS
Mflv_5015|M.gilvum_PYR-GCK IELALYRIAQECLQNVVKHARASAARLTFAVDDN-----TARLEIADDGV
TH_4203|M.thermoresistible__bu IELALYRIAQECLQNVVKHARARTARLTYAVDRGEHG-EVARLEIVDDGV
Mvan_1604|M.vanbaalenii_PYR-1 VGHHLLLMRVSGVDSIRDRYATAIARIAEYDRVKGTELLETLSVFLHYRS
MSMEG_6492|M.smegmatis_MC2_155 LGIAGLLLRINDPAALSTFARRTLAPILDYDHAHRTELLVTLRAYLECRQ
MAV_2195|M.avium_104 RELLPERALMGDASAIVALHTDVMGPLAD----AGPTLIETLDAFLDSGG
MAB_1391|M.abscessus_ATCC_1997 LLLEYQITRPGRARDLLAATVQPLA--------AHPHLQQALSAYLQHEH
: .
Mb1464|M.bovis_AF2122/97 -YVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWM
Rv1429|M.tuberculosis_H37Rv -YVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWM
Mflv_5015|M.gilvum_PYR-GCK -GFDTFEHPLGSDEMGGYGLLSMAERAEIVGGRLNIRSRPGSGTTVTATI
TH_4203|M.thermoresistible__bu -GFDTFEHPLGGDDMSGYGLLSMAERAEIVGGRLNIRSRPGAGTAVIATI
Mvan_1604|M.vanbaalenii_PYR-1 -QSAASRELYVHRNTLNQRLTRASTLSDVDVLEPSEWFPLQLALKVHQSR
MSMEG_6492|M.smegmatis_MC2_155 ERSATATRLVIHPNTVAQRLRRIESLCSVTLTDPAVILQFSAALTVYDIA
MAV_2195|M.avium_104 AIEACARKLFVHPNTVRYRLKRITDFTGRDPMQPRDAYVLRVAATVGQLN
MAB_1391|M.abscessus_ATCC_1997 GRQLAAKSLHVHPNTLDYRLRRVAELTGLDPAQPSAARTLAAALLAVKAR
: : . .
Mb1464|M.bovis_AF2122/97 APAVLRAKQ---------------------
Rv1429|M.tuberculosis_H37Rv APAVLRAKQ---------------------
Mflv_5015|M.gilvum_PYR-GCK PLHQGGA-----------------------
TH_4203|M.thermoresistible__bu PLPPATR-----------------------
Mvan_1604|M.vanbaalenii_PYR-1 AGMPTGEPRRPQTYPEPRDGSG--------
MSMEG_6492|M.smegmatis_MC2_155 ALD---------------------------
MAV_2195|M.avium_104 YPTHPPSAAGAAMPAVPLPVNGAARGQSGG
MAB_1391|M.abscessus_ATCC_1997 ------------------------------